3v6m - Revision history

OCA at 12:16, 8 November 2023

2023-11-08T12:16:48Z

←Older revision		Revision as of 12:16, 8 November 2023
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	<StructureSection load='3v6m' size='340' side='right'caption='[[3v6m]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='3v6m' size='340' side='right'caption='[[3v6m]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6M FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3v6l\|3v6l]], [[3nr2\|3nr2]], [[3od5\|3od5]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.692Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">CASP6 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [https://pdbe.org/3v6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [https://www.ebi.ac.uk/pdbsum/3v6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [https://pdbe.org/3v6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [https://www.ebi.ac.uk/pdbsum/3v6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.	+	[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-6]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cao, Q]]	+	[[Category: Cao Q]]
-	[[Category: Li~~, L F~~]]	+	[[Category: Li LF]]
-	[[Category: Liu~~, D F~~]]	+	[[Category: Liu DF]]
-	[[Category: Su~~, X D~~]]	+	[[Category: Su XD]]
-	[[Category: Wang~~, X J]]~~	+	[[Category: Wang XJ]]
-	~~[[Category: Caspase domain]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:35, 20 July 2022

2022-07-20T08:35:48Z

←Older revision		Revision as of 08:35, 20 July 2022
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	==Inhibition of caspase-6 activity by single mutation outside the active site==		==Inhibition of caspase-6 activity by single mutation outside the active site==
-	<StructureSection load='3v6m' size='340' side='right' caption='[[3v6m]], [[Resolution\|resolution]] 2.69Å' scene=''>	+	<StructureSection load='3v6m' size='340' side='right'caption='[[3v6m]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6M FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6l\|3v6l]], [[3nr2\|3nr2]], [[3od5\|3od5]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v6l\|3v6l]], [[3nr2\|3nr2]], [[3od5\|3od5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [~~http~~://pdbe.org/3v6m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v6m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [https://pdbe.org/3v6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [https://www.ebi.ac.uk/pdbsum/3v6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.	+	[[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Caspase\|Caspase]]	+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	[[Category: Caspase-6]]		[[Category: Caspase-6]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cao, Q]]		[[Category: Cao, Q]]
	[[Category: Li, L F]]		[[Category: Li, L F]]

OCA at 18:43, 4 August 2016

2016-08-04T18:43:05Z

←Older revision		Revision as of 18:43, 4 August 2016
Line 1:		Line 1:
		+
	==Inhibition of caspase-6 activity by single mutation outside the active site==		==Inhibition of caspase-6 activity by single mutation outside the active site==
	<StructureSection load='3v6m' size='340' side='right' caption='[[3v6m]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='3v6m' size='340' side='right' caption='[[3v6m]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6M FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6l\|3v6l]], [[3nr2\|3nr2]], [[3od5\|3od5]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6l\|3v6l]], [[3nr2\|3nr2]], [[3od5\|3od5]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [http://www.ebi.ac.uk/pdbsum/3v6m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [http://pdbe.org/3v6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [http://www.ebi.ac.uk/pdbsum/3v6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3v6m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Caspase-6]]		[[Category: Caspase-6]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cao, Q]]		[[Category: Cao, Q]]
	[[Category: Li, L F]]		[[Category: Li, L F]]

OCA at 12:03, 25 December 2014

2014-12-25T12:03:23Z

←Older revision		Revision as of 12:03, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [http://www.ebi.ac.uk/pdbsum/3v6m PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [http://www.ebi.ac.uk/pdbsum/3v6m PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:28, 9 December 2014

2014-12-09T17:28:47Z

←Older revision		Revision as of 17:28, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3v6m.~~png~~\|~~left~~\|~~200px~~]]	+	==Inhibition of caspase-6 activity by single mutation outside the active site==
		+	<StructureSection load='3v6m' size='340' side='right' caption='[[3v6m]], [[Resolution\|resolution]] 2.69Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6M FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v6l\|3v6l]], [[3nr2\|3nr2]], [[3od5\|3od5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6m RCSB], [http://www.ebi.ac.uk/pdbsum/3v6m PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The apoptotic effector caspase-6 (CASP6) has been clearly identified as a drug target due to its strong association with neurodegeneration and axonal pruning events as well as its crucial roles in Huntington disease and Alzheimer disease. CASP6 activity is suppressed by ARK5-mediated phosphorylation at Ser(257) with an unclear mechanism. In this work, we solved crystal structures of DeltaproCASP6S257E and p20/p10S257E, which mimicked the phosphorylated CASP6 zymogen and activated CASP6, respectively. The structural investigation combined with extensive biochemical assay and molecular dynamics simulation studies revealed that phosphorylation on Ser(257) inhibited self-activation of CASP6 zymogen by "locking" the enzyme in the TEVD(193)-bound "inhibited state." The structural and biochemical results also showed that phosphorylation on Ser(257) inhibited the CASP6 activity by steric hindrance. These results disclosed the inhibition mechanism of CASP6 phosphorylation and laid the foundation for a new strategy of rational CASP6 drug design.

-	~~{{STRUCTURE_3v6m\| PDB=3v6m \| SCENE= }}~~	+	Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays.,Cao Q, Wang XJ, Liu CW, Liu DF, Li LF, Gao YQ, Su XD J Biol Chem. 2012 May 4;287(19):15371-9. Epub 2012 Mar 20. PMID:22433863<ref>PMID:22433863</ref>

-	~~===Inhibition~~ of ~~caspase-6 activity by single mutation outside~~ the ~~active site===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22433863}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3v6m]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA].~~	+

	==See Also==		==See Also==
	*[[Caspase\|Caspase]]		*[[Caspase\|Caspase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022433863<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Caspase-6]]		[[Category: Caspase-6]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cao, Q.]]	+	[[Category: Cao, Q]]
-	[[Category: Li, L F.]]	+	[[Category: Li, L F]]
-	[[Category: Liu, D F.]]	+	[[Category: Liu, D F]]
-	[[Category: Su, X D.]]	+	[[Category: Su, X D]]
-	[[Category: Wang, X J.]]	+	[[Category: Wang, X J]]
	[[Category: Caspase domain]]		[[Category: Caspase domain]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 16:27, 20 October 2012

2012-10-20T16:27:04Z

←Older revision		Revision as of 16:27, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3v6m]] is a 8 chain structure ~~of [[Caspase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA].	+	[[3v6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA].

	==See Also==		==See Also==

OCA at 21:43, 26 July 2012

2012-07-26T21:43:38Z

←Older revision		Revision as of 21:43, 26 July 2012
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	[[Image:3v6m.png\|left\|200px]]		[[Image:3v6m.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3v6m", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_3v6m\| PDB=3v6m \| SCENE= }}		{{STRUCTURE_3v6m\| PDB=3v6m \| SCENE= }}

	===Inhibition of caspase-6 activity by single mutation outside the active site===		===Inhibition of caspase-6 activity by single mutation outside the active site===

-
-	<!--
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	{{ABSTRACT_PUBMED_22433863}}		{{ABSTRACT_PUBMED_22433863}}

OCA at 05:25, 13 June 2012

2012-06-13T05:25:12Z

←Older revision		Revision as of 05:25, 13 June 2012
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-	[[Image:3v6m.~~jpg~~\|left\|200px]]	+	[[Image:3v6m.png\|left\|200px]]

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	===Inhibition of caspase-6 activity by single mutation outside the active site===		===Inhibition of caspase-6 activity by single mutation outside the active site===

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		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22433863}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22433863 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22433863}}

	==About this Structure==		==About this Structure==
-	[[3v6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA].	+	[[3v6m]] is a 8 chain structure of [[Caspase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA].
		+
		+	==See Also==
		+	*[[Caspase\|Caspase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022433863</ref><references group="xtra"/>
	[[Category: Caspase-6]]		[[Category: Caspase-6]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 07:51, 28 March 2012

2012-03-28T07:51:33Z

←Older revision		Revision as of 07:51, 28 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3v6m.jpg\|left\|200px]]

-	The ~~entry 3v6m~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3v6m", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3v6m\| PDB=3v6m \| SCENE= }}

-	~~Authors: Cao, Q., Wang, X.J., Liu, D.F., Li, L.F., Su, X.D.~~	+	===Inhibition of caspase-6 activity by single mutation outside the active site===

-	~~Description~~: ~~Inhibition of caspase~~-6 ~~activity by single mutation outside the active site~~	+
		+	==About this Structure==
		+	[[3v6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6M OCA].
		+	[[Category: Caspase-6]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Cao, Q.]]
		+	[[Category: Li, L F.]]
		+	[[Category: Liu, D F.]]
		+	[[Category: Su, X D.]]
		+	[[Category: Wang, X J.]]
		+	[[Category: Caspase domain]]
		+	[[Category: Hydrolase]]

OCA at 06:02, 25 January 2012

2012-01-25T06:02:13Z

←Older revision		Revision as of 06:02, 25 January 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v6m is ON HOLD	+	The entry 3v6m is ON HOLD until Paper Publication

	Authors: Cao, Q., Wang, X.J., Liu, D.F., Li, L.F., Su, X.D.		Authors: Cao, Q., Wang, X.J., Liu, D.F., Li, L.F., Su, X.D.

	Description: Inhibition of caspase-6 activity by single mutation outside the active site		Description: Inhibition of caspase-6 activity by single mutation outside the active site