3zv6 - Revision history

OCA at 11:13, 20 December 2023

2023-12-20T11:13:49Z

←Older revision		Revision as of 11:13, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zv6' size='340' side='right'caption='[[3zv6]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='3zv6' size='340' side='right'caption='[[3zv6]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_11996 Atcc 11996~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=4HB:4,4~~-~~DIHYDROXYBIPHENYL'>4HB</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.14Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2y99\|2y99]], [[2y93\|2y93]], [[3zv5\|3zv5]], [[3zv4\|3zv4]], [[3zv3\|3zv3]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HB:4,4-DIHYDROXYBIPHENYL'>4HB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Cis-2,3-dihydrobiphenyl-2,3-diol_dehydrogenase Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.56 1.3.1.56] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [https://pdbe.org/3zv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [https://pdbe.org/3zv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BPHB_COMTE BPHB_COMTE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 11996]]~~	+	[[Category: Comamonas testosteroni]]
-	~~[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dhindwal, S]]	+	[[Category: Dhindwal S]]
-	[[Category: Kumar, P]]	+	[[Category: Kumar P]]
-	[[Category: Patil~~, D N]]~~	+	[[Category: Patil DN]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Sdr]]~~	+
-	~~[[Category: Short chain dehydrogenase/oxidoreductase~~]]	+

OCA at 07:20, 18 August 2022

2022-08-18T07:20:28Z

←Older revision		Revision as of 07:20, 18 August 2022
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B-356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4,4'-DIHYDROXYBIPHENYL==		==CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B-356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4,4'-DIHYDROXYBIPHENYL==
-	<StructureSection load='3zv6' size='340' side='right' caption='[[3zv6]], [[Resolution\|resolution]] 2.14Å' scene=''>	+	<StructureSection load='3zv6' size='340' side='right'caption='[[3zv6]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_11996 Atcc 11996]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_11996 Atcc 11996]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HB:4,4-DIHYDROXYBIPHENYL'>4HB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HB:4,4-DIHYDROXYBIPHENYL'>4HB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y99\|2y99]], [[2y93\|2y93]], [[3zv5\|3zv5]], [[3zv4\|3zv4]], [[3zv3\|3zv3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y99\|2y99]], [[2y93\|2y93]], [[3zv5\|3zv5]], [[3zv4\|3zv4]], [[3zv3\|3zv3]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cis-2,3-dihydrobiphenyl-2,3-diol_dehydrogenase Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.56 1.3.1.56] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cis-2,3-dihydrobiphenyl-2,3-diol_dehydrogenase Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.56 1.3.1.56] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [~~http~~://pdbe.org/3zv6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zv6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [https://pdbe.org/3zv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	[[Category: Atcc 11996]]		[[Category: Atcc 11996]]
	[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]		[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Dhindwal, S]]		[[Category: Dhindwal, S]]
	[[Category: Kumar, P]]		[[Category: Kumar, P]]

OCA at 09:55, 11 August 2016

2016-08-11T09:55:57Z

←Older revision		Revision as of 09:55, 11 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B-356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4,4'-DIHYDROXYBIPHENYL==		==CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B-356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4,4'-DIHYDROXYBIPHENYL==
	<StructureSection load='3zv6' size='340' side='right' caption='[[3zv6]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='3zv6' size='340' side='right' caption='[[3zv6]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Comamonas_testosteroni Comamonas testosteroni~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11996 Atcc 11996]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HB:4,4-DIHYDROXYBIPHENYL'>4HB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HB:4,4-DIHYDROXYBIPHENYL'>4HB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y99\|2y99]], [[2y93\|2y93]], [[3zv5\|3zv5]], [[3zv4\|3zv4]], [[3zv3\|3zv3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y99\|2y99]], [[2y93\|2y93]], [[3zv5\|3zv5]], [[3zv4\|3zv4]], [[3zv3\|3zv3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cis-2,3-dihydrobiphenyl-2,3-diol_dehydrogenase Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.56 1.3.1.56] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cis-2,3-dihydrobiphenyl-2,3-diol_dehydrogenase Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.56 1.3.1.56] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [http://pdbe.org/3zv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zv6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 11996]]
	[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]		[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]
-	[[Category: Comamonas testosteroni]]
	[[Category: Dhindwal, S]]		[[Category: Dhindwal, S]]
	[[Category: Kumar, P]]		[[Category: Kumar, P]]

OCA at 10:21, 4 January 2015

2015-01-04T10:21:21Z

←Older revision		Revision as of 10:21, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HB:4,4-DIHYDROXYBIPHENYL'>4HB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HB:4,4-DIHYDROXYBIPHENYL'>4HB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y99\|2y99]], [[2y93\|2y93]], [[3zv5\|3zv5]], [[3zv4\|3zv4]], [[3zv3\|3zv3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y99\|2y99]], [[2y93\|2y93]], [[3zv5\|3zv5]], [[3zv4\|3zv4]], [[3zv3\|3zv3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cis-2,3-dihydrobiphenyl-2,3-diol_dehydrogenase Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.56 1.3.1.56] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cis-2,3-dihydrobiphenyl-2,3-diol_dehydrogenase Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.56 1.3.1.56] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Biochemical Studies and Ligand-bound Structures of Biphenyl Dehydrogenase from Pandoraea pnomenusa Strain B-356 Reveal a Basis for Broad Specificity of the Enzyme.,Dhindwal S, Patil DN, Mohammadi M, Sylvestre M, Tomar S, Kumar P J Biol Chem. 2011 Oct 21;286(42):37011-22. Epub 2011 Aug 31. PMID:21880718<ref>PMID:21880718</ref>		Biochemical Studies and Ligand-bound Structures of Biphenyl Dehydrogenase from Pandoraea pnomenusa Strain B-356 Reveal a Basis for Broad Specificity of the Enzyme.,Dhindwal S, Patil DN, Mohammadi M, Sylvestre M, Tomar S, Kumar P J Biol Chem. 2011 Oct 21;286(42):37011-22. Epub 2011 Aug 31. PMID:21880718<ref>PMID:21880718</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]		[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]
	[[Category: Comamonas testosteroni]]		[[Category: Comamonas testosteroni]]
-	[[Category: Dhindwal, S.]]	+	[[Category: Dhindwal, S]]
-	[[Category: Kumar, P.]]	+	[[Category: Kumar, P]]
-	[[Category: Patil, D N.]]	+	[[Category: Patil, D N]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Sdr]]		[[Category: Sdr]]
	[[Category: Short chain dehydrogenase/oxidoreductase]]		[[Category: Short chain dehydrogenase/oxidoreductase]]

OCA at 07:22, 5 June 2014

2014-06-05T07:22:23Z

←Older revision		Revision as of 07:22, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zv6.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B-356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4,4'-DIHYDROXYBIPHENYL==
		+	<StructureSection load='3zv6' size='340' side='right' caption='[[3zv6]], [[Resolution\|resolution]] 2.14Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HB:4,4-DIHYDROXYBIPHENYL'>4HB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y99\|2y99]], [[2y93\|2y93]], [[3zv5\|3zv5]], [[3zv4\|3zv4]], [[3zv3\|3zv3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cis-2,3-dihydrobiphenyl-2,3-diol_dehydrogenase Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.56 1.3.1.56] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv6 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Biphenyl dehydrogenase, a member of short-chain dehydrogenase/reductase enzymes, catalyzes the second step of the biphenyl/polychlorinated biphenyls catabolic pathway in bacteria. To understand the molecular basis for the broad substrate specificity of Pandoraea pnomenusa strain B-356 biphenyl dehydrogenase (BphB(B-356)), the crystal structures of the apo-enzyme, the binary complex with NAD(+), and the ternary complexes with NAD(+)-2,3-dihydroxybiphenyl and NAD(+)-4,4'-dihydroxybiphenyl were determined at 2.2-, 2.5-, 2.4-, and 2.1-A resolutions, respectively. A crystal structure representing an intermediate state of the enzyme was also obtained in which the substrate binding loop was ordered as compared with the apo and binary forms but it was displaced significantly with respect to the ternary structures. These five structures reveal that the substrate binding loop is highly mobile and that its conformation changes during ligand binding, starting from a disorganized loop in the apo state to a well organized loop structure in the ligand-bound form. Conformational changes are induced during ligand binding; forming a well defined cavity to accommodate a wide variety of substrates. This explains the biochemical data that shows BphB(B-356) converts the dihydrodiol metabolites of 3,3'-dichlorobiphenyl, 2,4,4'-trichlorobiphenyl, and 2,6-dichlorobiphenyl to their respective dihydroxy metabolites. For the first time, a combination of structural, biochemical, and molecular docking studies of BphB(B-356) elucidate the unique ability of the enzyme to transform the cis-dihydrodiols of double meta-, para-, and ortho-substituted chlorobiphenyls.

-	<!--	+	Biochemical Studies and Ligand-bound Structures of Biphenyl Dehydrogenase from Pandoraea pnomenusa Strain B-356 Reveal a Basis for Broad Specificity of the Enzyme.,Dhindwal S, Patil DN, Mohammadi M, Sylvestre M, Tomar S, Kumar P J Biol Chem. 2011 Oct 21;286(42):37011-22. Epub 2011 Aug 31. PMID:21880718<ref>PMID:21880718</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zv6"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3zv6\| PDB=3zv6 \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF CIS-BIPHENYL-2~~,~~3-DIHYDRODIOL-2,3-DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B-356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4,4'-DIHYDROXYBIPHENYL===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21880718}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21880718 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21880718}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zv6]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021880718<~~/~~ref~~><~~ref group="xtra">PMID:021045310</ref><references group="xtra"~~/>	+
	[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]		[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]
	[[Category: Comamonas testosteroni]]		[[Category: Comamonas testosteroni]]

OCA at 07:33, 30 October 2011

2011-10-30T07:33:41Z

←Older revision		Revision as of 07:33, 30 October 2011
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-	[[Image:3zv6.~~jpg~~\|left\|200px]]	+	[[Image:3zv6.png\|left\|200px]]

	<!--		<!--
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	<!--		<!--
-	The line below this paragraph, {{~~ABSTRACT_PUBMED_21045310~~}}, adds the Publication Abstract to the page	+	The line below this paragraph, {{ABSTRACT_PUBMED_21880718}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where ~~21045310~~ is the PubMed ID number.	+	(as it appears on PubMed at http://www.pubmed.gov), where 21880718 is the PubMed ID number.
	-->		-->
-	{{~~ABSTRACT_PUBMED_21045310~~}}	+	{{ABSTRACT_PUBMED_21880718}}

	==About this Structure==		==About this Structure==
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021045310</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021880718</ref><ref group="xtra">PMID:021045310</ref><references group="xtra"/>
	[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]		[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]
	[[Category: Comamonas testosteroni]]		[[Category: Comamonas testosteroni]]

OCA at 07:07, 31 August 2011

2011-08-31T07:07:59Z

←Older revision		Revision as of 07:07, 31 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zv6.jpg\|left\|200px]]

-	The ~~entry 3zv6~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zv6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zv6\| PDB=3zv6 \| SCENE= }}

-	~~Authors: DHINDWAL~~, S., ~~PATIL~~, ~~D.N., KUMAR, P.~~	+	===CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B-356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4,4'-DIHYDROXYBIPHENYL===

-	~~Description~~: ~~CRYSTAL STRUCTURE OF CIS~~-~~BIPHENYL~~-2,3-~~DIHYDRODIOL~~-2,3-~~DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B~~-~~356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4~~,4'-~~DIHYDROXYBIPHENYL~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21045310}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21045310 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21045310}}
		+
		+	==About this Structure==
		+	[[3zv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021045310</ref><references group="xtra"/>
		+	[[Category: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase]]
		+	[[Category: Comamonas testosteroni]]
		+	[[Category: Dhindwal, S.]]
		+	[[Category: Kumar, P.]]
		+	[[Category: Patil, D N.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Sdr]]
		+	[[Category: Short chain dehydrogenase/oxidoreductase]]

OCA: Protected "3zv6" [edit=sysop:move=sysop]

2011-08-03T08:30:08Z

Protected "3zv6" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:30, 3 August 2011

OCA: New page: '''Unreleased structure''' The entry 3zv6 is ON HOLD until Paper Publication Authors: DHINDWAL, S., PATIL, D.N., KUMAR, P. Description: CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIO...

2011-08-03T08:30:07Z

New page: '''Unreleased structure''' The entry 3zv6 is ON HOLD until Paper Publication Authors: DHINDWAL, S., PATIL, D.N., KUMAR, P. Description: CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIO...

New page

'''Unreleased structure'''

The entry 3zv6 is ON HOLD until Paper Publication

Authors: DHINDWAL, S., PATIL, D.N., KUMAR, P.

Description: CRYSTAL STRUCTURE OF CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE (BPHB) FROM PANDORAEA PNOMENUSA STRAIN B-356 COMPLEX WITH CO-ENZYME NAD AND PRODUCT ANALOG 4,4'-DIHYDROXYBIPHENYL