3zm5 - Revision history

OCA at 11:05, 20 December 2023

2023-12-20T11:05:53Z

←Older revision		Revision as of 11:05, 20 December 2023
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	<StructureSection load='3zm5' size='340' side='right'caption='[[3zm5]], [[Resolution\|resolution]] 2.94Å' scene=''>		<StructureSection load='3zm5' size='340' side='right'caption='[[3zm5]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strr6 Strr6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZM5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZM5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IGM:2~~,~~4-BIS(CHLORANYL)-N-~~[~~3-CYANO-6-~~[~~(4-HYDROXYPHENYL)METHYL~~]~~-5,7-DIHYDRO-4H-THIENO[2,3-C~~]~~PYRIDIN-~~2~~-YL]-5-MORPHOLIN-4-YLSULFONYL-BENZAMIDE'>IGM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.94Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3zl8\|3zl8]], [[3zm6\|3zm6]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IGM:2,4-BIS(CHLORANYL)-N-[3-CYANO-6-[(4-HYDROXYPHENYL)METHYL]-5,7-DIHYDRO-4H-THIENO[2,3-C]PYRIDIN-2-YL]-5-MORPHOLIN-4-YLSULFONYL-BENZAMIDE'>IGM</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/UDP~~-N-~~acetylmuramoyl~~-~~tripeptide~~--D-~~alanyl~~-D-~~alanine_ligase UDP~~-N-~~acetylmuramoyl~~-~~tripeptide~~--D-~~alanyl~~-D-~~alanine ligase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=6.3.2.10 6.3.2.10]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [https://pdbe.org/3zm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zm5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [https://pdbe.org/3zm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zm5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6]] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]	+	[https://www.uniprot.org/uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strr6]]~~	+	[[Category: Streptococcus pneumoniae R6]]
-	~~[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase~~]]	+	[[Category: Barreteau H]]
-	[[Category: Barreteau, H]]	+	[[Category: Blanot D]]
-	[[Category: Blanot, D]]	+	[[Category: Contreras-Martel C]]
-	[[Category: Contreras-Martel, C]]	+	[[Category: Dessen A]]
-	[[Category: Dessen, A]]	+	[[Category: Gobec S]]
-	[[Category: Gobec, S]]	+	[[Category: Hrast M]]
-	[[Category: Hrast, M]]	+	[[Category: Knez D]]
-	[[Category: Knez, D]]	+	[[Category: Mengin-Lecreulx D]]
-	[[Category: Mengin-Lecreulx, D]]	+	[[Category: ONeill AJ]]
-	[[Category: ONeill~~, A J~~]]	+	[[Category: Randall CP]]
-	[[Category: Randall~~, C P~~]]	+	[[Category: Sosic I]]
-	[[Category: Sosic, I]]	+	[[Category: Turk S]]
-	[[Category: Turk, S]]	+
-	~~[[Category: Adp-forming enzyme]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell divison]]~~	+
-	~~[[Category: Cell shape]]~~	+
-	~~[[Category: Cell wall]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Peptidoglycan synthesis~~]]	+

OCA at 07:00, 18 August 2022

2022-08-18T07:00:27Z

←Older revision		Revision as of 07:00, 18 August 2022
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	==CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR==		==CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR==
-	<StructureSection load='3zm5' size='340' side='right' caption='[[3zm5]], [[Resolution\|resolution]] 2.94Å' scene=''>	+	<StructureSection load='3zm5' size='340' side='right'caption='[[3zm5]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zm5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZM5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZM5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IGM:2,4-BIS(CHLORANYL)-N-[3-CYANO-6-[(4-HYDROXYPHENYL)METHYL]-5,7-DIHYDRO-4H-THIENO[2,3-C]PYRIDIN-2-YL]-5-MORPHOLIN-4-YLSULFONYL-BENZAMIDE'>IGM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IGM:2,4-BIS(CHLORANYL)-N-[3-CYANO-6-[(4-HYDROXYPHENYL)METHYL]-5,7-DIHYDRO-4H-THIENO[2,3-C]PYRIDIN-2-YL]-5-MORPHOLIN-4-YLSULFONYL-BENZAMIDE'>IGM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zl8\|3zl8]], [[3zm6\|3zm6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zl8\|3zl8]], [[3zm6\|3zm6]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine_ligase UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.10 6.3.2.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine_ligase UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.10 6.3.2.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [~~http~~://pdbe.org/3zm5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zm5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zm5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [https://pdbe.org/3zm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zm5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6]] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]	+	[[https://www.uniprot.org/uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6]] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Strr6]]		[[Category: Strr6]]
	[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]		[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]

OCA at 16:26, 27 February 2019

2019-02-27T16:26:37Z

←Older revision		Revision as of 16:26, 27 February 2019
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[~~MurD~~ ligase\|~~MurD~~ ligase]]	+	*[[Mur ligase\|Mur ligase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:53, 4 August 2016

2016-08-04T22:53:56Z

←Older revision		Revision as of 22:53, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR==		==CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR==
	<StructureSection load='3zm5' size='340' side='right' caption='[[3zm5]], [[Resolution\|resolution]] 2.94Å' scene=''>		<StructureSection load='3zm5' size='340' side='right' caption='[[3zm5]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZM5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZM5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IGM:2,4-BIS(CHLORANYL)-N-[3-CYANO-6-[(4-HYDROXYPHENYL)METHYL]-5,7-DIHYDRO-4H-THIENO[2,3-C]PYRIDIN-2-YL]-5-MORPHOLIN-4-YLSULFONYL-BENZAMIDE'>IGM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IGM:2,4-BIS(CHLORANYL)-N-[3-CYANO-6-[(4-HYDROXYPHENYL)METHYL]-5,7-DIHYDRO-4H-THIENO[2,3-C]PYRIDIN-2-YL]-5-MORPHOLIN-4-YLSULFONYL-BENZAMIDE'>IGM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zl8\|3zl8]], [[3zm6\|3zm6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zl8\|3zl8]], [[3zm6\|3zm6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine_ligase UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.10 6.3.2.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine_ligase UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.10 6.3.2.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zm5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [http://pdbe.org/3zm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zm5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zm5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[MurD ligase\|MurD ligase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptococcus pneumoniae r6~~]]	+	[[Category: Strr6]]
	[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]		[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]
	[[Category: Barreteau, H]]		[[Category: Barreteau, H]]

OCA at 13:46, 25 December 2014

2014-12-25T13:46:51Z

←Older revision		Revision as of 13:46, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zm5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zm5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6]] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:04, 21 December 2014

2014-12-21T09:04:12Z

←Older revision		Revision as of 09:04, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zm5\| PDB=3zm5 \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR==
-	===CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR===	+	<StructureSection load='3zm5' size='340' side='right' caption='[[3zm5]], [[Resolution\|resolution]] 2.94Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23786712}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZM5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IGM:2,4-BIS(CHLORANYL)-N-[3-CYANO-6-[(4-HYDROXYPHENYL)METHYL]-5,7-DIHYDRO-4H-THIENO[2,3-C]PYRIDIN-2-YL]-5-MORPHOLIN-4-YLSULFONYL-BENZAMIDE'>IGM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zl8\|3zl8]], [[3zm6\|3zm6]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine_ligase UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.10 6.3.2.10] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zm5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptidoglycan is an essential component of the bacterial cell wall, and enzymes involved in its biosynthesis represent validated targets for antibacterial drug discovery. MurF catalyzes the final intracellular peptidoglycan biosynthesis step: the addition of d-Ala-d-Ala to the nucleotide precursor UDP-MurNAc-l-Ala-gamma-d-Glu-meso-DAP (or l-Lys). As MurF has no human counterpart, it represents an attractive target for the development of new antibacterial drugs. Using recently published cyanothiophene inhibitors of MurF from Streptococcus pneumoniae as a starting point, we designed and synthesized a series of structurally related derivatives and investigated their inhibition of MurF enzymes from different bacterial species. Systematic structural modifications of the parent compounds resulted in a series of nanomolar inhibitors of MurF from S. pneumoniae and micromolar inhibitors of MurF from Escherichia coli and Staphylococcus aureus. Some of the inhibitors also show antibacterial activity against S. pneumoniae R6. These findings, together with two new co-crystal structures, represent an excellent starting point for further optimization toward effective novel antibacterials.

