3zxq - Revision history

OCA at 11:15, 20 December 2023

2023-12-20T11:15:33Z

←Older revision		Revision as of 11:15, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zxq' size='340' side='right'caption='[[3zxq]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3zxq' size='340' side='right'caption='[[3zxq]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2vzw\|2vzw]], [[3zxo\|3zxo]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [https://pdbe.org/3zxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [https://www.ebi.ac.uk/pdbsum/3zxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [https://pdbe.org/3zxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [https://www.ebi.ac.uk/pdbsum/3zxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU]] Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref> <ref>PMID:18474359</ref> <ref>PMID:18400743</ref>	+	[https://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU] Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref> <ref>PMID:18474359</ref> <ref>PMID:18400743</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Cho~~, H J~~]]	+	[[Category: Cho HJ]]
-	[[Category: Cho~~, H Y~~]]	+	[[Category: Cho HY]]
-	[[Category: Kang~~, B S]]~~	+	[[Category: Kang BS]]
-	~~[[Category: Transferase~~]]	+

OCA at 07:26, 18 August 2022

2022-08-18T07:26:10Z

←Older revision		Revision as of 07:26, 18 August 2022
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST==		==CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST==
-	<StructureSection load='3zxq' size='340' side='right' caption='[[3zxq]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3zxq' size='340' side='right'caption='[[3zxq]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vzw\|2vzw]], [[3zxo\|3zxo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vzw\|2vzw]], [[3zxo\|3zxo]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [~~http~~://pdbe.org/3zxq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zxq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [https://pdbe.org/3zxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [https://www.ebi.ac.uk/pdbsum/3zxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU]] Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref> <ref>PMID:18474359</ref> <ref>PMID:18400743</ref>	+	[[https://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU]] Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref> <ref>PMID:18474359</ref> <ref>PMID:18400743</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Cho, H J]]		[[Category: Cho, H J]]

OCA at 22:59, 4 August 2016

2016-08-04T22:59:36Z

←Older revision		Revision as of 22:59, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST==		==CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST==
	<StructureSection load='3zxq' size='340' side='right' caption='[[3zxq]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3zxq' size='340' side='right' caption='[[3zxq]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vzw\|2vzw]], [[3zxo\|3zxo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vzw\|2vzw]], [[3zxo\|3zxo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [http://www.ebi.ac.uk/pdbsum/3zxq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [http://pdbe.org/3zxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [http://www.ebi.ac.uk/pdbsum/3zxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zxq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis h37rv~~]]	+	[[Category: Myctu]]
	[[Category: Cho, H J]]		[[Category: Cho, H J]]
	[[Category: Cho, H Y]]		[[Category: Cho, H Y]]
	[[Category: Kang, B S]]		[[Category: Kang, B S]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 13:48, 25 December 2014

2014-12-25T13:48:26Z

←Older revision		Revision as of 13:48, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [http://www.ebi.ac.uk/pdbsum/3zxq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [http://www.ebi.ac.uk/pdbsum/3zxq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU]] Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref> <ref>PMID:18474359</ref> <ref>PMID:18400743</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:11, 21 December 2014

2014-12-21T09:11:02Z

←Older revision		Revision as of 09:11, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zxq\| PDB=3zxq \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST==
-	===CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST===	+	<StructureSection load='3zxq' size='340' side='right' caption='[[3zxq]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23486471}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vzw\|2vzw]], [[3zxo\|3zxo]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxq RCSB], [http://www.ebi.ac.uk/pdbsum/3zxq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sensor histidine kinases of Mycobacterium tuberculosis, DosS and DosT, are responsible for sensing hypoxic conditions and consist of sensor and kinase cores responsible for accepting signals and phosphorylation activity, respectively. The kinase core contains a dimerization and histidine phosphate-accepting (DHp) domain and an ATP binding domain (ABD). The 13 histidine kinase genes of M. tuberculosis can be grouped based on the presence or absence of the ATP-lid motif and F box (elements known to play roles in ATP binding) in their ABDs; DosS and DosT have ABDs lacking both these elements, and the crystal structures of their ABDs indicated they were unsuitable for ATP binding, as a short loop covers the putative ATP binding site. Although the ABD alone cannot bind ATP, the kinase core is functional in autophosphorylation. Appropriate spatial arrangement of the ABD and DHp domain within the kinase core is required for both autophosphorylation and ATP binding. An ionic interaction between R440 in the DHp domain and E537 in the short loop of the ABD is available and may open the ATP binding site, by repositioning the short loop away from the site. Mutations at R440 and E537 reduce autophosphorylation activity. Unlike other histidine kinases containing an ATP-lid, which protects bound ATP, DosS is unable to accept ATP until the ABD is properly positioned relative to the histidine; this may prevent unexpected ATP reactions. ATP binding can, therefore, function as a control mechanism for histidine kinase activity.

