4ad0 - Revision history

OCA at 11:24, 20 December 2023

2023-12-20T11:24:19Z

←Older revision		Revision as of 11:24, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4ad0' size='340' side='right'caption='[[4ad0]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='4ad0' size='340' side='right'caption='[[4ad0]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ad0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bactn Bactn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AD0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ad0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AD0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=B3P:2~~-[~~3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO~~]-2~~-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.09Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[4ad4\|4ad4]], [[4acy\|4acy]], [[4ad3\|4ad3]], [[4ad1\|4ad1]], [[4ad2\|4ad2]], [[4ad5\|4ad5]], [[4acz\|4acz]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Glycoprotein_endo~~-~~alpha~~-1,2-~~mannosidase Glycoprotein endo-alpha~~-1,2-~~mannosidase~~]~~, with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~2.1~~.130~~ 3~~.2.1.130]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ad0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ad0 OCA], [https://pdbe.org/4ad0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ad0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ad0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ad0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ad0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ad0 OCA], [https://pdbe.org/4ad0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ad0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ad0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ad0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8A109_BACTN Q8A109_BACTN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bactn]]~~	+	[[Category: Bacteroides thetaiotaomicron VPI-5482]]
-	~~[[Category: Glycoprotein endo~~-~~alpha-1,2-mannosidase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alonzi~~, D S~~]]	+	[[Category: Alonzi DS]]
-	[[Category: Butters~~, T D~~]]	+	[[Category: Butters TD]]
-	[[Category: Davies~~, G J~~]]	+	[[Category: Davies GJ]]
-	[[Category: Gloster~~, T M~~]]	+	[[Category: Gloster TM]]
-	[[Category: Hakki, Z]]	+	[[Category: Hakki Z]]
-	[[Category: Songsrirote, K]]	+	[[Category: Songsrirote K]]
-	[[Category: Spreitz, J]]	+	[[Category: Spreitz J]]
-	[[Category: Stuetz~~, A E~~]]	+	[[Category: Stuetz AE]]
-	[[Category: Thomas-Oates~~, J E~~]]	+	[[Category: Thomas-Oates JE]]
-	[[Category: Thompson~~, A J~~]]	+	[[Category: Thompson AJ]]
-	[[Category: Wennekes, T]]	+	[[Category: Wennekes T]]
-	[[Category: Williams~~, R J~~]]	+	[[Category: Williams RJ]]
-	[[Category: Williams~~, S J~~]]	+	[[Category: Williams SJ]]
-	[[Category: Wrodnigg~~, T M]]~~	+	[[Category: Wrodnigg TM]]
-	~~[[Category: Cazy]]~~	+
-	~~[[Category: Endomannosidase]]~~	+
-	~~[[Category: Enzyme-carbohydrate interaction]]~~	+
-	~~[[Category: Glycoside hydrolase gh99]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mannose glycosidase inhibition~~]]	+

OCA at 05:29, 25 August 2022

2022-08-25T05:29:54Z

←Older revision		Revision as of 05:29, 25 August 2022
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	<StructureSection load='4ad0' size='340' side='right'caption='[[4ad0]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='4ad0' size='340' side='right'caption='[[4ad0]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ad0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AD0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ad0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AD0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ad4\|4ad4]], [[4acy\|4acy]], [[4ad3\|4ad3]], [[4ad1\|4ad1]], [[4ad2\|4ad2]], [[4ad5\|4ad5]], [[4acz\|4acz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4ad4\|4ad4]], [[4acy\|4acy]], [[4ad3\|4ad3]], [[4ad1\|4ad1]], [[4ad2\|4ad2]], [[4ad5\|4ad5]], [[4acz\|4acz]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycoprotein_endo-alpha-1,2-mannosidase Glycoprotein endo-alpha-1,2-mannosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.130 3.2.1.130] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycoprotein_endo-alpha-1,2-mannosidase Glycoprotein endo-alpha-1,2-mannosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.130 3.2.1.130] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ad0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ad0 OCA], [~~http~~://pdbe.org/4ad0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ad0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ad0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ad0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ad0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ad0 OCA], [https://pdbe.org/4ad0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ad0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ad0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ad0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Mannosidase\|Mannosidase]]	+	*[[Mannosidase 3D structures\|Mannosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	[[Category: Bactn]]		[[Category: Bactn]]
	[[Category: Glycoprotein endo-alpha-1,2-mannosidase]]		[[Category: Glycoprotein endo-alpha-1,2-mannosidase]]
		+	[[Category: Large Structures]]
	[[Category: Alonzi, D S]]		[[Category: Alonzi, D S]]
	[[Category: Butters, T D]]		[[Category: Butters, T D]]

OCA at 09:11, 6 March 2019

2019-03-06T09:11:33Z

←Older revision		Revision as of 09:11, 6 March 2019
Line 1:		Line 1:

	==Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane==		==Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane==
-	<StructureSection load='4ad0' size='340' side='right' caption='[[4ad0]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='4ad0' size='340' side='right'caption='[[4ad0]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ad0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AD0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ad0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AD0 FirstGlance]. <br>

OCA at 13:30, 19 April 2017

2017-04-19T13:30:57Z

←Older revision		Revision as of 13:30, 19 April 2017
Line 1:		Line 1:
-	[[Image:4ad0.png\|left\|200px]]

-	~~{{STRUCTURE_4ad0~~\| ~~PDB~~=4ad0 \| ~~SCENE~~= }}	+	==Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane==
		+	<StructureSection load='4ad0' size='340' side='right' caption='[[4ad0]], [[Resolution\|resolution]] 2.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ad0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AD0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ad4\|4ad4]], [[4acy\|4acy]], [[4ad3\|4ad3]], [[4ad1\|4ad1]], [[4ad2\|4ad2]], [[4ad5\|4ad5]], [[4acz\|4acz]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein_endo-alpha-1,2-mannosidase Glycoprotein endo-alpha-1,2-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.130 3.2.1.130] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ad0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ad0 OCA], [http://pdbe.org/4ad0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ad0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ad0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ad0 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-linked glycans play key roles in protein folding, stability, and function. Biosynthetic modification of N-linked glycans, within the endoplasmic reticulum, features sequential trimming and readornment steps. One unusual enzyme, endo-alpha-mannosidase, cleaves mannoside linkages internally within an N-linked glycan chain, short circuiting the classical N-glycan biosynthetic pathway. Here, using two bacterial orthologs, we present the first structural and mechanistic dissection of endo-alpha-mannosidase. Structures solved at resolutions 1.7-2.1 A reveal a (beta/alpha)(8) barrel fold in which the catalytic center is present in a long substrate-binding groove, consistent with cleavage within the N-glycan chain. Enzymatic cleavage of authentic Glc(1/3)Man(9)GlcNAc(2) yields Glc(1/3)-Man. Using the bespoke substrate alpha-Glc-1,3-alpha-Man fluoride, the enzyme was shown to act with retention of anomeric configuration. Complexes with the established endo-alpha-mannosidase inhibitor alpha-Glc-1,3-deoxymannonojirimycin and a newly developed inhibitor, alpha-Glc-1,3-isofagomine, and with the reducing-end product alpha-1,2-mannobiose structurally define the -2 to +2 subsites of the enzyme. These structural and mechanistic data provide a foundation upon which to develop new enzyme inhibitors targeting the hijacking of N-glycan synthesis in viral disease and cancer.

-	~~===Structure of the GH99~~ endo-alpha-mannosidase ~~from Bacteriodes thetaiotaomicron in complex with BIS-TRIS~~-~~Propane===~~	+	Structural and mechanistic insight into N-glycan processing by endo-alpha-mannosidase.,Thompson AJ, Williams RJ, Hakki Z, Alonzi DS, Wennekes T, Gloster TM, Songsrirote K, Thomas-Oates JE, Wrodnigg TM, Spreitz J, Stutz AE, Butters TD, Williams SJ, Davies GJ Proc Natl Acad Sci U S A. 2012 Jan 4. PMID:22219371<ref>PMID:22219371</ref>

-	~~{{ABSTRACT_PUBMED_22219371}}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~==About this Structure==~~	+	<div class="pdbe-citations 4ad0" style="background-color:#fffaf0;"></div>
-	~~[[4ad0]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca~~-~~bin~~/~~ocashort?id=4AD0 OCA].~~	+

	==See Also==		==See Also==
	*[[Mannosidase\|Mannosidase]]		*[[Mannosidase\|Mannosidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022219371<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
-	[[Category: ~~Bacteroides thetaiotaomicron~~]]	+	</StructureSection>
		+	[[Category: Bactn]]
	[[Category: Glycoprotein endo-alpha-1,2-mannosidase]]		[[Category: Glycoprotein endo-alpha-1,2-mannosidase]]
-	[[Category: Alonzi, D S.]]	+	[[Category: Alonzi, D S]]
-	[[Category: Butters, T D.]]	+	[[Category: Butters, T D]]
-	[[Category: Davies, G J.]]	+	[[Category: Davies, G J]]
-	[[Category: Gloster, T M.]]	+	[[Category: Gloster, T M]]
-	[[Category: Hakki, Z.]]	+	[[Category: Hakki, Z]]
-	[[Category: Songsrirote, K.]]	+	[[Category: Songsrirote, K]]
-	[[Category: Spreitz, J.]]	+	[[Category: Spreitz, J]]
-	[[Category: Stuetz, A E.]]	+	[[Category: Stuetz, A E]]
-	[[Category: Thomas-Oates, J E.]]	+	[[Category: Thomas-Oates, J E]]
-	[[Category: Thompson, A J.]]	+	[[Category: Thompson, A J]]
-	[[Category: Wennekes, T.]]	+	[[Category: Wennekes, T]]
-	[[Category: Williams, R J.]]	+	[[Category: Williams, R J]]
-	[[Category: Williams, S J.]]	+	[[Category: Williams, S J]]
-	[[Category: Wrodnigg, T M.]]	+	[[Category: Wrodnigg, T M]]
	[[Category: Cazy]]		[[Category: Cazy]]
	[[Category: Endomannosidase]]		[[Category: Endomannosidase]]

OCA at 08:05, 20 October 2012

2012-10-20T08:05:45Z

←Older revision		Revision as of 08:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[4ad0]] is a 4 chain structure ~~of [[Mannosidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA].	+	[[4ad0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA].

	==See Also==		==See Also==

OCA at 18:25, 25 July 2012

2012-07-25T18:25:04Z

←Older revision		Revision as of 18:25, 25 July 2012
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	[[Image:4ad0.png\|left\|200px]]		[[Image:4ad0.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_4ad0\| PDB=4ad0 \| SCENE= }}		{{STRUCTURE_4ad0\| PDB=4ad0 \| SCENE= }}

	===Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane===		===Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22219371}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22219371 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_22219371}}		{{ABSTRACT_PUBMED_22219371}}

	==About this Structure==		==About this Structure==
-	[[4ad0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA].	+	[[4ad0]] is a 4 chain structure of [[Mannosidase]] with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA].
		+
		+	==See Also==
		+	*[[Mannosidase\|Mannosidase]]

	==Reference==		==Reference==

OCA at 08:02, 29 February 2012

2012-02-29T08:02:37Z

←Older revision		Revision as of 08:02, 29 February 2012
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-	[[Image:4ad0.~~jpg~~\|left\|200px]]	+	[[Image:4ad0.png\|left\|200px]]

	<!--		<!--

OCA at 07:23, 1 February 2012

2012-02-01T07:23:23Z

←Older revision		Revision as of 07:23, 1 February 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4ad0.jpg\|left\|200px]]

-	The ~~entry 4ad0~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4ad0", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4ad0\| PDB=4ad0 \| SCENE= }}

-	~~Authors: Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas~~-~~Oates, J., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.~~	+	===Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane===

-	~~Description~~: ~~Structure of~~ the ~~GH99~~ endo-alpha-mannosidase ~~from Bacteriodes thetaiotaomicron in complex with BIS~~-~~TRIS~~-~~Propane~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22219371}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22219371 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22219371}}
		+
		+	==About this Structure==
		+	[[4ad0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD0 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022219371</ref><references group="xtra"/>
		+	[[Category: Bacteroides thetaiotaomicron]]
		+	[[Category: Glycoprotein endo-alpha-1,2-mannosidase]]
		+	[[Category: Alonzi, D S.]]
		+	[[Category: Butters, T D.]]
		+	[[Category: Davies, G J.]]
		+	[[Category: Gloster, T M.]]
		+	[[Category: Hakki, Z.]]
		+	[[Category: Songsrirote, K.]]
		+	[[Category: Spreitz, J.]]
		+	[[Category: Stuetz, A E.]]
		+	[[Category: Thomas-Oates, J E.]]
		+	[[Category: Thompson, A J.]]
		+	[[Category: Wennekes, T.]]
		+	[[Category: Williams, R J.]]
		+	[[Category: Williams, S J.]]
		+	[[Category: Wrodnigg, T M.]]
		+	[[Category: Cazy]]
		+	[[Category: Endomannosidase]]
		+	[[Category: Enzyme-carbohydrate interaction]]
		+	[[Category: Glycoside hydrolase gh99]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mannose glycosidase inhibition]]

OCA: Protected "4ad0" [edit=sysop:move=sysop]

2011-12-28T07:02:15Z

Protected "4ad0" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:02, 28 December 2011

OCA: New page: '''Unreleased structure''' The entry 4ad0 is ON HOLD Authors: Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J., Wr...

2011-12-28T07:02:14Z

New page: '''Unreleased structure''' The entry 4ad0 is ON HOLD Authors: Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J., Wr...

New page

'''Unreleased structure'''

The entry 4ad0 is ON HOLD

Authors: Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.

Description: Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane