4a7s - Revision history

OCA at 07:50, 18 August 2022

2022-08-18T07:50:45Z

←Older revision		Revision as of 07:50, 18 August 2022
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	<StructureSection load='4a7s' size='340' side='right'caption='[[4a7s]], [[Resolution\|resolution]] 1.06Å' scene=''>		<StructureSection load='4a7s' size='340' side='right'caption='[[4a7s]], [[Resolution\|resolution]] 1.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a7s]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A7S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wz6\|2wz6]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1azv\|1azv]], [[1hl4\|1hl4]], [[2wyz\|2wyz]], [[4a7q\|4a7q]], [[1ozu\|1ozu]], [[2vr6\|2vr6]], [[2c9v\|2c9v]], [[2wz5\|2wz5]], [[2xjl\|2xjl]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[2xjk\|2xjk]], [[1sos\|1sos]], [[1n19\|1n19]], [[1p1v\|1p1v]], [[2wz0\|2wz0]], [[1l3n\|1l3n]], [[2wko\|2wko]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[2vr8\|2vr8]], [[1rk7\|1rk7]], [[2vr7\|2vr7]], [[4sod\|4sod]], [[2c9s\|2c9s]], [[2v0a\|2v0a]], [[1mfm\|1mfm]], [[2wyt\|2wyt]], [[4a7g\|4a7g]], [[1dsw\|1dsw]], [[1kmg\|1kmg]], [[1ozt\|1ozt]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1spd\|1spd]], [[1uxm\|1uxm]], [[4a7u\|4a7u]], [[4a7t\|4a7t]], [[4a7r\|4a7r]], [[4a7v\|4a7v]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wz6\|2wz6]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1azv\|1azv]], [[1hl4\|1hl4]], [[2wyz\|2wyz]], [[4a7q\|4a7q]], [[1ozu\|1ozu]], [[2vr6\|2vr6]], [[2c9v\|2c9v]], [[2wz5\|2wz5]], [[2xjl\|2xjl]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[2xjk\|2xjk]], [[1sos\|1sos]], [[1n19\|1n19]], [[1p1v\|1p1v]], [[2wz0\|2wz0]], [[1l3n\|1l3n]], [[2wko\|2wko]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[2vr8\|2vr8]], [[1rk7\|1rk7]], [[2vr7\|2vr7]], [[4sod\|4sod]], [[2c9s\|2c9s]], [[2v0a\|2v0a]], [[1mfm\|1mfm]], [[2wyt\|2wyt]], [[4a7g\|4a7g]], [[1dsw\|1dsw]], [[1kmg\|1kmg]], [[1ozt\|1ozt]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1spd\|1spd]], [[1uxm\|1uxm]], [[4a7u\|4a7u]], [[4a7t\|4a7t]], [[4a7r\|4a7r]], [[4a7v\|4a7v]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7s OCA], [~~http~~://pdbe.org/4a7s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a7s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a7s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a7s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7s OCA], [https://pdbe.org/4a7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a7s RCSB], [https://www.ebi.ac.uk/pdbsum/4a7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a7s ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[~~http~~://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>	+	[[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[https://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.	+	[[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Superoxide ~~Dismutase~~\|Superoxide ~~Dismutase~~]]	+	*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Antonyuk, S V]]		[[Category: Antonyuk, S V]]

OCA at 08:55, 6 March 2019

2019-03-06T08:55:07Z

←Older revision		Revision as of 08:55, 6 March 2019
Line 1:		Line 1:

	==Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group==		==Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group==
-	<StructureSection load='4a7s' size='340' side='right' caption='[[4a7s]], [[Resolution\|resolution]] 1.06Å' scene=''>	+	<StructureSection load='4a7s' size='340' side='right'caption='[[4a7s]], [[Resolution\|resolution]] 1.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7S FirstGlance]. <br>