-	~~==Function==~~	+	Activation of ATP binding for the autophosphorylation of DosS, a Mycobacterium tuberculosis histidine kinase lacking an ATP-lid motif.,Cho HY, Lee YH, Bae YS, Kim E, Kang BS J Biol Chem. 2013 Mar 13. PMID:23486471<ref>PMID:23486471</ref>
-	~~[[http://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU]] Interacts with~~ the ~~two~~-~~component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response~~. ~~May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form~~, ~~while the deoxy form is probably active for phosphate transfer~~. ~~May be the secondary sensor for CO~~. ~~Donates a phosphate group to DevR (DosR).<ref>~~PMID:~~15033981</ref> <ref>PMID:18474359</ref>~~ <ref>PMID:~~18400743~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3zxq]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023486471</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
-	[[Category: Cho, H J.]]	+	[[Category: Cho, H J]]
-	[[Category: Cho, H Y.]]	+	[[Category: Cho, H Y]]
-	[[Category: Kang, B S.]]	+	[[Category: Kang, B S]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:32, 20 June 2013

2013-06-20T06:32:08Z

←Older revision		Revision as of 06:32, 20 June 2013
Line 4:		Line 4:

	==Function==		==Function==
-	[[http://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU]] Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref><ref>PMID:18474359</ref><ref>PMID:18400743</ref>	+	[[http://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU]] Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref> <ref>PMID:18474359</ref> <ref>PMID:18400743</ref>

	==About this Structure==		==About this Structure==
Line 10:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~016213520~~</ref><references group="xtra"/><references/>	+	<ref group="xtra">PMID:023486471</ref><references group="xtra"/><references/>
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
	[[Category: Cho, H J.]]		[[Category: Cho, H J.]]

OCA at 07:29, 27 March 2013

2013-03-27T07:29:44Z

←Older revision		Revision as of 07:29, 27 March 2013
Line 1:		Line 1:
-	[[Image:3zxq.png\|left\|200px]]
-
	{{STRUCTURE_3zxq\| PDB=3zxq \| SCENE= }}		{{STRUCTURE_3zxq\| PDB=3zxq \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST===		===CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST===
		+	{{ABSTRACT_PUBMED_23486471}}

-	~~{{ABSTRACT_PUBMED_16213520}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DOST_MYCTU DOST_MYCTU]] Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably active for phosphate transfer. May be the secondary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref><ref>PMID:18474359</ref><ref>PMID:18400743</ref>

	==About this Structure==		==About this Structure==
-	[[3zxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis~~ Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA].	+	[[3zxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016213520</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016213520</ref><references group="xtra"/><references/>
-	[[Category: Mycobacterium tuberculosis]]	+	[[Category: Mycobacterium tuberculosis h37rv]]
	[[Category: Cho, H J.]]		[[Category: Cho, H J.]]
	[[Category: Cho, H Y.]]		[[Category: Cho, H Y.]]
	[[Category: Kang, B S.]]		[[Category: Kang, B S.]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:34, 3 October 2012

2012-10-03T06:34:27Z

←Older revision		Revision as of 06:34, 3 October 2012
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-	[[Image:3zxq.~~jpg~~\|left\|200px]]	+	[[Image:3zxq.png\|left\|200px]]

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	{{STRUCTURE_3zxq\| PDB=3zxq \| SCENE= }}		{{STRUCTURE_3zxq\| PDB=3zxq \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST===		===CRYSTAL STRUCTURE OF THE ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOST===

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OCA: Protected "3zxq" [edit=sysop:move=sysop]

2011-08-24T07:52:27Z

Protected "3zxq" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:52, 24 August 2011