3zgn - Revision history

OCA at 11:01, 20 December 2023

2023-12-20T11:01:36Z

←Older revision		Revision as of 11:01, 20 December 2023
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	<StructureSection load='3zgn' size='340' side='right'caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3zgn' size='340' side='right'caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN~~-1~~-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3zgl\|3zgl]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/4-hydroxy~~-3-~~methylbut~~-~~2-enyl_diphosphate_reductase~~ 4-~~hydroxy~~-3-~~methylbut~~-2-~~enyl diphosphate reductase]~~, ~~with EC number [https~~:/~~/www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [https://pdbe.org/3zgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [https://www.ebi.ac.uk/pdbsum/3zgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [https://pdbe.org/3zgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [https://www.ebi.ac.uk/pdbsum/3zgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>	+	[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barbier, E]]	+	[[Category: Barbier E]]
-	[[Category: Borel, F]]	+	[[Category: Borel F]]
-	[[Category: ~~Ferrer, J L~~]]	+	[[Category: Dale Poulter C]]
-	[[Category: ~~Janthawornpong, K~~]]	+	[[Category: Ferrer JL]]
-	[[Category: ~~Kratsutsky, S~~]]	+	[[Category: Janthawornpong K]]
-	[[Category: ~~Poulter, C Dale~~]]	+	[[Category: Kratsutsky S]]
-	[[Category: Rohmer, M]]	+	[[Category: Rohmer M]]
-	[[Category: Seemann, M]]	+	[[Category: Seemann M]]
-	~~[[Category: 4fe-4s cluster]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Mep pathway]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 05:46, 10 August 2022

2022-08-10T05:46:07Z

←Older revision		Revision as of 05:46, 10 August 2022
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	<StructureSection load='3zgn' size='340' side='right'caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3zgn' size='340' side='right'caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zgl\|3zgl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zgl\|3zgl]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [~~http~~://pdbe.org/3zgn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zgn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [https://pdbe.org/3zgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [https://www.ebi.ac.uk/pdbsum/3zgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>	+	[[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:03, 1 January 2020

2020-01-01T13:03:25Z

←Older revision		Revision as of 13:03, 1 January 2020
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	==Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway==		==Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway==
-	<StructureSection load='3zgn' size='340' side='right' caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3zgn' size='340' side='right'caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3zgn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zgn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
		+	[[Category: Large Structures]]
	[[Category: Barbier, E]]		[[Category: Barbier, E]]
	[[Category: Borel, F]]		[[Category: Borel, F]]

OCA at 07:17, 29 November 2017

2017-11-29T07:17:58Z

←Older revision		Revision as of 07:17, 29 November 2017
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>		[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IspH, also called LytB, a protein involved in the biosynthesis of isoprenoids through the methylerythritol phosphate pathway, is an attractive target for the development of new antimicrobial drugs. Here, we report crystal structures of Escherichia coli IspH in complex with the two most potent inhibitors: (E)-4-mercapto-3-methylbut-2-en-1-yl diphosphate (TMBPP) and (E)-4-amino-3-methylbut-2-en-1-yl diphosphate (AMBPP) at 1.95 and 1.7 A resolution, respectively. The structure of the E. coli IspH:TMBPP complex exhibited two conformers of the inhibitor. This unexpected feature was exploited to design and evolve new antimicrobial candidates in silico.

-	~~==See Also==~~	+	Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials.,Borel F, Barbier E, Krasutsky S, Janthawornpong K, Chaignon P, Poulter CD, Ferrer JL, Seemann M Chembiochem. 2017 Nov 2;18(21):2137-2144. doi: 10.1002/cbic.201700363. Epub 2017 , Oct 2. PMID:28862365<ref>PMID:28862365</ref>
-	*[[4-hydroxy-3-methylbut-2-~~enyl diphosphate reductase\|4-hydroxy-3-methylbut-2~~-~~enyl diphosphate reductase]]~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3zgn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:30, 4 August 2016

2016-08-04T20:30:47Z

←Older revision		Revision as of 20:30, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway==		==Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway==
	<StructureSection load='3zgn' size='340' side='right' caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3zgn' size='340' side='right' caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zgl\|3zgl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zgl\|3zgl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [http://www.ebi.ac.uk/pdbsum/3zgn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [http://pdbe.org/3zgn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [http://www.ebi.ac.uk/pdbsum/3zgn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
-	[[Category: Escherichia coli]]
	[[Category: Barbier, E]]		[[Category: Barbier, E]]
	[[Category: Borel, F]]		[[Category: Borel, F]]

OCA at 12:53, 25 December 2014

2014-12-25T12:53:59Z

←Older revision		Revision as of 12:53, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3zgn.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway==
		+	<StructureSection load='3zgn' size='340' side='right' caption='[[3zgn]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10G:(2E)-3-METHYL-4-SULFANYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10G</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zgl\|3zgl]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zgn RCSB], [http://www.ebi.ac.uk/pdbsum/3zgn PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>

-	~~{{STRUCTURE_3zgn\| PDB~~=~~3zgn \| SCENE= }}~~	+	==See Also==
-		+	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
-	~~===Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway~~===	+	== References ==
-		+	<references/>
-		+	__TOC__
-	==~~About this Structure~~==	+	</StructureSection>
-	~~[[3zgn]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA].~~	+
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Barbier, E.]]	+	[[Category: Barbier, E]]
-	[[Category: Borel, F.]]	+	[[Category: Borel, F]]
-	[[Category: Ferrer, J L.]]	+	[[Category: Ferrer, J L]]
-	[[Category: Janthawornpong, K.]]	+	[[Category: Janthawornpong, K]]
-	[[Category: Kratsutsky, S.]]	+	[[Category: Kratsutsky, S]]
-	[[Category: Poulter, C Dale.]]	+	[[Category: Poulter, C Dale]]
-	[[Category: Rohmer, M.]]	+	[[Category: Rohmer, M]]
-	[[Category: Seemann, M.]]	+	[[Category: Seemann, M]]
	[[Category: 4fe-4s cluster]]		[[Category: 4fe-4s cluster]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Mep pathway]]		[[Category: Mep pathway]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:20, 9 January 2013

2013-01-09T08:20:53Z

←Older revision		Revision as of 08:20, 9 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zgn.jpg\|left\|200px]]

-	~~The entry~~ 3zgn ~~is ON HOLD~~	+	{{STRUCTURE_3zgn\| PDB=3zgn \| SCENE= }}

-	~~Authors: Borel, F., Barbier, E., Kratsutsky, S., Janthawornpong, K., Rohmer, M., Dale Poulter, C., Ferrer, J.L., Seemann, M.~~	+	===Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway===

-	~~Description~~: ~~Crystal structures of~~ Escherichia coli ~~IspH in complex with a potent inhibitors of the methylerythritol phosphate~~ pathway	+
		+	==About this Structure==
		+	[[3zgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGN OCA].
		+	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
		+	[[Category: Escherichia coli]]
		+	[[Category: Barbier, E.]]
		+	[[Category: Borel, F.]]
		+	[[Category: Ferrer, J L.]]
		+	[[Category: Janthawornpong, K.]]
		+	[[Category: Kratsutsky, S.]]
		+	[[Category: Poulter, C Dale.]]
		+	[[Category: Rohmer, M.]]
		+	[[Category: Seemann, M.]]
		+	[[Category: 4fe-4s cluster]]
		+	[[Category: Inhibitor]]
		+	[[Category: Mep pathway]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "3zgn" [edit=sysop:move=sysop]

2013-01-02T08:39:39Z

Protected "3zgn" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:39, 2 January 2013

OCA: New page: '''Unreleased structure''' The entry 3zgn is ON HOLD Authors: Borel, F., Barbier, E., Kratsutsky, S., Janthawornpong, K., Rohmer, M., Dale Poulter, C., Ferrer, J.L., Seemann, M. Descri...

2013-01-02T08:39:38Z

New page: '''Unreleased structure''' The entry 3zgn is ON HOLD Authors: Borel, F., Barbier, E., Kratsutsky, S., Janthawornpong, K., Rohmer, M., Dale Poulter, C., Ferrer, J.L., Seemann, M. Descri...

New page

'''Unreleased structure'''

The entry 3zgn is ON HOLD

Authors: Borel, F., Barbier, E., Kratsutsky, S., Janthawornpong, K., Rohmer, M., Dale Poulter, C., Ferrer, J.L., Seemann, M.

Description: Crystal structures of Escherichia coli IspH in complex with a potent inhibitors of the methylerythritol phosphate pathway