4a9h - Revision history

OCA at 10:48, 9 May 2024

2024-05-09T10:48:31Z

←Older revision		Revision as of 10:48, 9 May 2024
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	<StructureSection load='4a9h' size='340' side='right'caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4a9h' size='340' side='right'caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A9H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A9H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yek\|2yek]], [[4a9e\|4a9e]], [[1x0j\|1x0j]], [[4a9f\|4a9f]], [[2ydw\|2ydw]], [[4a9k\|4a9k]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9o\|4a9o]], [[4a9l\|4a9l]], [[4a9p\|4a9p]], [[4a9n\|4a9n]], [[4a9i\|4a9i]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [https://pdbe.org/4a9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [https://www.ebi.ac.uk/pdbsum/4a9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a9h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [https://pdbe.org/4a9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [https://www.ebi.ac.uk/pdbsum/4a9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a9h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>	+	[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bamborough, P]]	+	[[Category: Bamborough P]]
-	[[Category: Chung~~, C W]]~~	+	[[Category: Chung CW]]
-	~~[[Category: Epigenetic reader]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:54, 18 August 2022

2022-08-18T07:54:03Z

←Older revision		Revision as of 07:54, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='4a9h' size='340' side='right'caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4a9h' size='340' side='right'caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A9H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A9H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yek\|2yek]], [[4a9e\|4a9e]], [[1x0j\|1x0j]], [[4a9f\|4a9f]], [[2ydw\|2ydw]], [[4a9k\|4a9k]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9o\|4a9o]], [[4a9l\|4a9l]], [[4a9p\|4a9p]], [[4a9n\|4a9n]], [[4a9i\|4a9i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yek\|2yek]], [[4a9e\|4a9e]], [[1x0j\|1x0j]], [[4a9f\|4a9f]], [[2ydw\|2ydw]], [[4a9k\|4a9k]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9o\|4a9o]], [[4a9l\|4a9l]], [[4a9p\|4a9p]], [[4a9n\|4a9n]], [[4a9i\|4a9i]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [~~http~~://pdbe.org/4a9h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a9h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a9h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [https://pdbe.org/4a9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [https://www.ebi.ac.uk/pdbsum/4a9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a9h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>	+	[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:54, 21 May 2019

2019-05-21T07:54:22Z

←Older revision		Revision as of 07:54, 21 May 2019
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bamborough, P]]		[[Category: Bamborough, P]]
	[[Category: Chung, C W]]		[[Category: Chung, C W]]

OCA at 09:38, 6 March 2019

2019-03-06T09:38:23Z

←Older revision		Revision as of 09:38, 6 March 2019
Line 1:		Line 1:

	==N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one==		==N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one==
-	<StructureSection load='4a9h' size='340' side='right' caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4a9h' size='340' side='right'caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9H FirstGlance]. <br>

OCA at 18:53, 4 August 2016

2016-08-04T18:53:54Z

←Older revision		Revision as of 18:53, 4 August 2016
Line 1:		Line 1:
		+
	==N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one==		==N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one==
	<StructureSection load='4a9h' size='340' side='right' caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4a9h' size='340' side='right' caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yek\|2yek]], [[4a9e\|4a9e]], [[1x0j\|1x0j]], [[4a9f\|4a9f]], [[2ydw\|2ydw]], [[4a9k\|4a9k]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9o\|4a9o]], [[4a9l\|4a9l]], [[4a9p\|4a9p]], [[4a9n\|4a9n]], [[4a9i\|4a9i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yek\|2yek]], [[4a9e\|4a9e]], [[1x0j\|1x0j]], [[4a9f\|4a9f]], [[2ydw\|2ydw]], [[4a9k\|4a9k]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9o\|4a9o]], [[4a9l\|4a9l]], [[4a9p\|4a9p]], [[4a9n\|4a9n]], [[4a9i\|4a9i]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [http://www.ebi.ac.uk/pdbsum/4a9h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [http://pdbe.org/4a9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [http://www.ebi.ac.uk/pdbsum/4a9h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a9h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a9h" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bamborough, P]]		[[Category: Bamborough, P]]
	[[Category: Chung, C W]]		[[Category: Chung, C W]]

OCA at 18:26, 24 December 2014

2014-12-24T18:26:10Z

←Older revision		Revision as of 18:26, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9H FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yek\|2yek]], [[4a9e\|4a9e]], [[1x0j\|1x0j]], [[4a9f\|4a9f]], [[2ydw\|2ydw]], [[4a9k\|4a9k]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9o\|4a9o]], [[4a9l\|4a9l]], [[4a9p\|4a9p]], [[4a9n\|4a9n]], [[4a9i\|4a9i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yek\|2yek]], [[4a9e\|4a9e]], [[1x0j\|1x0j]], [[4a9f\|4a9f]], [[2ydw\|2ydw]], [[4a9k\|4a9k]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9o\|4a9o]], [[4a9l\|4a9l]], [[4a9p\|4a9p]], [[4a9n\|4a9n]], [[4a9i\|4a9i]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [http://www.ebi.ac.uk/pdbsum/4a9h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [http://www.ebi.ac.uk/pdbsum/4a9h PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bamborough, P.]]	+	[[Category: Bamborough, P]]
-	[[Category: Chung, C W.]]	+	[[Category: Chung, C W]]
	[[Category: Epigenetic reader]]		[[Category: Epigenetic reader]]
	[[Category: Histone]]		[[Category: Histone]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 08:29, 5 June 2014

2014-06-05T08:29:57Z

←Older revision		Revision as of 08:29, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4a9h.~~png~~\|~~left~~\|~~200px~~]]	+	==N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one==
		+	<StructureSection load='4a9h' size='340' side='right' caption='[[4a9h]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9H FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TVP:(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE'>TVP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yek\|2yek]], [[4a9e\|4a9e]], [[1x0j\|1x0j]], [[4a9f\|4a9f]], [[2ydw\|2ydw]], [[4a9k\|4a9k]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9o\|4a9o]], [[4a9l\|4a9l]], [[4a9p\|4a9p]], [[4a9n\|4a9n]], [[4a9i\|4a9i]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a9h RCSB], [http://www.ebi.ac.uk/pdbsum/4a9h PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bromodomain-containing proteins are key epigenetic regulators of gene transcription and readers of the histone code. However, the therapeutic benefits of modulating this target class are largely unexplored due to the lack of suitable chemical probes. This article describes the generation of lead molecules for the BET bromodomains through screening a fragment set chosen using structural insights and computational approaches. Analysis of 40 BRD2/fragment X-ray complexes highlights both shared and disparate interaction features, which that may be exploited for affinity and selectivity. Six representative crystal structures are then exemplified in detail. Two of the fragments are completely new bromodomain chemotypes, and three have never before been crystallized in a bromodomain, so our results significantly extend the limited public knowledge-base of crystallographic small molecule/bromodomain interactions. Certain fragments (including paracetamol) bind in a consistent mode to different bromodomains such as CREBBP, suggesting their potential to act as generic bromodomain templates. An important implication is that the bromodomains are not only a phylogenetic family, but also a system in which chemical and structural knowledge of one bromodomain gives insights transferrable to others.

-	<!--	+	Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery.,Chung CW, Dean TW, Woolven JM, Bamborough P J Med Chem. 2011 Dec 5. PMID:22136404<ref>PMID:22136404</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4a9h"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_4a9h\| PDB=4a9h \| SCENE= }}~~	+

-	~~===N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1~~,~~2,3,4-tetrahydroquinolin-1-yl)ethan-1-one===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22136404}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22136404 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22136404}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4a9h]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022136404<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bamborough, P.]]		[[Category: Bamborough, P.]]

OCA at 06:19, 11 January 2012

2012-01-11T06:19:19Z

←Older revision		Revision as of 06:19, 11 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4a9h.png\|left\|200px]]

-	The ~~entry 4a9h~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a9h", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a9h\| PDB=4a9h \| SCENE= }}

-	~~Authors: Chung~~, C., ~~Bamborough~~, P.	+	===N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one===

-	~~Description: N~~-~~TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1~~-~~(2-methyl-1~~,2,3,4-~~tetrahydroquinolin~~-1-~~yl)ethan-1-one~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22136404}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22136404 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22136404}}
		+
		+	==About this Structure==
		+	[[4a9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9H OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022136404</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bamborough, P.]]
		+	[[Category: Chung, C W.]]
		+	[[Category: Epigenetic reader]]
		+	[[Category: Histone]]
		+	[[Category: Inhibitor]]
		+	[[Category: Signaling protein]]

OCA: Protected "4a9h" [edit=sysop:move=sysop]

2011-12-07T07:45:05Z

Protected "4a9h" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:45, 7 December 2011

OCA: New page: '''Unreleased structure''' The entry 4a9h is ON HOLD Authors: Chung, C., Bamborough, P. Description: N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-...

2011-12-07T07:45:04Z

New page: '''Unreleased structure''' The entry 4a9h is ON HOLD Authors: Chung, C., Bamborough, P. Description: N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-...

New page

'''Unreleased structure'''

The entry 4a9h is ON HOLD

Authors: Chung, C., Bamborough, P.

Description: N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one