4b0f - Revision history

OCA at 05:52, 25 August 2022

2022-08-25T05:52:50Z

←Older revision		Revision as of 05:52, 25 August 2022
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	<StructureSection load='4b0f' size='340' side='right'caption='[[4b0f]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4b0f' size='340' side='right'caption='[[4b0f]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b0f]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B0F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b0f]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B0F FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a55\|2a55]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a55\|2a55]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b0f OCA], [~~http~~://pdbe.org/4b0f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b0f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b0f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b0f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b0f OCA], [https://pdbe.org/4b0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b0f RCSB], [https://www.ebi.ac.uk/pdbsum/4b0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b0f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	+	[[https://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]
	[[Category: Hofmeyer, T]]		[[Category: Hofmeyer, T]]

OCA at 09:01, 6 March 2019

2019-03-06T09:01:31Z

←Older revision		Revision as of 09:01, 6 March 2019
Line 1:		Line 1:

	==Heptameric core complex structure of C4b-binding (C4BP) protein from human==		==Heptameric core complex structure of C4b-binding (C4BP) protein from human==
-	<StructureSection load='4b0f' size='340' side='right' caption='[[4b0f]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4b0f' size='340' side='right'caption='[[4b0f]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b0f]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B0F FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b0f]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B0F FirstGlance]. <br>

OCA at 17:18, 5 August 2016

2016-08-05T17:18:27Z

←Older revision		Revision as of 17:18, 5 August 2016
Line 1:		Line 1:
		+
	==Heptameric core complex structure of C4b-binding (C4BP) protein from human==		==Heptameric core complex structure of C4b-binding (C4BP) protein from human==
	<StructureSection load='4b0f' size='340' side='right' caption='[[4b0f]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4b0f' size='340' side='right' caption='[[4b0f]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b0f]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B0F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b0f]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B0F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a55\|2a55]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a55\|2a55]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b0f RCSB], [http://www.ebi.ac.uk/pdbsum/4b0f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b0f OCA], [http://pdbe.org/4b0f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b0f RCSB], [http://www.ebi.ac.uk/pdbsum/4b0f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b0f ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b0f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]
	[[Category: Hofmeyer, T]]		[[Category: Hofmeyer, T]]

OCA at 09:13, 21 December 2014

2014-12-21T09:13:51Z

←Older revision		Revision as of 09:13, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4b0f\| PDB=4b0f \| SCENE= }}~~	+	==Heptameric core complex structure of C4b-binding (C4BP) protein from human==
-	===Heptameric core complex structure of C4b-binding (C4BP) protein from human===	+	<StructureSection load='4b0f' size='340' side='right' caption='[[4b0f]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23274142}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b0f]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B0F FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a55\|2a55]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b0f RCSB], [http://www.ebi.ac.uk/pdbsum/4b0f PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The complement system as major part of innate immunity is the first line of defense against invading microorganisms. Orchestrated by more than 60 proteins, its major task is to discriminate between host cells and pathogens and to initiate immune response. Additional recognition of necrotic or apoptotic cells demand a fine-tune regulation of this powerful system. C4b-binding protein (C4BP) is the major inhibitor of the classical complement and lectin pathway. The crystal structure of the human C4BP oligomerization domain in its 7alpha isoform and molecular simulations provide first structural insights of C4BP oligomerization. The heptameric core structure is stabilized by intermolecular disulfide bonds. In addition, thermal shift assays indicate that layers of electrostatic interactions mainly contribute to the extraordinary thermodynamic stability of the complex. These findings make C4BP a promising scaffold for multivalent ligand display with applications in immunology and biological chemistry.

-	~~==About this Structure==~~	+	Arranged sevenfold: structural insights into the C-terminal oligomerization domain of human C4b-binding protein.,Hofmeyer T, Schmelz S, Degiacomi MT, Peraro MD, Daneschdar M, Scrima A, den Heuvel JV, Heinz DW, Kolmar H J Mol Biol. 2012 Dec 27. pii: S0022-2836(12)00950-3. doi:, 10.1016/j.jmb.2012.12.017. PMID:23274142<ref>PMID:23274142</ref>
-	~~[[4b0f]] is a 7 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4B0F OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Heinz, D W.]]	+	[[Category: Heinz, D W]]
-	[[Category: Hofmeyer, T.]]	+	[[Category: Hofmeyer, T]]
-	[[Category: Kolmar, H.]]	+	[[Category: Kolmar, H]]
-	[[Category: Schmelz, S.]]	+	[[Category: Schmelz, S]]
	[[Category: Complement system]]		[[Category: Complement system]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 21:45, 10 April 2013

2013-04-10T21:45:15Z

←Older revision		Revision as of 21:45, 10 April 2013
Line 1:		Line 1:
-	[[Image:4b0f.jpg\|left\|200px]]
-
	{{STRUCTURE_4b0f\| PDB=4b0f \| SCENE= }}		{{STRUCTURE_4b0f\| PDB=4b0f \| SCENE= }}
-
	===Heptameric core complex structure of C4b-binding (C4BP) protein from human===		===Heptameric core complex structure of C4b-binding (C4BP) protein from human===
-
	{{ABSTRACT_PUBMED_23274142}}		{{ABSTRACT_PUBMED_23274142}}

OCA at 08:10, 9 January 2013

2013-01-09T08:10:37Z

←Older revision		Revision as of 08:10, 9 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4b0f.jpg\|left\|200px]]

-	~~The entry~~ 4b0f ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4b0f\| PDB=4b0f \| SCENE= }}

-	~~Authors: Schmelz, S., Hofmeyer, T., Kolmar, H., Heinz, D.W.~~	+	===Heptameric core complex structure of C4b-binding (C4BP) protein from human===

-	~~Description: Heptameric core complex~~ structure ~~of C4b-binding (C4BP) protein~~ from ~~human~~	+	{{ABSTRACT_PUBMED_23274142}}
		+
		+	==About this Structure==
		+	[[4b0f]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0F OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Heinz, D W.]]
		+	[[Category: Hofmeyer, T.]]
		+	[[Category: Kolmar, H.]]
		+	[[Category: Schmelz, S.]]
		+	[[Category: Complement system]]
		+	[[Category: Immune system]]

OCA at 04:43, 5 September 2012

2012-09-05T04:43:17Z

←Older revision		Revision as of 04:43, 5 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b0f is ON HOLD	+	The entry 4b0f is ON HOLD until Paper Publication

	Authors: Schmelz, S., Hofmeyer, T., Kolmar, H., Heinz, D.W.		Authors: Schmelz, S., Hofmeyer, T., Kolmar, H., Heinz, D.W.

	Description: Heptameric core complex structure of C4b-binding (C4BP) protein from human		Description: Heptameric core complex structure of C4b-binding (C4BP) protein from human

OCA: Protected "4b0f" [edit=sysop:move=sysop]

2012-07-11T07:41:23Z

Protected "4b0f" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:41, 11 July 2012

OCA: New page: '''Unreleased structure''' The entry 4b0f is ON HOLD Authors: Schmelz, S., Hofmeyer, T., Kolmar, H., Heinz, D.W. Description: Heptameric core complex structure of C4b-binding (C4BP) pr...

2012-07-11T07:41:22Z

New page: '''Unreleased structure''' The entry 4b0f is ON HOLD Authors: Schmelz, S., Hofmeyer, T., Kolmar, H., Heinz, D.W. Description: Heptameric core complex structure of C4b-binding (C4BP) pr...

New page

'''Unreleased structure'''

The entry 4b0f is ON HOLD

Authors: Schmelz, S., Hofmeyer, T., Kolmar, H., Heinz, D.W.

Description: Heptameric core complex structure of C4b-binding (C4BP) protein from human