3w00 - Revision history

OCA at 12:43, 8 November 2023

2023-11-08T12:43:44Z

←Older revision		Revision as of 12:43, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3w00' size='340' side='right'caption='[[3w00]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3w00' size='340' side='right'caption='[[3w00]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3w00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3w00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W00 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GP:SN-GLYCEROL-1-PHOSPHATE'>1GP</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vzx\|3vzx]], [[3vzy\|3vzy]], [[3vzz\|3vzz]], [[3w01\|3w01]], [[3w02\|3w02]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GP:SN-GLYCEROL-1-PHOSPHATE'>1GP</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcrB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w00 OCA], [https://pdbe.org/3w00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w00 RCSB], [https://www.ebi.ac.uk/pdbsum/3w00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w00 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w00 OCA], [https://pdbe.org/3w00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w00 RCSB], [https://www.ebi.ac.uk/pdbsum/3w00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w00 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU]] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>	+	[https://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacsu~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chan~~, H C~~]]	+	[[Category: Chan HC]]
-	[[Category: Chen~~, C C~~]]	+	[[Category: Chen CC]]
-	[[Category: Feng, X]]	+	[[Category: Feng X]]
-	[[Category: Guo~~, R T~~]]	+	[[Category: Guo RT]]
-	[[Category: He, M]]	+	[[Category: He M]]
-	[[Category: Hu, Y]]	+	[[Category: Hu Y]]
-	[[Category: Huang~~, C H~~]]	+	[[Category: Huang CH]]
-	[[Category: Ko~~, T P~~]]	+	[[Category: Ko TP]]
-	[[Category: Li, Y]]	+	[[Category: Li Y]]
-	[[Category: Liu~~, Y L~~]]	+	[[Category: Liu YL]]
-	[[Category: Oldfield, E]]	+	[[Category: Oldfield E]]
-	[[Category: Pang, X]]	+	[[Category: Pang X]]
-	[[Category: Ren, F]]	+	[[Category: Ren F]]
-	[[Category: Wang, K]]	+	[[Category: Wang K]]
-	~~[[Category: Biosynthesis]]~~	+
-	~~[[Category: Enzyme catalysis]]~~	+
-	~~[[Category: Prenyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:16, 3 August 2022

2022-08-03T05:16:19Z

←Older revision		Revision as of 05:16, 3 August 2022
Line 1:		Line 1:

	==Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168==		==Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168==
-	<StructureSection load='3w00' size='340' side='right' caption='[[3w00]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3w00' size='340' side='right'caption='[[3w00]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3w00]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W00 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3W00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3w00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W00 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GP:SN-GLYCEROL-1-PHOSPHATE'>1GP</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GP:SN-GLYCEROL-1-PHOSPHATE'>1GP</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vzx\|3vzx]], [[3vzy\|3vzy]], [[3vzz\|3vzz]], [[3w01\|3w01]], [[3w02\|3w02]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vzx\|3vzx]], [[3vzy\|3vzy]], [[3vzz\|3vzz]], [[3w01\|3w01]], [[3w02\|3w02]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcrB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcrB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3w00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w00 OCA], [~~http~~://pdbe.org/3w00 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3w00 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3w00 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3w00 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w00 OCA], [https://pdbe.org/3w00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w00 RCSB], [https://www.ebi.ac.uk/pdbsum/3w00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w00 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU]] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>	+	[[https://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU]] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Bacsu]]		[[Category: Bacsu]]
		+	[[Category: Large Structures]]
	[[Category: Chan, H C]]		[[Category: Chan, H C]]
	[[Category: Chen, C C]]		[[Category: Chen, C C]]

OCA at 11:53, 4 August 2016

2016-08-04T11:53:21Z

←Older revision		Revision as of 11:53, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168==		==Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168==
	<StructureSection load='3w00' size='340' side='right' caption='[[3w00]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3w00' size='340' side='right' caption='[[3w00]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3w00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3w00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W00 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GP:SN-GLYCEROL-1-PHOSPHATE'>1GP</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GP:SN-GLYCEROL-1-PHOSPHATE'>1GP</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vzx\|3vzx]], [[3vzy\|3vzy]], [[3vzz\|3vzz]], [[3w01\|3w01]], [[3w02\|3w02]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vzx\|3vzx]], [[3vzy\|3vzy]], [[3vzz\|3vzz]], [[3w01\|3w01]], [[3w02\|3w02]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 ~~Bacillus subtilis subsp. subtilis str. 168~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w00 RCSB], [http://www.ebi.ac.uk/pdbsum/3w00 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w00 OCA], [http://pdbe.org/3w00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w00 RCSB], [http://www.ebi.ac.uk/pdbsum/3w00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w00 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3w00" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus subtilis subsp. subtilis str. 168~~]]	+	[[Category: Bacsu]]
	[[Category: Chan, H C]]		[[Category: Chan, H C]]
	[[Category: Chen, C C]]		[[Category: Chen, C C]]

