4ali - Revision history

OCA at 11:29, 20 December 2023

2023-12-20T11:29:40Z

←Older revision		Revision as of 11:29, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4ali' size='340' side='right'caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4ali' size='340' side='right'caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE~~-~~ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~, ~~<scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[4alj\|4alj]], [[4alk\|4alk]], [[4all\|4all]], [[4alm\|4alm]], [[4aln\|4aln]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADPH,_B-specific) Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.10 1.3.1.10] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ali FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ali OCA], [https://pdbe.org/4ali PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ali RCSB], [https://www.ebi.ac.uk/pdbsum/4ali PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ali ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ali FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ali OCA], [https://pdbe.org/4ali PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ali RCSB], [https://www.ebi.ac.uk/pdbsum/4ali PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ali ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3JLH9_STAAN A0A0H3JLH9_STAAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chang, A~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Kisker, C~~]]	+	[[Category: Chang A]]
-	[[Category: ~~Schiebel, J~~]]	+	[[Category: Kisker C]]
-	[[Category: ~~Tonge, P~~ J]]	+	[[Category: Schiebel J]]
-	[[Category: ~~Fabi]]~~	+	[[Category: Tonge PJ]]
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Safabi]]~~	+
-	~~[[Category: Short-chain dehydrogenase/reductase superfamily~~]]	+

OCA at 05:38, 25 August 2022

2022-08-25T05:38:07Z

←Older revision		Revision as of 05:38, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4ali' size='340' side='right'caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4ali' size='340' side='right'caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ALI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4alj\|4alj]], [[4alk\|4alk]], [[4all\|4all]], [[4alm\|4alm]], [[4aln\|4aln]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4alj\|4alj]], [[4alk\|4alk]], [[4all\|4all]], [[4alm\|4alm]], [[4aln\|4aln]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADPH,_B-specific) Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.10 1.3.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADPH,_B-specific) Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.10 1.3.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ali FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ali OCA], [~~http~~://pdbe.org/4ali PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ali RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ali PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ali ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ali FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ali OCA], [https://pdbe.org/4ali PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ali RCSB], [https://www.ebi.ac.uk/pdbsum/4ali PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ali ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]	+	*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures\|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chang, A]]		[[Category: Chang, A]]
	[[Category: Kisker, C]]		[[Category: Kisker, C]]

OCA at 09:14, 6 March 2019

2019-03-06T09:14:59Z

←Older revision		Revision as of 09:14, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)==		==Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)==
-	<StructureSection load='4ali' size='340' side='right' caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4ali' size='340' side='right'caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALI FirstGlance]. <br>

OCA at 10:18, 11 August 2016

2016-08-11T10:18:16Z

←Older revision		Revision as of 10:18, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)==		==Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)==
	<StructureSection load='4ali' size='340' side='right' caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4ali' size='340' side='right' caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4alj\|4alj]], [[4alk\|4alk]], [[4all\|4all]], [[4alm\|4alm]], [[4aln\|4aln]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4alj\|4alj]], [[4alk\|4alk]], [[4all\|4all]], [[4alm\|4alm]], [[4aln\|4aln]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADPH,_B-specific) Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.10 1.3.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADPH,_B-specific) Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.10 1.3.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ali FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ali OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ali RCSB], [http://www.ebi.ac.uk/pdbsum/4ali PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ali FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ali OCA], [http://pdbe.org/4ali PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ali RCSB], [http://www.ebi.ac.uk/pdbsum/4ali PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ali ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ali" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Chang, A]]		[[Category: Chang, A]]
	[[Category: Kisker, C]]		[[Category: Kisker, C]]

OCA at 10:43, 4 January 2015

2015-01-04T10:43:10Z

←Older revision		Revision as of 10:43, 4 January 2015
Line 1:		Line 1:
-	[[~~Image:~~4ali.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)==
		+	<StructureSection load='4ali' size='340' side='right' caption='[[4ali]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ALI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4alj\|4alj]], [[4alk\|4alk]], [[4all\|4all]], [[4alm\|4alm]], [[4aln\|4aln]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADPH,_B-specific) Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.10 1.3.1.10] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ali FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ali OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ali RCSB], [http://www.ebi.ac.uk/pdbsum/4ali PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methicillin-resistant Staphylococcus aureus (MRSA) infections constitute a serious health threat worldwide, and novel antibiotics are therefore urgently needed. The enoyl-ACP reductase (saFabI) is essential for the S. aureus fatty acid biosynthesis and, hence, serves as an attractive drug target. We have obtained a series of snapshots of this enzyme that provide a mechanistic picture of ligand and inhibitor binding, including a dimer-tetramer transition combined with extensive conformational changes. Significantly, our results reveal key differences in ligand binding and recognition compared to orthologous proteins. The remarkable observed protein flexibility rationalizes our finding that saFabI is capable of efficiently reducing branched-chain fatty acid precursors. Importantly, branched-chain fatty acids represent a major fraction of the S. aureus cell membrane and are crucial for its in vivo fitness. Our discovery thus addresses a long-standing controversy regarding the essentiality of the fatty acid biosynthesis pathway in S. aureus rationalizing saFabI as a drug target.

-	~~{{STRUCTURE_4ali\| PDB=4ali \| SCENE= }}~~	+	Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo Essentiality.,Schiebel J, Chang A, Lu H, Baxter MV, Tonge PJ, Kisker C Structure. 2012 May 9;20(5):802-13. PMID:22579249<ref>PMID:22579249</ref>

-	~~===Crystal structure~~ of S. ~~aureus FabI in complex with NADP and triclosan (P1)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22579249}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4ali]] is a 8 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA].~~	+

	==See Also==		==See Also==
	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]		*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022579249<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Chang, A.]]	+	[[Category: Chang, A]]
-	[[Category: Kisker, C.]]	+	[[Category: Kisker, C]]
-	[[Category: Schiebel, J.]]	+	[[Category: Schiebel, J]]
-	[[Category: Tonge, P J.]]	+	[[Category: Tonge, P J]]
	[[Category: Fabi]]		[[Category: Fabi]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]

OCA at 06:11, 20 October 2012

2012-10-20T06:11:56Z

←Older revision		Revision as of 06:11, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[4ali]] is a 8 chain structure ~~of [[Enoyl-Acyl-Carrier Protein Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA].	+	[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA].

	==See Also==		==See Also==

OCA at 12:25, 25 July 2012

2012-07-25T12:25:57Z

←Older revision		Revision as of 12:25, 25 July 2012
Line 1:		Line 1:
	[[Image:4ali.png\|left\|200px]]		[[Image:4ali.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4ali", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4ali\| PDB=4ali \| SCENE= }}		{{STRUCTURE_4ali\| PDB=4ali \| SCENE= }}

	===Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)===		===Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22579249}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22579249 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22579249}}		{{ABSTRACT_PUBMED_22579249}}

	==About this Structure==		==About this Structure==
-	[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA].	+	[[4ali]] is a 8 chain structure of [[Enoyl-Acyl-Carrier Protein Reductase]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA].
		+
		+	==See Also==
		+	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]

	==Reference==		==Reference==

OCA at 04:57, 23 May 2012

2012-05-23T04:57:03Z

←Older revision		Revision as of 04:57, 23 May 2012
Line 1:		Line 1:
-	[[Image:4ali.~~jpg~~\|left\|200px]]	+	[[Image:4ali.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)===		===Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22579249}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22579249 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22579249}}

	==About this Structure==		==About this Structure==
	[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA].		[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022579249</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Chang, A.]]		[[Category: Chang, A.]]

OCA at 09:24, 9 May 2012

2012-05-09T09:24:36Z

←Older revision		Revision as of 09:24, 9 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ali.jpg\|left\|200px]]

-	The ~~entry 4ali~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4ali", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4ali\| PDB=4ali \| SCENE= }}

-	~~Authors: Schiebel, J., Chang, A., Tonge, P.J., Kisker, C~~.	+	===Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)===

-	~~Description: Crystal~~ structure ~~of S~~. aureus ~~FabI in complex with NADP and triclosan (P1)~~	+
		+	==About this Structure==
		+	[[4ali]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALI OCA].
		+	[[Category: Staphylococcus aureus]]
		+	[[Category: Chang, A.]]
		+	[[Category: Kisker, C.]]
		+	[[Category: Schiebel, J.]]
		+	[[Category: Tonge, P J.]]
		+	[[Category: Fabi]]
		+	[[Category: Fatty acid biosynthesis]]
		+	[[Category: Lipid synthesis]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Safabi]]
		+	[[Category: Short-chain dehydrogenase/reductase superfamily]]

OCA at 07:08, 21 March 2012

2012-03-21T07:08:52Z

←Older revision		Revision as of 07:08, 21 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ali is ON HOLD	+	The entry 4ali is ON HOLD until Paper Publication

	Authors: Schiebel, J., Chang, A., Tonge, P.J., Kisker, C.		Authors: Schiebel, J., Chang, A., Tonge, P.J., Kisker, C.

	Description: Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)		Description: Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)