4aqv - Revision history

OCA at 10:53, 9 May 2024

2024-05-09T10:53:11Z

←Older revision		Revision as of 10:53, 9 May 2024
Line 3:		Line 3:
	<SX load='4aqv' size='340' side='right' viewer='molstar' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>		<SX load='4aqv' size='340' side='right' viewer='molstar' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 9.7Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6\|1ii6]], [[1jff\|1jff]], [[1q0b\|1q0b]], [[1sa0\|1sa0]], [[1sa1\|1sa1]], [[1tvk\|1tvk]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[1z2b\|1z2b]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wbe\|2wbe]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[2xrp\|2xrp]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4atu\|4atu]], [[4atx\|4atx]], [[4b7b\|4b7b]], [[4bbg\|4bbg]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [https://pdbe.org/4aqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [https://www.ebi.ac.uk/pdbsum/4aqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [https://pdbe.org/4aqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [https://www.ebi.ac.uk/pdbsum/4aqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqv ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref> [[https://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	+	[https://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 28:
	</SX>		</SX>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Behnke-Parks~~, W M~~]]	+	[[Category: Behnke-Parks WM]]
-	[[Category: Goulet, A]]	+	[[Category: Goulet A]]
-	[[Category: Moores~~, C A~~]]	+	[[Category: Moores CA]]
-	[[Category: Rosenfeld~~, S S~~]]	+	[[Category: Rosenfeld SS]]
-	[[Category: Sindelar~~, C V]]~~	+	[[Category: Sindelar CV]]
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Mitosis]]~~	+
-	~~[[Category: Motor protein~~]]	+

OCA at 05:43, 25 August 2022

2022-08-25T05:43:15Z

OCA at 18:51, 10 April 2020

2020-04-10T18:51:31Z

←Older revision		Revision as of 18:51, 10 April 2020
Line 3:		Line 3:
	<SX load='4aqv' size='340' side='right' viewer='molstar' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>		<SX load='4aqv' size='340' side='right' viewer='molstar' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AQV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4AQV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1jff\|1jff]], [[1q0b\|1q0b]], [[1sa0\|1sa0]], [[1sa1\|1sa1]], [[1tvk\|1tvk]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[1z2b\|1z2b]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wbe\|2wbe]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[2xrp\|2xrp]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4atu\|4atu]], [[4atx\|4atx]], [[4b7b\|4b7b]], [[4bbg\|4bbg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1jff\|1jff]], [[1q0b\|1q0b]], [[1sa0\|1sa0]], [[1sa1\|1sa1]], [[1tvk\|1tvk]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[1z2b\|1z2b]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wbe\|2wbe]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[2xrp\|2xrp]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4atu\|4atu]], [[4atx\|4atx]], [[4b7b\|4b7b]], [[4bbg\|4bbg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [http://pdbe.org/4aqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [http://www.ebi.ac.uk/pdbsum/4aqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [http://pdbe.org/4aqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [http://www.ebi.ac.uk/pdbsum/4aqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	==See Also==		==See Also==
	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]		*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
-	*[[Tubulin\|Tubulin]]	+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:48, 6 March 2020

2020-03-06T17:48:33Z

←Older revision		Revision as of 17:48, 6 March 2020
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	==Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.==		==Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.==
-	<~~StructureSection~~ load='4aqv' size='340' side='right'caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>	+	<SX load='4aqv' size='340' side='right' viewer='molstar' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQV FirstGlance]. <br>
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Kinesin\|Kinesin]]	+	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
	*[[Tubulin\|Tubulin]]		*[[Tubulin\|Tubulin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Human]]		[[Category: Human]]

OCA at 16:53, 28 August 2019

2019-08-28T16:53:30Z

←Older revision		Revision as of 16:53, 28 August 2019
Line 1:		Line 1:

	==Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.==		==Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.==
-	<StructureSection load='4aqv' size='340' side='right' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>	+	<StructureSection load='4aqv' size='340' side='right'caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQV FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4aqv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4aqv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kinesin\|Kinesin]]
		+	*[[Tubulin\|Tubulin]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 31:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Behnke-Parks, W M]]		[[Category: Behnke-Parks, W M]]
	[[Category: Goulet, A]]		[[Category: Goulet, A]]

OCA at 22:15, 15 November 2017

2017-11-15T22:15:00Z

←Older revision		Revision as of 22:15, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4aqv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4aqv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Kinesin\|Kinesin]]
-	*[[Tubulin\|Tubulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:34, 11 August 2016

2016-08-11T10:34:02Z

←Older revision		Revision as of 10:34, 11 August 2016
Line 1:		Line 1:
		+
	==Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.==		==Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.==
	<StructureSection load='4aqv' size='340' side='right' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>		<StructureSection load='4aqv' size='340' side='right' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1jff\|1jff]], [[1q0b\|1q0b]], [[1sa0\|1sa0]], [[1sa1\|1sa1]], [[1tvk\|1tvk]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[1z2b\|1z2b]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wbe\|2wbe]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[2xrp\|2xrp]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4atu\|4atu]], [[4atx\|4atx]], [[4b7b\|4b7b]], [[4bbg\|4bbg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1jff\|1jff]], [[1q0b\|1q0b]], [[1sa0\|1sa0]], [[1sa1\|1sa1]], [[1tvk\|1tvk]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[1z2b\|1z2b]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wbe\|2wbe]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[2xrp\|2xrp]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4atu\|4atu]], [[4atx\|4atx]], [[4b7b\|4b7b]], [[4bbg\|4bbg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [http://www.ebi.ac.uk/pdbsum/4aqv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [http://pdbe.org/4aqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [http://www.ebi.ac.uk/pdbsum/4aqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4aqv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Behnke-Parks, W M]]		[[Category: Behnke-Parks, W M]]
	[[Category: Goulet, A]]		[[Category: Goulet, A]]

OCA at 11:48, 20 January 2015

2015-01-20T11:48:31Z

←Older revision		Revision as of 11:48, 20 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4aqv\| PDB=4aqv \| SCENE= }}~~	+	==Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.==
-	===Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.===	+	<StructureSection load='4aqv' size='340' side='right' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23135273}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1jff\|1jff]], [[1q0b\|1q0b]], [[1sa0\|1sa0]], [[1sa1\|1sa1]], [[1tvk\|1tvk]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[1z2b\|1z2b]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wbe\|2wbe]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[2xrp\|2xrp]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4atu\|4atu]], [[4atx\|4atx]], [[4b7b\|4b7b]], [[4bbg\|4bbg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [http://www.ebi.ac.uk/pdbsum/4aqv PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kinesin5 is required for forming the bipolar spindle during mitosis. Its motor domain, which contains nucleotide and microtubule binding sites and mechanical elements to generate force, has evolved distinct properties for its spindle based functions. In this study, we report subnanometer resolution cryoelectron microscopy reconstructions of microtubule bound human kinesin5 before and after nucleotide binding and combine this information with studies of the kinetics of nucleotide induced neck linker and cover strand movement. These studies reveal coupled, nucleotide dependent conformational changes that explain many of this motor's properties. We find that ATP binding induces a ratchet-like docking of the neck linker, and simultaneous, parallel docking of the amino-terminal cover strand. Loop L5-the binding site for allosteric inhibitors of kinesin5-also undergoes a dramatic reorientation when ATP binds, suggesting that it is directly involved in controlling nucleotide binding. Our structures indicate that allosteric inhibitors of human kinesin5, which are being developed as anti cancer therapeutics, bind to a motor conformation that occurs in the course of normal function. However, due to evolutionarily defined sequence variations in L5, this conformation is not adopted by invertebrate kinesin5s, explaining their resistance to drug inhibition. Together, our data reveal the precision with which the molecular mechanism of kinesin5 motors has evolved for force generation.

-	~~==Disease==~~	+	THE STRUCTURAL BASIS OF FORCE GENERATION BY THE MITOTIC MOTOR KINESIN-5.,Goulet A, Behnke-Parks WM, Sindelar CV, Major J, Rosenfeld SS, Moores C J Biol Chem. 2012 Nov 7. PMID:23135273<ref>PMID:23135273</ref>
-	~~[[http://www.uniprot~~.~~org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy~~, ~~lymphedema~~, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, ~~broad nose with rounded tip~~, ~~long philtrum with thin upper lip~~, ~~prominent chin~~, ~~and prominent ears~~. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:~~22284827~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP~~, ~~one at an exchangeable site on the beta chain and one at~~ a ~~non-exchangeable site on~~ the ~~alpha chain (By similarity)~~. ~~[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle~~. ~~Blocking~~ of ~~KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays~~.<~~ref~~>~~PMID:19001501~~</~~ref~~> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA].	+

	==See Also==		==See Also==
		+	*[[Kinesin\|Kinesin]]
	*[[Tubulin\|Tubulin]]		*[[Tubulin\|Tubulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Behnke-Parks, W M.]]	+	[[Category: Behnke-Parks, W M]]
-	[[Category: Goulet, A.]]	+	[[Category: Goulet, A]]
-	[[Category: Moores, C A.]]	+	[[Category: Moores, C A]]
-	[[Category: Rosenfeld, S S.]]	+	[[Category: Rosenfeld, S S]]
-	[[Category: Sindelar, C V.]]	+	[[Category: Sindelar, C V]]
	[[Category: Cancer]]		[[Category: Cancer]]
	[[Category: Microtubule]]		[[Category: Microtubule]]
	[[Category: Mitosis]]		[[Category: Mitosis]]
	[[Category: Motor protein]]		[[Category: Motor protein]]

OCA at 17:55, 24 March 2013

2013-03-24T17:55:58Z

←Older revision		Revision as of 17:55, 24 March 2013
Line 1:		Line 1:
-	[[Image:4aqv.png\|left\|200px]]
-
	{{STRUCTURE_4aqv\| PDB=4aqv \| SCENE= }}		{{STRUCTURE_4aqv\| PDB=4aqv \| SCENE= }}
-
	===Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.===		===Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.===
-
	{{ABSTRACT_PUBMED_23135273}}		{{ABSTRACT_PUBMED_23135273}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

	==About this Structure==		==About this Structure==
	[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA].		[[4aqv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA].
		+
		+	==See Also==
		+	*[[Tubulin\|Tubulin]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 09:19, 16 January 2013

2013-01-16T09:19:29Z

←Older revision		Revision as of 09:19, 16 January 2013
Line 1:		Line 1:
-	[[Image:4aqv.~~jpg~~\|left\|200px]]	+	[[Image:4aqv.png\|left\|200px]]

	{{STRUCTURE_4aqv\| PDB=4aqv \| SCENE= }}		{{STRUCTURE_4aqv\| PDB=4aqv \| SCENE= }}

←Older revision		Revision as of 05:43, 25 August 2022
Line 3:		Line 3:
	<SX load='4aqv' size='340' side='right' viewer='molstar' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>		<SX load='4aqv' size='340' side='right' viewer='molstar' caption='[[4aqv]], [[Resolution\|resolution]] 9.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4AQV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1jff\|1jff]], [[1q0b\|1q0b]], [[1sa0\|1sa0]], [[1sa1\|1sa1]], [[1tvk\|1tvk]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[1z2b\|1z2b]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wbe\|2wbe]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[2xrp\|2xrp]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4atu\|4atu]], [[4atx\|4atx]], [[4b7b\|4b7b]], [[4bbg\|4bbg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6\|1ii6]], [[1jff\|1jff]], [[1q0b\|1q0b]], [[1sa0\|1sa0]], [[1sa1\|1sa1]], [[1tvk\|1tvk]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[1z2b\|1z2b]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wbe\|2wbe]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[2xrp\|2xrp]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4atu\|4atu]], [[4atx\|4atx]], [[4b7b\|4b7b]], [[4bbg\|4bbg]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [~~http~~://pdbe.org/4aqv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aqv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqv OCA], [https://pdbe.org/4aqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqv RCSB], [https://www.ebi.ac.uk/pdbsum/4aqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[~~http~~://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>	+	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[~~http~~://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref> [[~~http~~://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	+	[[https://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref> [[https://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==