4ak8 - Revision history

OCA at 11:28, 20 December 2023

2023-12-20T11:28:55Z

←Older revision		Revision as of 11:28, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4ak8' size='340' side='right'caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4ak8' size='340' side='right'caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [https://pdbe.org/4ak8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ak8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ak8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [https://pdbe.org/4ak8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ak8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ak8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>	+	[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>	+	[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chabrol, E]]	+	[[Category: Chabrol E]]
-	[[Category: Dezutter-Dambuyant, C]]	+	[[Category: Dezutter-Dambuyant C]]
-	[[Category: Durand, D]]	+	[[Category: Durand D]]
-	[[Category: Fieschi, F]]	+	[[Category: Fieschi F]]
-	[[Category: Kahn, R]]	+	[[Category: Kahn R]]
-	[[Category: Marcoux, J]]	+	[[Category: Marcoux J]]
-	[[Category: Thepaut, M]]	+	[[Category: Thepaut M]]
-	[[Category: Vachette, P]]	+	[[Category: Vachette P]]
-	[[Category: Valadeau-Guilemond, J]]	+	[[Category: Valadeau-Guilemond J]]
-	[[Category: Vives, C]]	+	[[Category: Vives C]]
-	~~[[Category: Birbeck granule]]~~	+
-	~~[[Category: Dc-sign]]~~	+
-	~~[[Category: Hiv]]~~	+
-	~~[[Category: Langerhans cell]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 05:36, 25 August 2022

2022-08-25T05:36:54Z

←Older revision		Revision as of 05:36, 25 August 2022
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	<StructureSection load='4ak8' size='340' side='right'caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4ak8' size='340' side='right'caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [~~http~~://pdbe.org/4ak8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ak8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ak8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [https://pdbe.org/4ak8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ak8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ak8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[~~http~~://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>	+	[[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>	+	[[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:36, 10 May 2019

2019-05-10T12:36:13Z

←Older revision		Revision as of 12:36, 10 May 2019
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chabrol, E]]		[[Category: Chabrol, E]]
	[[Category: Dezutter-Dambuyant, C]]		[[Category: Dezutter-Dambuyant, C]]

OCA at 09:32, 6 March 2019

2019-03-06T09:32:56Z

←Older revision		Revision as of 09:32, 6 March 2019
Line 1:		Line 1:

	==Structure of F241L mutant of langerin carbohydrate recognition domain.==		==Structure of F241L mutant of langerin carbohydrate recognition domain.==
-	<StructureSection load='4ak8' size='340' side='right' caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='4ak8' size='340' side='right'caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>

OCA at 02:48, 11 December 2016

2016-12-11T02:48:04Z

←Older revision		Revision as of 02:48, 11 December 2016
Line 1:		Line 1:
		+
	==Structure of F241L mutant of langerin carbohydrate recognition domain.==		==Structure of F241L mutant of langerin carbohydrate recognition domain.==
	<StructureSection load='4ak8' size='340' side='right' caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4ak8' size='340' side='right' caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ak8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [http://pdbe.org/4ak8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ak8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ak8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ak8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:08, 25 February 2015

2015-02-25T08:08:44Z

←Older revision		Revision as of 08:08, 25 February 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>		[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate recognition domains (CRD). In the context of HIV-1 (human immunodeficiency virus-1) transmission, Langerhans cells of genital mucosa play a protective role by internalizing virions in Birbeck Granules (BG) for elimination. Langerin (Lg) is directly involved in virion binding and BG formation through its CRDs. However, nothing is known regarding the mechanism of langerin assembly underlying BG formation. We investigated at the molecular level the impact of two CRD mutations, W264R and F241L, on langerin structure, function, and BG assembly using a combination of biochemical and biophysical approaches. Although the W264R mutation causes CRD global unfolding, the F241L mutation does not affect the overall structure and gp120 (surface HIV-1 glycoprotein of 120 kDa) binding capacities of isolated Lg-CRD. In contrast, this mutation induces major functional and structural alterations of the whole trimeric langerin extracellular domain (Lg-ECD). As demonstrated by small-angle x-ray scattering comparative analysis of wild-type and mutant forms, the F241L mutation perturbs the oligomerization state and the global architecture of Lg-ECD. Correlatively, despite conserved intrinsic lectin activity of the CRD, avidity property of Lg-ECD is affected as shown by a marked decrease of gp120 binding. Beyond the change of residue itself, the F241L mutation induces relocation of the K200 side chain also located within the interface between protomers of trimeric Lg-ECD, thereby explaining the defective oligomerization of mutant Lg. We conclude that not only functional CRDs but also their correct spatial presentation are critical for BG formation as well as gp120 binding.
		+
		+	Alteration of the langerin oligomerization state affects birbeck granule formation.,Chabrol E, Thepaut M, Dezutter-Dambuyant C, Vives C, Marcoux J, Kahn R, Valladeau-Guilemond J, Vachette P, Durand D, Fieschi F Biophys J. 2015 Feb 3;108(3):666-77. doi: 10.1016/j.bpj.2014.10.075. PMID:25650933<ref>PMID:25650933</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:17, 12 February 2015

2015-02-12T06:17:26Z

←Older revision		Revision as of 06:17, 12 February 2015
Line 2:		Line 2:
	<StructureSection load='4ak8' size='340' side='right' caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4ak8' size='340' side='right' caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ak8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ak8 PDBsum]</span></td></tr>
Line 14:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chabrol, E]]		[[Category: Chabrol, E]]
	[[Category: Dezutter-Dambuyant, C]]		[[Category: Dezutter-Dambuyant, C]]

OCA at 09:56, 21 December 2014

2014-12-21T09:56:26Z

←Older revision		Revision as of 09:56, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ak8\| PDB=4ak8 \| SCENE= }}~~	+	==Structure of F241L mutant of langerin carbohydrate recognition domain.==
-	===Structure of F241L mutant of langerin carbohydrate recognition domain.===	+	<StructureSection load='4ak8' size='340' side='right' caption='[[4ak8]], [[Resolution\|resolution]] 1.40Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AK8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ak8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ak8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ak8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ak8 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>		[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>		[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chabrol, E.]]	+	[[Category: Chabrol, E]]
-	[[Category: Dezutter-Dambuyant, C.]]	+	[[Category: Dezutter-Dambuyant, C]]
-	[[Category: Durand, D.]]	+	[[Category: Durand, D]]
-	[[Category: Fieschi, F.]]	+	[[Category: Fieschi, F]]
-	[[Category: Kahn, R.]]	+	[[Category: Kahn, R]]
-	[[Category: Marcoux, J.]]	+	[[Category: Marcoux, J]]
-	[[Category: Thepaut, M.]]	+	[[Category: Thepaut, M]]
-	[[Category: Vachette, P.]]	+	[[Category: Vachette, P]]
-	[[Category: Valadeau-Guilemond, J.]]	+	[[Category: Valadeau-Guilemond, J]]
-	[[Category: Vives, C.]]	+	[[Category: Vives, C]]
	[[Category: Birbeck granule]]		[[Category: Birbeck granule]]
	[[Category: Dc-sign]]		[[Category: Dc-sign]]

OCA at 01:44, 4 April 2013

2013-04-04T01:44:56Z

←Older revision		Revision as of 01:44, 4 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ak8\| PDB=4ak8 \| SCENE= }}
		+	===Structure of F241L mutant of langerin carbohydrate recognition domain.===

-	~~The~~ entry ~~4ak8~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>

-	~~Authors~~: ~~Chabrol, E~~.~~, Thepaut, M~~.~~, Dezutter~~-~~Dambuyant, C~~.~~, Vives, C~~., ~~Marcoux, J~~., ~~Kahn~~, R.~~, Valadeau~~-~~Guilemond, J~~.~~, Vachette, P., Durand, D., Fieschi, F~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>

-	~~Description:~~ Structure ~~of F241L mutant of langerin carbohydrate recognition domain~~.	+	==About this Structure==
		+	[[4ak8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AK8 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chabrol, E.]]
		+	[[Category: Dezutter-Dambuyant, C.]]
		+	[[Category: Durand, D.]]
		+	[[Category: Fieschi, F.]]
		+	[[Category: Kahn, R.]]
		+	[[Category: Marcoux, J.]]
		+	[[Category: Thepaut, M.]]
		+	[[Category: Vachette, P.]]
		+	[[Category: Valadeau-Guilemond, J.]]
		+	[[Category: Vives, C.]]
		+	[[Category: Birbeck granule]]
		+	[[Category: Dc-sign]]
		+	[[Category: Hiv]]
		+	[[Category: Langerhans cell]]
		+	[[Category: Sugar binding protein]]

OCA at 06:21, 17 October 2012

2012-10-17T06:21:53Z

←Older revision		Revision as of 06:21, 17 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ak8 is ON HOLD	+	The entry 4ak8 is ON HOLD until Paper Publication

	Authors: Chabrol, E., Thepaut, M., Dezutter-Dambuyant, C., Vives, C., Marcoux, J., Kahn, R., Valadeau-Guilemond, J., Vachette, P., Durand, D., Fieschi, F.		Authors: Chabrol, E., Thepaut, M., Dezutter-Dambuyant, C., Vives, C., Marcoux, J., Kahn, R., Valadeau-Guilemond, J., Vachette, P., Durand, D., Fieschi, F.

-	Description: ~~Alteration~~ of ~~Langerin oligomerisation state affects gp120 recognition and Birbeck Granules formation: Effect of the~~ F241L ~~mutation~~.	+	Description: Structure of F241L mutant of langerin carbohydrate recognition domain.