4ael - Revision history

OCA at 11:25, 20 December 2023

2023-12-20T11:25:15Z

←Older revision		Revision as of 11:25, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y5v\|2y5v]], [[1lrb\|1lrb]], [[2wey\|2wey]], [[2y5x\|2y5x]], [[2y5u\|2y5u]], [[2y0j\|2y0j]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [https://pdbe.org/4ael PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [https://www.ebi.ac.uk/pdbsum/4ael PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [https://pdbe.org/4ael PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [https://www.ebi.ac.uk/pdbsum/4ael PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>	+	[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bauer, M]]	+	[[Category: Bauer M]]
-	[[Category: Bauer, U]]	+	[[Category: Bauer U]]
-	~~[[Category: Carlsson, E Toppner~~]]	+	[[Category: Enroth C]]
-	[[Category: Enroth, C]]	+	[[Category: Giordanetto F]]
-	[[Category: Giordanetto, F]]	+	[[Category: Hartleib-Geschwindner J]]
-	[[Category: Hartleib-Geschwindner, J]]	+	[[Category: Johansson KE]]
-	[[Category: Johansson~~, K E~~]]	+	[[Category: Knecht W]]
-	[[Category: Knecht, W]]	+	[[Category: OMahony G]]
-	[[Category: OMahony, G]]	+	[[Category: Sjogren T]]
-	[[Category: Sjogren, T]]	+	[[Category: Toppner Carlsson E]]
-	[[Category: ~~Enzyme inhibitor]]~~	+
-	~~[[Category: Hit-to-lead]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Naphtyridine~~]]	+

OCA at 05:31, 25 August 2022

2022-08-25T05:31:39Z

←Older revision		Revision as of 05:31, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5v\|2y5v]], [[1lrb\|1lrb]], [[2wey\|2wey]], [[2y5x\|2y5x]], [[2y5u\|2y5u]], [[2y0j\|2y0j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y5v\|2y5v]], [[1lrb\|1lrb]], [[2wey\|2wey]], [[2y5x\|2y5x]], [[2y5u\|2y5u]], [[2y0j\|2y0j]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [~~http~~://pdbe.org/4ael PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ael PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [https://pdbe.org/4ael PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [https://www.ebi.ac.uk/pdbsum/4ael PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>	+	[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bauer, M]]		[[Category: Bauer, M]]
	[[Category: Bauer, U]]		[[Category: Bauer, U]]

OCA at 09:07, 6 March 2019

2019-03-06T09:07:19Z

←Older revision		Revision as of 09:07, 6 March 2019
Line 1:		Line 1:

	==PDE10A in complex with the inhibitor AZ5==		==PDE10A in complex with the inhibitor AZ5==
-	<StructureSection load='4ael' size='340' side='right' caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
Line 35:		Line 35:
	[[Category: Johansson, K E]]		[[Category: Johansson, K E]]
	[[Category: Knecht, W]]		[[Category: Knecht, W]]
-	[[Category: ~~Omahony~~, G]]	+	[[Category: OMahony, G]]
	[[Category: Sjogren, T]]		[[Category: Sjogren, T]]
	[[Category: Enzyme inhibitor]]		[[Category: Enzyme inhibitor]]

OCA at 01:45, 5 August 2016

2016-08-05T01:45:55Z

←Older revision		Revision as of 01:45, 5 August 2016
Line 1:		Line 1:
		+
	==PDE10A in complex with the inhibitor AZ5==		==PDE10A in complex with the inhibitor AZ5==
	<StructureSection load='4ael' size='340' side='right' caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4ael' size='340' side='right' caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5v\|2y5v]], [[1lrb\|1lrb]], [[2wey\|2wey]], [[2y5x\|2y5x]], [[2y5u\|2y5u]], [[2y0j\|2y0j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5v\|2y5v]], [[1lrb\|1lrb]], [[2wey\|2wey]], [[2y5x\|2y5x]], [[2y5u\|2y5u]], [[2y0j\|2y0j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [http://www.ebi.ac.uk/pdbsum/4ael PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [http://pdbe.org/4ael PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [http://www.ebi.ac.uk/pdbsum/4ael PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ael" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bauer, M]]		[[Category: Bauer, M]]
	[[Category: Bauer, U]]		[[Category: Bauer, U]]

OCA at 14:48, 25 December 2014

2014-12-25T14:48:51Z

←Older revision		Revision as of 14:48, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5v\|2y5v]], [[1lrb\|1lrb]], [[2wey\|2wey]], [[2y5x\|2y5x]], [[2y5u\|2y5u]], [[2y0j\|2y0j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5v\|2y5v]], [[1lrb\|1lrb]], [[2wey\|2wey]], [[2y5x\|2y5x]], [[2y5u\|2y5u]], [[2y0j\|2y0j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [http://www.ebi.ac.uk/pdbsum/4ael PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [http://www.ebi.ac.uk/pdbsum/4ael PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bauer, M.]]	+	[[Category: Bauer, M]]
-	[[Category: Bauer, U.]]	+	[[Category: Bauer, U]]
-	[[Category: Carlsson, E Toppner.]]	+	[[Category: Carlsson, E Toppner]]
-	[[Category: Enroth, C.]]	+	[[Category: Enroth, C]]
-	[[Category: Giordanetto, F.]]	+	[[Category: Giordanetto, F]]
-	[[Category: Hartleib-Geschwindner, J.]]	+	[[Category: Hartleib-Geschwindner, J]]
-	[[Category: Johansson, K E.]]	+	[[Category: Johansson, K E]]
-	[[Category: Knecht, W.]]	+	[[Category: Knecht, W]]
-	[[Category: Omahony, G.]]	+	[[Category: Omahony, G]]
-	[[Category: Sjogren, T.]]	+	[[Category: Sjogren, T]]
	[[Category: Enzyme inhibitor]]		[[Category: Enzyme inhibitor]]
	[[Category: Hit-to-lead]]		[[Category: Hit-to-lead]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Naphtyridine]]		[[Category: Naphtyridine]]

OCA at 09:23, 11 June 2014

2014-06-11T09:23:42Z

←Older revision		Revision as of 09:23, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4ael.~~png~~\|~~left~~\|~~200px~~]]	+	==PDE10A in complex with the inhibitor AZ5==
		+	<StructureSection load='4ael' size='340' side='right' caption='[[4ael]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5v\|2y5v]], [[1lrb\|1lrb]], [[2wey\|2wey]], [[2y5x\|2y5x]], [[2y5u\|2y5u]], [[2y0j\|2y0j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [http://www.ebi.ac.uk/pdbsum/4ael PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A series of 1,6-naphthyridine-based compounds was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. Structure-based chemical modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.

-	~~{{STRUCTURE_4ael\| PDB=4ael \| SCENE= }}~~	+	Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors.,Bauer U, Giordanetto F, Bauer M, O'Mahony G, Johansson KE, Knecht W, Hartleib-Geschwindner J, Carlsson ET, Enroth C Bioorg Med Chem Lett. 2012 Mar 1;22(5):1944-8. Epub 2012 Jan 26. PMID:22321214<ref>PMID:22321214</ref>

-	~~===PDE10A in complex with~~ the ~~inhibitor AZ5===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22321214}}~~	+	==See Also==
-		+	*[[Phosphodiesterase\|Phosphodiesterase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4ael~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:022321214<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bauer, M.]]		[[Category: Bauer, M.]]

OCA at 04:53, 15 August 2012

2012-08-15T04:53:41Z

←Older revision		Revision as of 04:53, 15 August 2012
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	[[Image:4ael.png\|left\|200px]]		[[Image:4ael.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4ael", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4ael\| PDB=4ael \| SCENE= }}		{{STRUCTURE_4ael\| PDB=4ael \| SCENE= }}

	===PDE10A in complex with the inhibitor AZ5===		===PDE10A in complex with the inhibitor AZ5===

		+	{{ABSTRACT_PUBMED_22321214}}

	==About this Structure==		==About this Structure==
	[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA].		[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022321214</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bauer, M.]]		[[Category: Bauer, M.]]

OCA at 07:34, 1 February 2012

2012-02-01T07:34:20Z

←Older revision		Revision as of 07:34, 1 February 2012
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-	[[Image:4ael.~~jpg~~\|left\|200px]]	+	[[Image:4ael.png\|left\|200px]]

	<!--		<!--

OCA at 06:51, 25 January 2012

2012-01-25T06:51:52Z

←Older revision		Revision as of 06:51, 25 January 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4ael.jpg\|left\|200px]]

-	The ~~entry 4ael~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4ael", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4ael\| PDB=4ael \| SCENE= }}

-	~~Authors: Bauer, U., Giordanetto, F., Bauer, M., OMahony, G., Johansson, K.E., Knecht, W., Hartleib-Geschwindner, J., Toppner Carlsson, E., Enroth, C., Sjogren, T.~~	+	===PDE10A in complex with the inhibitor AZ5===

-	~~Description: PDE10A in complex~~ with ~~the~~ inhibitor ~~AZ5~~	+
		+	==About this Structure==
		+	[[4ael]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Bauer, M.]]
		+	[[Category: Bauer, U.]]
		+	[[Category: Carlsson, E Toppner.]]
		+	[[Category: Enroth, C.]]
		+	[[Category: Giordanetto, F.]]
		+	[[Category: Hartleib-Geschwindner, J.]]
		+	[[Category: Johansson, K E.]]
		+	[[Category: Knecht, W.]]
		+	[[Category: Omahony, G.]]
		+	[[Category: Sjogren, T.]]
		+	[[Category: Enzyme inhibitor]]
		+	[[Category: Hit-to-lead]]
		+	[[Category: Hydrolase]]
		+	[[Category: Naphtyridine]]

OCA: Protected "4ael" [edit=sysop:move=sysop]

2012-01-18T10:25:47Z

Protected "4ael" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:25, 18 January 2012