4a33 - Revision history

OCA at 11:19, 20 December 2023

2023-12-20T11:19:00Z

←Older revision		Revision as of 11:19, 20 December 2023
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	<StructureSection load='4a33' size='340' side='right'caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4a33' size='340' side='right'caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Leima Leima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A33 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A33 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a32\|4a32]], [[4a2z\|4a2z]], [[4a30\|4a30]], [[2wsa\|2wsa]], [[4a31\|4a31]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [https://pdbe.org/4a33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [https://www.ebi.ac.uk/pdbsum/4a33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a33 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [https://pdbe.org/4a33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [https://www.ebi.ac.uk/pdbsum/4a33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a33 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).	+	[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leima~~]]	+	[[Category: Leishmania major]]
-	[[Category: Brand, S]]	+	[[Category: Brand S]]
-	[[Category: Brenk, R]]	+	[[Category: Brenk R]]
-	[[Category: Cleghorn~~, L A.T~~]]	+	[[Category: Cleghorn LAT]]
-	[[Category: Fairlamb~~, A H~~]]	+	[[Category: Fairlamb AH]]
-	[[Category: Ferguson~~, M A.J~~]]	+	[[Category: Ferguson MAJ]]
-	[[Category: Frearson~~, J A~~]]	+	[[Category: Frearson JA]]
-	[[Category: Gilbert~~, I H~~]]	+	[[Category: Gilbert IH]]
-	[[Category: Hallyburton, I]]	+	[[Category: Hallyburton I]]
-	[[Category: Harrison~~, J R~~]]	+	[[Category: Harrison JR]]
-	[[Category: McElroy~~, S P~~]]	+	[[Category: McElroy SP]]
-	[[Category: Norcross~~, N R~~]]	+	[[Category: Norcross NR]]
-	[[Category: Norval, S]]	+	[[Category: Norval S]]
-	[[Category: Read~~, K D~~]]	+	[[Category: Read KD]]
-	[[Category: Robinson~~, D A~~]]	+	[[Category: Robinson DA]]
-	[[Category: Smith~~, V C~~]]	+	[[Category: Smith VC]]
-	[[Category: Spinks, D]]	+	[[Category: Spinks D]]
-	[[Category: Stojanovski, L]]	+	[[Category: Stojanovski L]]
-	[[Category: Torrie~~, L S~~]]	+	[[Category: Torrie LS]]
-	[[Category: Wyatt~~, P G]]~~	+	[[Category: Wyatt PG]]
-	~~[[Category: Drug discovery]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:41, 18 August 2022

2022-08-18T07:41:49Z

←Older revision		Revision as of 07:41, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='4a33' size='340' side='right'caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4a33' size='340' side='right'caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A33 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A33 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a2z\|4a2z]], [[4a30\|4a30]], [[2wsa\|2wsa]], [[4a31\|4a31]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a32\|4a32]], [[4a2z\|4a2z]], [[4a30\|4a30]], [[2wsa\|2wsa]], [[4a31\|4a31]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [~~http~~://pdbe.org/4a33 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a33 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a33 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [https://pdbe.org/4a33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [https://www.ebi.ac.uk/pdbsum/4a33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a33 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).	+	[[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:09, 1 January 2020

2020-01-01T13:09:44Z

←Older revision		Revision as of 13:09, 1 January 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==		==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
-	<StructureSection load='4a33' size='340' side='right' caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4a33' size='340' side='right'caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A33 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A33 FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Leima]]		[[Category: Leima]]
	[[Category: Brand, S]]		[[Category: Brand, S]]

OCA at 06:49, 15 February 2018

2018-02-15T06:49:13Z

←Older revision		Revision as of 06:49, 15 February 2018
Line 35:		Line 35:
	[[Category: Hallyburton, I]]		[[Category: Hallyburton, I]]
	[[Category: Harrison, J R]]		[[Category: Harrison, J R]]
-	[[Category: ~~Mcelroy~~, S P]]	+	[[Category: McElroy, S P]]
	[[Category: Norcross, N R]]		[[Category: Norcross, N R]]
	[[Category: Norval, S]]		[[Category: Norval, S]]

OCA at 16:16, 4 August 2016

2016-08-04T16:16:56Z

←Older revision		Revision as of 16:16, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==		==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
	<StructureSection load='4a33' size='340' side='right' caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4a33' size='340' side='right' caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_major Leishmania major~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A33 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A33 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a2z\|4a2z]], [[4a30\|4a30]], [[2wsa\|2wsa]], [[4a31\|4a31]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a2z\|4a2z]], [[4a30\|4a30]], [[2wsa\|2wsa]], [[4a31\|4a31]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [http://www.ebi.ac.uk/pdbsum/4a33 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [http://pdbe.org/4a33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [http://www.ebi.ac.uk/pdbsum/4a33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a33 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a33" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
-	[[Category: ~~Leishmania major~~]]	+	[[Category: Leima]]
	[[Category: Brand, S]]		[[Category: Brand, S]]
	[[Category: Brenk, R]]		[[Category: Brenk, R]]

OCA at 16:56, 24 December 2014

2014-12-24T16:56:00Z

←Older revision		Revision as of 16:56, 24 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4a33.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
		+	<StructureSection load='4a33' size='340' side='right' caption='[[4a33]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A33 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a32\|4a32]], [[4a2z\|4a2z]], [[4a30\|4a30]], [[2wsa\|2wsa]], [[4a31\|4a31]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [http://www.ebi.ac.uk/pdbsum/4a33 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma brucei. We report the optimization of a high throughput screening hit (1) to give a lead molecule DDD85646 (63), which has potent activity against the enzyme (IC(50) = 2 nM) and T. brucei (EC(50) = 2 nM) in culture. The compound has good oral pharmacokinetics and cures rodent models of peripheral HAT infection. This compound provides an excellent tool for validation of T. brucei NMT as a drug target for HAT as well as a valuable lead for further optimization.

-	<!--	+	Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.,Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH J Med Chem. 2012 Jan 12;55(1):140-52. Epub 2011 Dec 7. PMID:22148754<ref>PMID:22148754</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4a33"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_4a33\| PDB=4a33 \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22148754}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22148754 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22148754}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4a33]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022148754<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
-	[[Category: Brand, S.]]	+	[[Category: Brand, S]]
-	[[Category: Brenk, R.]]	+	[[Category: Brenk, R]]
-	[[Category: Cleghorn, L A.T.]]	+	[[Category: Cleghorn, L A.T]]
-	[[Category: Fairlamb, A H.]]	+	[[Category: Fairlamb, A H]]
-	[[Category: Ferguson, M A.J.]]	+	[[Category: Ferguson, M A.J]]
-	[[Category: Frearson, J A.]]	+	[[Category: Frearson, J A]]
-	[[Category: Gilbert, I H.]]	+	[[Category: Gilbert, I H]]
-	[[Category: Hallyburton, I.]]	+	[[Category: Hallyburton, I]]
-	[[Category: Harrison, J R.]]	+	[[Category: Harrison, J R]]
-	[[Category: Mcelroy, S P.]]	+	[[Category: Mcelroy, S P]]
-	[[Category: Norcross, N R.]]	+	[[Category: Norcross, N R]]
-	[[Category: Norval, S.]]	+	[[Category: Norval, S]]
-	[[Category: Read, K D.]]	+	[[Category: Read, K D]]
-	[[Category: Robinson, D A.]]	+	[[Category: Robinson, D A]]
-	[[Category: Smith, V C.]]	+	[[Category: Smith, V C]]
-	[[Category: Spinks, D.]]	+	[[Category: Spinks, D]]
-	[[Category: Stojanovski, L.]]	+	[[Category: Stojanovski, L]]
-	[[Category: Torrie, L S.]]	+	[[Category: Torrie, L S]]
-	[[Category: Wyatt, P G.]]	+	[[Category: Wyatt, P G]]
	[[Category: Drug discovery]]		[[Category: Drug discovery]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:46, 25 January 2012

2012-01-25T05:46:24Z

←Older revision		Revision as of 05:46, 25 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4a33.png\|left\|200px]]

-	The ~~entry 4a33~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a33", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a33\| PDB=4a33 \| SCENE= }}

-	~~Authors: Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross,~~ N~~.R., Norval, S., Spinks, D., Stojanovski, L., Torrie, L.S., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.~~A~~.J., Read, K.D., Wyatt, P.G., Gilbert, I.H.~~	+	===CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND===

-	~~Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N~~-~~MYRISTOYLTRANSFERASE~~ (~~NMT~~) ~~WITH BOUND MYRISTOYL~~-~~COA AND~~ A ~~PYRAZOLE SULPHONAMIDE LIGAND~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22148754}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22148754 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22148754}}
		+
		+	==About this Structure==
		+	[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022148754</ref><references group="xtra"/>
		+	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Leishmania major]]
		+	[[Category: Brand, S.]]
		+	[[Category: Brenk, R.]]
		+	[[Category: Cleghorn, L A.T.]]
		+	[[Category: Fairlamb, A H.]]
		+	[[Category: Ferguson, M A.J.]]
		+	[[Category: Frearson, J A.]]
		+	[[Category: Gilbert, I H.]]
		+	[[Category: Hallyburton, I.]]
		+	[[Category: Harrison, J R.]]
		+	[[Category: Mcelroy, S P.]]
		+	[[Category: Norcross, N R.]]
		+	[[Category: Norval, S.]]
		+	[[Category: Read, K D.]]
		+	[[Category: Robinson, D A.]]
		+	[[Category: Smith, V C.]]
		+	[[Category: Spinks, D.]]
		+	[[Category: Stojanovski, L.]]
		+	[[Category: Torrie, L S.]]
		+	[[Category: Wyatt, P G.]]
		+	[[Category: Drug discovery]]
		+	[[Category: Transferase]]

OCA: Protected "4a33" [edit=sysop:move=sysop]

2011-10-05T06:20:12Z

Protected "4a33" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:20, 5 October 2011

OCA: New page: '''Unreleased structure''' The entry 4a33 is ON HOLD Authors: Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., N...

2011-10-05T06:20:10Z

New page: '''Unreleased structure''' The entry 4a33 is ON HOLD Authors: Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., N...

New page

'''Unreleased structure'''

The entry 4a33 is ON HOLD

Authors: Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., Norval, S., Spinks, D., Stojanovski, L., Torrie, L.S., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Read, K.D., Wyatt, P.G., Gilbert, I.H.

Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND