3wvm - Revision history

OCA at 19:22, 29 May 2024

2024-05-29T19:22:35Z

←Older revision		Revision as of 19:22, 29 May 2024
Line 1:		Line 1:

	==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==		==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==
-	<StructureSection load='3wvm' size='340' side='right'caption='[[3wvm]]' scene=''>	+	<StructureSection load='3wvm' size='340' side='right'caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wvm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [https://pdbe.org/3wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [https://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.88Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [https://pdbe.org/3wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [https://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FABPH_HUMAN FABPH_HUMAN] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Long-chain fatty acids (FAs) with low water solubility require fatty-acid-binding proteins (FABPs) to transport them from cytoplasm to the mitochondria for energy production. However, the precise mechanism by which these proteins recognize the various lengths of simple alkyl chains of FAs with similar high affinity remains unknown. To address this question, we employed a newly developed calorimetric method for comprehensively evaluating the affinity of FAs, sub-Angstrom X-ray crystallography to accurately determine their 3D structure, and energy calculations of the coexisting water molecules using the computer program WaterMap. Our results clearly showed that the heart-type FABP (FABP3) preferentially incorporates a U-shaped FA of C10-C18 using a lipid-compatible water cluster, and excludes longer FAs using a chain-length-limiting water cluster. These mechanisms could help us gain a general understanding of how proteins recognize diverse lipids with different chain lengths.
		+
		+	Water-mediated recognition of simple alkyl chains by heart-type Fatty-Acid-binding protein.,Matsuoka S, Sugiyama S, Matsuoka D, Hirose M, Lethu S, Ano H, Hara T, Ichihara O, Kimura SR, Murakami S, Ishida H, Mizohata E, Inoue T, Murata M Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1508-11. doi: 10.1002/anie.201409830., Epub 2014 Dec 9. PMID:25491543<ref>PMID:25491543</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3wvm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]		*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hara T]]		[[Category: Hara T]]

OCA at 10:36, 31 August 2022

2022-08-31T10:36:51Z

←Older revision		Revision as of 10:36, 31 August 2022
Line 1:		Line 1:

	==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==		==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==
-	<StructureSection load='3wvm' size='340' side='right'caption='[[3wvm]]~~, [[Resolution\|resolution]] 0.88Å~~' scene=''>	+	<StructureSection load='3wvm' size='340' side='right'caption='[[3wvm]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[3wvm]] is a 1 chain structure.~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [https://pdbe.org/3wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [https://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wbg\|3wbg]]</div></td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [https://pdbe.org/3wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [https://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Function ==
-	[[https://www.uniprot.org/uniprot/FABPH_HUMAN FABPH_HUMAN]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Long-chain fatty acids (FAs) with low water solubility require fatty-acid-binding proteins (FABPs) to transport them from cytoplasm to the mitochondria for energy production. However, the precise mechanism by which these proteins recognize the various lengths of simple alkyl chains of FAs with similar high affinity remains unknown. To address this question, we employed a newly developed calorimetric method for comprehensively evaluating the affinity of FAs, sub-Angstrom X-ray crystallography to accurately determine their 3D structure, and energy calculations of the coexisting water molecules using the computer program WaterMap. Our results clearly showed that the heart-type FABP (FABP3) preferentially incorporates a U-shaped FA of C10-C18 using a lipid-compatible water cluster, and excludes longer FAs using a chain-length-limiting water cluster. These mechanisms could help us gain a general understanding of how proteins recognize diverse lipids with different chain lengths.
-
-	Water-mediated recognition of simple alkyl chains by heart-type Fatty-Acid-binding protein.,Matsuoka S, Sugiyama S, Matsuoka D, Hirose M, Lethu S, Ano H, Hara T, Ichihara O, Kimura SR, Murakami S, Ishida H, Mizohata E, Inoue T, Murata M Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1508-11. doi: 10.1002/anie.201409830., Epub 2014 Dec 9. PMID:25491543<ref>PMID:25491543</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3wvm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]		*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hara, T]]	+	[[Category: Hara T]]
-	[[Category: Hirose, M]]	+	[[Category: Hirose M]]
-	[[Category: Inoue, T]]	+	[[Category: Inoue T]]
-	[[Category: Ishida, H]]	+	[[Category: Ishida H]]
-	[[Category: Kakinouchi, K]]	+	[[Category: Kakinouchi K]]
-	[[Category: Matsumura, H]]	+	[[Category: Matsumura H]]
-	[[Category: Matsuoka, D]]	+	[[Category: Matsuoka D]]
-	[[Category: Matsuoka, S]]	+	[[Category: Matsuoka S]]
-	[[Category: Mizohata, E]]	+	[[Category: Mizohata E]]
-	[[Category: Murakami, S]]	+	[[Category: Murakami S]]
-	[[Category: Murata, M]]	+	[[Category: Murata M]]
-	[[Category: Sugiyama, S]]	+	[[Category: Sugiyama S]]
-	~~[[Category: Antiparallel beta barrel]]~~	+
-	~~[[Category: Lipid binding protein~~]]	+

OCA at 04:59, 25 August 2022

2022-08-25T04:59:40Z

←Older revision		Revision as of 04:59, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='3wvm' size='340' side='right'caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>		<StructureSection load='3wvm' size='340' side='right'caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wvm]] is a 1 chain structure ~~with sequence from [https://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wvm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wbg\|3wbg]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wbg\|3wbg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [https://pdbe.org/3wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [https://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [https://pdbe.org/3wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [https://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>
	</table>		</table>
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hara, T]]		[[Category: Hara, T]]

OCA at 05:33, 10 August 2022

2022-08-10T05:33:03Z

←Older revision		Revision as of 05:33, 10 August 2022
Line 1:		Line 1:

	==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==		==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==
-	<StructureSection load='3wvm' size='340' side='right' caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>	+	<StructureSection load='3wvm' size='340' side='right'caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wvm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wvm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wbg\|3wbg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wbg\|3wbg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [~~http~~://pdbe.org/3wvm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [https://pdbe.org/3wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [https://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABPH_HUMAN FABPH_HUMAN]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.	+	[[https://www.uniprot.org/uniprot/FABPH_HUMAN FABPH_HUMAN]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]	+	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hara, T]]		[[Category: Hara, T]]
	[[Category: Hirose, M]]		[[Category: Hirose, M]]

OCA at 09:26, 21 February 2019

2019-02-21T09:26:04Z

←Older revision		Revision as of 09:26, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3wvm' size='340' side='right' caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>		<StructureSection load='3wvm' size='340' side='right' caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wvm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wvm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wbg\|3wbg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wbg\|3wbg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [http://pdbe.org/3wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [http://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [http://pdbe.org/3wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [http://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3wvm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3wvm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Hara, T]]		[[Category: Hara, T]]
	[[Category: Hirose, M]]		[[Category: Hirose, M]]

OCA at 14:38, 11 August 2016

2016-08-11T14:38:52Z

←Older revision		Revision as of 14:38, 11 August 2016
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		+
	==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==		==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==
	<StructureSection load='3wvm' size='340' side='right' caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>		<StructureSection load='3wvm' size='340' side='right' caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wbg\|3wbg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wbg\|3wbg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [http://www.ebi.ac.uk/pdbsum/3wvm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [http://pdbe.org/3wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [http://www.ebi.ac.uk/pdbsum/3wvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wvm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:35, 28 January 2015

2015-01-28T16:35:15Z

←Older revision		Revision as of 16:35, 28 January 2015
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-	'''~~Unreleased~~ structure'''	+	==The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid==
		+	<StructureSection load='3wvm' size='340' side='right' caption='[[3wvm]], [[Resolution\|resolution]] 0.88Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3wvm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WVM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wbg\|3wbg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wvm RCSB], [http://www.ebi.ac.uk/pdbsum/3wvm PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABPH_HUMAN FABPH_HUMAN]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Long-chain fatty acids (FAs) with low water solubility require fatty-acid-binding proteins (FABPs) to transport them from cytoplasm to the mitochondria for energy production. However, the precise mechanism by which these proteins recognize the various lengths of simple alkyl chains of FAs with similar high affinity remains unknown. To address this question, we employed a newly developed calorimetric method for comprehensively evaluating the affinity of FAs, sub-Angstrom X-ray crystallography to accurately determine their 3D structure, and energy calculations of the coexisting water molecules using the computer program WaterMap. Our results clearly showed that the heart-type FABP (FABP3) preferentially incorporates a U-shaped FA of C10-C18 using a lipid-compatible water cluster, and excludes longer FAs using a chain-length-limiting water cluster. These mechanisms could help us gain a general understanding of how proteins recognize diverse lipids with different chain lengths.

-	~~The entry 3wvm is ON HOLD until Paper Publication~~	+	Water-mediated recognition of simple alkyl chains by heart-type Fatty-Acid-binding protein.,Matsuoka S, Sugiyama S, Matsuoka D, Hirose M, Lethu S, Ano H, Hara T, Ichihara O, Kimura SR, Murakami S, Ishida H, Mizohata E, Inoue T, Murata M Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1508-11. doi: 10.1002/anie.201409830., Epub 2014 Dec 9. PMID:25491543<ref>PMID:25491543</ref>

-	~~Authors: Sugiyama~~, S.~~, Matsuoka,~~ S.~~, Mizohata, E., Matsuoka, D., Ishida, H., Hirose, M., Kakinouchi, K., Hara, T., Matsumura, H., Murakami, S., Inoue, T., Murata, M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	[[Category: ~~Mizohata~~, E]]	+	__TOC__
-	[[Category: ~~Matsuoka~~, S]]	+	</StructureSection>
		+	[[Category: Hara, T]]
		+	[[Category: Hirose, M]]
	[[Category: Inoue, T]]		[[Category: Inoue, T]]
-	[[Category: Hirose, M]]
-	[[Category: Murakami, S]]
-	[[Category: Hara, T]]
-	[[Category: Sugiyama, S]]
-	[[Category: Matsuoka, D]]
	[[Category: Ishida, H]]		[[Category: Ishida, H]]
	[[Category: Kakinouchi, K]]		[[Category: Kakinouchi, K]]
	[[Category: Matsumura, H]]		[[Category: Matsumura, H]]
		+	[[Category: Matsuoka, D]]
		+	[[Category: Matsuoka, S]]
		+	[[Category: Mizohata, E]]
		+	[[Category: Murakami, S]]
	[[Category: Murata, M]]		[[Category: Murata, M]]
		+	[[Category: Sugiyama, S]]
		+	[[Category: Antiparallel beta barrel]]
		+	[[Category: Lipid binding protein]]

OCA at 08:55, 14 January 2015

2015-01-14T08:55:35Z

←Older revision		Revision as of 08:55, 14 January 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wvm is ON HOLD	+	The entry 3wvm is ON HOLD until Paper Publication

-	Authors: Sugiyama, S., Matsuoka, S., Mizohata, E., Matsuoka, D., Ishida, H., Hirose, M., Kakinouchi, K., Hara, T., Matsumura, H, Murakami, S., Inoue, T., Murata, M.	+	Authors: Sugiyama, S., Matsuoka, S., Mizohata, E., Matsuoka, D., Ishida, H., Hirose, M., Kakinouchi, K., Hara, T., Matsumura, H., Murakami, S., Inoue, T., Murata, M.

	Description: The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid		Description: The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid
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	[[Category: Inoue, T]]		[[Category: Inoue, T]]
	[[Category: Hirose, M]]		[[Category: Hirose, M]]
		+	[[Category: Murakami, S]]
	[[Category: Hara, T]]		[[Category: Hara, T]]
	[[Category: Sugiyama, S]]		[[Category: Sugiyama, S]]
	[[Category: Matsuoka, D]]		[[Category: Matsuoka, D]]
-	[[Category: Matsumura, H, Murakami, S]]
	[[Category: Ishida, H]]		[[Category: Ishida, H]]
	[[Category: Kakinouchi, K]]		[[Category: Kakinouchi, K]]
		+	[[Category: Matsumura, H]]
	[[Category: Murata, M]]		[[Category: Murata, M]]

OCA at 13:00, 24 December 2014

2014-12-24T13:00:38Z

←Older revision		Revision as of 13:00, 24 December 2014
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	Description: The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid		Description: The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with stearic acid
		+	[[Category: Unreleased Structures]]
		+	[[Category: Mizohata, E]]
		+	[[Category: Matsuoka, S]]
		+	[[Category: Inoue, T]]
		+	[[Category: Hirose, M]]
		+	[[Category: Hara, T]]
		+	[[Category: Sugiyama, S]]
		+	[[Category: Matsuoka, D]]
		+	[[Category: Matsumura, H, Murakami, S]]
		+	[[Category: Ishida, H]]
		+	[[Category: Kakinouchi, K]]
		+	[[Category: Murata, M]]

OCA: Protected "3wvm" [edit=sysop:move=sysop]

2014-06-04T04:48:36Z

Protected "3wvm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:48, 4 June 2014