4a81 - Revision history

OCA at 11:21, 20 December 2023

2023-12-20T11:21:32Z

←Older revision		Revision as of 11:21, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4a81' size='340' side='right'caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4a81' size='340' side='right'caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Betpn Betpn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A81 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fsk\|1fsk]], [[4a8g\|4a8g]], [[1b6f\|1b6f]], [[4a84\|4a84]], [[1bv1\|1bv1]], [[4a80\|4a80]], [[4a85\|4a85]], [[4a88\|4a88]], [[1llt\|1llt]], [[1qmr\|1qmr]], [[4a86\|4a86]], [[1btv\|1btv]], [[4a83\|4a83]], [[4a87\|4a87]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [https://pdbe.org/4a81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [https://www.ebi.ac.uk/pdbsum/4a81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a81 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [https://pdbe.org/4a81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [https://www.ebi.ac.uk/pdbsum/4a81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity).	+	[https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN] May be a general steroid carrier protein (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Betpn~~]]	+	[[Category: Betula pendula]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brandstetter, H]]	+	[[Category: Brandstetter H]]
-	[[Category: Kofler, S]]	+	[[Category: Kofler S]]
-	~~[[Category: Allergen]]~~	+
-	~~[[Category: Pr-10 protein~~]]	+

OCA at 07:51, 18 August 2022

2022-08-18T07:51:16Z

←Older revision		Revision as of 07:51, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='4a81' size='340' side='right'caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4a81' size='340' side='right'caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Betpn Betpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betpn Betpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A81 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fsk\|1fsk]], [[4a8g\|4a8g]], [[1b6f\|1b6f]], [[4a84\|4a84]], [[1bv1\|1bv1]], [[4a80\|4a80]], [[4a85\|4a85]], [[4a88\|4a88]], [[1llt\|1llt]], [[1qmr\|1qmr]], [[4a86\|4a86]], [[1btv\|1btv]], [[4a83\|4a83]], [[4a87\|4a87]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fsk\|1fsk]], [[4a8g\|4a8g]], [[1b6f\|1b6f]], [[4a84\|4a84]], [[1bv1\|1bv1]], [[4a80\|4a80]], [[4a85\|4a85]], [[4a88\|4a88]], [[1llt\|1llt]], [[1qmr\|1qmr]], [[4a86\|4a86]], [[1btv\|1btv]], [[4a83\|4a83]], [[4a87\|4a87]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [~~http~~://pdbe.org/4a81 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a81 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a81 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [https://pdbe.org/4a81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [https://www.ebi.ac.uk/pdbsum/4a81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity).	+	[[https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:23, 28 August 2019

2019-08-28T16:23:00Z

←Older revision		Revision as of 16:23, 28 August 2019
Line 1:		Line 1:

	==Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid==		==Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid==
-	<StructureSection load='4a81' size='340' side='right' caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4a81' size='340' side='right'caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betpn Betpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betpn Betpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A81 FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Betpn]]		[[Category: Betpn]]
		+	[[Category: Large Structures]]
	[[Category: Brandstetter, H]]		[[Category: Brandstetter, H]]
	[[Category: Kofler, S]]		[[Category: Kofler, S]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Pr-10 protein]]		[[Category: Pr-10 protein]]

OCA at 17:07, 5 August 2016

2016-08-05T17:07:59Z

←Older revision		Revision as of 17:07, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid==		==Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid==
	<StructureSection load='4a81' size='340' side='right' caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4a81' size='340' side='right' caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Betula_pendula Betula pendula~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betpn Betpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A81 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fsk\|1fsk]], [[4a8g\|4a8g]], [[1b6f\|1b6f]], [[4a84\|4a84]], [[1bv1\|1bv1]], [[4a80\|4a80]], [[4a85\|4a85]], [[4a88\|4a88]], [[1llt\|1llt]], [[1qmr\|1qmr]], [[4a86\|4a86]], [[1btv\|1btv]], [[4a83\|4a83]], [[4a87\|4a87]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fsk\|1fsk]], [[4a8g\|4a8g]], [[1b6f\|1b6f]], [[4a84\|4a84]], [[1bv1\|1bv1]], [[4a80\|4a80]], [[4a85\|4a85]], [[4a88\|4a88]], [[1llt\|1llt]], [[1qmr\|1qmr]], [[4a86\|4a86]], [[1btv\|1btv]], [[4a83\|4a83]], [[4a87\|4a87]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [http://www.ebi.ac.uk/pdbsum/4a81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [http://pdbe.org/4a81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [http://www.ebi.ac.uk/pdbsum/4a81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a81" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Betula pendula~~]]	+	[[Category: Betpn]]
	[[Category: Brandstetter, H]]		[[Category: Brandstetter, H]]
	[[Category: Kofler, S]]		[[Category: Kofler, S]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Pr-10 protein]]		[[Category: Pr-10 protein]]

OCA at 20:31, 25 December 2014

2014-12-25T20:31:55Z

←Older revision		Revision as of 20:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A81 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fsk\|1fsk]], [[4a8g\|4a8g]], [[1b6f\|1b6f]], [[4a84\|4a84]], [[1bv1\|1bv1]], [[4a80\|4a80]], [[4a85\|4a85]], [[4a88\|4a88]], [[1llt\|1llt]], [[1qmr\|1qmr]], [[4a86\|4a86]], [[1btv\|1btv]], [[4a83\|4a83]], [[4a87\|4a87]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fsk\|1fsk]], [[4a8g\|4a8g]], [[1b6f\|1b6f]], [[4a84\|4a84]], [[1bv1\|1bv1]], [[4a80\|4a80]], [[4a85\|4a85]], [[4a88\|4a88]], [[1llt\|1llt]], [[1qmr\|1qmr]], [[4a86\|4a86]], [[1btv\|1btv]], [[4a83\|4a83]], [[4a87\|4a87]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [http://www.ebi.ac.uk/pdbsum/4a81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [http://www.ebi.ac.uk/pdbsum/4a81 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Betula pendula]]		[[Category: Betula pendula]]
-	[[Category: Brandstetter, H.]]	+	[[Category: Brandstetter, H]]
-	[[Category: Kofler, S.]]	+	[[Category: Kofler, S]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Pr-10 protein]]		[[Category: Pr-10 protein]]

OCA at 09:15, 11 June 2014

2014-06-11T09:15:23Z

←Older revision		Revision as of 09:15, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4a81.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid==
		+	<StructureSection load='4a81' size='340' side='right' caption='[[4a81]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A81 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fsk\|1fsk]], [[4a8g\|4a8g]], [[1b6f\|1b6f]], [[4a84\|4a84]], [[1bv1\|1bv1]], [[4a80\|4a80]], [[4a85\|4a85]], [[4a88\|4a88]], [[1llt\|1llt]], [[1qmr\|1qmr]], [[4a86\|4a86]], [[1btv\|1btv]], [[4a83\|4a83]], [[4a87\|4a87]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a81 RCSB], [http://www.ebi.ac.uk/pdbsum/4a81 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ability of pathogenesis-related proteins of family 10 to bind a broad spectrum of ligands is considered to play a key role for their physiological and pathological functions. In particular, Bet v 1, an archetypical allergen from birch pollen, is described as a highly promiscuous ligand acceptor. However, the detailed recognition mechanisms, including specificity factors discriminating binding properties of naturally occurring Bet v 1 variants, are poorly understood. Here, we report crystal structures of Bet v 1 variants in complex with an array of ligands at a resolution of up to 1.2 A. Residue 30 within the hydrophobic pocket not only discriminates in high and low IgE binding Bet v 1 isoforms but also induces a drastic change in the binding mode of the model ligand deoxycholate. Ternary crystal structure complexes of Bet v 1 with several ligands together with the fluorogenic reporter 1-anilino-8-naphthalene sulfonate explain anomalous fluorescence binding curves obtained from 1-anilino-8-naphthalene sulfonate displacement assays. The structures reveal key interaction residues such as Tyr83 and rationalize both the binding specificity and promiscuity of the so-called hydrophobic pocket in Bet v 1. The intermolecular interactions of Bet v 1 reveal an unexpected complexity that will be indispensable to fully understand its roles within the physiological and allergenic context.

-	~~{{STRUCTURE_4a81\| PDB=4a81 \| SCENE= }}~~	+	Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1.,Kofler S, Asam C, Eckhard U, Wallner M, Ferreira F, Brandstetter H J Mol Biol. 2012 Sep 7;422(1):109-23. Epub 2012 May 23. PMID:22634284<ref>PMID:22634284</ref>

-	~~===Crystal Structure~~ of ~~Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22634284}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4a81]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Betula_pendula Betula pendula]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022634284<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Betula pendula]]		[[Category: Betula pendula]]
	[[Category: Brandstetter, H.]]		[[Category: Brandstetter, H.]]

OCA at 04:58, 15 August 2012

2012-08-15T04:58:15Z

←Older revision		Revision as of 04:58, 15 August 2012
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-	[[Image:4a81.~~jpg~~\|left\|200px]]	+	[[Image:4a81.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4a81", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4a81\| PDB=4a81 \| SCENE= }}		{{STRUCTURE_4a81\| PDB=4a81 \| SCENE= }}

	===Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid===		===Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid===

		+	{{ABSTRACT_PUBMED_22634284}}

	==About this Structure==		==About this Structure==
	[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA].		[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022634284</ref><references group="xtra"/>
	[[Category: Betula pendula]]		[[Category: Betula pendula]]
	[[Category: Brandstetter, H.]]		[[Category: Brandstetter, H.]]

OCA at 06:02, 30 May 2012

2012-05-30T06:02:35Z

←Older revision		Revision as of 06:02, 30 May 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4a81.jpg\|left\|200px]]

-	The ~~entry 4a81~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a81", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a81\| PDB=4a81 \| SCENE= }}

-	~~Authors: Kofler, S., Brandstetter, H.~~	+	===Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid===

-	~~Description: Crystal~~ Structure ~~of Major Birch Pollen Allergen Bet v 1~~ a ~~in ternary complex~~ with 8-~~Anilinonaphthalene-1~~-~~sulfonate (ANS) and deoxycholic acid~~	+
		+	==About this Structure==
		+	[[4a81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A81 OCA].
		+	[[Category: Betula pendula]]
		+	[[Category: Brandstetter, H.]]
		+	[[Category: Kofler, S.]]
		+	[[Category: Allergen]]
		+	[[Category: Pr-10 protein]]

OCA: Protected "4a81" [edit=sysop:move=sysop]

2011-11-30T06:00:16Z

Protected "4a81" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 30 November 2011

OCA: New page: '''Unreleased structure''' The entry 4a81 is ON HOLD until Paper Publication Authors: Kofler, S., Brandstetter, H. Description: Crystal Structure of Major Birch Pollen Allergen Bet v 1...

2011-11-30T06:00:15Z

New page: '''Unreleased structure''' The entry 4a81 is ON HOLD until Paper Publication Authors: Kofler, S., Brandstetter, H. Description: Crystal Structure of Major Birch Pollen Allergen Bet v 1...

New page

'''Unreleased structure'''

The entry 4a81 is ON HOLD until Paper Publication

Authors: Kofler, S., Brandstetter, H.

Description: Crystal Structure of Major Birch Pollen Allergen Bet v 1 a in ternary complex with 8-Anilinonaphthalene-1-sulfonate (ANS) and deoxycholic acid