4b21 - Revision history

OCA at 10:55, 9 May 2024

2024-05-09T10:55:55Z

←Older revision		Revision as of 10:55, 9 May 2024
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	<StructureSection load='4b21' size='340' side='right'caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4b21' size='340' side='right'caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B21 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BGC:BETA~~-~~D-GLUCOSE'>BGC</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[4b22\|4b22]], [[4b23\|4b23]], [[4b24\|4b24]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b21 OCA], [https://pdbe.org/4b21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b21 RCSB], [https://www.ebi.ac.uk/pdbsum/4b21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b21 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b21 OCA], [https://pdbe.org/4b21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b21 RCSB], [https://www.ebi.ac.uk/pdbsum/4b21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b21 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO]] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>	+	[https://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: DNA-3-methyladenine glycosylase II]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alseth, I]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: Bjoras, M]]	+	[[Category: Synthetic construct]]
-	[[Category: Dalhus, B]]	+	[[Category: Alseth I]]
-	[[Category: Forstrom~~, R J~~]]	+	[[Category: Bjoras M]]
-	[[Category: Huffman, J]]	+	[[Category: Dalhus B]]
-	[[Category: Korvald, H]]	+	[[Category: Forstrom RJ]]
-	[[Category: McMurray~~, C T~~]]	+	[[Category: Huffman J]]
-	[[Category: Nilsen, L]]	+	[[Category: Korvald H]]
-	[[Category: Tainer~~, J A]]~~	+	[[Category: McMurray CT]]
-	~~[[Category: Helix-hairpin-helix]]~~	+	[[Category: Nilsen L]]
-	~~[[Category: Hydrolase-dna complex~~]]	+	[[Category: Tainer JA]]

OCA at 06:57, 31 August 2022

2022-08-31T06:57:08Z

←Older revision		Revision as of 06:57, 31 August 2022
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	<StructureSection load='4b21' size='340' side='right'caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4b21' size='340' side='right'caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B21 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b22\|4b22]], [[4b23\|4b23]], [[4b24\|4b24]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b22\|4b22]], [[4b23\|4b23]], [[4b24\|4b24]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b21 OCA], [~~http~~://pdbe.org/4b21 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b21 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b21 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b21 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b21 OCA], [https://pdbe.org/4b21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b21 RCSB], [https://www.ebi.ac.uk/pdbsum/4b21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b21 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO]] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>	+	[[https://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO]] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 356]]
	[[Category: DNA-3-methyladenine glycosylase II]]		[[Category: DNA-3-methyladenine glycosylase II]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 13:09, 13 March 2019

2019-03-13T13:09:39Z

←Older revision		Revision as of 13:09, 13 March 2019
Line 1:		Line 1:

	==Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2==		==Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2==
-	<StructureSection load='4b21' size='340' side='right' caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='4b21' size='340' side='right'caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B21 FirstGlance]. <br>
Line 27:		Line 27:
	[[Category: Cbs 356]]		[[Category: Cbs 356]]
	[[Category: DNA-3-methyladenine glycosylase II]]		[[Category: DNA-3-methyladenine glycosylase II]]
		+	[[Category: Large Structures]]
	[[Category: Alseth, I]]		[[Category: Alseth, I]]
	[[Category: Bjoras, M]]		[[Category: Bjoras, M]]
Line 33:		Line 34:
	[[Category: Huffman, J]]		[[Category: Huffman, J]]
	[[Category: Korvald, H]]		[[Category: Korvald, H]]
-	[[Category: ~~Mcmurray~~, C T]]	+	[[Category: McMurray, C T]]
	[[Category: Nilsen, L]]		[[Category: Nilsen, L]]
	[[Category: Tainer, J A]]		[[Category: Tainer, J A]]
	[[Category: Helix-hairpin-helix]]		[[Category: Helix-hairpin-helix]]
	[[Category: Hydrolase-dna complex]]		[[Category: Hydrolase-dna complex]]

OCA at 02:45, 11 December 2016

2016-12-11T02:45:31Z

←Older revision		Revision as of 02:45, 11 December 2016
Line 1:		Line 1:
		+
	==Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2==		==Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2==
	<StructureSection load='4b21' size='340' side='right' caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4b21' size='340' side='right' caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B21 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b22\|4b22]], [[4b23\|4b23]], [[4b24\|4b24]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b22\|4b22]], [[4b23\|4b23]], [[4b24\|4b24]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b21 RCSB], [http://www.ebi.ac.uk/pdbsum/4b21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b21 OCA], [http://pdbe.org/4b21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b21 RCSB], [http://www.ebi.ac.uk/pdbsum/4b21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b21 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MAG2_SCHPO MAG2_SCHPO]] Invlved in base excision repair of methyl methanesulfonate-damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.<ref>PMID:18270439</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b21" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 356]]
	[[Category: DNA-3-methyladenine glycosylase II]]		[[Category: DNA-3-methyladenine glycosylase II]]
-	[[Category: Schizosaccharomyces pombe]]
	[[Category: Alseth, I]]		[[Category: Alseth, I]]
	[[Category: Bjoras, M]]		[[Category: Bjoras, M]]

OCA at 14:49, 9 December 2014

2014-12-09T14:49:49Z

←Older revision		Revision as of 14:49, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4b21.~~png~~\|~~left~~\|~~200px~~]]	+	==Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2==
		+	<StructureSection load='4b21' size='340' side='right' caption='[[4b21]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b21]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B21 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b22\|4b22]], [[4b23\|4b23]], [[4b24\|4b24]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b21 RCSB], [http://www.ebi.ac.uk/pdbsum/4b21 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Modifications and loss of bases are frequent types of DNA lesions, often handled by the base excision repair (BER) pathway. BER is initiated by DNA glycosylases, generating abasic (AP) sites that are subsequently cleaved by AP endonucleases, which further pass on nicked DNA to downstream DNA polymerases and ligases. The coordinated handover of cytotoxic intermediates between different BER enzymes is most likely facilitated by the DNA conformation. Here, we present the atomic structure of Schizosaccharomyces pombe Mag2 in complex with DNA to reveal an unexpected structural basis for nonenzymatic AP site recognition with an unflipped AP site. Two surface-exposed loops intercalate and widen the DNA minor groove to generate a DNA conformation previously only found in the mismatch repair MutS-DNA complex. Consequently, the molecular role of Mag2 appears to be AP site recognition and protection, while possibly facilitating damage signaling by structurally sculpting the DNA substrate.

-	~~{{STRUCTURE_4b21\| PDB=4b21 \| SCENE= }}~~	+	Sculpting of DNA at Abasic Sites by DNA Glycosylase Homolog Mag2.,Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrom RJ, McMurray CT, Alseth I, Tainer JA, Bjoras M Structure. 2012 Dec 11. pii: S0969-2126(12)00419-4. doi:, 10.1016/j.str.2012.11.004. PMID:23245849<ref>PMID:23245849</ref>

-	~~===Unprecedented sculpting~~ of ~~DNA at abasic sites by DNA glycosylase homolog Mag2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23245849}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4b21]] is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA].~~	+	</StructureSection>
	[[Category: DNA-3-methyladenine glycosylase II]]		[[Category: DNA-3-methyladenine glycosylase II]]
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Alseth, I.]]	+	[[Category: Alseth, I]]
-	[[Category: Bjoras, M.]]	+	[[Category: Bjoras, M]]
-	[[Category: Dalhus, B.]]	+	[[Category: Dalhus, B]]
-	[[Category: Forstrom, R J.]]	+	[[Category: Forstrom, R J]]
-	[[Category: Huffman, J.]]	+	[[Category: Huffman, J]]
-	[[Category: Korvald, H.]]	+	[[Category: Korvald, H]]
-	[[Category: Mcmurray, C T.]]	+	[[Category: Mcmurray, C T]]
-	[[Category: Nilsen, L.]]	+	[[Category: Nilsen, L]]
-	[[Category: Tainer, J A.]]	+	[[Category: Tainer, J A]]
	[[Category: Helix-hairpin-helix]]		[[Category: Helix-hairpin-helix]]
	[[Category: Hydrolase-dna complex]]		[[Category: Hydrolase-dna complex]]

OCA at 12:48, 30 January 2013

2013-01-30T12:48:55Z

←Older revision		Revision as of 12:48, 30 January 2013
Line 1:		Line 1:
-	[[Image:4b21.~~jpg~~\|left\|200px]]	+	[[Image:4b21.png\|left\|200px]]

	{{STRUCTURE_4b21\| PDB=4b21 \| SCENE= }}		{{STRUCTURE_4b21\| PDB=4b21 \| SCENE= }}

OCA at 08:17, 9 January 2013

2013-01-09T08:17:53Z

←Older revision		Revision as of 08:17, 9 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4b21.jpg\|left\|200px]]

-	~~The entry~~ 4b21 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4b21\| PDB=4b21 \| SCENE= }}

-	~~Authors: Dalhus, B., Nilsen, L., Korvald, H., Huffman, J., Forstrom, R.J., McMurray, C.T., Alseth, I., Tainer, J.A., Bjoras, M.~~	+	===Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2===

-	~~Description~~: ~~Unprecedented sculpting of DNA at abasic sites by~~ DNA glycosylase ~~homolog Mag2~~	+	{{ABSTRACT_PUBMED_23245849}}
		+
		+	==About this Structure==
		+	[[4b21]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B21 OCA].
		+	[[Category: DNA-3-methyladenine glycosylase II]]
		+	[[Category: Schizosaccharomyces pombe]]
		+	[[Category: Alseth, I.]]
		+	[[Category: Bjoras, M.]]
		+	[[Category: Dalhus, B.]]
		+	[[Category: Forstrom, R J.]]
		+	[[Category: Huffman, J.]]
		+	[[Category: Korvald, H.]]
		+	[[Category: Mcmurray, C T.]]
		+	[[Category: Nilsen, L.]]
		+	[[Category: Tainer, J A.]]
		+	[[Category: Helix-hairpin-helix]]
		+	[[Category: Hydrolase-dna complex]]

OCA at 06:06, 14 November 2012

2012-11-14T06:06:48Z

←Older revision		Revision as of 06:06, 14 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b21 is ON HOLD	+	The entry 4b21 is ON HOLD until Paper Publication

	Authors: Dalhus, B., Nilsen, L., Korvald, H., Huffman, J., Forstrom, R.J., McMurray, C.T., Alseth, I., Tainer, J.A., Bjoras, M.		Authors: Dalhus, B., Nilsen, L., Korvald, H., Huffman, J., Forstrom, R.J., McMurray, C.T., Alseth, I., Tainer, J.A., Bjoras, M.

-	Description: Unprecedented ~~shaping~~ of abasic sites by DNA glycosylase homolog Mag2 ~~from Schizosaccharomyces pombe~~	+	Description: Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2

OCA at 06:38, 25 July 2012

2012-07-25T06:38:45Z

←Older revision		Revision as of 06:38, 25 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b21 is ON HOLD ~~until sometime in the future~~	+	The entry 4b21 is ON HOLD

	Authors: Dalhus, B., Nilsen, L., Korvald, H., Huffman, J., Forstrom, R.J., McMurray, C.T., Alseth, I., Tainer, J.A., Bjoras, M.		Authors: Dalhus, B., Nilsen, L., Korvald, H., Huffman, J., Forstrom, R.J., McMurray, C.T., Alseth, I., Tainer, J.A., Bjoras, M.

	Description: Unprecedented shaping of abasic sites by DNA glycosylase homolog Mag2 from Schizosaccharomyces pombe		Description: Unprecedented shaping of abasic sites by DNA glycosylase homolog Mag2 from Schizosaccharomyces pombe

OCA: Protected "4b21" [edit=sysop:move=sysop]

2012-07-18T04:55:24Z

Protected "4b21" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 18 July 2012