4aua - Revision history

OCA at 10:54, 9 May 2024

2024-05-09T10:54:04Z

←Older revision		Revision as of 10:54, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='4aua' size='340' side='right'caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='4aua' size='340' side='right'caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=4AU:1H-BENZIMIDAZOL~~-2~~-YL(1H-PYRROL-2-YL)METHANONE'>4AU</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.31Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1bi7\|1bi7]], [[1bi8\|1bi8]], [[1blx\|1blx]], [[1g3n\|1g3n]], [[1jow\|1jow]], [[1xo2\|1xo2]], [[2euf\|2euf]], [[2f2c\|2f2c]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4AU:1H-BENZIMIDAZOL-2-YL(1H-PYRROL-2-YL)METHANONE'>4AU</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Cyclin~~-~~dependent_kinase Cyclin~~-~~dependent kinase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.7.11.22 2.7.11.22]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [https://pdbe.org/4aua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [https://www.ebi.ac.uk/pdbsum/4aua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aua ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [https://pdbe.org/4aua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [https://www.ebi.ac.uk/pdbsum/4aua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aua ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CDK6_HUMAN CDK6_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.<ref>PMID:8114739</ref> <ref>PMID:12833137</ref> <ref>PMID:14985467</ref> <ref>PMID:15254224</ref> <ref>PMID:15809340</ref> <ref>PMID:17431401</ref> <ref>PMID:17420273</ref> <ref>PMID:20668294</ref> <ref>PMID:20333249</ref>	+	[https://www.uniprot.org/uniprot/CDK6_HUMAN CDK6_HUMAN] Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.<ref>PMID:8114739</ref> <ref>PMID:12833137</ref> <ref>PMID:14985467</ref> <ref>PMID:15254224</ref> <ref>PMID:15809340</ref> <ref>PMID:17431401</ref> <ref>PMID:17420273</ref> <ref>PMID:20668294</ref> <ref>PMID:20333249</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cyclin-dependent kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Angove, H]]	+	[[Category: Angove H]]
-	[[Category: Benning, R]]	+	[[Category: Benning R]]
-	[[Category: Brain, C]]	+	[[Category: Brain C]]
-	[[Category: Chen~~, C H.T~~]]	+	[[Category: Chen CHT]]
-	[[Category: Cheng, R]]	+	[[Category: Cheng R]]
-	[[Category: Cho~~, Y S~~]]	+	[[Category: Cho YS]]
-	[[Category: Chopra, R]]	+	[[Category: Chopra R]]
-	[[Category: Chung, K]]	+	[[Category: Chung K]]
-	[[Category: Congreve, M]]	+	[[Category: Congreve M]]
-	[[Category: Dagostin, C]]	+	[[Category: Dagostin C]]
-	[[Category: Davis, D]]	+	[[Category: Davis D]]
-	[[Category: Feltell, R]]	+	[[Category: Feltell R]]
-	[[Category: Giraldes, J]]	+	[[Category: Giraldes J]]
-	[[Category: Hiscock, S]]	+	[[Category: Hiscock S]]
-	[[Category: Howard, S]]	+	[[Category: Howard S]]
-	[[Category: Kim, S]]	+	[[Category: Kim S]]
-	[[Category: Kovats, S]]	+	[[Category: Kovats S]]
-	[[Category: Lagu, B]]	+	[[Category: Lagu B]]
-	[[Category: Lewry, K]]	+	[[Category: Lewry K]]
-	[[Category: Loo, A]]	+	[[Category: Loo A]]
-	[[Category: Lu, Y]]	+	[[Category: Lu Y]]
-	[[Category: Luzzio, M]]	+	[[Category: Luzzio M]]
-	[[Category: Maniara, W]]	+	[[Category: Maniara W]]
-	[[Category: Mcmenamin, R]]	+	[[Category: Mcmenamin R]]
-	[[Category: Mortenson, P]]	+	[[Category: Mortenson P]]
-	[[Category: ~~Rees, D~~]]	+	[[Category: O'Reilly M]]
-	[[Category: ~~Reilly, M O~~]]	+	[[Category: Rees D]]
-	[[Category: Shen, J]]	+	[[Category: Shen J]]
-	[[Category: Smith, T]]	+	[[Category: Smith T]]
-	[[Category: Wang, Y]]	+	[[Category: Wang Y]]
-	[[Category: Williams, G]]	+	[[Category: Williams G]]
-	[[Category: Woolford, A]]	+	[[Category: Woolford A]]
-	[[Category: Wrona, W]]	+	[[Category: Wrona W]]
-	[[Category: Xu, M]]	+	[[Category: Xu M]]
-	[[Category: Yang, F]]	+	[[Category: Yang F]]
-	~~[[Category: Transferase~~]]	+

OCA at 05:46, 25 August 2022

2022-08-25T05:46:31Z

←Older revision		Revision as of 05:46, 25 August 2022
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	<StructureSection load='4aua' size='340' side='right'caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='4aua' size='340' side='right'caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AUA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4AU:1H-BENZIMIDAZOL-2-YL(1H-PYRROL-2-YL)METHANONE'>4AU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4AU:1H-BENZIMIDAZOL-2-YL(1H-PYRROL-2-YL)METHANONE'>4AU</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bi7\|1bi7]], [[1bi8\|1bi8]], [[1blx\|1blx]], [[1g3n\|1g3n]], [[1jow\|1jow]], [[1xo2\|1xo2]], [[2euf\|2euf]], [[2f2c\|2f2c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bi7\|1bi7]], [[1bi8\|1bi8]], [[1blx\|1blx]], [[1g3n\|1g3n]], [[1jow\|1jow]], [[1xo2\|1xo2]], [[2euf\|2euf]], [[2f2c\|2f2c]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [~~http~~://pdbe.org/4aua PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aua PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aua ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [https://pdbe.org/4aua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [https://www.ebi.ac.uk/pdbsum/4aua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aua ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CDK6_HUMAN CDK6_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.<ref>PMID:8114739</ref> <ref>PMID:12833137</ref> <ref>PMID:14985467</ref> <ref>PMID:15254224</ref> <ref>PMID:15809340</ref> <ref>PMID:17431401</ref> <ref>PMID:17420273</ref> <ref>PMID:20668294</ref> <ref>PMID:20333249</ref>	+	[[https://www.uniprot.org/uniprot/CDK6_HUMAN CDK6_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.<ref>PMID:8114739</ref> <ref>PMID:12833137</ref> <ref>PMID:14985467</ref> <ref>PMID:15254224</ref> <ref>PMID:15809340</ref> <ref>PMID:17431401</ref> <ref>PMID:17420273</ref> <ref>PMID:20668294</ref> <ref>PMID:20333249</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]	+	*[[Cyclin-dependent kinase 3D structures\|Cyclin-dependent kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:43, 3 April 2019

2019-04-03T07:43:26Z

←Older revision		Revision as of 07:43, 3 April 2019
Line 1:		Line 1:

	==Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)==		==Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)==
-	<StructureSection load='4aua' size='340' side='right' caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>	+	<StructureSection load='4aua' size='340' side='right'caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUA FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4aua" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4aua" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Angove, H]]		[[Category: Angove, H]]
	[[Category: Benning, R]]		[[Category: Benning, R]]

OCA at 06:34, 7 February 2018

2018-02-07T06:34:07Z

←Older revision		Revision as of 06:34, 7 February 2018
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4aua" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4aua" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 54:		Line 51:
	[[Category: Mcmenamin, R]]		[[Category: Mcmenamin, R]]
	[[Category: Mortenson, P]]		[[Category: Mortenson, P]]
-	[[Category: Oreilly, M]]
	[[Category: Rees, D]]		[[Category: Rees, D]]
		+	[[Category: Reilly, M O]]
	[[Category: Shen, J]]		[[Category: Shen, J]]
	[[Category: Smith, T]]		[[Category: Smith, T]]

OCA at 18:40, 4 August 2016

2016-08-04T18:40:30Z

←Older revision		Revision as of 18:40, 4 August 2016
Line 1:		Line 1:
		+
	==Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)==		==Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)==
	<StructureSection load='4aua' size='340' side='right' caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='4aua' size='340' side='right' caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bi7\|1bi7]], [[1bi8\|1bi8]], [[1blx\|1blx]], [[1g3n\|1g3n]], [[1jow\|1jow]], [[1xo2\|1xo2]], [[2euf\|2euf]], [[2f2c\|2f2c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bi7\|1bi7]], [[1bi8\|1bi8]], [[1blx\|1blx]], [[1g3n\|1g3n]], [[1jow\|1jow]], [[1xo2\|1xo2]], [[2euf\|2euf]], [[2f2c\|2f2c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [http://www.ebi.ac.uk/pdbsum/4aua PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [http://pdbe.org/4aua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [http://www.ebi.ac.uk/pdbsum/4aua PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aua ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4aua" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:00, 25 December 2014

2014-12-25T12:00:59Z

←Older revision		Revision as of 12:00, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4AU:1H-BENZIMIDAZOL-2-YL(1H-PYRROL-2-YL)METHANONE'>4AU</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4AU:1H-BENZIMIDAZOL-2-YL(1H-PYRROL-2-YL)METHANONE'>4AU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bi7\|1bi7]], [[1bi8\|1bi8]], [[1blx\|1blx]], [[1g3n\|1g3n]], [[1jow\|1jow]], [[1xo2\|1xo2]], [[2euf\|2euf]], [[2f2c\|2f2c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bi7\|1bi7]], [[1bi8\|1bi8]], [[1blx\|1blx]], [[1g3n\|1g3n]], [[1jow\|1jow]], [[1xo2\|1xo2]], [[2euf\|2euf]], [[2f2c\|2f2c]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [http://www.ebi.ac.uk/pdbsum/4aua PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [http://www.ebi.ac.uk/pdbsum/4aua PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDK6_HUMAN CDK6_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.<ref>PMID:8114739</ref> <ref>PMID:12833137</ref> <ref>PMID:14985467</ref> <ref>PMID:15254224</ref> <ref>PMID:15809340</ref> <ref>PMID:17431401</ref> <ref>PMID:17420273</ref> <ref>PMID:20668294</ref> <ref>PMID:20333249</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 27:
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Angove, H.]]	+	[[Category: Angove, H]]
-	[[Category: Benning, R.]]	+	[[Category: Benning, R]]
-	[[Category: Brain, C.]]	+	[[Category: Brain, C]]
-	[[Category: Chen, C H.T.]]	+	[[Category: Chen, C H.T]]
-	[[Category: Cheng, R.]]	+	[[Category: Cheng, R]]
-	[[Category: Cho, Y S.]]	+	[[Category: Cho, Y S]]
-	[[Category: Chopra, R.]]	+	[[Category: Chopra, R]]
-	[[Category: Chung, K.]]	+	[[Category: Chung, K]]
-	[[Category: Congreve, M.]]	+	[[Category: Congreve, M]]
-	[[Category: Dagostin, C.]]	+	[[Category: Dagostin, C]]
-	[[Category: Davis, D.]]	+	[[Category: Davis, D]]
-	[[Category: Feltell, R.]]	+	[[Category: Feltell, R]]
-	[[Category: Giraldes, J.]]	+	[[Category: Giraldes, J]]
-	[[Category: Hiscock, S.]]	+	[[Category: Hiscock, S]]
-	[[Category: Howard, S.]]	+	[[Category: Howard, S]]
-	[[Category: Kim, S.]]	+	[[Category: Kim, S]]
-	[[Category: Kovats, S.]]	+	[[Category: Kovats, S]]
-	[[Category: Lagu, B.]]	+	[[Category: Lagu, B]]
-	[[Category: Lewry, K.]]	+	[[Category: Lewry, K]]
-	[[Category: Loo, A.]]	+	[[Category: Loo, A]]
-	[[Category: Lu, Y.]]	+	[[Category: Lu, Y]]
-	[[Category: Luzzio, M.]]	+	[[Category: Luzzio, M]]
-	[[Category: Maniara, W.]]	+	[[Category: Maniara, W]]
-	[[Category: Mcmenamin, R.]]	+	[[Category: Mcmenamin, R]]
-	[[Category: Mortenson, P.]]	+	[[Category: Mortenson, P]]
-	[[Category: Oreilly, M.]]	+	[[Category: Oreilly, M]]
-	[[Category: Rees, D.]]	+	[[Category: Rees, D]]
-	[[Category: Shen, J.]]	+	[[Category: Shen, J]]
-	[[Category: Smith, T.]]	+	[[Category: Smith, T]]
-	[[Category: Wang, Y.]]	+	[[Category: Wang, Y]]
-	[[Category: Williams, G.]]	+	[[Category: Williams, G]]
-	[[Category: Woolford, A.]]	+	[[Category: Woolford, A]]
-	[[Category: Wrona, W.]]	+	[[Category: Wrona, W]]
-	[[Category: Xu, M.]]	+	[[Category: Xu, M]]
-	[[Category: Yang, F.]]	+	[[Category: Yang, F]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:37, 18 June 2014

2014-06-18T05:37:04Z

←Older revision		Revision as of 05:37, 18 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4aua.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)==
		+	<StructureSection load='4aua' size='340' side='right' caption='[[4aua]], [[Resolution\|resolution]] 2.31Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4aua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4AU:1H-BENZIMIDAZOL-2-YL(1H-PYRROL-2-YL)METHANONE'>4AU</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bi7\|1bi7]], [[1bi8\|1bi8]], [[1blx\|1blx]], [[1g3n\|1g3n]], [[1jow\|1jow]], [[1xo2\|1xo2]], [[2euf\|2euf]], [[2f2c\|2f2c]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aua OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aua RCSB], [http://www.ebi.ac.uk/pdbsum/4aua PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Herein, we describe the discovery of potent and highly selective inhibitors of both CDK4 and CDK6 via structure-guided optimization of a fragment-based screening hit. CDK6 X-ray crystallography and pharmacokinetic data steered efforts in identifying compound 6, which showed >1000-fold selectivity for CDK4 over CDKs 1 and 2 in an enzymatic assay. Furthermore, 6 demonstrated in vivo inhibition of pRb-phosphorylation and oral efficacy in a Jeko-1 mouse xenograft model.

-	~~{{STRUCTURE_4aua\| PDB=4aua \| SCENE= }}~~	+	Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.,Cho YS, Angove H, Brain C, Chen CH, Cheng H, Cheng R, Chopra R, Chung K, Congreve M, Dagostin C, Davis DJ, Feltell R, Giraldes J, Hiscock SD, Kim S, Kovats S, Lagu B, Lewry K, Loo A, Lu Y, Luzzio M, Maniara W, McMenamin R, Mortenson PN, Benning R, O'Reilly M, Rees DC, Shen J, Smith T, Wang Y, Williams G, Woolford AJ, Wrona W, Xu M, Yang F, Howard S ACS Med Chem Lett. 2012 May 17;3(6):445-9. doi: 10.1021/ml200241a. eCollection, 2012 Jun 14. PMID:24900493<ref>PMID:24900493</ref>

-	~~===Liganded X-ray crystal structure~~ of ~~cyclin dependent kinase 6 (CDK6)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	==~~About this Structure~~==	+	<references/>
-	~~[[4aua]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA].~~	+	__TOC__
		+	</StructureSection>
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Angove, H.]]		[[Category: Angove, H.]]
	[[Category: Benning, R.]]		[[Category: Benning, R.]]

OCA at 13:03, 6 February 2013

2013-02-06T13:03:57Z

←Older revision		Revision as of 13:03, 6 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4aua.jpg\|left\|200px]]

-	~~The entry~~ 4aua ~~is ON HOLD~~	+	{{STRUCTURE_4aua\| PDB=4aua \| SCENE= }}

-	Authors: Cho, Y.S., Angove, H., Brain, C., Chen, C.H.T., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D., Feltell, R., Giraldes, J., Hiscock, S., Kim, S., Kovats, S., Lagu, B., Lewry, K., Loo, A., Lu, Y., Luzzio, M., Maniara, W., Mcmenamin, R., Mortenson, P., Benning, R., Oreilly, M., Rees, D., Shen, J., Smith, T., Wang, Y., Williams, G., Woolford, A., Wrona, W., Xu, M., Yang, F., Howard, S.	+	===Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)===

-	~~Description~~: ~~Liganded X~~-~~ray crystal structure of cyclin~~ dependent kinase ~~6 (CDK6)~~	+
		+	==About this Structure==
		+	[[4aua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUA OCA].
		+	[[Category: Cyclin-dependent kinase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Angove, H.]]
		+	[[Category: Benning, R.]]
		+	[[Category: Brain, C.]]
		+	[[Category: Chen, C H.T.]]
		+	[[Category: Cheng, R.]]
		+	[[Category: Cho, Y S.]]
		+	[[Category: Chopra, R.]]
		+	[[Category: Chung, K.]]
		+	[[Category: Congreve, M.]]
		+	[[Category: Dagostin, C.]]
		+	[[Category: Davis, D.]]
		+	[[Category: Feltell, R.]]
		+	[[Category: Giraldes, J.]]
		+	[[Category: Hiscock, S.]]
		+	[[Category: Howard, S.]]
		+	[[Category: Kim, S.]]
		+	[[Category: Kovats, S.]]
		+	[[Category: Lagu, B.]]
		+	[[Category: Lewry, K.]]
		+	[[Category: Loo, A.]]
		+	[[Category: Lu, Y.]]
		+	[[Category: Luzzio, M.]]
		+	[[Category: Maniara, W.]]
		+	[[Category: Mcmenamin, R.]]
		+	[[Category: Mortenson, P.]]
		+	[[Category: Oreilly, M.]]
		+	[[Category: Rees, D.]]
		+	[[Category: Shen, J.]]
		+	[[Category: Smith, T.]]
		+	[[Category: Wang, Y.]]
		+	[[Category: Williams, G.]]
		+	[[Category: Woolford, A.]]
		+	[[Category: Wrona, W.]]
		+	[[Category: Xu, M.]]
		+	[[Category: Yang, F.]]
		+	[[Category: Transferase]]

OCA: Protected "4aua" [edit=sysop:move=sysop]

2012-05-23T05:32:57Z

Protected "4aua" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:32, 23 May 2012

OCA: New page: '''Unreleased structure''' The entry 4aua is ON HOLD Authors: Cho, Y.S., Angove, H., Brain, C., Chen, C.H.T., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D., Fe...

2012-05-23T05:32:56Z

New page: '''Unreleased structure''' The entry 4aua is ON HOLD Authors: Cho, Y.S., Angove, H., Brain, C., Chen, C.H.T., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D., Fe...

New page

'''Unreleased structure'''

The entry 4aua is ON HOLD

Authors: Cho, Y.S., Angove, H., Brain, C., Chen, C.H.T., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D., Feltell, R., Giraldes, J., Hiscock, S., Kim, S., Kovats, S., Lagu, B., Lewry, K., Loo, A., Lu, Y., Luzzio, M., Maniara, W., Mcmenamin, R., Mortenson, P., Benning, R., Oreilly, M., Rees, D., Shen, J., Smith, T., Wang, Y., Williams, G., Woolford, A., Wrona, W., Xu, M., Yang, F., Howard, S.

Description: Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)