3wyg - Revision history

OCA at 13:33, 8 November 2023

2023-11-08T13:33:33Z

←Older revision		Revision as of 13:33, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3wyg' size='340' side='right'caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3wyg' size='340' side='right'caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_AWRI796 Saccharomyces cerevisiae AWRI796] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GTP:GUANOSINE~~-~~5-TRIPHOSPHATE'>GTP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3wyf\|3wyf]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">AWRI796_3356 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PKIA, PRKACN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [https://pdbe.org/3wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [https://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [https://pdbe.org/3wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [https://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~IPKA_HUMAN IPKA_HUMAN~~]~~] Extremely potent competitive inhibitor of cAMP~~-~~dependent~~ protein ~~kinase activity, this protein interacts with~~ the ~~catalytic subunit~~ of the ~~enzyme after the cAMP-induced dissociation of its regulatory chains~~. ~~[[https://www~~.~~uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor~~ for ~~the leucine-rich nuclear export signal (NES)~~.	+	[https://www.uniprot.org/uniprot/GSP1_YEAST GSP1_YEAST] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Baker's yeast]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Koyama, M~~]]	+	[[Category: Saccharomyces cerevisiae AWRI796]]
-	[[Category: ~~Matsuura, Y~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Shirai, N~~]]	+	[[Category: Koyama M]]
-	[[Category: ~~Gtp-binding protein-gtp-binding protein inhibitor complex~~]]	+	[[Category: Matsuura Y]]
-	[[Category: ~~Heat repeat]]~~	+	[[Category: Shirai N]]
-	~~[[Category: Nuclear export~~]]	+

OCA at 05:35, 10 August 2022

2022-08-10T05:35:41Z

←Older revision		Revision as of 05:35, 10 August 2022
Line 1:		Line 1:

	==Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex==		==Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex==
-	<StructureSection load='3wyg' size='340' side='right' caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='3wyg' size='340' side='right'caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3WYG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyf\|3wyf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wyf\|3wyf]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AWRI796_3356 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PKIA, PRKACN1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AWRI796_3356 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PKIA, PRKACN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [~~http~~://pdbe.org/3wyg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [https://pdbe.org/3wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [https://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. [[~~http~~://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES).	+	[[https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. [[https://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]	+	*[[CAMP-dependent protein kinase 3D structures\|CAMP-dependent protein kinase 3D structures]]
-	*[[Exportin\|Exportin]]	+	*[[Exportin 3D structures\|Exportin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Koyama, M]]		[[Category: Koyama, M]]
	[[Category: Matsuura, Y]]		[[Category: Matsuura, Y]]

OCA at 09:25, 21 February 2019

2019-02-21T09:25:22Z

←Older revision		Revision as of 09:25, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='3wyg' size='340' side='right' caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3wyg' size='340' side='right' caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyf\|3wyf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyf\|3wyf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AWRI796_3356 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PKIA, PRKACN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://pdbe.org/3wyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://pdbe.org/3wyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:

	==See Also==		==See Also==
		+	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]
	*[[Exportin\|Exportin]]		*[[Exportin\|Exportin]]
	== References ==		== References ==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
		+	[[Category: Human]]
	[[Category: Koyama, M]]		[[Category: Koyama, M]]
	[[Category: Matsuura, Y]]		[[Category: Matsuura, Y]]

OCA at 07:20, 5 August 2016

2016-08-05T07:20:50Z

←Older revision		Revision as of 07:20, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex==		==Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex==
	<StructureSection load='3wyg' size='340' side='right' caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3wyg' size='340' side='right' caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyf\|3wyf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyf\|3wyf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://pdbe.org/3wyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3wyg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Exportin\|Exportin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:49, 25 December 2014

2014-12-25T16:49:40Z

←Older revision		Revision as of 16:49, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. [[http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:42, 10 December 2014

2014-12-10T11:42:32Z

←Older revision		Revision as of 11:42, 10 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins and ribonucleoproteins containing a nuclear export signal (NES) assemble with the exportin Xpo1p (yeast CRM1) and Gsp1p-GTP (yeast Ran-GTP) in the nucleus and exit through the nuclear pore complex. In the cytoplasm, Yrb1p (yeast RanBP1) displaces NES from Xpo1p. Efficient export of NES-cargoes requires Yrb2p (yeast RanBP3), a primarily nuclear protein containing nucleoporin-like phenylalanine-glycine (FG) repeats and a low-affinity Gsp1p-binding domain (RanBD). Here, we show that Yrb2p strikingly accelerates the association of Gsp1p-GTP and NES to Xpo1p. We have solved the crystal structure of the Xpo1p-Yrb2p-Gsp1p-GTP complex, a key assembly intermediate that can bind cargo rapidly. Although the NES-binding cleft of Xpo1p is closed in this intermediate, our data suggest that preloading of Gsp1p-GTP onto Xpo1p by Yrb2p, conformational flexibility of Xpo1p, and the low affinity of RanBD enable active displacement of Yrb2p RanBD by NES to occur effectively. The structure also reveals the major binding sites for FG repeats on Xpo1p.
		+
		+	Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex.,Koyama M, Shirai N, Matsuura Y Cell Rep. 2014 Nov 6;9(3):983-95. doi: 10.1016/j.celrep.2014.09.052. Epub 2014, Oct 30. PMID:25437554<ref>PMID:25437554</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:49, 12 November 2014

2014-11-12T06:49:42Z

←Older revision		Revision as of 06:49, 12 November 2014
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-	'''~~Unreleased structure~~'''	+	==Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex==
-		+	<StructureSection load='3wyg' size='340' side='right' caption='[[3wyg]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~The entry~~ 3wyg is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYG FirstGlance]. <br>
-	~~Authors~~: ~~Koyama~~, M., ~~Shirai~~, N., Matsuura, Y.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wyf\|3wyf]]</td></tr>
-	~~Description~~: ~~Transport~~ complex 2	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [http://www.ebi.ac.uk/pdbsum/3wyg PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Koyama, M]]
		+	[[Category: Matsuura, Y]]
		+	[[Category: Shirai, N]]
		+	[[Category: Gtp-binding protein-gtp-binding protein inhibitor complex]]
		+	[[Category: Heat repeat]]
		+	[[Category: Nuclear export]]

OCA at 07:48, 10 September 2014

2014-09-10T07:48:28Z

←Older revision		Revision as of 07:48, 10 September 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3wyg is ON HOLD	+	The entry 3wyg is ON HOLD until Paper Publication

	Authors: Koyama, M., Shirai, N., Matsuura, Y.		Authors: Koyama, M., Shirai, N., Matsuura, Y.

-	Description: ~~TRANSPORT COMPLEX~~ 2	+	Description: Transport complex 2

OCA: Protected "3wyg" [edit=sysop:move=sysop]

2014-09-04T03:35:10Z

Protected "3wyg" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:35, 4 September 2014

OCA: New page: '''Unreleased structure''' The entry 3wyg is ON HOLD Authors: Koyama, M., Shirai, N., Matsuura, Y. Description: TRANSPORT COMPLEX 2

2014-09-04T03:35:08Z

New page: '''Unreleased structure''' The entry 3wyg is ON HOLD Authors: Koyama, M., Shirai, N., Matsuura, Y. Description: TRANSPORT COMPLEX 2

New page

'''Unreleased structure'''

The entry 3wyg is ON HOLD

Authors: Koyama, M., Shirai, N., Matsuura, Y.

Description: TRANSPORT COMPLEX 2