OCA at 09:02, 25 December 2014

2014-12-25T09:02:25Z

←Older revision		Revision as of 09:02, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3w00\| PDB=3w00 \| SCENE= }}~~	+	==Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168==
-	===Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168===	+	<StructureSection load='3w00' size='340' side='right' caption='[[3w00]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23322418}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3w00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W00 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GP:SN-GLYCEROL-1-PHOSPHATE'>1GP</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vzx\|3vzx]], [[3vzy\|3vzy]], [[3vzz\|3vzz]], [[3w01\|3w01]], [[3w02\|3w02]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 Bacillus subtilis subsp. subtilis str. 168])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w00 RCSB], [http://www.ebi.ac.uk/pdbsum/3w00 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU]] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>		[[http://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU]] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Well structured: As a new triose phosphate isomerase (TIM) barrel-fold prenyl transferase, PcrB catalyzes the production of heptaprenylglyceryl phosphate from heptaprenyl diphosphate and glycerol-1-phosphate. Crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus in complex with ligands were solved, and together with site-directed mutagenesis and bioinformatics analyses, clearly reveal the catalytic mechanism of the enzyme.

-	~~==About this Structure==~~	+	Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus.,Ren F, Feng X, Ko TP, Huang CH, Hu Y, Chan HC, Liu YL, Wang K, Chen CC, Pang X, He M, Li Y, Oldfield E, Guo RT Chembiochem. 2013 Jan 21;14(2):195-9. doi: 10.1002/cbic.201200748. Epub 2013 Jan , 15. PMID:23322418<ref>PMID:23322418</ref>
-	~~[[3w00]] is a 2 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168~~ Bacillus subtilis ~~subsp~~. ~~subtilis str~~. ~~168]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3W00 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023322418</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis subsp. subtilis str. 168]]		[[Category: Bacillus subtilis subsp. subtilis str. 168]]
-	[[Category: Chan, H C.]]	+	[[Category: Chan, H C]]
-	[[Category: Chen, C C.]]	+	[[Category: Chen, C C]]
-	[[Category: Feng, X.]]	+	[[Category: Feng, X]]
-	[[Category: Guo, R T.]]	+	[[Category: Guo, R T]]
-	[[Category: He, M.]]	+	[[Category: He, M]]
-	[[Category: Hu, Y.]]	+	[[Category: Hu, Y]]
-	[[Category: Huang, C H.]]	+	[[Category: Huang, C H]]
-	[[Category: Ko, T P.]]	+	[[Category: Ko, T P]]
-	[[Category: Li, Y.]]	+	[[Category: Li, Y]]
-	[[Category: Liu, Y L.]]	+	[[Category: Liu, Y L]]
-	[[Category: Oldfield, E.]]	+	[[Category: Oldfield, E]]
-	[[Category: Pang, X.]]	+	[[Category: Pang, X]]
-	[[Category: Ren, F.]]	+	[[Category: Ren, F]]
-	[[Category: Wang, K.]]	+	[[Category: Wang, K]]
	[[Category: Biosynthesis]]		[[Category: Biosynthesis]]
	[[Category: Enzyme catalysis]]		[[Category: Enzyme catalysis]]
	[[Category: Prenyltransferase]]		[[Category: Prenyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 03:40, 1 August 2013

2013-08-01T03:40:16Z

←Older revision		Revision as of 03:40, 1 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_3w00\| PDB=3w00 \| SCENE= }}
		+	===Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168===
		+	{{ABSTRACT_PUBMED_23322418}}

-	~~The entry 3w00~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU]] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>

-	~~Authors~~: ~~Ren, F~~.~~, Feng, X~~.~~, Ko, T~~.P.~~, Huang, C~~.H.~~, Hu, Y~~.~~, Chan, H.C., Liu, Y.L., Wang, K., Chen, C.C., Pang, X., He, M., Li, Y~~.~~, Oldfield, E~~.~~, Guo, R~~.T.	+	==About this Structure==
		+	[[3w00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W00 OCA].

-	~~Description~~: ~~Crystal structure of PcrB complexed with G1P and FsPP from bacillus~~ subtilis ~~subap~~. subtilis str. 168	+	==Reference==
		+	<ref group="xtra">PMID:023322418</ref><references group="xtra"/><references/>
		+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
		+	[[Category: Chan, H C.]]
		+	[[Category: Chen, C C.]]
		+	[[Category: Feng, X.]]
		+	[[Category: Guo, R T.]]
		+	[[Category: He, M.]]
		+	[[Category: Hu, Y.]]
		+	[[Category: Huang, C H.]]
		+	[[Category: Ko, T P.]]
		+	[[Category: Li, Y.]]
		+	[[Category: Liu, Y L.]]
		+	[[Category: Oldfield, E.]]
		+	[[Category: Pang, X.]]
		+	[[Category: Ren, F.]]
		+	[[Category: Wang, K.]]
		+	[[Category: Biosynthesis]]
		+	[[Category: Enzyme catalysis]]
		+	[[Category: Prenyltransferase]]
		+	[[Category: Transferase]]

OCA at 13:10, 8 November 2012

2012-11-08T13:10:08Z

←Older revision		Revision as of 13:10, 8 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3w00 is ON HOLD	+	The entry 3w00 is ON HOLD until Paper Publication

	Authors: Ren, F., Feng, X., Ko, T.P., Huang, C.H., Hu, Y., Chan, H.C., Liu, Y.L., Wang, K., Chen, C.C., Pang, X., He, M., Li, Y., Oldfield, E., Guo, R.T.		Authors: Ren, F., Feng, X., Ko, T.P., Huang, C.H., Hu, Y., Chan, H.C., Liu, Y.L., Wang, K., Chen, C.C., Pang, X., He, M., Li, Y., Oldfield, E., Guo, R.T.

-	Description~~: Insights into TIM barrel Prenyltransferase Mechanisms~~: Crystal ~~Structures~~ of PcrB from ~~Bacillus~~ subtilis ~~and Staphylococcus aureus~~	+	Description: Crystal structure of PcrB complexed with G1P and FsPP from bacillus subtilis subap. subtilis str. 168

OCA at 08:26, 31 October 2012

2012-10-31T08:26:49Z

←Older revision		Revision as of 08:26, 31 October 2012
Line 3:		Line 3:
	The entry 3w00 is ON HOLD		The entry 3w00 is ON HOLD

-	Authors: Ren,F., Feng,X., Ko,T.P., Huang,C.H., Hu,Y., Chan,H.C., Liu,Y.L., Wang,K., Chen,C.C., Pang,X., He,M., Li,Y., Oldfield,E., Guo,R.T.	+	Authors: Ren, F., Feng, X., Ko, T.P., Huang, C.H., Hu, Y., Chan, H.C., Liu, Y.L., Wang, K., Chen, C.C., Pang, X., He, M., Li, Y., Oldfield, E., Guo, R.T.

	Description: Insights into TIM barrel Prenyltransferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus		Description: Insights into TIM barrel Prenyltransferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus

OCA: Protected "3w00" [edit=sysop:move=sysop]

2012-10-24T06:56:37Z

Protected "3w00" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:56, 24 October 2012

OCA: New page: '''Unreleased structure''' The entry 3w00 is ON HOLD Authors: Ren,F., Feng,X., Ko,T.P., Huang,C.H., Hu,Y., Chan,H.C., Liu,Y.L., Wang,K., Chen,C.C., Pang,X., He,M., Li,Y., Oldfield,E., G...

2012-10-24T06:56:36Z

New page: '''Unreleased structure''' The entry 3w00 is ON HOLD Authors: Ren,F., Feng,X., Ko,T.P., Huang,C.H., Hu,Y., Chan,H.C., Liu,Y.L., Wang,K., Chen,C.C., Pang,X., He,M., Li,Y., Oldfield,E., G...

New page

'''Unreleased structure'''

The entry 3w00 is ON HOLD

Authors: Ren,F., Feng,X., Ko,T.P., Huang,C.H., Hu,Y., Chan,H.C., Liu,Y.L., Wang,K., Chen,C.C., Pang,X., He,M., Li,Y., Oldfield,E., Guo,R.T.

Description: Insights into TIM barrel Prenyltransferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus