4ami - Revision history

OCA at 11:30, 20 December 2023

2023-12-20T11:30:15Z

←Older revision		Revision as of 11:30, 20 December 2023
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	<StructureSection load='4ami' size='340' side='right'caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4ami' size='340' side='right'caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Melga Melga~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [https://pdbe.org/4ami PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [https://www.ebi.ac.uk/pdbsum/4ami PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ami ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [https://pdbe.org/4ami PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [https://www.ebi.ac.uk/pdbsum/4ami PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ami ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.	+	[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Melga~~]]	+	[[Category: Meleagris gallopavo]]
-	[[Category: Edwards~~, P C~~]]	+	[[Category: Edwards PC]]
-	[[Category: Leslie~~, A G~~]]	+	[[Category: Leslie AG]]
-	[[Category: Tate~~, C G~~]]	+	[[Category: Tate CG]]
-	[[Category: Warne, T]]	+	[[Category: Warne T]]
-	~~[[Category: 7tmr beta1-adrenoceptor]]~~	+
-	~~[[Category: Biased agonist]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Stabilising mutation~~]]	+

OCA at 05:39, 25 August 2022

2022-08-25T05:39:03Z

←Older revision		Revision as of 05:39, 25 August 2022
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	<StructureSection load='4ami' size='340' side='right'caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4ami' size='340' side='right'caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [~~http~~://pdbe.org/4ami PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ami PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ami ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [https://pdbe.org/4ami PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [https://www.ebi.ac.uk/pdbsum/4ami PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ami ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.	+	[[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:42, 3 April 2019

2019-04-03T07:42:38Z

←Older revision		Revision as of 07:42, 3 April 2019
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Melga]]		[[Category: Melga]]
	[[Category: Edwards, P C]]		[[Category: Edwards, P C]]

OCA at 09:41, 6 March 2019

2019-03-06T09:41:27Z

←Older revision		Revision as of 09:41, 6 March 2019
Line 1:		Line 1:

	==Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol==		==Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol==
-	<StructureSection load='4ami' size='340' side='right' caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4ami' size='340' side='right'caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Common_turkey Common turkey~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</td></tr>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Adrenergic receptor\|Adrenergic receptor]]	+	*[[Adrenergic receptor 3D structures\|Adrenergic receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Common turkey~~]]	+	[[Category: Melga]]
	[[Category: Edwards, P C]]		[[Category: Edwards, P C]]
	[[Category: Leslie, A G]]		[[Category: Leslie, A G]]

OCA at 09:08, 5 August 2016

2016-08-05T09:08:11Z

←Older revision		Revision as of 09:08, 5 August 2016
Line 1:		Line 1:
		+
	==Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol==		==Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol==
	<StructureSection load='4ami' size='340' side='right' caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4ami' size='340' side='right' caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [http://www.ebi.ac.uk/pdbsum/4ami PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [http://pdbe.org/4ami PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [http://www.ebi.ac.uk/pdbsum/4ami PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ami ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ami" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:32, 25 December 2014

2014-12-25T17:32:41Z

←Older revision		Revision as of 17:32, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [http://www.ebi.ac.uk/pdbsum/4ami PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [http://www.ebi.ac.uk/pdbsum/4ami PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:47, 3 December 2014

2014-12-03T07:47:36Z

←Older revision		Revision as of 07:47, 3 December 2014
Line 2:		Line 2:
	<StructureSection load='4ami' size='340' side='right' caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4ami' size='340' side='right' caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Meleagris_gallopavo Meleagris gallopavo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_turkey Common turkey]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [http://www.ebi.ac.uk/pdbsum/4ami PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [http://www.ebi.ac.uk/pdbsum/4ami PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Meleagris gallopavo~~]]	+	[[Category: Common turkey]]
-	[[Category: Edwards, P C.]]	+	[[Category: Edwards, P C]]
-	[[Category: Leslie, A G.]]	+	[[Category: Leslie, A G]]
-	[[Category: Tate, C G.]]	+	[[Category: Tate, C G]]
-	[[Category: Warne, T.]]	+	[[Category: Warne, T]]
	[[Category: 7tmr beta1-adrenoceptor]]		[[Category: 7tmr beta1-adrenoceptor]]
	[[Category: Biased agonist]]		[[Category: Biased agonist]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Stabilising mutation]]		[[Category: Stabilising mutation]]

OCA at 08:34, 5 June 2014

2014-06-05T08:34:32Z

←Older revision		Revision as of 08:34, 5 June 2014
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-	[[~~Image:~~4ami.~~png~~\|~~left~~\|~~200px~~]]	+	==Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol==
		+	<StructureSection load='4ami' size='340' side='right' caption='[[4ami]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dep\|1dep]], [[2vt4\|2vt4]], [[2y00\|2y00]], [[2y01\|2y01]], [[2y02\|2y02]], [[2y03\|2y03]], [[2y04\|2y04]], [[2ycw\|2ycw]], [[2ycx\|2ycx]], [[2ycy\|2ycy]], [[2ycz\|2ycz]], [[4amj\|4amj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [http://www.ebi.ac.uk/pdbsum/4ami PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The beta(1)-adrenoceptor (beta(1)AR) is the site of action of beta blockers used in the treatment of cardiac-related illnesses. Two beta blockers, carvedilol and bucindolol, show distinctive activities compared to other beta blockers and have been proposed as treatments tailored to the Arg/Gly389(8.56) polymorphism of the human beta(1)AR. Both carvedilol and bucindolol are classified as biased agonists, because they stimulate G protein-independent signaling, while acting as either inverse or partial agonists of the G protein pathway. We have determined the crystal structures of a thermostabilized avian beta(1)AR mutant bound to bucindolol and to carvedilol at 3.2 and 2.3 A resolution, respectively. In comparison to other beta blockers, bucindolol and carvedilol interact with additional residues, in extracellular loop 2 and transmembrane helix 7, which may promote G protein-independent signaling. The structures also suggest that there may be a structural explanation for the pharmacological differences arising from the Arg/Gly389(8.56) polymorphism.

-	<!--	+	Crystal Structures of a Stabilized beta(1)-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol.,Warne T, Edwards PC, Leslie AG, Tate CG Structure. 2012 May 9;20(5):841-9. PMID:22579251<ref>PMID:22579251</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4ami"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_4ami\| PDB=4ami \| SCENE= }}~~	+

-	~~===Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-		+	==See Also==
-	~~<!--~~	+	*[[Adrenergic receptor\|Adrenergic receptor]]
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22579251}}, adds the Publication Abstract to the page~~	+	== References ==
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 22579251 is the PubMed ID number.~~	+	<references/>
-	~~-->~~	+	__TOC__
-	~~{{ABSTRACT_PUBMED_22579251}}~~	+	</StructureSection>
-		+
-	==~~About this Structure~~==	+
-	[[~~4ami~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022579251<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]
	[[Category: Edwards, P C.]]		[[Category: Edwards, P C.]]

OCA at 05:05, 30 May 2012

2012-05-30T05:05:43Z

←Older revision		Revision as of 05:05, 30 May 2012
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-	[[Image:4ami.~~jpg~~\|left\|200px]]	+	[[Image:4ami.png\|left\|200px]]

	<!--		<!--
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	===Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol===		===Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22579251}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22579251 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22579251}}

	==About this Structure==		==About this Structure==
	[[4ami]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA].		[[4ami]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022579251</ref><references group="xtra"/>
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]
	[[Category: Edwards, P C.]]		[[Category: Edwards, P C.]]

OCA at 06:15, 23 May 2012

2012-05-23T06:15:02Z

←Older revision		Revision as of 06:15, 23 May 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4ami.jpg\|left\|200px]]

-	The ~~entry 4ami~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4ami", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4ami\| PDB=4ami \| SCENE= }}

-	~~Authors: Warne, T., Edwards, P.C., Leslie, A.G., Tate, C.G.~~	+	===Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol===

-	~~Description~~: ~~Turkey~~ beta1 ~~adrenergic receptor with stabilising mutations and bound biased~~ agonist ~~bucindolol~~	+
		+	==About this Structure==
		+	[[4ami]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA].
		+	[[Category: Meleagris gallopavo]]
		+	[[Category: Edwards, P C.]]
		+	[[Category: Leslie, A G.]]
		+	[[Category: Tate, C G.]]
		+	[[Category: Warne, T.]]
		+	[[Category: 7tmr beta1-adrenoceptor]]
		+	[[Category: Biased agonist]]
		+	[[Category: Membrane protein]]
		+	[[Category: Stabilising mutation]]