3zld - Revision history

OCA at 11:05, 20 December 2023

2023-12-20T11:05:09Z

←Older revision		Revision as of 11:05, 20 December 2023
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	<StructureSection load='3zld' size='340' side='right'caption='[[3zld]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3zld' size='340' side='right'caption='[[3zld]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Toxgo Toxgo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZLD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZLD FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~3zle~~\|~~3zle~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [https://pdbe.org/3zld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [https://www.ebi.ac.uk/pdbsum/3zld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zld ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [https://pdbe.org/3zld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [https://www.ebi.ac.uk/pdbsum/3zld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zld ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~AMA1L_TOXGO AMA1L_TOXGO]] May play a role in host cell invasion (By similarity). [[https://www.uniprot.org/uniprot/RON22_TOXGO RON22_TOXGO]~~] May play a role in host cell invasion ~~(By similarity)~~.	+	[https://www.uniprot.org/uniprot/AMA1L_TOXGV AMA1L_TOXGV] May play a role in host cell invasion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Toxgo~~]]	+	[[Category: Toxoplasma gondii]]
-	[[Category: Boulanger~~, M J~~]]	+	[[Category: Boulanger MJ]]
-	[[Category: Tonkin~~, M L]]~~	+	[[Category: Tonkin ML]]
-	~~[[Category: Invasion]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Moving junction~~]]	+

OCA at 05:50, 10 August 2022

2022-08-10T05:50:32Z

←Older revision		Revision as of 05:50, 10 August 2022
Line 1:		Line 1:

	==Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2==		==Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2==
-	<StructureSection load='3zld' size='340' side='right' caption='[[3zld]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3zld' size='340' side='right'caption='[[3zld]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zld]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZLD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZLD FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zle\|3zle]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zle\|3zle]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [~~http~~://pdbe.org/3zld PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zld PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zld ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [https://pdbe.org/3zld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [https://www.ebi.ac.uk/pdbsum/3zld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zld ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AMA1L_TOXGO AMA1L_TOXGO]] May play a role in host cell invasion (By similarity). [[~~http~~://www.uniprot.org/uniprot/RON22_TOXGO RON22_TOXGO]] May play a role in host cell invasion (By similarity).	+	[[https://www.uniprot.org/uniprot/AMA1L_TOXGO AMA1L_TOXGO]] May play a role in host cell invasion (By similarity). [[https://www.uniprot.org/uniprot/RON22_TOXGO RON22_TOXGO]] May play a role in host cell invasion (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Toxgo]]		[[Category: Toxgo]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]

OCA at 15:30, 5 August 2016

2016-08-05T15:30:33Z

←Older revision		Revision as of 15:30, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2==		==Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2==
	<StructureSection load='3zld' size='340' side='right' caption='[[3zld]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3zld' size='340' side='right' caption='[[3zld]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Toxoplasma_gondii Toxoplasma gondii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZLD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZLD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zle\|3zle]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zle\|3zle]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [http://www.ebi.ac.uk/pdbsum/3zld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [http://pdbe.org/3zld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [http://www.ebi.ac.uk/pdbsum/3zld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zld ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zld" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Toxoplasma gondii~~]]	+	[[Category: Toxgo]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]
	[[Category: Tonkin, M L]]		[[Category: Tonkin, M L]]

OCA at 19:55, 25 December 2014

2014-12-25T19:55:28Z

←Older revision		Revision as of 19:55, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [http://www.ebi.ac.uk/pdbsum/3zld PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [http://www.ebi.ac.uk/pdbsum/3zld PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AMA1L_TOXGO AMA1L_TOXGO]] May play a role in host cell invasion (By similarity). [[http://www.uniprot.org/uniprot/RON22_TOXGO RON22_TOXGO]] May play a role in host cell invasion (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:05, 21 December 2014

2014-12-21T10:05:11Z

←Older revision		Revision as of 10:05, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zld\| PDB=3zld \| SCENE= }}~~	+	==Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2==
-	===Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2===	+	<StructureSection load='3zld' size='340' side='right' caption='[[3zld]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23940612}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZLD FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zle\|3zle]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zld RCSB], [http://www.ebi.ac.uk/pdbsum/3zld PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Toxoplasma gondii is an obligate intracellular parasite of the phylum Apicomplexa. The interaction of two well-studied proteins, Apical Membrane Antigen 1 (AMA1) and Rhoptry Neck protein 2 (RON2), has been shown to be critical for invasion by the asexual tachyzoite stage. Recently, two paralogues of these proteins, dubbed sporoAMA1 and sporoRON2 (or RON2L2), respectively, have been identified but not further characterized in proteomic and transcriptomic analyses of Toxoplasma sporozoites. Here, we show that sporoAMA1 and sporoRON2 localize to the apical region of sporozoites and that, in vitro, they interact specifically and exclusively, with no detectable interaction of sporoAMA1 with generic RON2 or sporoRON2 with generic AMA1. Structural studies of the interacting domains of sporoRON2 and sporoAMA1 indicate a novel pairing that is similar in overall form but distinct in detail from the previously described interaction of the generic pairing. Most notably, binding of sporoRON2 domain 3 to domains I/II of sporoAMA1 results in major alterations in the latter protein at the site of binding and allosterically in the membrane-proximal domain III of sporoAMA1 suggesting a possible role in signaling. Lastly, pretreatment of sporozoites with domain 3 of sporoRON2 substantially impedes their invasion into host cells while having no effect on tachyzoites, and vice versa for domain 3 of generic RON2 (which inhibits tachyzoite but not sporozoite invasion). These data indicate that sporozoites and tachyzoites each use a distinct pair of paralogous AMA1 and RON2 proteins for invasion into host cells, possibly due to the very different environment in which they each must function.

-	~~==Function==~~	+	Toxoplasma gondii Sporozoites Invade Host Cells Using Two Novel Paralogues of RON2 and AMA1.,Poukchanski A, Fritz HM, Tonkin ML, Treeck M, Boulanger MJ, Boothroyd JC PLoS One. 2013 Aug 5;8(8):e70637. doi: 10.1371/journal.pone.0070637. Print 2013. PMID:23940612<ref>PMID:23940612</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/AMA1L_TOXGO AMA1L_TOXGO]] May play a role in host cell invasion~~ (~~By similarity~~). ~~[[http~~:/~~/www~~.~~uniprot~~.~~org~~/~~uniprot/RON22_TOXGO RON22_TOXGO]] May play a role in host cell invasion (By similarity).~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3zld]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Toxoplasma_gondii Toxoplasma gondii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023940612</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
-	[[Category: Boulanger, M J.]]	+	[[Category: Boulanger, M J]]
-	[[Category: Tonkin, M L.]]	+	[[Category: Tonkin, M L]]
	[[Category: Invasion]]		[[Category: Invasion]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Moving junction]]		[[Category: Moving junction]]

OCA at 07:30, 28 August 2013

2013-08-28T07:30:44Z

←Older revision		Revision as of 07:30, 28 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_3zld\| PDB=3zld \| SCENE= }}
		+	===Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2===
		+	{{ABSTRACT_PUBMED_23940612}}

-	~~The entry 3zld is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/AMA1L_TOXGO AMA1L_TOXGO]] May play a role in host cell invasion (By similarity). [[http://www.uniprot.org/uniprot/RON22_TOXGO RON22_TOXGO]] May play a role in host cell invasion (By similarity).

-	~~Authors~~: ~~Tonkin, M~~.L.~~, Boulanger, M~~.J.	+	==About this Structure==
		+	[[3zld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLD OCA].

-	~~Description~~: ~~Crystal structure of~~ Toxoplasma gondii ~~sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2~~	+	==Reference==
		+	<ref group="xtra">PMID:023940612</ref><references group="xtra"/><references/>
		+	[[Category: Toxoplasma gondii]]
		+	[[Category: Boulanger, M J.]]
		+	[[Category: Tonkin, M L.]]
		+	[[Category: Invasion]]
		+	[[Category: Membrane protein]]
		+	[[Category: Moving junction]]

OCA at 09:52, 13 February 2013

2013-02-13T09:52:54Z

←Older revision		Revision as of 09:52, 13 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zld is ON HOLD	+	The entry 3zld is ON HOLD until Paper Publication

	Authors: Tonkin, M.L., Boulanger, M.J.		Authors: Tonkin, M.L., Boulanger, M.J.

	Description: Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2		Description: Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2

OCA: Protected "3zld" [edit=sysop:move=sysop]

2013-02-06T12:16:13Z

Protected "3zld" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:16, 6 February 2013

OCA: New page: '''Unreleased structure''' The entry 3zld is ON HOLD Authors: Tonkin, M.L., Boulanger, M.J. Description: Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa ...

2013-02-06T12:16:12Z

New page: '''Unreleased structure''' The entry 3zld is ON HOLD Authors: Tonkin, M.L., Boulanger, M.J. Description: Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa ...

New page

'''Unreleased structure'''

The entry 3zld is ON HOLD

Authors: Tonkin, M.L., Boulanger, M.J.

Description: Crystal structure of Toxoplasma gondii sporozoite AMA1 in complex with a 36 aa region of sporozoite RON2