-	~~==Function==~~	+	Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.,Hrast M, Turk S, Sosic I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S Eur J Med Chem. 2013 May 21;66C:32-45. doi: 10.1016/j.ejmech.2013.05.013. PMID:23786712<ref>PMID:23786712</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6]] Involved in cell wall formation~~. ~~Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)~~.~~[RuleBase~~:~~RU004136]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3zm5]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023786712</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Streptococcus pneumoniae r6]]		[[Category: Streptococcus pneumoniae r6]]
	[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]		[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]
-	[[Category: Barreteau, H.]]	+	[[Category: Barreteau, H]]
-	[[Category: Blanot, D.]]	+	[[Category: Blanot, D]]
-	[[Category: Contreras-Martel, C.]]	+	[[Category: Contreras-Martel, C]]
-	[[Category: Dessen, A.]]	+	[[Category: Dessen, A]]
-	[[Category: Gobec, S.]]	+	[[Category: Gobec, S]]
-	[[Category: Hrast, M.]]	+	[[Category: Hrast, M]]
-	[[Category: Knez, D.]]	+	[[Category: Knez, D]]
-	[[Category: Mengin-Lecreulx, D.]]	+	[[Category: Mengin-Lecreulx, D]]
-	[[Category: ONeill, A J.]]	+	[[Category: ONeill, A J]]
-	[[Category: Randall, C P.]]	+	[[Category: Randall, C P]]
-	[[Category: Sosic, I.]]	+	[[Category: Sosic, I]]
-	[[Category: Turk, S.]]	+	[[Category: Turk, S]]
	[[Category: Adp-forming enzyme]]		[[Category: Adp-forming enzyme]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 14:09, 3 July 2013

2013-07-03T14:09:12Z

←Older revision		Revision as of 14:09, 3 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3zm5\| PDB=3zm5 \| SCENE= }}
		+	===CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR===
		+	{{ABSTRACT_PUBMED_23786712}}

-	~~The entry 3zm5 is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6]] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]

-	~~Authors~~: ~~Hrast, M~~.~~, Turk, S~~.~~, Sosic, I~~.~~, Knez, D~~.~~, Randall, C~~.P.~~, Barreteau, H., Contreras~~-~~Martel, C., Dessen, A., ONeill, A.J., Mengin-Lecreulx, D., Blanot, D., Gobec, S~~.	+	==About this Structure==
		+	[[3zm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA].

-	~~Description~~: ~~CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR~~	+	==Reference==
		+	<ref group="xtra">PMID:023786712</ref><references group="xtra"/><references/>
		+	[[Category: Streptococcus pneumoniae r6]]
		+	[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]
		+	[[Category: Barreteau, H.]]
		+	[[Category: Blanot, D.]]
		+	[[Category: Contreras-Martel, C.]]
		+	[[Category: Dessen, A.]]
		+	[[Category: Gobec, S.]]
		+	[[Category: Hrast, M.]]
		+	[[Category: Knez, D.]]
		+	[[Category: Mengin-Lecreulx, D.]]
		+	[[Category: ONeill, A J.]]
		+	[[Category: Randall, C P.]]
		+	[[Category: Sosic, I.]]
		+	[[Category: Turk, S.]]
		+	[[Category: Adp-forming enzyme]]
		+	[[Category: Atp-binding]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell divison]]
		+	[[Category: Cell shape]]
		+	[[Category: Cell wall]]
		+	[[Category: Ligase]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Peptidoglycan synthesis]]

OCA: Protected "3zm5" [edit=sysop:move=sysop]

2013-02-13T09:53:48Z

Protected "3zm5" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:53, 13 February 2013

OCA: New page: '''Unreleased structure''' The entry 3zm5 is ON HOLD until Paper Publication Authors: Hrast, M., Turk, S., Sosic, I., Knez, D., Randall, C.P., Barreteau, H., Contreras-Martel, C., Desse...

2013-02-13T09:53:46Z

New page: '''Unreleased structure''' The entry 3zm5 is ON HOLD until Paper Publication Authors: Hrast, M., Turk, S., Sosic, I., Knez, D., Randall, C.P., Barreteau, H., Contreras-Martel, C., Desse...

New page

'''Unreleased structure'''

The entry 3zm5 is ON HOLD until Paper Publication

Authors: Hrast, M., Turk, S., Sosic, I., Knez, D., Randall, C.P., Barreteau, H., Contreras-Martel, C., Dessen, A., ONeill, A.J., Mengin-Lecreulx, D., Blanot, D., Gobec, S.

Description: CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR