4a30 - Revision history

OCA at 11:18, 20 December 2023

2023-12-20T11:18:55Z

←Older revision		Revision as of 11:18, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4a30' size='340' side='right'caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4a30' size='340' side='right'caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Leima Leima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A30 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A30 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a32\|4a32]], [[4a33\|4a33]], [[2wsa\|2wsa]], [[4a2z\|4a2z]], [[4a31\|4a31]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [https://pdbe.org/4a30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [https://www.ebi.ac.uk/pdbsum/4a30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a30 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [https://pdbe.org/4a30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [https://www.ebi.ac.uk/pdbsum/4a30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a30 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).	+	[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leima~~]]	+	[[Category: Leishmania major]]
-	[[Category: Brand, S]]	+	[[Category: Brand S]]
-	[[Category: Fairlamb~~, A H~~]]	+	[[Category: Fairlamb AH]]
-	[[Category: Ferguson~~, M A.J~~]]	+	[[Category: Ferguson MAJ]]
-	[[Category: Frearson~~, J A~~]]	+	[[Category: Frearson JA]]
-	[[Category: Robinson~~, D A~~]]	+	[[Category: Robinson DA]]
-	[[Category: Wyatt~~, P G]]~~	+	[[Category: Wyatt PG]]
-	~~[[Category: Acyltransferase]]~~	+
-	~~[[Category: Drug discovery]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:41, 18 August 2022

2022-08-18T07:41:38Z

←Older revision		Revision as of 07:41, 18 August 2022
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	<StructureSection load='4a30' size='340' side='right'caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4a30' size='340' side='right'caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A30 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A30 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a33\|4a33]], [[2wsa\|2wsa]], [[4a2z\|4a2z]], [[4a31\|4a31]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a32\|4a32]], [[4a33\|4a33]], [[2wsa\|2wsa]], [[4a2z\|4a2z]], [[4a31\|4a31]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [~~http~~://pdbe.org/4a30 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a30 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a30 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [https://pdbe.org/4a30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [https://www.ebi.ac.uk/pdbsum/4a30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a30 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).	+	[[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:22, 1 January 2020

2020-01-01T13:22:49Z

←Older revision		Revision as of 13:22, 1 January 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==		==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
-	<StructureSection load='4a30' size='340' side='right' caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4a30' size='340' side='right'caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A30 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A30 FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Leima]]		[[Category: Leima]]
	[[Category: Brand, S]]		[[Category: Brand, S]]

OCA at 05:02, 5 August 2016

2016-08-05T05:02:34Z

←Older revision		Revision as of 05:02, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==		==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
	<StructureSection load='4a30' size='340' side='right' caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4a30' size='340' side='right' caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_major Leishmania major~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A30 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A30 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a33\|4a33]], [[2wsa\|2wsa]], [[4a2z\|4a2z]], [[4a31\|4a31]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a33\|4a33]], [[2wsa\|2wsa]], [[4a2z\|4a2z]], [[4a31\|4a31]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [http://www.ebi.ac.uk/pdbsum/4a30 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [http://pdbe.org/4a30 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [http://www.ebi.ac.uk/pdbsum/4a30 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a30 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a30" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
-	[[Category: ~~Leishmania major~~]]	+	[[Category: Leima]]
	[[Category: Brand, S]]		[[Category: Brand, S]]
	[[Category: Fairlamb, A H]]		[[Category: Fairlamb, A H]]

OCA at 15:58, 25 December 2014

2014-12-25T15:58:54Z

←Older revision		Revision as of 15:58, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A30 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A30 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a33\|4a33]], [[2wsa\|2wsa]], [[4a2z\|4a2z]], [[4a31\|4a31]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a33\|4a33]], [[2wsa\|2wsa]], [[4a2z\|4a2z]], [[4a31\|4a31]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [http://www.ebi.ac.uk/pdbsum/4a30 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [http://www.ebi.ac.uk/pdbsum/4a30 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
-	[[Category: Brand, S.]]	+	[[Category: Brand, S]]
-	[[Category: Fairlamb, A H.]]	+	[[Category: Fairlamb, A H]]
-	[[Category: Ferguson, M A.J.]]	+	[[Category: Ferguson, M A.J]]
-	[[Category: Frearson, J A.]]	+	[[Category: Frearson, J A]]
-	[[Category: Robinson, D A.]]	+	[[Category: Robinson, D A]]
-	[[Category: Wyatt, P G.]]	+	[[Category: Wyatt, P G]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Drug discovery]]		[[Category: Drug discovery]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:26, 5 June 2014

2014-06-05T08:26:16Z

←Older revision		Revision as of 08:26, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4a30.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
		+	<StructureSection load='4a30' size='340' side='right' caption='[[4a30]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A30 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QMI:4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>QMI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a33\|4a33]], [[2wsa\|2wsa]], [[4a2z\|4a2z]], [[4a31\|4a31]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a30 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a30 RCSB], [http://www.ebi.ac.uk/pdbsum/4a30 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma brucei. We report the optimization of a high throughput screening hit (1) to give a lead molecule DDD85646 (63), which has potent activity against the enzyme (IC(50) = 2 nM) and T. brucei (EC(50) = 2 nM) in culture. The compound has good oral pharmacokinetics and cures rodent models of peripheral HAT infection. This compound provides an excellent tool for validation of T. brucei NMT as a drug target for HAT as well as a valuable lead for further optimization.

-	<!--	+	Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.,Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH J Med Chem. 2012 Jan 12;55(1):140-52. Epub 2011 Dec 7. PMID:22148754<ref>PMID:22148754</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4a30"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_4a30\| PDB=4a30 \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22148754}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22148754 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22148754}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4a30]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022148754<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Leishmania major]]		[[Category: Leishmania major]]

OCA at 05:46, 25 January 2012

2012-01-25T05:46:31Z

←Older revision		Revision as of 05:46, 25 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4a30.png\|left\|200px]]

-	The ~~entry 4a30~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a30", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a30\| PDB=4a30 \| SCENE= }}

-	~~Authors: Robinson, D.~~A~~., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G.~~	+	===CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND===

-	~~Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N~~-~~MYRISTOYLTRANSFERASE~~ (~~NMT~~) ~~WITH BOUND MYRISTOYL~~-~~COA AND~~ A ~~PYRAZOLE SULPHONAMIDE LIGAND~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22148754}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22148754 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22148754}}
		+
		+	==About this Structure==
		+	[[4a30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A30 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022148754</ref><references group="xtra"/>
		+	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Leishmania major]]
		+	[[Category: Brand, S.]]
		+	[[Category: Fairlamb, A H.]]
		+	[[Category: Ferguson, M A.J.]]
		+	[[Category: Frearson, J A.]]
		+	[[Category: Robinson, D A.]]
		+	[[Category: Wyatt, P G.]]
		+	[[Category: Acyltransferase]]
		+	[[Category: Drug discovery]]
		+	[[Category: Transferase]]

OCA at 09:01, 30 October 2011

2011-10-30T09:01:06Z

←Older revision		Revision as of 09:01, 30 October 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4a30 is ON HOLD ~~until sometime in the future~~	+	The entry 4a30 is ON HOLD

	Authors: Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G.		Authors: Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G.

	Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND		Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

OCA: Protected "4a30" [edit=sysop:move=sysop]

2011-10-05T06:20:05Z

Protected "4a30" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:20, 5 October 2011

OCA: New page: '''Unreleased structure''' The entry 4a30 is ON HOLD until sometime in the future Authors: Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G. Desc...

2011-10-05T06:20:04Z

New page: '''Unreleased structure''' The entry 4a30 is ON HOLD until sometime in the future Authors: Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G. Desc...

New page

'''Unreleased structure'''

The entry 4a30 is ON HOLD until sometime in the future

Authors: Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G.

Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND