3zhx - Revision history

OCA at 10:39, 9 May 2024

2024-05-09T10:39:44Z

←Older revision		Revision as of 10:39, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='3zhx' size='340' side='right'caption='[[3zhx]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3zhx' size='340' side='right'caption='[[3zhx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zhx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zhx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZHX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FM6:[(1S)~~-~~1-(3~~,~~4-DICHLOROPHENYL)-3-~~[~~OXIDANYL(PHENYLCARBONYL)AMINO~~]~~PROPYL~~]~~PHOSPHONIC+ACID'>FM6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;'>~~[~~[3zhy\|3zhy]]~~, [~~[3zhz\|3zhz~~]]~~, [[3zi0\|3zi0]]</div~~></td><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FM6:[(1S)-1-(3,4-DICHLOROPHENYL)-3-[OXIDANYL(PHENYLCARBONYL)AMINO]PROPYL]PHOSPHONIC+ACID'>FM6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhx OCA], [https://pdbe.org/3zhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zhx RCSB], [https://www.ebi.ac.uk/pdbsum/3zhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zhx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhx OCA], [https://pdbe.org/3zhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zhx RCSB], [https://www.ebi.ac.uk/pdbsum/3zhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DXR_MYCTU DXR_MYCTU]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).	+	[https://www.uniprot.org/uniprot/DXR_MYCTU DXR_MYCTU] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:

	==See Also==		==See Also==
-	*[[DXP reductoisomerase\|DXP reductoisomerase]]	+	*[[DXP reductoisomerase 3D Structures\|DXP reductoisomerase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Bergfors, T]]	+	[[Category: Bergfors T]]
-	[[Category: Bjorkelid, C]]	+	[[Category: Bjorkelid C]]
-	[[Category: Jansson~~, A M~~]]	+	[[Category: Jansson AM]]
-	[[Category: Jones~~, T A~~]]	+	[[Category: Jones TA]]
-	[[Category: Mowbray~~, S L~~]]	+	[[Category: Mowbray SL]]
-	[[Category: Unge, T]]	+	[[Category: Unge T]]
-	~~[[Category: Doxp/mep pathway]]~~	+
-	~~[[Category: ISPC, Israel Structural Proteomics Center]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rv2870c~~]]	+

OCA at 05:47, 10 August 2022

2022-08-10T05:47:09Z

←Older revision		Revision as of 05:47, 10 August 2022
Line 1:		Line 1:

	==Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue==		==Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue==
-	<StructureSection load='3zhx' size='340' side='right' caption='[[3zhx]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3zhx' size='340' side='right'caption='[[3zhx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zhx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zhx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZHX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FM6:[(1S)-1-(3,4-DICHLOROPHENYL)-3-[OXIDANYL(PHENYLCARBONYL)AMINO]PROPYL]PHOSPHONIC+ACID'>FM6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FM6:[(1S)-1-(3,4-DICHLOROPHENYL)-3-[OXIDANYL(PHENYLCARBONYL)AMINO]PROPYL]PHOSPHONIC+ACID'>FM6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zhy\|3zhy]], [[3zhz\|3zhz]], [[3zi0\|3zi0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zhy\|3zhy]], [[3zhz\|3zhz]], [[3zi0\|3zi0]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhx OCA], [~~http~~://pdbe.org/3zhx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zhx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zhx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zhx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhx OCA], [https://pdbe.org/3zhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zhx RCSB], [https://www.ebi.ac.uk/pdbsum/3zhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DXR_MYCTU DXR_MYCTU]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).	+	[[https://www.uniprot.org/uniprot/DXR_MYCTU DXR_MYCTU]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]		[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]

OCA at 14:55, 5 August 2016

2016-08-05T14:55:51Z

←Older revision		Revision as of 14:55, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue==		==Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue==
	<StructureSection load='3zhx' size='340' side='right' caption='[[3zhx]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3zhx' size='340' side='right' caption='[[3zhx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zhx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zhx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZHX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FM6:[(1S)-1-(3,4-DICHLOROPHENYL)-3-[OXIDANYL(PHENYLCARBONYL)AMINO]PROPYL]PHOSPHONIC+ACID'>FM6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FM6:[(1S)-1-(3,4-DICHLOROPHENYL)-3-[OXIDANYL(PHENYLCARBONYL)AMINO]PROPYL]PHOSPHONIC+ACID'>FM6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zhy\|3zhy]], [[3zhz\|3zhz]], [[3zi0\|3zi0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zhy\|3zhy]], [[3zhz\|3zhz]], [[3zi0\|3zi0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zhx RCSB], [http://www.ebi.ac.uk/pdbsum/3zhx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhx OCA], [http://pdbe.org/3zhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zhx RCSB], [http://www.ebi.ac.uk/pdbsum/3zhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zhx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DXR_MYCTU DXR_MYCTU]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zhx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DXP reductoisomerase\|DXP reductoisomerase]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]		[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
-	[[Category: ~~Mycobacterium tuberculosis h37rv~~]]	+	[[Category: Myctu]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]
	[[Category: Bjorkelid, C]]		[[Category: Bjorkelid, C]]

OCA at 09:35, 21 December 2014

2014-12-21T09:35:46Z

←Older revision		Revision as of 09:35, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zhx\| PDB=3zhx \| SCENE= }}~~	+	==Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue==
-	===Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue===	+	<StructureSection load='3zhx' size='340' side='right' caption='[[3zhx]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23819803}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zhx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZHX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FM6:[(1S)-1-(3,4-DICHLOROPHENYL)-3-[OXIDANYL(PHENYLCARBONYL)AMINO]PROPYL]PHOSPHONIC+ACID'>FM6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zhy\|3zhy]], [[3zhz\|3zhz]], [[3zi0\|3zi0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zhx RCSB], [http://www.ebi.ac.uk/pdbsum/3zhx PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The antimalarial compound fosmidomycin targets DXR, the enzyme that catalyzes the first committed step in the MEP pathway, producing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. The MEP pathway is used by a number of pathogens, including Mycobacterium tuberculosis and apicomplexan parasites, and differs from the classical mevalonate pathway that is essential in humans. Using a structure-based approach, we designed a number of analogues of fosmidomycin, including a series that are substituted in both the Calpha and the hydroxamate positions. The latter proved to be a stable framework for the design of inhibitors that extend from the polar and cramped (and so not easily druggable) substrate-binding site and can, for the first time, bridge the substrate and cofactor binding sites. A number of these compounds are more potent than fosmidomycin in terms of killing Plasmodium falciparum in an in vitro assay; the best has an IC50 of 40 nM.

-	~~==About this Structure==~~	+	DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.,Jansson AM, Wieckowska A, Bjorkelid C, Yahiaoui S, Sooriyaarachchi S, Lindh M, Bergfors T, Dharavath S, Desroses M, Suresh S, Andaloussi M, Nikhil R, Sreevalli S, Srinivasa BR, Larhed M, Jones TA, Karlen A, Mowbray SL J Med Chem. 2013 Aug 8;56(15):6190-9. doi: 10.1021/jm4006498. Epub 2013 Jul 17. PMID:23819803<ref>PMID:23819803</ref>
-	~~[[3zhx]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3ZHX OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023819803</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]		[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
-	[[Category: Bergfors, T.]]	+	[[Category: Bergfors, T]]
-	[[Category: Bjorkelid, C.]]	+	[[Category: Bjorkelid, C]]
-	[[Category: Jansson, A M.]]	+	[[Category: Jansson, A M]]
-	[[Category: Jones, T A.]]	+	[[Category: Jones, T A]]
-	[[Category: Mowbray, S L.]]	+	[[Category: Mowbray, S L]]
-	[[Category: Unge, T.]]	+	[[Category: Unge, T]]
	[[Category: Doxp/mep pathway]]		[[Category: Doxp/mep pathway]]
-	[[Category: ISPC]]	+	[[Category: ISPC, Israel Structural Proteomics Center]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rv2870c]]		[[Category: Rv2870c]]

OCA at 06:21, 10 October 2013

2013-10-10T06:21:19Z

←Older revision		Revision as of 06:21, 10 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3zhx\| PDB=3zhx \| SCENE= }}
		+	===Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue===
		+	{{ABSTRACT_PUBMED_23819803}}

-	~~The entry~~ 3zhx is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[3zhx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHX OCA].

-	~~Authors~~: Bjorkelid, C., Jansson, A.M.~~, Bergfors~~, T.~~, Unge, T.,~~ Mowbray, S.L.~~, Jones~~, T.A.	+	==Reference==
-		+	<ref group="xtra">PMID:023819803</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue~~	+	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
		+	[[Category: Mycobacterium tuberculosis h37rv]]
		+	[[Category: Bergfors, T.]]
		+	[[Category: Bjorkelid, C.]]
		+	[[Category: Jansson, A M.]]
		+	[[Category: Jones, T A.]]
		+	[[Category: Mowbray, S L.]]
		+	[[Category: Unge, T.]]
		+	[[Category: Doxp/mep pathway]]
		+	[[Category: ISPC]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rv2870c]]

OCA at 08:02, 27 March 2013

2013-03-27T08:02:51Z

←Older revision		Revision as of 08:02, 27 March 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zhx is ON HOLD	+	The entry 3zhx is ON HOLD until Paper Publication

	Authors: Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.		Authors: Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.

	Description: Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue		Description: Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue

OCA: Protected "3zhx" [edit=sysop:move=sysop]

2013-01-09T07:38:41Z

Protected "3zhx" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:38, 9 January 2013

OCA: New page: '''Unreleased structure''' The entry 3zhx is ON HOLD Authors: Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A. Description: Structure of Mycobacterium t...

2013-01-09T07:38:39Z

New page: '''Unreleased structure''' The entry 3zhx is ON HOLD Authors: Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A. Description: Structure of Mycobacterium t...

New page

'''Unreleased structure'''

The entry 3zhx is ON HOLD

Authors: Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.

Description: Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue