3v6f - Revision history

OCA at 08:35, 20 July 2022

2022-07-20T08:35:01Z

←Older revision		Revision as of 08:35, 20 July 2022
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	==Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound==		==Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound==
-	<StructureSection load='3v6f' size='340' side='right' caption='[[3v6f]], [[Resolution\|resolution]] 2.52Å' scene=''>	+	<StructureSection load='3v6f' size='340' side='right'caption='[[3v6f]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v6f]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v6f]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6F FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6z\|3v6z]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v6z\|3v6z]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6f OCA], [~~http~~://pdbe.org/3v6f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v6f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v6f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6f OCA], [https://pdbe.org/3v6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6f RCSB], [https://www.ebi.ac.uk/pdbsum/3v6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6f ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dimattia, M A]]		[[Category: Dimattia, M A]]

OCA at 19:07, 10 December 2016

2016-12-10T19:07:07Z

←Older revision		Revision as of 19:07, 10 December 2016
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		+
	==Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound==		==Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound==
	<StructureSection load='3v6f' size='340' side='right' caption='[[3v6f]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='3v6f' size='340' side='right' caption='[[3v6f]], [[Resolution\|resolution]] 2.52Å' scene=''>
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	<table><tr><td colspan='2'>[[3v6f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[3v6f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6F FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6z\|3v6z]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6z\|3v6z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6f RCSB], [http://www.ebi.ac.uk/pdbsum/3v6f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6f OCA], [http://pdbe.org/3v6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v6f RCSB], [http://www.ebi.ac.uk/pdbsum/3v6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6f ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3v6f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:41, 9 December 2014

2014-12-09T17:41:23Z

←Older revision		Revision as of 17:41, 9 December 2014
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-	[[~~Image:~~3v6f.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound==
		+	<StructureSection load='3v6f' size='340' side='right' caption='[[3v6f]], [[Resolution\|resolution]] 2.52Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v6f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6F FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6z\|3v6z]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6f RCSB], [http://www.ebi.ac.uk/pdbsum/3v6f PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chronic hepatitis B virus (HBV) infection afflicts millions worldwide with cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease severity, is a nonparticulate variant of the protein (core antigen, HBcAg) that forms the building-blocks of capsids. HBeAg is not required for virion production, but is implicated in establishing immune tolerance and chronic infection. Here, we report the crystal structure of HBeAg, which clarifies how the short N-terminal propeptide of HBeAg induces a radically altered mode of dimerization relative to HBcAg ( approximately 140 degrees rotation), locked into place through formation of intramolecular disulfide bridges. This structural switch precludes capsid assembly and engenders a distinct antigenic repertoire, explaining why the two antigens are cross-reactive at the T cell level (through sequence identity) but not at the B cell level (through conformation). The structure offers insight into how HBeAg may establish immune tolerance for HBcAg while evading its robust immunogenicity.

-	~~{{STRUCTURE_3v6f\| PDB=3v6f \| SCENE= }}~~	+	Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.,Dimattia MA, Watts NR, Stahl SJ, Grimes JM, Steven AC, Stuart DI, Wingfield PT Structure. 2013 Jan 8;21(1):133-42. doi: 10.1016/j.str.2012.10.017. Epub 2012 Dec, 6. PMID:23219881<ref>PMID:23219881</ref>

-	~~===Crystal Structure~~ of ~~an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23219881}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3v6f]] is a 8 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6F OCA].~~	+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Dimattia, M A.]]	+	[[Category: Dimattia, M A]]
-	[[Category: Grimes, J M.]]	+	[[Category: Grimes, J M]]
-	[[Category: Stahl, S J.]]	+	[[Category: Stahl, S J]]
-	[[Category: Steven, A C.]]	+	[[Category: Steven, A C]]
-	[[Category: Stuart, D I.]]	+	[[Category: Stuart, D I]]
-	[[Category: Watts, N R.]]	+	[[Category: Watts, N R]]
-	[[Category: Wingfield, P T.]]	+	[[Category: Wingfield, P T]]
	[[Category: Antibody fab fragment]]		[[Category: Antibody fab fragment]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin domain]]		[[Category: Immunoglobulin domain]]

OCA at 12:54, 6 February 2013

2013-02-06T12:54:17Z

←Older revision		Revision as of 12:54, 6 February 2013
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-	~~'''Unreleased structure'''~~	+	[[Image:3v6f.jpg\|left\|200px]]

-	~~The entry~~ 3v6f ~~is ON HOLD~~	+	{{STRUCTURE_3v6f\| PDB=3v6f \| SCENE= }}

-	~~Authors: Dimattia~~, ~~M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.~~	+	===Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound===

-	~~Description: Crystal~~ Structure ~~of an anti~~-~~HBV e-antigen monoclonal Fab fragment (e6)~~, ~~unbound~~	+	{{ABSTRACT_PUBMED_23219881}}
		+
		+	==About this Structure==
		+	[[3v6f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6F OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Dimattia, M A.]]
		+	[[Category: Grimes, J M.]]
		+	[[Category: Stahl, S J.]]
		+	[[Category: Steven, A C.]]
		+	[[Category: Stuart, D I.]]
		+	[[Category: Watts, N R.]]
		+	[[Category: Wingfield, P T.]]
		+	[[Category: Antibody fab fragment]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin domain]]

OCA at 06:51, 1 February 2012

2012-02-01T06:51:17Z

←Older revision		Revision as of 06:51, 1 February 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v6f is ON HOLD ~~until sometime in the future~~	+	The entry 3v6f is ON HOLD

-	Authors: ~~DiMattia~~, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.	+	Authors: Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.

	Description: Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound		Description: Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound

OCA at 10:18, 18 January 2012

2012-01-18T10:18:00Z

←Older revision		Revision as of 10:18, 18 January 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v6f is ON HOLD	+	The entry 3v6f is ON HOLD until sometime in the future

	Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.		Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.

	Description: Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound		Description: Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound

OCA: Protected "3v6f" [edit=sysop:move=sysop]

2011-12-28T06:52:25Z

Protected "3v6f" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 28 December 2011

OCA: New page: '''Unreleased structure''' The entry 3v6f is ON HOLD Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. Description: Crystal S...

2011-12-28T06:52:24Z

New page: '''Unreleased structure''' The entry 3v6f is ON HOLD Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. Description: Crystal S...

New page

'''Unreleased structure'''

The entry 3v6f is ON HOLD

Authors: DiMattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.

Description: Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound