3wcl - Revision history

OCA at 13:04, 8 November 2023

2023-11-08T13:04:03Z

←Older revision		Revision as of 13:04, 8 November 2023
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	<StructureSection load='3wcl' size='340' side='right'caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='3wcl' size='340' side='right'caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WCL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WCL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BH3:HYDROGEN+[(1R)~~-~~2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.24Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; max-height: 3em;'>[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BH3:HYDROGEN+[(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>FDFT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number~~ [~~https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.5.~~1~~.21 2.5.~~1~~.21~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [https://pdbe.org/3wcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [https://www.ebi.ac.uk/pdbsum/3wcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [https://pdbe.org/3wcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [https://www.ebi.ac.uk/pdbsum/3wcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Squalene synthase]]~~	+	[[Category: Chan HC]]
-	[[Category: Chan~~, H C~~]]	+	[[Category: Chen CC]]
-	[[Category: Chen~~, C C~~]]	+	[[Category: Guo RT]]
-	[[Category: Guo~~, R T~~]]	+	[[Category: Huang CH]]
-	[[Category: Huang~~, C H~~]]	+	[[Category: Ko TP]]
-	[[Category: Ko~~, T P~~]]	+	[[Category: Li Q]]
-	[[Category: Li, Q]]	+	[[Category: Ren F]]
-	[[Category: Ren, F]]	+	[[Category: Shang N]]
-	[[Category: Shang, N]]	+	[[Category: Zheng Y]]
-	[[Category: Zheng, Y]]	+	[[Category: Zhu Z]]
-	[[Category: Zhu, Z]]	+
-	~~[[Category: Drug discovery]]~~	+
-	~~[[Category: Isoprenoid]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:31, 3 August 2022

2022-08-03T05:31:34Z

←Older revision		Revision as of 05:31, 3 August 2022
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	==The complex structure of HsSQS wtih ligand,BPH1344==		==The complex structure of HsSQS wtih ligand,BPH1344==
-	<StructureSection load='3wcl' size='340' side='right' caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>	+	<StructureSection load='3wcl' size='340' side='right'caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WCL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WCL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BH3:HYDROGEN+[(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BH3:HYDROGEN+[(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [~~http~~://pdbe.org/3wcl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wcl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [https://pdbe.org/3wcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [https://www.ebi.ac.uk/pdbsum/3wcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
	[[Category: Chan, H C]]		[[Category: Chan, H C]]

OCA at 09:34, 21 February 2019

2019-02-21T09:34:42Z

←Older revision		Revision as of 09:34, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3wcl' size='340' side='right' caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='3wcl' size='340' side='right' caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WCL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WCL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BH3:HYDROGEN+[(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BH3:HYDROGEN+[(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [http://pdbe.org/3wcl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [http://www.ebi.ac.uk/pdbsum/3wcl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [http://pdbe.org/3wcl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [http://www.ebi.ac.uk/pdbsum/3wcl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcl ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
	[[Category: Chan, H C]]		[[Category: Chan, H C]]

OCA at 16:32, 11 August 2016

2016-08-11T16:32:24Z

←Older revision		Revision as of 16:32, 11 August 2016
Line 1:		Line 1:
		+
	==The complex structure of HsSQS wtih ligand,BPH1344==		==The complex structure of HsSQS wtih ligand,BPH1344==
	<StructureSection load='3wcl' size='340' side='right' caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='3wcl' size='340' side='right' caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [http://www.ebi.ac.uk/pdbsum/3wcl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [http://pdbe.org/3wcl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [http://www.ebi.ac.uk/pdbsum/3wcl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wcl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Squalene synthase\|Squalene synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:56, 4 January 2015

2015-01-04T09:56:45Z

←Older revision		Revision as of 09:56, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WCL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WCL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BH3:HYDROGEN+[(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BH3:HYDROGEN+[(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [http://www.ebi.ac.uk/pdbsum/3wcl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [http://www.ebi.ac.uk/pdbsum/3wcl PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
-	[[Category: Chan, H C.]]	+	[[Category: Chan, H C]]
-	[[Category: Chen, C C.]]	+	[[Category: Chen, C C]]
-	[[Category: Guo, R T.]]	+	[[Category: Guo, R T]]
-	[[Category: Huang, C H.]]	+	[[Category: Huang, C H]]
-	[[Category: Ko, T P.]]	+	[[Category: Ko, T P]]
-	[[Category: Li, Q.]]	+	[[Category: Li, Q]]
-	[[Category: Ren, F.]]	+	[[Category: Ren, F]]
-	[[Category: Shang, N.]]	+	[[Category: Shang, N]]
-	[[Category: Zheng, Y.]]	+	[[Category: Zheng, Y]]
-	[[Category: Zhu, Z.]]	+	[[Category: Zhu, Z]]
	[[Category: Drug discovery]]		[[Category: Drug discovery]]
	[[Category: Isoprenoid]]		[[Category: Isoprenoid]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:00, 18 June 2014

2014-06-18T08:00:34Z

←Older revision		Revision as of 08:00, 18 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The complex structure of HsSQS wtih ligand,BPH1344==
		+	<StructureSection load='3wcl' size='340' side='right' caption='[[3wcl]], [[Resolution\|resolution]] 2.24Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3wcl]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WCL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BH3:HYDROGEN+[(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE'>BH3</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wc9\|3wc9]], [[3wca\|3wca]], [[3wcb\|3wcb]], [[3wcc\|3wcc]], [[3wcd\|3wcd]], [[3wce\|3wce]], [[3wcf\|3wcf]], [[3wcg\|3wcg]], [[3wch\|3wch]], [[3wci\|3wci]], [[3wcj\|3wcj]], [[3wcm\|3wcm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wcl RCSB], [http://www.ebi.ac.uk/pdbsum/3wcl PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous sterol biosynthesis in these organisms as a route to the development of novel anti-infective drugs. Here, we report the first x-ray crystallographic structures of the enzyme squalene synthase (SQS) from a trypanosomatid parasite, Trypanosoma cruzi, the causative agent of Chagas disease. We obtained five structures of T. cruzi SQS and eight structures of human SQS with four classes of inhibitors: the substrate-analog S-thiolo-farnesyl diphosphate, the quinuclidines E5700 and ER119884, several lipophilic bisphosphonates, and the thiocyanate WC-9, with the structures of the two very potent quinuclidines suggesting strategies for selective inhibitor development. We also show that the lipophilic bisphosphonates have low nM activity against T. cruzi and inhibit endogenous sterol biosynthesis and that E5700 acts synergistically with the azole drug, posaconazole. The determination of the structures of trypanosomatid and human SQS enzymes with a diverse set of inhibitors active in cells provides insights into SQS inhibition, of interest in the context of the development of drugs against Chagas disease.

-	~~The entry 3wcl is ON HOLD until Paper Publication~~	+	Squalene synthase as a target for Chagas disease therapeutics.,Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, de Carvalho TM, de Souza W, Urbina JA, Wang AH, Docampo R, Li K, Liu YL, Oldfield E, Guo RT PLoS Pathog. 2014 May 1;10(5):e1004114. doi: 10.1371/journal.ppat.1004114., eCollection 2014 May. PMID:24789335<ref>PMID:24789335</ref>

-	~~Authors: Shang~~, N.~~, Li, Q~~.~~, Ko, T.P~~., Chan, H.C., Huang, C.H., Ren, F., Zheng, Y., Zhu, Z.~~, Chen, C.C., Guo, R.T.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~The complex structure of HsSQS wtih ligand,BPH1344~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Squalene synthase]]
		+	[[Category: Chan, H C.]]
		+	[[Category: Chen, C C.]]
		+	[[Category: Guo, R T.]]
		+	[[Category: Huang, C H.]]
		+	[[Category: Ko, T P.]]
		+	[[Category: Li, Q.]]
		+	[[Category: Ren, F.]]
		+	[[Category: Shang, N.]]
		+	[[Category: Zheng, Y.]]
		+	[[Category: Zhu, Z.]]
		+	[[Category: Drug discovery]]
		+	[[Category: Isoprenoid]]
		+	[[Category: Transferase]]

OCA at 11:55, 24 July 2013

2013-07-24T11:55:59Z

←Older revision		Revision as of 11:55, 24 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wcl is ON HOLD	+	The entry 3wcl is ON HOLD until Paper Publication

-	Authors: Shang, N., Li, Q., Ko, T.P., Chan, H.C., Huang, C.H., ~~Oldfield~~, E., Guo, R.T.	+	Authors: Shang, N., Li, Q., Ko, T.P., Chan, H.C., Huang, C.H., Ren, F., Zheng, Y., Zhu, Z., Chen, C.C., Guo, R.T.

	Description: The complex structure of HsSQS wtih ligand,BPH1344		Description: The complex structure of HsSQS wtih ligand,BPH1344

OCA: Protected "3wcl" [edit=sysop:move=sysop]

2013-06-19T10:40:27Z

Protected "3wcl" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:40, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 3wcl is ON HOLD Authors: Shang, N., Li, Q., Ko, T.P., Chan, H.C., Huang, C.H., Oldfield, E., Guo, R.T. Description: The complex structure of HsSQS ...

2013-06-19T10:40:25Z

New page: '''Unreleased structure''' The entry 3wcl is ON HOLD Authors: Shang, N., Li, Q., Ko, T.P., Chan, H.C., Huang, C.H., Oldfield, E., Guo, R.T. Description: The complex structure of HsSQS ...

New page

'''Unreleased structure'''

The entry 3wcl is ON HOLD

Authors: Shang, N., Li, Q., Ko, T.P., Chan, H.C., Huang, C.H., Oldfield, E., Guo, R.T.

Description: The complex structure of HsSQS wtih ligand,BPH1344