3vt5 - Revision history

OCA at 12:36, 8 November 2023

2023-11-08T12:36:53Z

←Older revision		Revision as of 12:36, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3vt5' size='340' side='right'caption='[[3vt5]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='3vt5' size='340' side='right'caption='[[3vt5]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vt5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VT5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vt5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VT5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YI2:(1R,2E,3R,5Z,7E)-17-{(1S)-1-[(2-ETHYL-2-HYDROXYBUTYL)SULFANYL]ETHYL}-2-(2-HYDROXYETHYLIDENE)-9,10-SECOESTRA-5,7,16-TRIENE-1,3-DIOL'>YI2</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.11Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zlc\|2zlc]], [[3vt3\|3vt3]], [[3vt4\|3vt4]], [[3vt6\|3vt6]], [[3vt7\|3vt7]], [[3vt8\|3vt8]], [[3vt9\|3vt9]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YI2:(1R,2E,3R,5Z,7E)-17-{(1S)-1-[(2-ETHYL-2-HYDROXYBUTYL)SULFANYL]ETHYL}-2-(2-HYDROXYETHYLIDENE)-9,10-SECOESTRA-5,7,16-TRIENE-1,3-DIOL'>YI2</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt5 OCA], [https://pdbe.org/3vt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vt5 RCSB], [https://www.ebi.ac.uk/pdbsum/3vt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt5 OCA], [https://pdbe.org/3vt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vt5 RCSB], [https://www.ebi.ac.uk/pdbsum/3vt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>	+	[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ikura, T]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Ito, N]]	+	[[Category: Ikura T]]
-	[[Category: Nakabayashi, M]]	+	[[Category: Ito N]]
-	[[Category: Shimizu, M]]	+	[[Category: Nakabayashi M]]
-	~~[[Category: Hormone receptor]]~~	+	[[Category: Shimizu M]]
-	~~[[Category: Transcription~~]]	+

OCA at 19:02, 27 July 2022

2022-07-27T19:02:53Z

←Older revision		Revision as of 19:02, 27 July 2022
Line 1:		Line 1:

	==Crystal structures of rat VDR-LBD with R270L mutation==		==Crystal structures of rat VDR-LBD with R270L mutation==
-	<StructureSection load='3vt5' size='340' side='right' caption='[[3vt5]], [[Resolution\|resolution]] 2.11Å' scene=''>	+	<StructureSection load='3vt5' size='340' side='right'caption='[[3vt5]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3vt5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3VT5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3vt5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VT5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YI2:(1R,2E,3R,5Z,7E)-17-{(1S)-1-[(2-ETHYL-2-HYDROXYBUTYL)SULFANYL]ETHYL}-2-(2-HYDROXYETHYLIDENE)-9,10-SECOESTRA-5,7,16-TRIENE-1,3-DIOL'>YI2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YI2:(1R,2E,3R,5Z,7E)-17-{(1S)-1-[(2-ETHYL-2-HYDROXYBUTYL)SULFANYL]ETHYL}-2-(2-HYDROXYETHYLIDENE)-9,10-SECOESTRA-5,7,16-TRIENE-1,3-DIOL'>YI2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zlc\|2zlc]], [[3vt3\|3vt3]], [[3vt4\|3vt4]], [[3vt6\|3vt6]], [[3vt7\|3vt7]], [[3vt8\|3vt8]], [[3vt9\|3vt9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zlc\|2zlc]], [[3vt3\|3vt3]], [[3vt4\|3vt4]], [[3vt6\|3vt6]], [[3vt7\|3vt7]], [[3vt8\|3vt8]], [[3vt9\|3vt9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3vt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt5 OCA], [~~http~~://pdbe.org/3vt5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3vt5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3vt5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt5 OCA], [https://pdbe.org/3vt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vt5 RCSB], [https://www.ebi.ac.uk/pdbsum/3vt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>	+	[[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Ikura, T]]		[[Category: Ikura, T]]
	[[Category: Ito, N]]		[[Category: Ito, N]]

OCA at 15:26, 4 August 2016

2016-08-04T15:26:06Z

←Older revision		Revision as of 15:26, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structures of rat VDR-LBD with R270L mutation==		==Crystal structures of rat VDR-LBD with R270L mutation==
	<StructureSection load='3vt5' size='340' side='right' caption='[[3vt5]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='3vt5' size='340' side='right' caption='[[3vt5]], [[Resolution\|resolution]] 2.11Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zlc\|2zlc]], [[3vt3\|3vt3]], [[3vt4\|3vt4]], [[3vt6\|3vt6]], [[3vt7\|3vt7]], [[3vt8\|3vt8]], [[3vt9\|3vt9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zlc\|2zlc]], [[3vt3\|3vt3]], [[3vt4\|3vt4]], [[3vt6\|3vt6]], [[3vt7\|3vt7]], [[3vt8\|3vt8]], [[3vt9\|3vt9]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vt5 RCSB], [http://www.ebi.ac.uk/pdbsum/3vt5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt5 OCA], [http://pdbe.org/3vt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vt5 RCSB], [http://www.ebi.ac.uk/pdbsum/3vt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3vt5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:24, 24 December 2014

2014-12-24T16:24:09Z

←Older revision		Revision as of 16:24, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3vt5\| PDB=3vt5 \| SCENE= }}~~	+	==Crystal structures of rat VDR-LBD with R270L mutation==
-	===Crystal structures of rat VDR-LBD with R270L mutation===	+	<StructureSection load='3vt5' size='340' side='right' caption='[[3vt5]], [[Resolution\|resolution]] 2.11Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23944708}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3vt5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VT5 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YI2:(1R,2E,3R,5Z,7E)-17-{(1S)-1-[(2-ETHYL-2-HYDROXYBUTYL)SULFANYL]ETHYL}-2-(2-HYDROXYETHYLIDENE)-9,10-SECOESTRA-5,7,16-TRIENE-1,3-DIOL'>YI2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zlc\|2zlc]], [[3vt3\|3vt3]], [[3vt4\|3vt4]], [[3vt6\|3vt6]], [[3vt7\|3vt7]], [[3vt8\|3vt8]], [[3vt9\|3vt9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vt5 RCSB], [http://www.ebi.ac.uk/pdbsum/3vt5 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>		[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, functions as a ligand-dependent transcription factor for various genes. Hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disease, is caused by mutations in the VDR. In particular, the missense mutations R274L and W286R in the ligand-binding domain of the VDR can severely reduce or even eliminate natural hormone responsiveness. Here, we report a crystal structure analysis of the R270L and W282R mutants of rat VDR (human R274L and W286R, respectively) in complex with the natural hormone and synthetic ligands. We also studied the folding properties of the mutant proteins by using circular dichroism spectra. Our study indicates that these mutations result in only local structural modifications. We discuss why these mutations disrupt the VDR function and provide clues to develop effective ligands for the treatment of HVDRR.

-	~~==About this Structure==~~	+	Crystal Structures of Hereditary Vitamin D-Resistant Rickets-Associated Vitamin D Receptor Mutants R270L and W282R Bound to 1,25-Dihydroxyvitamin D and Synthetic Ligands.,Nakabayashi M, Tsukahara Y, Iwasaki-Miyamoto Y, Mihori-Shimazaki M, Yamada S, Inaba S, Oda M, Shimizu M, Makishima M, Tokiwa H, Ikura T, Ito N J Med Chem. 2013 Aug 29. PMID:23944708<ref>PMID:23944708</ref>
-	~~[[3vt5]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Buffalo_rat Buffalo rat]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023944708</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
-	[[Category: Ikura, T.]]	+	[[Category: Ikura, T]]
-	[[Category: Ito, N.]]	+	[[Category: Ito, N]]
-	[[Category: Nakabayashi, M.]]	+	[[Category: Nakabayashi, M]]
-	[[Category: Shimizu, M.]]	+	[[Category: Shimizu, M]]
	[[Category: Hormone receptor]]		[[Category: Hormone receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 04:25, 13 February 2014

2014-02-13T04:25:38Z

←Older revision		Revision as of 04:25, 13 February 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3vt5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA].	+	[[3vt5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:023944708</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023944708</ref><references group="xtra"/><references/>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Ikura, T.]]		[[Category: Ikura, T.]]
	[[Category: Ito, N.]]		[[Category: Ito, N.]]

OCA at 04:08, 12 September 2013

2013-09-12T04:08:37Z

←Older revision		Revision as of 04:08, 12 September 2013
Line 1:		Line 1:
	{{STRUCTURE_3vt5\| PDB=3vt5 \| SCENE= }}		{{STRUCTURE_3vt5\| PDB=3vt5 \| SCENE= }}
	===Crystal structures of rat VDR-LBD with R270L mutation===		===Crystal structures of rat VDR-LBD with R270L mutation===
		+	{{ABSTRACT_PUBMED_23944708}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023944708</ref><references group="xtra"/><references/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Ikura, T.]]		[[Category: Ikura, T.]]

OCA at 06:23, 20 June 2013

2013-06-20T06:23:10Z

←Older revision		Revision as of 06:23, 20 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3vt5\| PDB=3vt5 \| SCENE= }}
		+	===Crystal structures of rat VDR-LBD with R270L mutation===

-	~~The entry 3vt5 is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>

-	~~Authors~~: ~~Nakabayashi, M~~.~~, Shimizu, M~~.~~, Ikura, T~~.~~, Ito, N~~.	+	==About this Structure==
		+	[[3vt5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VT5 OCA].

-	~~Description~~: ~~Crystal structures of rat VDR-LBD with R270L mutation~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Ikura, T.]]
		+	[[Category: Ito, N.]]
		+	[[Category: Nakabayashi, M.]]
		+	[[Category: Shimizu, M.]]
		+	[[Category: Hormone receptor]]
		+	[[Category: Transcription]]

OCA at 05:12, 27 June 2012

2012-06-27T05:12:34Z

←Older revision		Revision as of 05:12, 27 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3vt5 is ON HOLD	+	The entry 3vt5 is ON HOLD until Paper Publication

	Authors: Nakabayashi, M., Shimizu, M., Ikura, T., Ito, N.		Authors: Nakabayashi, M., Shimizu, M., Ikura, T., Ito, N.

	Description: Crystal structures of rat VDR-LBD with R270L mutation		Description: Crystal structures of rat VDR-LBD with R270L mutation

OCA at 05:36, 13 June 2012

2012-06-13T05:36:29Z

←Older revision		Revision as of 05:36, 13 June 2012
Line 3:		Line 3:
	The entry 3vt5 is ON HOLD		The entry 3vt5 is ON HOLD

-	Authors: Nakabayashi M., Shimizu M., Ikura T., Ito N.	+	Authors: Nakabayashi, M., Shimizu, M., Ikura, T., Ito, N.

	Description: Crystal structures of rat VDR-LBD with R270L mutation		Description: Crystal structures of rat VDR-LBD with R270L mutation

OCA: Protected "3vt5" [edit=sysop:move=sysop]

2012-05-30T05:18:54Z

Protected "3vt5" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 30 May 2012