4ayq - Revision history

OCA at 07:16, 1 May 2024

2024-05-01T07:16:59Z

←Older revision		Revision as of 07:16, 1 May 2024
Line 3:		Line 3:
	<StructureSection load='4ayq' size='340' side='right'caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4ayq' size='340' side='right'caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Causk Causk~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_sp._K31 Caulobacter sp. K31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4ayo\|4ayo]], [[4ayp\|4ayp]], [[4ayr\|4ayr]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [https://pdbe.org/4ayq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [https://www.ebi.ac.uk/pdbsum/4ayq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [https://pdbe.org/4ayq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [https://www.ebi.ac.uk/pdbsum/4ayq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayq ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/B0SWV2_CAUSK B0SWV2_CAUSK]
-	~~Mannosides in the southern hemisphere~~: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhibition and inspires solutions to mannoside synthesis. Atomic resolution structures along the reaction coordinate of an inverting alpha-mannosidase show how the enzyme distorts the substrate and transition state. QM/~~MM calculations reveal how the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conformationally accessible reaction coordinate.~~	+
-		+
-	The reaction coordinate of a bacterial GH47 alpha-mannosidase: a combined quantum mechanical and structural approach.,Thompson AJ, Dabin J, Iglesias-Fernandez J, Ardevol A, Dinev Z, Williams SJ, Bande O, Siriwardena A, Moreland C, Hu TC, Smith DK, Gilbert HJ, Rovira C, Davies GJ Angew Chem Int Ed Engl. 2012 Oct 29;51(44):10997-1001. doi:, 10.1002/~~anie~~.~~201205338~~. ~~Epub 2012 Sep 26. PMID:23012075<ref>PMID:23012075<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4ayq" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Mannosidase 3D structures\|Mannosidase 3D structures]]		*[[Mannosidase 3D structures\|Mannosidase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Causk~~]]	+	[[Category: Caulobacter sp. K31]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]~~	+	[[Category: Dabin J]]
-	[[Category: Dabin, J]]	+	[[Category: Davies GJ]]
-	[[Category: Davies~~, G J~~]]	+	[[Category: Dinev Z]]
-	[[Category: Dinev, Z]]	+	[[Category: Gilbert HJ]]
-	[[Category: Gilbert~~, H J~~]]	+	[[Category: Hu TC]]
-	[[Category: Hu~~, T C~~]]	+	[[Category: Iglesias-Fernandez A]]
-	[[Category: Iglesias-Fernandez, A]]	+	[[Category: Iglesias-Fernandez J]]
-	[[Category: Iglesias-Fernandez, J]]	+	[[Category: Moreland C]]
-	[[Category: Moreland, C]]	+	[[Category: Rovira C]]
-	[[Category: Rovira, C]]	+	[[Category: Siriwardena A]]
-	[[Category: Siriwardena, A]]	+	[[Category: Smith DK]]
-	[[Category: Smith~~, D K~~]]	+	[[Category: Thompson AJ]]
-	[[Category: Thompson~~, A J~~]]	+	[[Category: Williams SJ]]
-	[[Category: Williams~~, S J]]~~	+
-	~~[[Category: Cazy]]~~	+
-	~~[[Category: Enzyme-carbohydrate interaction]]~~	+
-	~~[[Category: Gh47]]~~	+
-	~~[[Category: Glycosidase inhibition]]~~	+
-	~~[[Category: Glycoside hydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mannose]]~~	+
-	~~[[Category: Quantum mechanic~~]]	+

OCA at 05:51, 25 August 2022

2022-08-25T05:51:04Z

←Older revision		Revision as of 05:51, 25 August 2022
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	<StructureSection load='4ayq' size='340' side='right'caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4ayq' size='340' side='right'caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Causk Causk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Causk Causk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayo\|4ayo]], [[4ayp\|4ayp]], [[4ayr\|4ayr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4ayo\|4ayo]], [[4ayp\|4ayp]], [[4ayr\|4ayr]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [~~http~~://pdbe.org/4ayq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ayq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [https://pdbe.org/4ayq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [https://www.ebi.ac.uk/pdbsum/4ayq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Mannosidase\|Mannosidase]]	+	*[[Mannosidase 3D structures\|Mannosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Causk]]		[[Category: Causk]]
		+	[[Category: Large Structures]]
	[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]
	[[Category: Dabin, J]]		[[Category: Dabin, J]]

OCA at 08:44, 6 March 2019

2019-03-06T08:44:39Z

←Older revision		Revision as of 08:44, 6 March 2019
Line 1:		Line 1:

	==Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole==		==Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole==
-	<StructureSection load='4ayq' size='340' side='right' caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='4ayq' size='340' side='right'caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Causk Causk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Causk Causk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>

OCA at 16:52, 2 January 2017

2017-01-02T16:52:30Z

←Older revision		Revision as of 16:52, 2 January 2017
Line 1:		Line 1:
		+
	==Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole==		==Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole==
	<StructureSection load='4ayq' size='340' side='right' caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4ayq' size='340' side='right' caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayo\|4ayo]], [[4ayp\|4ayp]], [[4ayr\|4ayr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayo\|4ayo]], [[4ayp\|4ayp]], [[4ayr\|4ayr]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [http://www.ebi.ac.uk/pdbsum/4ayq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [http://pdbe.org/4ayq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [http://www.ebi.ac.uk/pdbsum/4ayq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ayq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:22, 26 March 2015

2015-03-26T07:22:52Z

←Older revision		Revision as of 07:22, 26 March 2015
Line 2:		Line 2:
	<StructureSection load='4ayq' size='340' side='right' caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4ayq' size='340' side='right' caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Caulobacter_sp._k31 Caulobacter sp. k31~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Causk Causk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayo\|4ayo]], [[4ayp\|4ayp]], [[4ayr\|4ayr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayo\|4ayo]], [[4ayp\|4ayp]], [[4ayr\|4ayr]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caulobacter sp. k31~~]]	+	[[Category: Causk]]
	[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]
	[[Category: Dabin, J]]		[[Category: Dabin, J]]

OCA at 13:36, 4 January 2015

2015-01-04T13:36:02Z

←Older revision		Revision as of 13:36, 4 January 2015
Line 1:		Line 1:
-	[[~~Image:~~4ayq.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole==
		+	<StructureSection load='4ayq' size='340' side='right' caption='[[4ayq]], [[Resolution\|resolution]] 1.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_sp._k31 Caulobacter sp. k31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayo\|4ayo]], [[4ayp\|4ayp]], [[4ayr\|4ayr]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [http://www.ebi.ac.uk/pdbsum/4ayq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mannosides in the southern hemisphere: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhibition and inspires solutions to mannoside synthesis. Atomic resolution structures along the reaction coordinate of an inverting alpha-mannosidase show how the enzyme distorts the substrate and transition state. QM/MM calculations reveal how the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conformationally accessible reaction coordinate.

-	~~{{STRUCTURE_4ayq\| PDB=4ayq \| SCENE= }}~~	+	The reaction coordinate of a bacterial GH47 alpha-mannosidase: a combined quantum mechanical and structural approach.,Thompson AJ, Dabin J, Iglesias-Fernandez J, Ardevol A, Dinev Z, Williams SJ, Bande O, Siriwardena A, Moreland C, Hu TC, Smith DK, Gilbert HJ, Rovira C, Davies GJ Angew Chem Int Ed Engl. 2012 Oct 29;51(44):10997-1001. doi:, 10.1002/anie.201205338. Epub 2012 Sep 26. PMID:23012075<ref>PMID:23012075</ref>

-	~~===Structure of The GH47 processing alpha-1~~,~~2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23012075}}~~	+	==See Also==
-		+	*[[Mannosidase\|Mannosidase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4ayq~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Caulobacter_sp._k31 Caulobacter sp. k31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Caulobacter sp. k31]]		[[Category: Caulobacter sp. k31]]
	[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]
-	[[Category: Dabin, J.]]	+	[[Category: Dabin, J]]
-	[[Category: Davies, G J.]]	+	[[Category: Davies, G J]]
-	[[Category: Dinev, Z.]]	+	[[Category: Dinev, Z]]
-	[[Category: Gilbert, H J.]]	+	[[Category: Gilbert, H J]]
-	[[Category: Hu, T C.]]	+	[[Category: Hu, T C]]
-	[[Category: Iglesias-Fernandez, A.]]	+	[[Category: Iglesias-Fernandez, A]]
-	[[Category: Iglesias-Fernandez, J.]]	+	[[Category: Iglesias-Fernandez, J]]
-	[[Category: Moreland, C.]]	+	[[Category: Moreland, C]]
-	[[Category: Rovira, C.]]	+	[[Category: Rovira, C]]
-	[[Category: Siriwardena, A.]]	+	[[Category: Siriwardena, A]]
-	[[Category: Smith, D K.]]	+	[[Category: Smith, D K]]
-	[[Category: Thompson, A J.]]	+	[[Category: Thompson, A J]]
-	[[Category: Williams, S J.]]	+	[[Category: Williams, S J]]
	[[Category: Cazy]]		[[Category: Cazy]]
	[[Category: Enzyme-carbohydrate interaction]]		[[Category: Enzyme-carbohydrate interaction]]

OCA at 12:25, 30 January 2013

2013-01-30T12:25:09Z

←Older revision		Revision as of 12:25, 30 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ayq.jpg\|left\|200px]]

-	~~The entry~~ 4ayq ~~is ON HOLD~~	+	{{STRUCTURE_4ayq\| PDB=4ayq \| SCENE= }}

-	~~Authors: Thompson, A.J., Dabin, J., Iglesias~~-~~Fernandez~~, ~~J., Iglesias~~-~~Fernandez, A., Dinev, Z., Williams, S.J., Siriwardena, A., Moreland, C., Hu, T.C., Smith, D.K., Gilbert, H.J., Rovira, C., Davies, G.J.~~	+	===Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole===

-	~~Description:~~ Structure ~~of The GH47 processing alpha~~-1,2-mannosidase ~~from Caulobacter strain K31 in complex with mannoimidazole~~	+	{{ABSTRACT_PUBMED_23012075}}
		+
		+	==About this Structure==
		+	[[4ayq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_sp._k31 Caulobacter sp. k31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA].
		+	[[Category: Caulobacter sp. k31]]
		+	[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]
		+	[[Category: Dabin, J.]]
		+	[[Category: Davies, G J.]]
		+	[[Category: Dinev, Z.]]
		+	[[Category: Gilbert, H J.]]
		+	[[Category: Hu, T C.]]
		+	[[Category: Iglesias-Fernandez, A.]]
		+	[[Category: Iglesias-Fernandez, J.]]
		+	[[Category: Moreland, C.]]
		+	[[Category: Rovira, C.]]
		+	[[Category: Siriwardena, A.]]
		+	[[Category: Smith, D K.]]
		+	[[Category: Thompson, A J.]]
		+	[[Category: Williams, S J.]]
		+	[[Category: Cazy]]
		+	[[Category: Enzyme-carbohydrate interaction]]
		+	[[Category: Gh47]]
		+	[[Category: Glycosidase inhibition]]
		+	[[Category: Glycoside hydrolase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mannose]]
		+	[[Category: Quantum mechanic]]

OCA: Protected "4ayq" [edit=sysop:move=sysop]

2012-06-27T05:16:37Z

Protected "4ayq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:16, 27 June 2012

OCA: New page: '''Unreleased structure''' The entry 4ayq is ON HOLD Authors: Thompson, A.J., Dabin, J., Iglesias-Fernandez, J., Iglesias-Fernandez, A., Dinev, Z., Williams, S.J., Siriwardena, A., More...

2012-06-27T05:16:36Z

New page: '''Unreleased structure''' The entry 4ayq is ON HOLD Authors: Thompson, A.J., Dabin, J., Iglesias-Fernandez, J., Iglesias-Fernandez, A., Dinev, Z., Williams, S.J., Siriwardena, A., More...

New page

'''Unreleased structure'''

The entry 4ayq is ON HOLD

Authors: Thompson, A.J., Dabin, J., Iglesias-Fernandez, J., Iglesias-Fernandez, A., Dinev, Z., Williams, S.J., Siriwardena, A., Moreland, C., Hu, T.C., Smith, D.K., Gilbert, H.J., Rovira, C., Davies, G.J.

Description: Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole