3zzz - Revision history

OCA at 11:17, 20 December 2023

2023-12-20T11:17:07Z

←Older revision		Revision as of 11:17, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zzz' size='340' side='right'caption='[[3zzz]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3zzz' size='340' side='right'caption='[[3zzz]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1qm9\|1qm9]], [[1sjr\|1sjr]], [[2adb\|2adb]], [[2ad9\|2ad9]], [[2adc\|2adc]], [[2evz\|2evz]], [[1sjq\|1sjq]], [[1wi6\|1wi6]], [[3zzy\|3zzy]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [https://pdbe.org/3zzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [https://www.ebi.ac.uk/pdbsum/3zzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [https://pdbe.org/3zzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [https://www.ebi.ac.uk/pdbsum/3zzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN]] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref> [[https://www.uniprot.org/uniprot/RAVR1_MOUSE RAVR1_MOUSE]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.<ref>PMID:14633994</ref>	+	[https://www.uniprot.org/uniprot/RAVR1_MOUSE RAVR1_MOUSE] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.<ref>PMID:14633994</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Curry, S]]	+	[[Category: Curry S]]
-	[[Category: Joshi, A]]	+	[[Category: Joshi A]]
-	[[Category: Kotik-Kogan, O]]	+	[[Category: Kotik-Kogan O]]
-	~~[[Category: Peptide binding]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Rna recognition motif~~]]	+

OCA at 07:31, 18 August 2022

2022-08-18T07:31:18Z

←Older revision		Revision as of 07:31, 18 August 2022
Line 1:		Line 1:

	==Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2==		==Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2==
-	<StructureSection load='3zzz' size='340' side='right' caption='[[3zzz]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='3zzz' size='340' side='right'caption='[[3zzz]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qm9\|1qm9]], [[1sjr\|1sjr]], [[2adb\|2adb]], [[2ad9\|2ad9]], [[2adc\|2adc]], [[2evz\|2evz]], [[1sjq\|1sjq]], [[1wi6\|1wi6]], [[3zzy\|3zzy]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qm9\|1qm9]], [[1sjr\|1sjr]], [[2adb\|2adb]], [[2ad9\|2ad9]], [[2adc\|2adc]], [[2evz\|2evz]], [[1sjq\|1sjq]], [[1wi6\|1wi6]], [[3zzy\|3zzy]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [~~http~~://pdbe.org/3zzz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zzz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [https://pdbe.org/3zzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [https://www.ebi.ac.uk/pdbsum/3zzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN]] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref> [[~~http~~://www.uniprot.org/uniprot/RAVR1_MOUSE RAVR1_MOUSE]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.<ref>PMID:14633994</ref>	+	[[https://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN]] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref> [[https://www.uniprot.org/uniprot/RAVR1_MOUSE RAVR1_MOUSE]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.<ref>PMID:14633994</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Curry, S]]		[[Category: Curry, S]]

OCA at 16:37, 4 August 2016

2016-08-04T16:37:38Z

←Older revision		Revision as of 16:37, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2==		==Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2==
	<StructureSection load='3zzz' size='340' side='right' caption='[[3zzz]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3zzz' size='340' side='right' caption='[[3zzz]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qm9\|1qm9]], [[1sjr\|1sjr]], [[2adb\|2adb]], [[2ad9\|2ad9]], [[2adc\|2adc]], [[2evz\|2evz]], [[1sjq\|1sjq]], [[1wi6\|1wi6]], [[3zzy\|3zzy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qm9\|1qm9]], [[1sjr\|1sjr]], [[2adb\|2adb]], [[2ad9\|2ad9]], [[2adc\|2adc]], [[2evz\|2evz]], [[1sjq\|1sjq]], [[1wi6\|1wi6]], [[3zzy\|3zzy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [http://www.ebi.ac.uk/pdbsum/3zzz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [http://pdbe.org/3zzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [http://www.ebi.ac.uk/pdbsum/3zzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zzz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Curry, S]]		[[Category: Curry, S]]
	[[Category: Joshi, A]]		[[Category: Joshi, A]]

OCA at 17:06, 24 December 2014

2014-12-24T17:06:38Z

←Older revision		Revision as of 17:06, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qm9\|1qm9]], [[1sjr\|1sjr]], [[2adb\|2adb]], [[2ad9\|2ad9]], [[2adc\|2adc]], [[2evz\|2evz]], [[1sjq\|1sjq]], [[1wi6\|1wi6]], [[3zzy\|3zzy]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qm9\|1qm9]], [[1sjr\|1sjr]], [[2adb\|2adb]], [[2ad9\|2ad9]], [[2adc\|2adc]], [[2evz\|2evz]], [[1sjq\|1sjq]], [[1wi6\|1wi6]], [[3zzy\|3zzy]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [http://www.ebi.ac.uk/pdbsum/3zzz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [http://www.ebi.ac.uk/pdbsum/3zzz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN]] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref> [[http://www.uniprot.org/uniprot/RAVR1_MOUSE RAVR1_MOUSE]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.<ref>PMID:14633994</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Curry, S.]]	+	[[Category: Curry, S]]
-	[[Category: Joshi, A.]]	+	[[Category: Joshi, A]]
-	[[Category: Kotik-Kogan, O.]]	+	[[Category: Kotik-Kogan, O]]
	[[Category: Peptide binding]]		[[Category: Peptide binding]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Rna recognition motif]]		[[Category: Rna recognition motif]]

OCA at 08:25, 5 June 2014

2014-06-05T08:25:00Z

←Older revision		Revision as of 08:25, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zzz.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2==
		+	<StructureSection load='3zzz' size='340' side='right' caption='[[3zzz]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zzz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qm9\|1qm9]], [[1sjr\|1sjr]], [[2adb\|2adb]], [[2ad9\|2ad9]], [[2adc\|2adc]], [[2evz\|2evz]], [[1sjq\|1sjq]], [[1wi6\|1wi6]], [[3zzy\|3zzy]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zzz RCSB], [http://www.ebi.ac.uk/pdbsum/3zzz PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The polypyrimidine tract-binding protein (PTB) is an important regulator of alternative splicing. PTB-regulated splicing of alpha-tropomyosin is enhanced by Raver1, a protein with four PTB-Raver1 interacting motifs (PRIs) that bind to the helical face of the second RNA recognition motif (RRM2) in PTB. We present the crystal structures of RRM2 in complex with PRI3 and PRI4 from Raver1, which-along with structure-based mutagenesis-reveal the molecular basis of their differential binding. High-affinity binding by Raver1 PRI3 involves shape-matched apolar contacts complemented by specific hydrogen bonds, a new variant of an established mode of peptide-RRM interaction. Our results refine the sequence of the PRI motif and place important structural constraints on functional models of PTB-Raver1 interactions. Our analysis indicates that the observed Raver1-PTB interaction is a general mode of binding that applies to Raver1 complexes with PTB paralogues such as nPTB and to complexes of Raver2 with PTB.

-	<!--	+	Crystallographic analysis of polypyrimidine tract-binding protein-raver1 interactions involved in regulation of alternative splicing.,Joshi A, Coelho MB, Kotik-Kogan O, Simpson PJ, Matthews SJ, Smith CW, Curry S Structure. 2011 Dec 7;19(12):1816-25. PMID:22153504<ref>PMID:22153504</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zzz"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3zzz\| PDB=3zzz \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22153504}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22153504 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22153504}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zzz]] is a 4 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022153504<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 07:21, 28 December 2011

2011-12-28T07:21:47Z

←Older revision		Revision as of 07:21, 28 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zzz.jpg\|left\|200px]]

-	The ~~entry 3zzz~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zzz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zzz\| PDB=3zzz \| SCENE= }}

-	~~Authors: Joshi, A., Kotik-Kogan, O., Curry, S.~~	+	===Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2===

-	~~Description~~: ~~Crystal structure of~~ a ~~Raver1 PRI4 peptide in complex~~ with ~~polypyrimidine tract~~ binding ~~protein RRM2~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22153504}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22153504 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22153504}}
		+
		+	==About this Structure==
		+	[[3zzz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022153504</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
		+	[[Category: Curry, S.]]
		+	[[Category: Joshi, A.]]
		+	[[Category: Kotik-Kogan, O.]]
		+	[[Category: Peptide binding]]
		+	[[Category: Protein binding]]
		+	[[Category: Rna recognition motif]]

OCA: Protected "3zzz" [edit=sysop:move=sysop]

2011-09-21T05:37:24Z

Protected "3zzz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 21 September 2011

OCA: New page: '''Unreleased structure''' The entry 3zzz is ON HOLD until Paper Publication Authors: Joshi, A., Kotik-Kogan, O., Curry, S. Description: Crystal structure of a Raver1 PRI4 peptide in c...

2011-09-21T05:37:23Z

New page: '''Unreleased structure''' The entry 3zzz is ON HOLD until Paper Publication Authors: Joshi, A., Kotik-Kogan, O., Curry, S. Description: Crystal structure of a Raver1 PRI4 peptide in c...

New page

'''Unreleased structure'''

The entry 3zzz is ON HOLD until Paper Publication

Authors: Joshi, A., Kotik-Kogan, O., Curry, S.

Description: Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2