3v4x - Revision history

OCA at 14:17, 14 March 2024

2024-03-14T14:17:58Z

←Older revision		Revision as of 14:17, 14 March 2024
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	<StructureSection load='3v4x' size='340' side='right'caption='[[3v4x]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3v4x' size='340' side='right'caption='[[3v4x]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v4x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V4X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v4x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V4X FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=F24:(7R,12R,13R)~~-~~13-FORMYL-12~~,~~14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECA-2,4-DIENOIC+ACID'>F24</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.952Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3v4n\|3v4n]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F24:(7R,12R,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECA-2,4-DIENOIC+ACID'>F24</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>mvaS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1351~~ "~~Enterococcus proteiformis~~" ~~Thiercelin and Jouhaud 1903])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydroxymethylglutaryl~~-~~CoA_synthase Hydroxymethylglutaryl~~-~~CoA synthase]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.~~3~~.3.10~~ 2~~.3.3.10]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4x OCA], [https://pdbe.org/3v4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v4x RCSB], [https://www.ebi.ac.uk/pdbsum/3v4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4x OCA], [https://pdbe.org/3v4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v4x RCSB], [https://www.ebi.ac.uk/pdbsum/3v4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4x ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/HMGCS_ENTFL HMGCS_ENTFL] Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds.<ref>PMID:12107122</ref> <ref>PMID:23794621</ref>
-	~~Hymeglusin (1233A, F244, L~~-~~659~~-~~699) is established as a specific beta~~-~~lactone inhibitor of eukaryotic hydroxymethylglutaryl~~-CoA ~~synthase~~ (~~HMGCS). Inhibition results from formation of a thioester adduct to the active site cysteine. In contrast, the effects of hymeglusin on bacterial~~ HMG-CoA ~~synthase, mvaS, have been minimally characterized~~. ~~Hymeglusin blocks growth of Enterococcus faecalis. After removal of~~ the ~~inhibitor from culture media, a growth curve inflection point at 3.1 h is observed~~ (~~vs 0.7 h for the uninhibited control~~). Upon hymeglusin inactivation of purified E. faecalis mvaS, the thioester adduct is more stable than that measured for human HMGCS. Hydroxylamine cleaves the thioester adduct; substantial enzyme activity is restored at a rate that is 8-fold faster for human HMGCS than for mvaS. Structural results explain these differences in enzyme-inhibitor thioester adduct stability and solvent accessibility. The E. faecalis mvaS-hymeglusin cocrystal structure (~~1.95 A~~) ~~reveals virtually complete occlusion of the bound inhibitor in a narrow tunnel that is largely sequestered from bulk solvent. In contrast~~, ~~eukaryotic (Brassica juncea) HMGCS binds hymeglusin in~~ a ~~more solvent-exposed cavity.~~	+
-		+
-	~~Biochemical and structural basis~~ for ~~inhibition~~ of ~~Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin~~.~~,Skaff DA, Ramyar KX, McWhorter WJ, Barta ML, Geisbrecht BV, Miziorko HM Biochemistry. 2012 Jun 12;51(23):4713-22. doi: 10.1021/bi300037k. Epub 2012 May, 25. PMID:22510038~~<ref>PMID:~~22510038~~</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.~~<br>	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3v4x" style="background-color~~:~~#fffaf0;">~~</~~div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Enterococcus ~~proteiformis thiercelin and jouhaud 1903]]~~	+	[[Category: Enterococcus faecalis]]
-	~~[[Category: Hydroxymethylglutaryl-CoA synthase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Geisbrecht~~, B V~~]]	+	[[Category: Geisbrecht BV]]
-	[[Category: McWhorter~~, W J~~]]	+	[[Category: McWhorter WJ]]
-	[[Category: Miziorko~~, H M~~]]	+	[[Category: Miziorko HM]]
-	[[Category: Ramyar~~, K X~~]]	+	[[Category: Ramyar KX]]
-	[[Category: Skaff~~, D A]]~~	+	[[Category: Skaff DA]]
-	~~[[Category: Hydroxymethylglutaryl-coa synthase]]~~	+
-	~~[[Category: Hymeglusin covalent adduct]]~~	+
-	~~[[Category: Transferase-inhibitor complex~~]]	+

OCA at 08:31, 20 July 2022

2022-07-20T08:31:22Z

←Older revision		Revision as of 08:31, 20 July 2022
Line 1:		Line 1:

	==The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin==		==The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin==
-	<StructureSection load='3v4x' size='340' side='right' caption='[[3v4x]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3v4x' size='340' side='right'caption='[[3v4x]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v4x]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V4X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v4x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V4X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F24:(7R,12R,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECA-2,4-DIENOIC+ACID'>F24</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F24:(7R,12R,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECA-2,4-DIENOIC+ACID'>F24</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v4n\|3v4n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v4n\|3v4n]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4x OCA], [~~http~~://pdbe.org/3v4x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v4x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v4x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4x OCA], [https://pdbe.org/3v4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v4x RCSB], [https://www.ebi.ac.uk/pdbsum/3v4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4x ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]		[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
	[[Category: Hydroxymethylglutaryl-CoA synthase]]		[[Category: Hydroxymethylglutaryl-CoA synthase]]
		+	[[Category: Large Structures]]
	[[Category: Geisbrecht, B V]]		[[Category: Geisbrecht, B V]]
	[[Category: McWhorter, W J]]		[[Category: McWhorter, W J]]

OCA at 19:05, 11 August 2016

2016-08-11T19:05:07Z

←Older revision		Revision as of 19:05, 11 August 2016
Line 1:		Line 1:
		+
	==The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin==		==The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin==
	<StructureSection load='3v4x' size='340' side='right' caption='[[3v4x]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3v4x' size='340' side='right' caption='[[3v4x]], [[Resolution\|resolution]] 1.95Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v4x RCSB], [http://www.ebi.ac.uk/pdbsum/3v4x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4x OCA], [http://pdbe.org/3v4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v4x RCSB], [http://www.ebi.ac.uk/pdbsum/3v4x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4x ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3v4x" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:23, 20 January 2015

2015-01-20T09:23:58Z

←Older revision		Revision as of 09:23, 20 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3v4x\| PDB=3v4x \| SCENE= }}~~	+	==The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin==
-	===The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin===	+	<StructureSection load='3v4x' size='340' side='right' caption='[[3v4x]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22510038}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v4x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F24:(7R,12R,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECA-2,4-DIENOIC+ACID'>F24</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v4n\|3v4n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v4x RCSB], [http://www.ebi.ac.uk/pdbsum/3v4x PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hymeglusin (1233A, F244, L-659-699) is established as a specific beta-lactone inhibitor of eukaryotic hydroxymethylglutaryl-CoA synthase (HMGCS). Inhibition results from formation of a thioester adduct to the active site cysteine. In contrast, the effects of hymeglusin on bacterial HMG-CoA synthase, mvaS, have been minimally characterized. Hymeglusin blocks growth of Enterococcus faecalis. After removal of the inhibitor from culture media, a growth curve inflection point at 3.1 h is observed (vs 0.7 h for the uninhibited control). Upon hymeglusin inactivation of purified E. faecalis mvaS, the thioester adduct is more stable than that measured for human HMGCS. Hydroxylamine cleaves the thioester adduct; substantial enzyme activity is restored at a rate that is 8-fold faster for human HMGCS than for mvaS. Structural results explain these differences in enzyme-inhibitor thioester adduct stability and solvent accessibility. The E. faecalis mvaS-hymeglusin cocrystal structure (1.95 A) reveals virtually complete occlusion of the bound inhibitor in a narrow tunnel that is largely sequestered from bulk solvent. In contrast, eukaryotic (Brassica juncea) HMGCS binds hymeglusin in a more solvent-exposed cavity.

-	~~==About this Structure==~~	+	Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.,Skaff DA, Ramyar KX, McWhorter WJ, Barta ML, Geisbrecht BV, Miziorko HM Biochemistry. 2012 Jun 12;51(23):4713-22. doi: 10.1021/bi300037k. Epub 2012 May, 25. PMID:22510038<ref>PMID:22510038</ref>
-	~~[[3v4x]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3V4X OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:022510038</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]		[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
	[[Category: Hydroxymethylglutaryl-CoA synthase]]		[[Category: Hydroxymethylglutaryl-CoA synthase]]
-	[[Category: Geisbrecht, B V.]]	+	[[Category: Geisbrecht, B V]]
-	[[Category: McWhorter, W J.]]	+	[[Category: McWhorter, W J]]
-	[[Category: Miziorko, H M.]]	+	[[Category: Miziorko, H M]]
-	[[Category: Ramyar, K X.]]	+	[[Category: Ramyar, K X]]
-	[[Category: Skaff, D A.]]	+	[[Category: Skaff, D A]]
	[[Category: Hydroxymethylglutaryl-coa synthase]]		[[Category: Hydroxymethylglutaryl-coa synthase]]
	[[Category: Hymeglusin covalent adduct]]		[[Category: Hymeglusin covalent adduct]]
	[[Category: Transferase-inhibitor complex]]		[[Category: Transferase-inhibitor complex]]

OCA at 08:22, 27 November 2013

2013-11-27T08:22:20Z

←Older revision		Revision as of 08:22, 27 November 2013
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	{{STRUCTURE_3v4x\| PDB=3v4x \| SCENE= }}		{{STRUCTURE_3v4x\| PDB=3v4x \| SCENE= }}
-
	===The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin===		===The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin===
		+	{{ABSTRACT_PUBMED_22510038}}

		+	==About this Structure==
		+	[[3v4x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4X OCA].

-	==~~About this Structure~~==	+	==Reference==
-	~~[[3v4x]] is a 4 chain structure with sequence from [http~~://~~en.wikipedia.org~~/~~wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4X OCA].~~	+	<ref group="xtra">PMID:022510038</ref><references group="xtra"/><references/>
-	[[Category: Enterococcus ~~faecalis~~]]	+	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
	[[Category: Hydroxymethylglutaryl-CoA synthase]]		[[Category: Hydroxymethylglutaryl-CoA synthase]]
	[[Category: Geisbrecht, B V.]]		[[Category: Geisbrecht, B V.]]

OCA at 09:23, 25 April 2012

2012-04-25T09:23:29Z

←Older revision		Revision as of 09:23, 25 April 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:3v4x.jpg\|left\|200px]]

-	The ~~entry 3v4x~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3v4x", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3v4x\| PDB=3v4x \| SCENE= }}

-	~~Authors: Skaff~~, ~~D.A.~~, ~~Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V., Miziorko, H.M.~~	+	===The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin===

-	~~Description~~: ~~The Biochemical and Structural Basis for Inhibition of~~ Enterococcus faecalis ~~HMG~~-CoA ~~Synthase~~, ~~mvaS~~, by Hymeglusin	+
		+	==About this Structure==
		+	[[3v4x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4X OCA].
		+	[[Category: Enterococcus faecalis]]
		+	[[Category: Hydroxymethylglutaryl-CoA synthase]]
		+	[[Category: Geisbrecht, B V.]]
		+	[[Category: McWhorter, W J.]]
		+	[[Category: Miziorko, H M.]]
		+	[[Category: Ramyar, K X.]]
		+	[[Category: Skaff, D A.]]
		+	[[Category: Hydroxymethylglutaryl-coa synthase]]
		+	[[Category: Hymeglusin covalent adduct]]
		+	[[Category: Transferase-inhibitor complex]]

OCA at 07:04, 21 March 2012

2012-03-21T07:04:54Z

←Older revision		Revision as of 07:04, 21 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v4x is ON HOLD	+	The entry 3v4x is ON HOLD until Paper Publication

	Authors: Skaff, D.A., Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V., Miziorko, H.M.		Authors: Skaff, D.A., Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V., Miziorko, H.M.

	Description: The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin		Description: The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin

OCA: Protected "3v4x" [edit=sysop:move=sysop]

2011-12-28T06:50:47Z

Protected "3v4x" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:50, 28 December 2011

OCA: New page: '''Unreleased structure''' The entry 3v4x is ON HOLD Authors: Skaff, D.A., Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V., Miziorko, H.M. Description: The Biochemical and Structural B...

2011-12-28T06:50:46Z

New page: '''Unreleased structure''' The entry 3v4x is ON HOLD Authors: Skaff, D.A., Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V., Miziorko, H.M. Description: The Biochemical and Structural B...

New page

'''Unreleased structure'''

The entry 3v4x is ON HOLD

Authors: Skaff, D.A., Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V., Miziorko, H.M.

Description: The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin