459d - Revision history

OCA at 00:35, 28 December 2023

2023-12-28T00:35:41Z

←Older revision		Revision as of 00:35, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[459d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=459D FirstGlance]. <br>		<table><tr><td colspan='2'>[[459d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=459D FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5~~-~~(3-AMINO-1-PYRROLIDINYL)-2,5~~,2~~,5-TRI-BENZIMIDAZOLE'>TBZ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5,2,5-TRI-BENZIMIDAZOLE'>TBZ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [https://pdbe.org/459d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [https://www.ebi.ac.uk/pdbsum/459d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=459d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [https://pdbe.org/459d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [https://www.ebi.ac.uk/pdbsum/459d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=459d ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aymami, J]]	+	[[Category: Aymami J]]
-	[[Category: Neidle, S]]	+	[[Category: Neidle S]]
-	[[Category: Nunn~~, C M]]~~	+	[[Category: Nunn CM]]
-	~~[[Category: B-dna]]~~	+
-	~~[[Category: Complexed with tris-benzimidazole]]~~	+
-	~~[[Category: Deoxyribonucleic acid]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Minor groove binding~~]]	+

OCA at 07:34, 18 August 2022

2022-08-18T07:34:16Z

←Older revision		Revision as of 07:34, 18 August 2022
Line 1:		Line 1:

	==DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG==		==DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG==
-	<StructureSection load='459d' size='340' side='right' caption='[[459d]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='459d' size='340' side='right'caption='[[459d]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[459d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=459D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[459d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=459D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5,2,5-TRI-BENZIMIDAZOLE'>TBZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5,2,5-TRI-BENZIMIDAZOLE'>TBZ</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [~~http~~://pdbe.org/459d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/459d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=459d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [https://pdbe.org/459d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [https://www.ebi.ac.uk/pdbsum/459d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=459d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aymami, J]]		[[Category: Aymami, J]]
	[[Category: Neidle, S]]		[[Category: Neidle, S]]

OCA at 10:37, 11 August 2016

2016-08-11T10:37:44Z

←Older revision		Revision as of 10:37, 11 August 2016
Line 1:		Line 1:
		+
	==DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG==		==DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG==
	<StructureSection load='459d' size='340' side='right' caption='[[459d]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='459d' size='340' side='right' caption='[[459d]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5,2,5-TRI-BENZIMIDAZOLE'>TBZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5,2,5-TRI-BENZIMIDAZOLE'>TBZ</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [http://www.ebi.ac.uk/pdbsum/459d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [http://pdbe.org/459d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [http://www.ebi.ac.uk/pdbsum/459d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=459d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 459d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:06, 4 January 2015

2015-01-04T11:06:34Z

←Older revision		Revision as of 11:06, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[459d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459D FirstGlance]. <br>		<table><tr><td colspan='2'>[[459d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5,2,5-TRI-BENZIMIDAZOLE'>TBZ</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5,2,5-TRI-BENZIMIDAZOLE'>TBZ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [http://www.ebi.ac.uk/pdbsum/459d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [http://www.ebi.ac.uk/pdbsum/459d PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aymami, J.]]	+	[[Category: Aymami, J]]
-	[[Category: Neidle, S.]]	+	[[Category: Neidle, S]]
-	[[Category: Nunn, C M.]]	+	[[Category: Nunn, C M]]
	[[Category: B-dna]]		[[Category: B-dna]]
	[[Category: Complexed with tris-benzimidazole]]		[[Category: Complexed with tris-benzimidazole]]

OCA: Protected "459d" [edit=sysop:move=sysop]

2014-06-05T08:34:29Z

Protected "459d" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:34, 5 June 2014

OCA at 08:34, 5 June 2014

2014-06-05T08:34:27Z

←Older revision		Revision as of 08:34, 5 June 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG==
-	[[~~Image:~~459d.~~png~~\|~~left~~\|~~200px~~]]	+	<StructureSection load='459d' size='340' side='right' caption='[[459d]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[459d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBZ:2-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5,2,5-TRI-BENZIMIDAZOLE'>TBZ</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=459d RCSB], [http://www.ebi.ac.uk/pdbsum/459d PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the non-self-complementary dodecamer DNA duplex formed by d(CG[5BrC]ATAT-TTGCG) and d(CGCAAATATGCG) has been solved to 2.3 A resolution, together with that of its complex with the tris-benzimidazole minor groove binding ligand TRIBIZ. The inclusion of a bromine atom on one strand in each structure enabled the possibility of disorder to be discounted. The native structure has an exceptional narrow minor groove, of 2.5-2.6 A in the central part of the A/T region, which is increased in width by approximately 0.8 A on drug binding. The ligand molecule binds in the central part of the sequence. The benzimidazole subunits of the ligand participate in six bifurcated hydrogen bonds with A:T base pair edges, three to each DNA strand. The presence of a pair of C-H...O hydrogen bonds has been deduced from the close proximity of the pyrrolidine group of the ligand to the TpA step in the sequence.

-	<!--	+	DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand.,Aymami J, Nunn CM, Neidle S Nucleic Acids Res. 1999 Jul 1;27(13):2691-8. PMID:10373586<ref>PMID:10373586</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_459d"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_459d\| PDB=459d \| SCENE= }}~~	+

-	~~===DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_10373586}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 10373586 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_10373586}}~~	+
-		+
-	==~~About this Structure~~==	+
-	~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA].~~	+
-		+
-	~~==Reference==~~	+
-	~~DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand., Aymami J, Nunn CM, Neidle S, Nucleic Acids Res. 1999 Jul 1;27(13):2691-8. PMID:[http:~~/~~/www.ncbi.nlm.nih.gov/pubmed/10373586 10373586]~~	+
	[[Category: Aymami, J.]]		[[Category: Aymami, J.]]
	[[Category: Neidle, S.]]		[[Category: Neidle, S.]]
Line 30:		Line 25:
	[[Category: Complexed with tris-benzimidazole]]		[[Category: Complexed with tris-benzimidazole]]
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]
		+	[[Category: Dna]]
	[[Category: Minor groove binding]]		[[Category: Minor groove binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:22:45 2008''

OCA at 10:22, 3 July 2008

2008-07-03T10:22:46Z

←Older revision		Revision as of 10:22, 3 July 2008
Line 1:		Line 1:
-	[[Image:459d.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:459d.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_459d\| PDB=459d \| SCENE= }}		{{STRUCTURE_459d\| PDB=459d \| SCENE= }}

-	~~'''~~DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG~~'''~~	+	===DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG===


-	~~==Overview==~~	+	<!--
-	The ~~crystal structure of~~ the ~~non-self-complementary dodecamer DNA duplex formed by d(CG[5BrC]ATAT-TTGCG) and d(CGCAAATATGCG) has been solved~~ to ~~2.3 A resolution, together with that of its complex with~~ the ~~tris-benzimidazole minor groove binding ligand TRIBIZ. The inclusion of a bromine atom~~ on ~~one strand in each structure enabled the possibility of disorder to be discounted~~. ~~The native structure has an exceptional narrow minor groove, of 2~~.~~5-2.6 A in the central part of the A/T region~~, ~~which~~ is ~~increased in width by approximately 0.8 A on drug binding. The ligand molecule binds in~~ the ~~central part of the sequence~~. ~~The benzimidazole subunits of the ligand participate in six bifurcated hydrogen bonds with A:T base pair edges, three to each DNA strand. The presence of a pair of C~~-~~H...O hydrogen bonds has been deduced from the close proximity of the pyrrolidine group of the ligand to the TpA step in the sequence.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_10373586}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10373586 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10373586}}

	==About this Structure==		==About this Structure==
Line 27:		Line 31:
	[[Category: Deoxyribonucleic acid]]		[[Category: Deoxyribonucleic acid]]
	[[Category: Minor groove binding]]		[[Category: Minor groove binding]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:18:53 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:22:45 2008''

OCA at 19:18, 4 May 2008

2008-05-04T19:18:54Z

←Older revision		Revision as of 19:18, 4 May 2008
Line 1:		Line 1:
	[[Image:459d.gif\|left\|200px]]		[[Image:459d.gif\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 459d \|SIZE=350\|CAPTION=~~ <~~scene name='initialview01'>459d</scene>, resolution 2.3Å~~	+	The line below this paragraph, containing "STRUCTURE_459d", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=CBR:5~~-~~BROMO~~-~~2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE'>CBR</scene>~~, ~~<scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>~~, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=TBZ:2''-(~~4-METHOXYPHENYL~~)~~-5-~~(~~3-AMINO-1-PYRROLIDINYL~~)-2,~~5',2',5''~~-~~TRI~~-~~BENZIMIDAZOLE'>TBZ</scene~~>	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	\|~~ACTIVITY~~=	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_459d\| PDB=459d \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [http://www.ebi.ac.uk/pdbsum/459d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=459d RCSB]</span>	+
-	}}	+

	'''DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG'''		'''DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG'''
Line 19:		Line 16:

	==About this Structure==		==About this Structure==
-	~~459D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA].	+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=459D OCA].

	==Reference==		==Reference==
	DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand., Aymami J, Nunn CM, Neidle S, Nucleic Acids Res. 1999 Jul 1;27(13):2691-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10373586 10373586]		DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand., Aymami J, Nunn CM, Neidle S, Nucleic Acids Res. 1999 Jul 1;27(13):2691-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10373586 10373586]
-	[[Category: Protein complex]]
	[[Category: Aymami, J.]]		[[Category: Aymami, J.]]
	[[Category: Neidle, S.]]		[[Category: Neidle, S.]]
	[[Category: Nunn, C M.]]		[[Category: Nunn, C M.]]
-	[[Category: b-dna]]	+	[[Category: B-dna]]
-	[[Category: ~~complexed~~ with tris-benzimidazole]]	+	[[Category: Complexed with tris-benzimidazole]]
-	[[Category: ~~deoxyribonucleic~~ acid]]	+	[[Category: Deoxyribonucleic acid]]
-	[[Category: ~~minor~~ groove binding]]	+	[[Category: Minor groove binding]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:18:53 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:37:33 2008''	+

OCA at 02:37, 31 March 2008

2008-03-31T02:37:34Z

←Older revision		Revision as of 02:37, 31 March 2008
Line 4:		Line 4:
	\|PDB= 459d \|SIZE=350\|CAPTION= <scene name='initialview01'>459d</scene>, resolution 2.3Å		\|PDB= 459d \|SIZE=350\|CAPTION= <scene name='initialview01'>459d</scene>, resolution 2.3Å
	\|SITE=		\|SITE=
-	\|LIGAND= <scene name='pdbligand=TBZ:2''-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5',2',5''-TRI-BENZIMIDAZOLE'>TBZ</scene>	+	\|LIGAND= <scene name='pdbligand=CBR:5-BROMO-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=TBZ:2''-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5',2',5''-TRI-BENZIMIDAZOLE'>TBZ</scene>
	\|ACTIVITY=		\|ACTIVITY=
	\|GENE=		\|GENE=
		+	\|DOMAIN=
		+	\|RELATEDENTRY=
		+	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=459d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=459d OCA], [http://www.ebi.ac.uk/pdbsum/459d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=459d RCSB]</span>
	}}		}}

Line 24:		Line 27:
	[[Category: Neidle, S.]]		[[Category: Neidle, S.]]
	[[Category: Nunn, C M.]]		[[Category: Nunn, C M.]]
-	[[Category: TBZ]]
	[[Category: b-dna]]		[[Category: b-dna]]
	[[Category: complexed with tris-benzimidazole]]		[[Category: complexed with tris-benzimidazole]]
Line 30:		Line 32:
	[[Category: minor groove binding]]		[[Category: minor groove binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun~~ Mar ~~23 16~~:03:56 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:37:33 2008''

OCA at 14:03, 23 March 2008

2008-03-23T14:03:57Z

←Older revision		Revision as of 14:03, 23 March 2008
Line 4:		Line 4:
	\|PDB= 459d \|SIZE=350\|CAPTION= <scene name='initialview01'>459d</scene>, resolution 2.3Å		\|PDB= 459d \|SIZE=350\|CAPTION= <scene name='initialview01'>459d</scene>, resolution 2.3Å
	\|SITE=		\|SITE=
-	\|LIGAND= <scene name='pdbligand=TBZ:2''-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5',2',5''-TRI-BENZIMIDAZOLE'>TBZ</scene>	+	\|LIGAND= <scene name='pdbligand=TBZ:2''-(4-METHOXYPHENYL)-5-(3-AMINO-1-PYRROLIDINYL)-2,5',2',5''-TRI-BENZIMIDAZOLE'>TBZ</scene>
	\|ACTIVITY=		\|ACTIVITY=
	\|GENE=		\|GENE=
Line 30:		Line 30:
	[[Category: minor groove binding]]		[[Category: minor groove binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Mar ~~20 19~~:08:29 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 16:03:56 2008''