OCA at 01:31, 5 August 2016

2016-08-05T01:31:07Z

←Older revision		Revision as of 01:31, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group==		==Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group==
	<StructureSection load='4a7s' size='340' side='right' caption='[[4a7s]], [[Resolution\|resolution]] 1.06Å' scene=''>		<StructureSection load='4a7s' size='340' side='right' caption='[[4a7s]], [[Resolution\|resolution]] 1.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wz6\|2wz6]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1azv\|1azv]], [[1hl4\|1hl4]], [[2wyz\|2wyz]], [[4a7q\|4a7q]], [[1ozu\|1ozu]], [[2vr6\|2vr6]], [[2c9v\|2c9v]], [[2wz5\|2wz5]], [[2xjl\|2xjl]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[2xjk\|2xjk]], [[1sos\|1sos]], [[1n19\|1n19]], [[1p1v\|1p1v]], [[2wz0\|2wz0]], [[1l3n\|1l3n]], [[2wko\|2wko]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[2vr8\|2vr8]], [[1rk7\|1rk7]], [[2vr7\|2vr7]], [[4sod\|4sod]], [[2c9s\|2c9s]], [[2v0a\|2v0a]], [[1mfm\|1mfm]], [[2wyt\|2wyt]], [[4a7g\|4a7g]], [[1dsw\|1dsw]], [[1kmg\|1kmg]], [[1ozt\|1ozt]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1spd\|1spd]], [[1uxm\|1uxm]], [[4a7u\|4a7u]], [[4a7t\|4a7t]], [[4a7r\|4a7r]], [[4a7v\|4a7v]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wz6\|2wz6]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1azv\|1azv]], [[1hl4\|1hl4]], [[2wyz\|2wyz]], [[4a7q\|4a7q]], [[1ozu\|1ozu]], [[2vr6\|2vr6]], [[2c9v\|2c9v]], [[2wz5\|2wz5]], [[2xjl\|2xjl]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[2xjk\|2xjk]], [[1sos\|1sos]], [[1n19\|1n19]], [[1p1v\|1p1v]], [[2wz0\|2wz0]], [[1l3n\|1l3n]], [[2wko\|2wko]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[2vr8\|2vr8]], [[1rk7\|1rk7]], [[2vr7\|2vr7]], [[4sod\|4sod]], [[2c9s\|2c9s]], [[2v0a\|2v0a]], [[1mfm\|1mfm]], [[2wyt\|2wyt]], [[4a7g\|4a7g]], [[1dsw\|1dsw]], [[1kmg\|1kmg]], [[1ozt\|1ozt]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1spd\|1spd]], [[1uxm\|1uxm]], [[4a7u\|4a7u]], [[4a7t\|4a7t]], [[4a7r\|4a7r]], [[4a7v\|4a7v]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a7s RCSB], [http://www.ebi.ac.uk/pdbsum/4a7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7s OCA], [http://pdbe.org/4a7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a7s RCSB], [http://www.ebi.ac.uk/pdbsum/4a7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a7s ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a7s" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Antonyuk, S V]]		[[Category: Antonyuk, S V]]

OCA at 09:04, 21 December 2014

2014-12-21T09:04:41Z

←Older revision		Revision as of 09:04, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4a7s\| PDB=4a7s \| SCENE= }}~~	+	==Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group==
-	===Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group===	+	<StructureSection load='4a7s' size='340' side='right' caption='[[4a7s]], [[Resolution\|resolution]] 1.06Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23612299}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4a7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7S FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wz6\|2wz6]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1azv\|1azv]], [[1hl4\|1hl4]], [[2wyz\|2wyz]], [[4a7q\|4a7q]], [[1ozu\|1ozu]], [[2vr6\|2vr6]], [[2c9v\|2c9v]], [[2wz5\|2wz5]], [[2xjl\|2xjl]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[2xjk\|2xjk]], [[1sos\|1sos]], [[1n19\|1n19]], [[1p1v\|1p1v]], [[2wz0\|2wz0]], [[1l3n\|1l3n]], [[2wko\|2wko]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[2vr8\|2vr8]], [[1rk7\|1rk7]], [[2vr7\|2vr7]], [[4sod\|4sod]], [[2c9s\|2c9s]], [[2v0a\|2v0a]], [[1mfm\|1mfm]], [[2wyt\|2wyt]], [[4a7g\|4a7g]], [[1dsw\|1dsw]], [[1kmg\|1kmg]], [[1ozt\|1ozt]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1spd\|1spd]], [[1uxm\|1uxm]], [[4a7u\|4a7u]], [[4a7t\|4a7t]], [[4a7r\|4a7r]], [[4a7v\|4a7v]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a7s RCSB], [http://www.ebi.ac.uk/pdbsum/4a7s PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[http://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>		[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[http://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.		[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mutations in the gene encoding Cu/Zn superoxide dismutase-1 cause amyotrophic lateral sclerosis. Superoxide dismutase-1 mutations decrease protein stability and promote aggregation. The mutant monomer is thought to be an intermediate in the pathway from the superoxide dismutase-1 dimer to aggregate. Here we find that the monomeric copper-apo, zinc-holo protein is structurally perturbed and the apo-protein aggregates without reattainment of the monomer-dimer equilibrium. Intervention to stabilize the superoxide dismutase-1 dimer and inhibit aggregation is regarded as a potential therapeutic strategy. We describe protein-ligand interactions for two compounds, Isoproterenol and 5-fluorouridine, highlighted as superoxide dismutase-1 stabilizers. We find both compounds interact with superoxide dismutase-1 at a key region identified at the core of the superoxide dismutase-1 fibrillar aggregates, beta-barrel loop II-strand 3, rather than the proposed dimer interface site. This illustrates the need for direct structural observations when developing compounds for protein-targeted therapeutics.

-	~~==About this Structure==~~	+	Ligand binding and aggregation of pathogenic SOD1.,Wright GS, Antonyuk SV, Kershaw NM, Strange RW, Samar Hasnain S Nat Commun. 2013 Apr 23;4:1758. doi: 10.1038/ncomms2750. PMID:23612299<ref>PMID:23612299</ref>
-	~~[[4a7s]] is a 2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4A7S OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Superoxide Dismutase\|Superoxide Dismutase]]		*[[Superoxide Dismutase\|Superoxide Dismutase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
-	[[Category: Antonyuk, S V.]]	+	[[Category: Antonyuk, S V]]
-	[[Category: Hasnain, S S.]]	+	[[Category: Hasnain, S S]]
-	[[Category: Kershaw, N M.]]	+	[[Category: Kershaw, N M]]
-	[[Category: ONeil, P M.]]	+	[[Category: ONeil, P M]]
-	[[Category: Strange, R W.]]	+	[[Category: Strange, R W]]
-	[[Category: Wright, G S.A.]]	+	[[Category: Wright, G S.A]]
	[[Category: Amyotrophic lateral sclerosis]]		[[Category: Amyotrophic lateral sclerosis]]
	[[Category: Antioxidant]]		[[Category: Antioxidant]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 06:56, 8 May 2013

2013-05-08T06:56:25Z

←Older revision		Revision as of 06:56, 8 May 2013
Line 1:		Line 1:
	{{STRUCTURE_4a7s\| PDB=4a7s \| SCENE= }}		{{STRUCTURE_4a7s\| PDB=4a7s \| SCENE= }}
	===Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group===		===Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group===
		+	{{ABSTRACT_PUBMED_23612299}}

	==Disease==		==Disease==

OCA at 10:34, 24 April 2013

2013-04-24T10:34:50Z

←Older revision		Revision as of 10:34, 24 April 2013
Line 3:		Line 3:

	==Disease==		==Disease==
-	[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[http://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref><ref>PMID:19741096</ref><ref>PMID:8528216</ref><ref>PMID:8682505</ref><ref>PMID:9541385</ref><ref>PMID:12754496</ref><ref>PMID:15056757</ref><ref>PMID:18378676</ref>[:]<ref>PMID:8446170</ref><ref>PMID:8351519</ref><ref>PMID:8179602</ref><ref>PMID:7980516</ref><ref>PMID:8069312</ref><ref>PMID:7951252</ref><ref>PMID:7881433</ref><ref>PMID:7836951</ref><ref>PMID:7997024</ref><ref>PMID:7870076</ref><ref>PMID:7887412</ref><ref>PMID:7795609</ref><ref>PMID:7655468</ref><ref>PMID:7655469</ref><ref>PMID:7655471</ref><ref>PMID:7700376</ref><ref>PMID:7647793</ref><ref>PMID:7501156</ref><ref>PMID:7496169</ref><ref>PMID:8938700</ref><ref>PMID:8907321</ref><ref>PMID:8990014</ref><ref>PMID:9101297</ref><ref>PMID:9455977</ref><ref>PMID:10732812</ref><ref>PMID:9131652</ref><ref>PMID:10400992</ref><ref>PMID:10430435</ref><ref>PMID:11535232</ref><ref>PMID:11369193</ref><ref>PMID:12402272</ref><ref>PMID:12145308</ref><ref>PMID:14506936</ref><ref>PMID:18552350</ref><ref>PMID:18301754</ref><ref>PMID:21247266</ref><ref>PMID:21220647</ref>	+	[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[http://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>

	==Function==		==Function==
Line 21:		Line 21:
	[[Category: Hasnain, S S.]]		[[Category: Hasnain, S S.]]
	[[Category: Kershaw, N M.]]		[[Category: Kershaw, N M.]]
		+	[[Category: ONeil, P M.]]
	[[Category: Strange, R W.]]		[[Category: Strange, R W.]]
	[[Category: Wright, G S.A.]]		[[Category: Wright, G S.A.]]

OCA at 06:33, 25 March 2013

2013-03-25T06:33:47Z

←Older revision		Revision as of 06:33, 25 March 2013
Line 1:		Line 1:
-	[[Image:4a7s.jpg\|left\|200px]]
-
	{{STRUCTURE_4a7s\| PDB=4a7s \| SCENE= }}		{{STRUCTURE_4a7s\| PDB=4a7s \| SCENE= }}
-
	===Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group===		===Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[http://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref><ref>PMID:19741096</ref><ref>PMID:8528216</ref><ref>PMID:8682505</ref><ref>PMID:9541385</ref><ref>PMID:12754496</ref><ref>PMID:15056757</ref><ref>PMID:18378676</ref>[:]<ref>PMID:8446170</ref><ref>PMID:8351519</ref><ref>PMID:8179602</ref><ref>PMID:7980516</ref><ref>PMID:8069312</ref><ref>PMID:7951252</ref><ref>PMID:7881433</ref><ref>PMID:7836951</ref><ref>PMID:7997024</ref><ref>PMID:7870076</ref><ref>PMID:7887412</ref><ref>PMID:7795609</ref><ref>PMID:7655468</ref><ref>PMID:7655469</ref><ref>PMID:7655471</ref><ref>PMID:7700376</ref><ref>PMID:7647793</ref><ref>PMID:7501156</ref><ref>PMID:7496169</ref><ref>PMID:8938700</ref><ref>PMID:8907321</ref><ref>PMID:8990014</ref><ref>PMID:9101297</ref><ref>PMID:9455977</ref><ref>PMID:10732812</ref><ref>PMID:9131652</ref><ref>PMID:10400992</ref><ref>PMID:10430435</ref><ref>PMID:11535232</ref><ref>PMID:11369193</ref><ref>PMID:12402272</ref><ref>PMID:12145308</ref><ref>PMID:14506936</ref><ref>PMID:18552350</ref><ref>PMID:18301754</ref><ref>PMID:21247266</ref><ref>PMID:21220647</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

	==About this Structure==		==About this Structure==
	[[4a7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA].		[[4a7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA].
		+
		+	==See Also==
		+	*[[Superoxide Dismutase\|Superoxide Dismutase]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]

OCA at 10:57, 5 December 2012

2012-12-05T10:57:23Z

←Older revision		Revision as of 10:57, 5 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4a7s.jpg\|left\|200px]]

-	~~The entry~~ 4a7s ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4a7s\| PDB=4a7s \| SCENE= }}

-	~~Authors: Wright, G.S.A., Kershaw, N.M., Antonyuk, S.V., Strange, R.W., ONeil, P.M., Hasnain, S.S.~~	+	===Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group===

-	~~Description:~~ Structure ~~of human I113T SOD1 mutant complexed~~ with 5-~~Fluorouridine in the p21 space group~~	+
		+	==About this Structure==
		+	[[4a7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7S OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Superoxide dismutase]]
		+	[[Category: Antonyuk, S V.]]
		+	[[Category: Hasnain, S S.]]
		+	[[Category: Kershaw, N M.]]
		+	[[Category: Strange, R W.]]
		+	[[Category: Wright, G S.A.]]
		+	[[Category: Amyotrophic lateral sclerosis]]
		+	[[Category: Antioxidant]]
		+	[[Category: Oxidoreductase]]

OCA at 13:52, 28 November 2012

2012-11-28T13:52:16Z

←Older revision		Revision as of 13:52, 28 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4a7s is ON HOLD	+	The entry 4a7s is ON HOLD until Paper Publication

	Authors: Wright, G.S.A., Kershaw, N.M., Antonyuk, S.V., Strange, R.W., ONeil, P.M., Hasnain, S.S.		Authors: Wright, G.S.A., Kershaw, N.M., Antonyuk, S.V., Strange, R.W., ONeil, P.M., Hasnain, S.S.

	Description: Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group		Description: Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group

OCA: Protected "4a7s" [edit=sysop:move=sysop]

2011-11-23T18:46:11Z

Protected "4a7s" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:46, 23 November 2011