3vlc - Revision history

OCA at 12:25, 8 November 2023

2023-11-08T12:25:11Z

←Older revision		Revision as of 12:25, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3vlc' size='340' side='right'caption='[[3vlc]], [[Resolution\|resolution]] 4.50Å' scene=''>		<StructureSection load='3vlc' size='340' side='right'caption='[[3vlc]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~] and [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VLC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-5~~-DIPHOSPHATE'>ADP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~GET1, MDM39, YGL020C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=559292 Baker~~'~~s yeast])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [https://pdbe.org/3vlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [https://www.ebi.ac.uk/pdbsum/3vlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vlc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [https://pdbe.org/3vlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [https://www.ebi.ac.uk/pdbsum/3vlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vlc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~GET1_YEAST GET1_YEAST~~]~~] Required~~ for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. ~~Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes~~ and selectively binds the transmembrane domain of TA proteins in the cytosol. ~~The GET~~ complex ~~cooperates~~ with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in ~~mitochondrial distribution~~ and ~~morphology~~.<ref>PMID:~~11907266~~</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:~~21835666~~</ref> <ref>PMID:21719644</ref>	+	[https://www.uniprot.org/uniprot/GET3_YEAST GET3_YEAST] ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.<ref>PMID:12680698</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21866104</ref> <ref>PMID:21719644</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Fukai, S~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Kubota, K~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Yamagata, A~~]]	+	[[Category: Fukai S]]
-	[[Category: ~~Atp binding~~]]	+	[[Category: Kubota K]]
-	[[Category: ~~Atpase]]~~	+	[[Category: Yamagata A]]
-	~~[[Category: Hydrolase-transport protein complex]]~~	+
-	~~[[Category: Membrane protein binding]]~~	+
-	~~[[Category: Membrane protein insertion~~]]	+

OCA at 18:51, 27 July 2022

2022-07-27T18:51:29Z

←Older revision		Revision as of 18:51, 27 July 2022
Line 1:		Line 1:

	==Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution==		==Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution==
-	<StructureSection load='3vlc' size='340' side='right' caption='[[3vlc]], [[Resolution\|resolution]] 4.50Å' scene=''>	+	<StructureSection load='3vlc' size='340' side='right'caption='[[3vlc]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vlc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VLC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GET1, MDM39, YGL020C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GET1, MDM39, YGL020C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [~~http~~://pdbe.org/3vlc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vlc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vlc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [https://pdbe.org/3vlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [https://www.ebi.ac.uk/pdbsum/3vlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vlc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GET1_YEAST GET1_YEAST]] Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology.<ref>PMID:11907266</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21835666</ref> <ref>PMID:21719644</ref>	+	[[https://www.uniprot.org/uniprot/GET1_YEAST GET1_YEAST]] Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology.<ref>PMID:11907266</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21835666</ref> <ref>PMID:21719644</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[ATPase\|ATPase]]	+	*[[ATPase 3D structures\|ATPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Fukai, S]]		[[Category: Fukai, S]]
	[[Category: Kubota, K]]		[[Category: Kubota, K]]

OCA at 06:35, 5 August 2016

2016-08-05T06:35:37Z

←Older revision		Revision as of 06:35, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution==		==Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution==
	<StructureSection load='3vlc' size='340' side='right' caption='[[3vlc]], [[Resolution\|resolution]] 4.50Å' scene=''>		<StructureSection load='3vlc' size='340' side='right' caption='[[3vlc]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~] and [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VLC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GET1, MDM39, YGL020C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GET1, MDM39, YGL020C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [http://www.ebi.ac.uk/pdbsum/3vlc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [http://pdbe.org/3vlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [http://www.ebi.ac.uk/pdbsum/3vlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vlc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3vlc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
-	[[Category: ~~Saccharomyces cerevisiae s288c~~]]	+	[[Category: Baker's yeast]]
	[[Category: Fukai, S]]		[[Category: Fukai, S]]
	[[Category: Kubota, K]]		[[Category: Kubota, K]]

OCA at 16:33, 25 December 2014

2014-12-25T16:33:30Z

←Older revision		Revision as of 16:33, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [http://www.ebi.ac.uk/pdbsum/3vlc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [http://www.ebi.ac.uk/pdbsum/3vlc PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GET1_YEAST GET1_YEAST]] Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology.<ref>PMID:11907266</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21835666</ref> <ref>PMID:21719644</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:29, 21 December 2014

2014-12-21T06:29:15Z

←Older revision		Revision as of 06:29, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3vlc\| PDB=3vlc \| SCENE= }}~~	+	==Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution==
-	===Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution===	+	<StructureSection load='3vlc' size='340' side='right' caption='[[3vlc]], [[Resolution\|resolution]] 4.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22684149}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3vlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VLC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GET1, MDM39, YGL020C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vlc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vlc RCSB], [http://www.ebi.ac.uk/pdbsum/3vlc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tail-anchored (TA) proteins are integral membrane proteins that possess a single transmembrane domain near their carboxy terminus. TA proteins play critical roles in many important cellular processes such as membrane trafficking, protein translocation, and apoptosis. The GET complex mediates posttranslational insertion of newly synthesized TA proteins to the endoplasmic reticulum membrane. The GET complex is composed of the homodimeric Get3 ATPase and its heterooligomeric receptor, Get1/2. During insertion, the Get3 dimer shuttles between open and closed conformational states, coupled with ATP hydrolysis and the binding/release of TA proteins. We report crystal structures of ADP-bound Get3 in complex with the cytoplasmic domain of Get1 (Get1CD) in open and semi-open conformations at 3.0- and 4.5-A resolutions, respectively. Our structures and biochemical data suggest that Get1 uses two interfaces to stabilize the open dimer conformation of Get3. We propose that one interface is sufficient for binding of Get1 by Get3, while the second interface stabilizes the open dimer conformation of Get3.

-	~~==Function==~~	+	Get1 Stabilizes an Open Dimer Conformation of Get3 ATPase by Binding Two Distinct Interfaces.,Kubota K, Yamagata A, Sato Y, Goto-Ito S, Fukai S J Mol Biol. 2012 Jun 7. PMID:22684149<ref>PMID:22684149</ref>
-	~~[[http://www.uniprot.org/uniprot/GET1_YEAST GET1_YEAST]] Required for the post-translational delivery~~ of ~~tail-anchored (TA) proteins to the endoplasmic reticulum~~. ~~Together with GET2~~, ~~acts as a membrane receptor for soluble GET3~~, ~~which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP~~-~~dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER~~. ~~Involved in mitochondrial distribution and morphology~~.~~<ref>~~PMID:~~11907266</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21835666</ref>~~ <ref>PMID:~~21719644~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3vlc]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en~~.~~wikipedia.org~~/~~wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:022684149</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[ATPase\|ATPase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
-	[[Category: Fukai, S.]]	+	[[Category: Fukai, S]]
-	[[Category: Kubota, K.]]	+	[[Category: Kubota, K]]
-	[[Category: Yamagata, A.]]	+	[[Category: Yamagata, A]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	[[Category: Atpase]]		[[Category: Atpase]]

OCA at 15:08, 19 June 2013

2013-06-19T15:08:17Z

←Older revision		Revision as of 15:08, 19 June 2013
Line 1:		Line 1:
-	[[Image:3vlc.jpg\|left\|200px]]
-
	{{STRUCTURE_3vlc\| PDB=3vlc \| SCENE= }}		{{STRUCTURE_3vlc\| PDB=3vlc \| SCENE= }}
-
	===Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution===		===Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution===
		+	{{ABSTRACT_PUBMED_22684149}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/GET1_YEAST GET1_YEAST]] Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology.<ref>PMID:11907266</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21835666</ref> <ref>PMID:21719644</ref>

	==About this Structure==		==About this Structure==
-	[[3vlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA].	+	[[3vlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022684149</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Saccharomyces cerevisiae s288c]]
	[[Category: Fukai, S.]]		[[Category: Fukai, S.]]
	[[Category: Kubota, K.]]		[[Category: Kubota, K.]]

OCA at 07:56, 20 June 2012

2012-06-20T07:56:49Z

←Older revision		Revision as of 07:56, 20 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3vlc.jpg\|left\|200px]]

-	~~The entry~~ 3vlc ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3vlc\| PDB=3vlc \| SCENE= }}

-	~~Authors: Kubota, K~~.~~, Yamagata, A., Fukai, S~~.	+	===Crystal structure of S. cerevisiae Get3 in the semi open conformation in complex with Get1 cytosolic domain at 4.5 angstrom resolution===

-	~~Description~~:	+
		+	==About this Structure==
		+	[[3vlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VLC OCA].
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Fukai, S.]]
		+	[[Category: Kubota, K.]]
		+	[[Category: Yamagata, A.]]
		+	[[Category: Atp binding]]
		+	[[Category: Atpase]]
		+	[[Category: Hydrolase-transport protein complex]]
		+	[[Category: Membrane protein binding]]
		+	[[Category: Membrane protein insertion]]

OCA at 07:22, 22 February 2012

2012-02-22T07:22:59Z

←Older revision		Revision as of 07:22, 22 February 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3vlc is ON HOLD	+	The entry 3vlc is ON HOLD until Paper Publication

	Authors: Kubota, K., Yamagata, A., Fukai, S.		Authors: Kubota, K., Yamagata, A., Fukai, S.

	Description:		Description:

OCA at 06:56, 28 December 2011

2011-12-28T06:56:06Z

←Older revision		Revision as of 06:56, 28 December 2011
Line 5:		Line 5:
	Authors: Kubota, K., Yamagata, A., Fukai, S.		Authors: Kubota, K., Yamagata, A., Fukai, S.

-	Description: ~~crystal structure of protein~~	+	Description:

OCA: Protected "3vlc" [edit=sysop:move=sysop]

2011-12-07T07:42:45Z

Protected "3vlc" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:42, 7 December 2011