4a0s - Revision history

OCA at 11:17, 20 December 2023

2023-12-20T11:17:41Z

←Older revision		Revision as of 11:17, 20 December 2023
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	<StructureSection load='4a0s' size='340' side='right'caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4a0s' size='340' side='right'caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Dsm_101724 Dsm 101724~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cinnabarigriseus Streptomyces cinnabarigriseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0S FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CO8:OCTANOYL~~-~~COENZYME+A'>CO8</scene>~~, ~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[4a10\|4a10]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [https://pdbe.org/4a0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [https://www.ebi.ac.uk/pdbsum/4a0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [https://pdbe.org/4a0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [https://www.ebi.ac.uk/pdbsum/4a0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F0V3Z3_9ACTN F0V3Z3_9ACTN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dsm 101724]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Heinz~~, D W~~]]	+	[[Category: Streptomyces cinnabarigriseus]]
-	[[Category: Huo, L]]	+	[[Category: Heinz DW]]
-	[[Category: Muller, R]]	+	[[Category: Huo L]]
-	[[Category: Quade, N]]	+	[[Category: Muller R]]
-	[[Category: Rachid, S]]	+	[[Category: Quade N]]
-	~~[[Category: Cinnabaramide pks biosynthesis]]~~	+	[[Category: Rachid S]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:37, 18 August 2022

2022-08-18T07:37:37Z

←Older revision		Revision as of 07:37, 18 August 2022
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	<StructureSection load='4a0s' size='340' side='right'caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4a0s' size='340' side='right'caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dsm_101724 Dsm 101724]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4A0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Dsm_101724 Dsm 101724]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a10\|4a10]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [~~http~~://pdbe.org/4a0s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a0s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [https://pdbe.org/4a0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [https://www.ebi.ac.uk/pdbsum/4a0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:04, 21 October 2020

2020-10-21T09:04:33Z

←Older revision		Revision as of 09:04, 21 October 2020
Line 1:		Line 1:

	==STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA==		==STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA==
-	<StructureSection load='4a0s' size='340' side='right' caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4a0s' size='340' side='right'caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_101724 Dsm 101724]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_101724 Dsm 101724]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4A0S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [http://pdbe.org/4a0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [http://www.ebi.ac.uk/pdbsum/4a0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [http://pdbe.org/4a0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [http://www.ebi.ac.uk/pdbsum/4a0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Dsm 101724]]		[[Category: Dsm 101724]]
		+	[[Category: Large Structures]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]
	[[Category: Huo, L]]		[[Category: Huo, L]]

OCA at 12:18, 16 January 2019

2019-01-16T12:18:53Z

←Older revision		Revision as of 12:18, 16 January 2019
Line 3:		Line 3:
	<StructureSection load='4a0s' size='340' side='right' caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4a0s' size='340' side='right' caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_sp._js360 Streptomyces sp. js360~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_101724 Dsm 101724]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptomyces sp. js360~~]]	+	[[Category: Dsm 101724]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]
	[[Category: Huo, L]]		[[Category: Huo, L]]

OCA at 10:37, 11 August 2016

2016-08-11T10:37:01Z

←Older revision		Revision as of 10:37, 11 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA==		==STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA==
	<StructureSection load='4a0s' size='340' side='right' caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4a0s' size='340' side='right' caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._js360 Streptomyces sp. js360]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [http://www.ebi.ac.uk/pdbsum/4a0s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [http://pdbe.org/4a0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [http://www.ebi.ac.uk/pdbsum/4a0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a0s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptomyces sp]]	+	[[Category: Streptomyces sp. js360]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]
	[[Category: Huo, L]]		[[Category: Huo, L]]

OCA at 11:05, 4 January 2015

2015-01-04T11:05:46Z

←Older revision		Revision as of 11:05, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [http://www.ebi.ac.uk/pdbsum/4a0s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [http://www.ebi.ac.uk/pdbsum/4a0s PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptomyces sp.]]	+	[[Category: Streptomyces sp]]
-	[[Category: Heinz, D W.]]	+	[[Category: Heinz, D W]]
-	[[Category: Huo, L.]]	+	[[Category: Huo, L]]
-	[[Category: Muller, R.]]	+	[[Category: Muller, R]]
-	[[Category: Quade, N.]]	+	[[Category: Quade, N]]
-	[[Category: Rachid, S.]]	+	[[Category: Rachid, S]]
	[[Category: Cinnabaramide pks biosynthesis]]		[[Category: Cinnabaramide pks biosynthesis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:32, 5 June 2014

2014-06-05T08:32:59Z

←Older revision		Revision as of 08:32, 5 June 2014
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-	[[~~Image:~~4a0s.~~png~~\|~~left~~\|~~200px~~]]	+	==STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA==
		+	<StructureSection load='4a0s' size='340' side='right' caption='[[4a0s]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a10\|4a10]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a0s RCSB], [http://www.ebi.ac.uk/pdbsum/4a0s PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polyketides are structurally diverse and medically important natural products that have various biological activities. During biosynthesis, chain elongation uses activated dicarboxylic acid building blocks, and their availability therefore limits side chain variation in polyketides. Recently, the crotonyl-CoA carboxylase-reductase (CCR) class of enzymes was identified in primary metabolism and was found to be involved in extender-unit biosynthesis of polyketides. These enzymes are, in theory, capable of forming dicarboxylic acids that show any side chain from the respective unsaturated fatty acid precursor. To our knowledge, we here report the first crystal structure of a CCR, the hexylmalonyl-CoA synthase from Streptomyces sp. JS360, in complex with its substrate. Structural analysis and biochemical characterization of the enzyme, including active site mutations, are reported. Our analysis reveals how primary metabolic CCRs can evolve to produce various dicarboxylic acid building blocks, setting the stage to use CCRs for the production of unique extender units and, consequently, altered polyketides.

-	~~<!--~~	+	Unusual carbon fixation gives rise to diverse polyketide extender units.,Quade N, Huo L, Rachid S, Heinz DW, Muller R Nat Chem Biol. 2011 Dec 4;8(1):117-24. doi: 10.1038/nchembio.734. PMID:22138621<ref>PMID:22138621</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4a0s"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_4a0s\| PDB=4a0s \| SCENE= }}~~	+

-	~~===STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22138621}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22138621 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22138621}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4a0s]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022138621<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptomyces sp.]]		[[Category: Streptomyces sp.]]
	[[Category: Heinz, D W.]]		[[Category: Heinz, D W.]]

OCA at 06:19, 28 December 2011

2011-12-28T06:19:34Z

←Older revision		Revision as of 06:19, 28 December 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:4a0s.png\|left\|200px]]

-	The ~~entry 4a0s~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a0s", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a0s\| PDB=4a0s \| SCENE= }}

-	~~Authors: Quade, N., Huo, L., Rachid, S., Heinz, D.W., Muller, R.~~	+	===STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA===

-	~~Description: STRUCTURE OF THE 2~~-~~OCTENOYL~~-~~COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2~~-~~OCTENOYL~~-~~COA~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22138621}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22138621 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22138621}}
		+
		+	==About this Structure==
		+	[[4a0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0S OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022138621</ref><references group="xtra"/>
		+	[[Category: Streptomyces sp.]]
		+	[[Category: Heinz, D W.]]
		+	[[Category: Huo, L.]]
		+	[[Category: Muller, R.]]
		+	[[Category: Quade, N.]]
		+	[[Category: Rachid, S.]]
		+	[[Category: Cinnabaramide pks biosynthesis]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Transferase]]

OCA at 09:00, 30 October 2011

2011-10-30T09:00:14Z

←Older revision		Revision as of 09:00, 30 October 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4a0s is ON HOLD	+	The entry 4a0s is ON HOLD until Paper Publication

	Authors: Quade, N., Huo, L., Rachid, S., Heinz, D.W., Muller, R.		Authors: Quade, N., Huo, L., Rachid, S., Heinz, D.W., Muller, R.

	Description: STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA		Description: STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA

OCA at 06:18, 5 October 2011

2011-10-05T06:18:42Z

←Older revision		Revision as of 06:18, 5 October 2011
Line 5:		Line 5:
	Authors: Quade, N., Huo, L., Rachid, S., Heinz, D.W., Muller, R.		Authors: Quade, N., Huo, L., Rachid, S., Heinz, D.W., Muller, R.

-	Description: ~~Structure of the~~ 2-~~octenoyl~~-~~CoA carboxylase reductase CinF~~	+	Description: STRUCTURE OF THE 2-OCTENOYL-COA CARBOXYLASE REDUCTASE CINF IN COMPLEX WITH NADP AND 2-OCTENOYL-COA