3v60 - Revision history

OCA at 14:19, 14 March 2024

2024-03-14T14:19:02Z

←Older revision		Revision as of 14:19, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3v60' size='340' side='right'caption='[[3v60]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3v60' size='340' side='right'caption='[[3v60]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V60 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3v61\|3v61]]~~, [[~~3v62~~\|~~3v62~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~D9719.15, SMT3, YDR510W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=559292 Baker~~'~~s yeast]), POL30, YBR0811, YBR088C ([https:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [https://pdbe.org/3v60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [https://www.ebi.ac.uk/pdbsum/3v60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v60 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [https://pdbe.org/3v60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [https://www.ebi.ac.uk/pdbsum/3v60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v60 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations. [[https://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>	+	[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers such as SUMO (also known as Smt3 in Saccharomyces cerevisiae) mediate signal transduction through post-translational modification of substrate proteins in pathways that control differentiation, apoptosis and the cell cycle, and responses to stress such as the DNA damage response. In yeast, the proliferating cell nuclear antigen PCNA (also known as Pol30) is modified by ubiquitin in response to DNA damage and by SUMO during S phase. Whereas Ub-PCNA can signal for recruitment of translesion DNA polymerases, SUMO-PCNA signals for recruitment of the anti-recombinogenic DNA helicase Srs2. It remains unclear how receptors such as Srs2 specifically recognize substrates after conjugation to Ub and Ubls. Here we show, through structural, biochemical and functional studies, that the Srs2 carboxy-terminal domain harbours tandem receptor motifs that interact independently with PCNA and SUMO and that both motifs are required to recognize SUMO-PCNA specifically. The mechanism presented is pertinent to understanding how other receptors specifically recognize Ub- and Ubl-modified substrates to facilitate signal transduction.	+
-		+
-	Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2.,Armstrong AA, Mohideen F, Lima CD Nature. 2012 Feb 29;483(7387):59-63. doi: 10.1038/nature10883. PMID:22382979<ref>PMID:22382979</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3v60" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Proliferating cell nuclear antigen 3D structures\|Proliferating cell nuclear antigen 3D structures]]		*[[Proliferating cell nuclear antigen 3D structures\|Proliferating cell nuclear antigen 3D structures]]
	*[[SUMO 3D Structures\|SUMO 3D Structures]]		*[[SUMO 3D Structures\|SUMO 3D Structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Armstrong, A A~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Lima, C D~~]]	+	[[Category: Armstrong AA]]
-	[[Category: ~~Mohideen, F~~]]	+	[[Category: Lima CD]]
-	[[Category: ~~Nuclear]]~~	+	[[Category: Mohideen F]]
-	~~[[Category: Post-translational modification dna replication dna damage response]]~~	+
-	~~[[Category: Protein binding-dna binding protein complex]]~~	+
-	~~[[Category: Srs2]]~~	+
-	~~[[Category: Ubiquitin-like protein pcna~~]]	+

OCA at 08:33, 20 July 2022

2022-07-20T08:33:54Z

←Older revision		Revision as of 08:33, 20 July 2022
Line 1:		Line 1:

	==Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164==		==Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164==
-	<StructureSection load='3v60' size='340' side='right' caption='[[3v60]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3v60' size='340' side='right'caption='[[3v60]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v60]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V60 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v61\|3v61]], [[3v62\|3v62]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v61\|3v61]], [[3v62\|3v62]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9719.15, SMT3, YDR510W ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), POL30, YBR0811, YBR088C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9719.15, SMT3, YDR510W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), POL30, YBR0811, YBR088C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [~~http~~://pdbe.org/3v60 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v60 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v60 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [https://pdbe.org/3v60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [https://www.ebi.ac.uk/pdbsum/3v60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v60 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations. [[~~http~~://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>	+	[[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations. [[https://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3v60" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3v60" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Proliferating cell nuclear antigen 3D structures\|Proliferating cell nuclear antigen 3D structures]]
		+	*[[SUMO 3D Structures\|SUMO 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Armstrong, A A]]		[[Category: Armstrong, A A]]
	[[Category: Lima, C D]]		[[Category: Lima, C D]]

OCA at 10:13, 8 November 2017

2017-11-08T10:13:10Z

←Older revision		Revision as of 10:13, 8 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3v60" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3v60" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]
-	*[[SUMO\|SUMO]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:12, 4 August 2016

2016-08-04T13:12:55Z

←Older revision		Revision as of 13:12, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164==		==Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164==
	<StructureSection load='3v60' size='340' side='right' caption='[[3v60]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3v60' size='340' side='right' caption='[[3v60]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V60 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v61\|3v61]], [[3v62\|3v62]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v61\|3v61]], [[3v62\|3v62]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9719.15, SMT3, YDR510W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~]), POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9719.15, SMT3, YDR510W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [http://www.ebi.ac.uk/pdbsum/3v60 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [http://pdbe.org/3v60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [http://www.ebi.ac.uk/pdbsum/3v60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v60 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3v60" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae s288c~~]]	+	[[Category: Baker's yeast]]
	[[Category: Armstrong, A A]]		[[Category: Armstrong, A A]]
	[[Category: Lima, C D]]		[[Category: Lima, C D]]

OCA at 14:54, 24 December 2014

2014-12-24T14:54:42Z

←Older revision		Revision as of 14:54, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [http://www.ebi.ac.uk/pdbsum/3v60 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [http://www.ebi.ac.uk/pdbsum/3v60 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations. [[http://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:33, 21 December 2014

2014-12-21T07:33:44Z

←Older revision		Revision as of 07:33, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3v60\| PDB=3v60 \| SCENE= }}~~	+	==Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164==
-	===Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164===	+	<StructureSection load='3v60' size='340' side='right' caption='[[3v60]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22382979}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V60 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v61\|3v61]], [[3v62\|3v62]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D9719.15, SMT3, YDR510W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [http://www.ebi.ac.uk/pdbsum/3v60 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers such as SUMO (also known as Smt3 in Saccharomyces cerevisiae) mediate signal transduction through post-translational modification of substrate proteins in pathways that control differentiation, apoptosis and the cell cycle, and responses to stress such as the DNA damage response. In yeast, the proliferating cell nuclear antigen PCNA (also known as Pol30) is modified by ubiquitin in response to DNA damage and by SUMO during S phase. Whereas Ub-PCNA can signal for recruitment of translesion DNA polymerases, SUMO-PCNA signals for recruitment of the anti-recombinogenic DNA helicase Srs2. It remains unclear how receptors such as Srs2 specifically recognize substrates after conjugation to Ub and Ubls. Here we show, through structural, biochemical and functional studies, that the Srs2 carboxy-terminal domain harbours tandem receptor motifs that interact independently with PCNA and SUMO and that both motifs are required to recognize SUMO-PCNA specifically. The mechanism presented is pertinent to understanding how other receptors specifically recognize Ub- and Ubl-modified substrates to facilitate signal transduction.

-	~~==Function==~~	+	Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2.,Armstrong AA, Mohideen F, Lima CD Nature. 2012 Feb 29;483(7387):59-63. doi: 10.1038/nature10883. PMID:22382979<ref>PMID:22382979</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known~~; ~~suppressor of MIF2 mutations~~. ~~[[http~~:~~//www~~.~~uniprot.org~~/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. ~~Involved in DNA repair.<ref>~~PMID:~~11545742</ref>~~ <ref>PMID:~~12226657~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3v60]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]		*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]
	*[[SUMO\|SUMO]]		*[[SUMO\|SUMO]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
-	[[Category: Armstrong, A A.]]	+	[[Category: Armstrong, A A]]
-	[[Category: Lima, C D.]]	+	[[Category: Lima, C D]]
-	[[Category: Mohideen, F.]]	+	[[Category: Mohideen, F]]
	[[Category: Nuclear]]		[[Category: Nuclear]]
	[[Category: Post-translational modification dna replication dna damage response]]		[[Category: Post-translational modification dna replication dna damage response]]

OCA at 00:21, 4 April 2013

2013-04-04T00:21:24Z

←Older revision		Revision as of 00:21, 4 April 2013
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-	[[Image:3v60.png\|left\|200px]]
-
	{{STRUCTURE_3v60\| PDB=3v60 \| SCENE= }}		{{STRUCTURE_3v60\| PDB=3v60 \| SCENE= }}
-
	===Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164===		===Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164===
		+	{{ABSTRACT_PUBMED_22382979}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations. [[http://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>

	==About this Structure==		==About this Structure==
-	[[3v60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae~~ Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA].	+	[[3v60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA].

	==See Also==		==See Also==
	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]		*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]
	*[[SUMO\|SUMO]]		*[[SUMO\|SUMO]]
-	[[Category: Saccharomyces cerevisiae]]	+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Armstrong, A A.]]		[[Category: Armstrong, A A.]]
	[[Category: Lima, C D.]]		[[Category: Lima, C D.]]

OCA at 06:34, 20 October 2012

2012-10-20T06:34:08Z

←Older revision		Revision as of 06:34, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3v60]] is a 2 chain structure ~~of [[Proliferating Cell Nuclear Antigen]] and [[SUMO]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA].	+	[[3v60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA].

	==See Also==		==See Also==

OCA at 13:36, 25 July 2012

2012-07-25T13:36:20Z

←Older revision		Revision as of 13:36, 25 July 2012
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	[[Image:3v60.png\|left\|200px]]		[[Image:3v60.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3v60", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3v60\| PDB=3v60 \| SCENE= }}		{{STRUCTURE_3v60\| PDB=3v60 \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3v60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA].	+	[[3v60]] is a 2 chain structure of [[Proliferating Cell Nuclear Antigen]] and [[SUMO]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA].
		+
		+	==See Also==
		+	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]
		+	*[[SUMO\|SUMO]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Armstrong, A A.]]		[[Category: Armstrong, A A.]]

OCA at 05:03, 8 March 2012

2012-03-08T05:03:19Z

←Older revision		Revision as of 05:03, 8 March 2012
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-	[[Image:3v60.~~jpg~~\|left\|200px]]	+	[[Image:3v60.png\|left\|200px]]

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