4b1q - Revision history

OCA at 06:56, 31 August 2022

2022-08-31T06:56:49Z

←Older revision		Revision as of 06:56, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4b1q' size='340' side='right'caption='[[4b1q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4b1q' size='340' side='right'caption='[[4b1q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b1q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B1Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b1q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B1Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL~~</scene>, <scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL~~</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [~~http~~://pdbe.org/4b1q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b1q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [https://pdbe.org/4b1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [https://www.ebi.ac.uk/pdbsum/4b1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CEX_CONCN CEX_CONCN]] May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations.	+	[[https://www.uniprot.org/uniprot/CEX_CONCN CEX_CONCN]] May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:53, 13 March 2019

2019-03-13T13:53:31Z

←Older revision		Revision as of 13:53, 13 March 2019
Line 1:		Line 1:

	==NMR structure of the glycosylated conotoxin CcTx from Conus consors==		==NMR structure of the glycosylated conotoxin CcTx from Conus consors==
-	<StructureSection load='4b1q' size='340' side='right' caption='[[4b1q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='4b1q' size='340' side='right'caption='[[4b1q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B1Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B1Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>,~~ <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [http://pdbe.org/4b1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [http://www.ebi.ac.uk/pdbsum/4b1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [http://pdbe.org/4b1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [http://www.ebi.ac.uk/pdbsum/4b1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1q ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Conus consors]]		[[Category: Conus consors]]
		+	[[Category: Large Structures]]
	[[Category: Boelens, R]]		[[Category: Boelens, R]]
	[[Category: Favreau, P]]		[[Category: Favreau, P]]

OCA at 06:21, 5 August 2016

2016-08-05T06:21:08Z

←Older revision		Revision as of 06:21, 5 August 2016
Line 1:		Line 1:
		+
	==NMR structure of the glycosylated conotoxin CcTx from Conus consors==		==NMR structure of the glycosylated conotoxin CcTx from Conus consors==
	<StructureSection load='4b1q' size='340' side='right' caption='[[4b1q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4b1q' size='340' side='right' caption='[[4b1q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [http://www.ebi.ac.uk/pdbsum/4b1q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [http://pdbe.org/4b1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [http://www.ebi.ac.uk/pdbsum/4b1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b1q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:47, 24 December 2014

2014-12-24T23:47:08Z

←Older revision		Revision as of 23:47, 24 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4b1q.~~jpg~~\|~~left~~\|~~200px~~]]	+	==NMR structure of the glycosylated conotoxin CcTx from Conus consors==
		+	<StructureSection load='4b1q' size='340' side='right' caption='[[4b1q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B1Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [http://www.ebi.ac.uk/pdbsum/4b1q PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CEX_CONCN CEX_CONCN]] May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The glycopeptide CcTx, isolated from the venom of the piscivorous cone snail Conus consors, belongs to the kappaA-family of conopeptides. These toxins elicit excitotoxic responses in the prey by acting on voltage-gated sodium channels. The structure of CcTx, a first in the kappaA-family, has been determined by high-resolution NMR spectroscopy together with the analysis of its O-glycan at Ser7. A new type of glycopeptide O-glycan core structure, here registered as core type 9, containing two terminal L-galactose units {alpha-L-Galp-(1-->4)-alpha-D-GlcpNAc-(1-->6)-[alpha-L-Galp-(1-->2)-beta-D-Galp-( 1-->3)-]alpha-D-GalpNAc-(1-->O)}, is highlighted. A sequence comparison to other putative members of the kappaA-family suggests that O-linked glycosylation might be more common than previously thought. This observation alone underlines the requirement for more careful and in-depth investigations into this type of post-translational modification in conotoxins.

-	~~{{STRUCTURE_4b1q\| PDB=4b1q \| SCENE= }}~~	+	Structure of the O-Glycosylated Conopeptide CcTx from Conus consors Venom.,Hocking HG, Gerwig GJ, Dutertre S, Violette A, Favreau P, Stocklin R, Kamerling JP, Boelens R Chemistry. 2013 Jan 14;19(3):870-9. doi: 10.1002/chem.201202713. Epub 2012 Dec, 27. PMID:23281027<ref>PMID:23281027</ref>

-	~~===NMR structure~~ of the ~~glycosylated conotoxin CcTx from Conus consors===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23281027}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4b1q]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA].~~	+	</StructureSection>
	[[Category: Conus consors]]		[[Category: Conus consors]]
-	[[Category: Boelens, R.]]	+	[[Category: Boelens, R]]
-	[[Category: Favreau, P.]]	+	[[Category: Favreau, P]]
-	[[Category: Gerwig, G J.]]	+	[[Category: Gerwig, G J]]
-	[[Category: Hocking, H G.]]	+	[[Category: Hocking, H G]]
-	[[Category: Kamerling, J P.]]	+	[[Category: Kamerling, J P]]
-	[[Category: Stocklin, R.]]	+	[[Category: Stocklin, R]]
	[[Category: O-glycan]]		[[Category: O-glycan]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 12:55, 6 February 2013

2013-02-06T12:55:26Z

←Older revision		Revision as of 12:55, 6 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4b1q.jpg\|left\|200px]]

-	~~The entry~~ 4b1q ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4b1q\| PDB=4b1q \| SCENE= }}

-	~~Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R.~~	+	===NMR structure of the glycosylated conotoxin CcTx from Conus consors===

-	~~Description: NMR~~ structure ~~of the glycosylated conotoxin CcTx~~ from Conus consors	+	{{ABSTRACT_PUBMED_23281027}}
		+
		+	==About this Structure==
		+	[[4b1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA].
		+	[[Category: Conus consors]]
		+	[[Category: Boelens, R.]]
		+	[[Category: Favreau, P.]]
		+	[[Category: Gerwig, G J.]]
		+	[[Category: Hocking, H G.]]
		+	[[Category: Kamerling, J P.]]
		+	[[Category: Stocklin, R.]]
		+	[[Category: O-glycan]]
		+	[[Category: Toxin]]

OCA at 10:51, 19 December 2012

2012-12-19T10:51:05Z

←Older revision		Revision as of 10:51, 19 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b1q is ON HOLD	+	The entry 4b1q is ON HOLD until Paper Publication

	Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R.		Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R.

	Description: NMR structure of the glycosylated conotoxin CcTx from Conus consors		Description: NMR structure of the glycosylated conotoxin CcTx from Conus consors

OCA at 06:38, 25 July 2012

2012-07-25T06:38:38Z

←Older revision		Revision as of 06:38, 25 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b1q is ON HOLD ~~until sometime in the future~~	+	The entry 4b1q is ON HOLD

	Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R.		Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R.

	Description: NMR structure of the glycosylated conotoxin CcTx from Conus consors		Description: NMR structure of the glycosylated conotoxin CcTx from Conus consors

OCA: Protected "4b1q" [edit=sysop:move=sysop]

2012-07-18T04:55:05Z

Protected "4b1q" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 18 July 2012

OCA: New page: '''Unreleased structure''' The entry 4b1q is ON HOLD until sometime in the future Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R. Descript...

2012-07-18T04:55:04Z

New page: '''Unreleased structure''' The entry 4b1q is ON HOLD until sometime in the future Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R. Descript...

New page

'''Unreleased structure'''

The entry 4b1q is ON HOLD until sometime in the future

Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R.

Description: NMR structure of the glycosylated conotoxin CcTx from Conus consors