4b2d - Revision history

OCA at 11:41, 20 December 2023

2023-12-20T11:41:33Z

←Older revision		Revision as of 11:41, 20 December 2023
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	<StructureSection load='4b2d' size='340' side='right'caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4b2d' size='340' side='right'caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2D FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FBP:BETA~~-~~FRUCTOSE-1~~,~~6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1t5a\|1t5a]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2d OCA], [https://pdbe.org/4b2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2d RCSB], [https://www.ebi.ac.uk/pdbsum/4b2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2d OCA], [https://pdbe.org/4b2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2d RCSB], [https://www.ebi.ac.uk/pdbsum/4b2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN]] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>	+	[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pyruvate kinase]]~~	+	[[Category: Chaneton B]]
-	[[Category: Chaneton, B]]	+	[[Category: Chokkathukalam A]]
-	[[Category: Chokkathukalam, A]]	+	[[Category: Coyle JE]]
-	[[Category: Coyle~~, J E~~]]	+	[[Category: Frezza C]]
-	[[Category: Frezza, C]]	+	[[Category: Gottlieb E]]
-	[[Category: Gottlieb, E]]	+	[[Category: Hillmann P]]
-	[[Category: Hillmann, P]]	+	[[Category: Holding FP]]
-	[[Category: Holding~~, F P~~]]	+	[[Category: Jankevics A]]
-	[[Category: Jankevics, A]]	+	[[Category: Maddocks ODK]]
-	[[Category: Maddocks~~, O D.K~~]]	+	[[Category: Martin ACL]]
-	[[Category: Martin~~, A C.L~~]]	+	[[Category: O'Reilly M]]
-	[[Category: Reilly, M O]]	+	[[Category: Vousden KH]]
-	[[Category: Vousden~~, K H~~]]	+	[[Category: Zheng L]]
-	[[Category: Zheng, L]]	+
-	~~[[Category: Glycolysis]]~~	+
-	~~[[Category: Pkm2]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Tumour~~]]	+

OCA at 06:57, 31 August 2022

2022-08-31T06:57:27Z

←Older revision		Revision as of 06:57, 31 August 2022
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	<StructureSection load='4b2d' size='340' side='right'caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4b2d' size='340' side='right'caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B2D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5a\|1t5a]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t5a\|1t5a]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2d OCA], [~~http~~://pdbe.org/4b2d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b2d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b2d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2d OCA], [https://pdbe.org/4b2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2d RCSB], [https://www.ebi.ac.uk/pdbsum/4b2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN]] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>	+	[[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN]] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Pyruvate kinase]]		[[Category: Pyruvate kinase]]

OCA at 16:36, 29 January 2020

2020-01-29T16:36:11Z

←Older revision		Revision as of 16:36, 29 January 2020
Line 1:		Line 1:

	==human PKM2 with L-serine and FBP bound.==		==human PKM2 with L-serine and FBP bound.==
-	<StructureSection load='4b2d' size='340' side='right' caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4b2d' size='340' side='right'caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2D FirstGlance]. <br>
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Pyruvate ~~Kinase~~\|Pyruvate ~~Kinase~~]]	+	*[[Pyruvate kinase 3D structures\|Pyruvate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Pyruvate kinase]]		[[Category: Pyruvate kinase]]
	[[Category: Chaneton, B]]		[[Category: Chaneton, B]]

OCA at 06:34, 7 February 2018

2018-02-07T06:34:14Z

←Older revision		Revision as of 06:34, 7 February 2018
Line 39:		Line 39:
	[[Category: Maddocks, O D.K]]		[[Category: Maddocks, O D.K]]
	[[Category: Martin, A C.L]]		[[Category: Martin, A C.L]]
-	[[Category: ~~OReilly~~, M]]	+	[[Category: Reilly, M O]]
	[[Category: Vousden, K H]]		[[Category: Vousden, K H]]
	[[Category: Zheng, L]]		[[Category: Zheng, L]]

OCA at 07:58, 5 August 2016

2016-08-05T07:58:27Z

←Older revision		Revision as of 07:58, 5 August 2016
Line 1:		Line 1:
		+
	==human PKM2 with L-serine and FBP bound.==		==human PKM2 with L-serine and FBP bound.==
	<StructureSection load='4b2d' size='340' side='right' caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4b2d' size='340' side='right' caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5a\|1t5a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5a\|1t5a]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b2d RCSB], [http://www.ebi.ac.uk/pdbsum/4b2d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2d OCA], [http://pdbe.org/4b2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b2d RCSB], [http://www.ebi.ac.uk/pdbsum/4b2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b2d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Pyruvate kinase]]		[[Category: Pyruvate kinase]]
	[[Category: Chaneton, B]]		[[Category: Chaneton, B]]

OCA at 00:29, 25 December 2014

2014-12-25T00:29:43Z

←Older revision		Revision as of 00:29, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4b2d.~~png~~\|~~left~~\|~~200px~~]]	+	==human PKM2 with L-serine and FBP bound.==
		+	<StructureSection load='4b2d' size='340' side='right' caption='[[4b2d]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2D FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t5a\|1t5a]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b2d RCSB], [http://www.ebi.ac.uk/pdbsum/4b2d PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN]] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and proliferation. Specifically, they overexpress the M2 isoform of the tightly regulated enzyme pyruvate kinase (PKM2), which controls glycolytic flux, and are highly dependent on de novo biosynthesis of serine and glycine. Here we describe a new rheostat-like mechanistic relationship between PKM2 activity and serine biosynthesis. We show that serine can bind to and activate human PKM2, and that PKM2 activity in cells is reduced in response to serine deprivation. This reduction in PKM2 activity shifts cells to a fuel-efficient mode in which more pyruvate is diverted to the mitochondria and more glucose-derived carbon is channelled into serine biosynthesis to support cell proliferation.

-	~~{{STRUCTURE_4b2d\| PDB=4b2d \| SCENE= }}~~	+	Serine is a natural ligand and allosteric activator of pyruvate kinase M2.,Chaneton B, Hillmann P, Zheng L, Martin AC, Maddocks OD, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O'Reilly M, Gottlieb E Nature. 2012 Oct 14. doi: 10.1038/nature11540. PMID:23064226<ref>PMID:23064226</ref>

-	~~===human PKM2 with L-serine and FBP bound~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23064226}}~~	+	==See Also==
-		+	*[[Pyruvate Kinase\|Pyruvate Kinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4b2d~~]] ~~is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pyruvate kinase]]		[[Category: Pyruvate kinase]]
-	[[Category: Chaneton, B.]]	+	[[Category: Chaneton, B]]
-	[[Category: Chokkathukalam, A.]]	+	[[Category: Chokkathukalam, A]]
-	[[Category: Coyle, J E.]]	+	[[Category: Coyle, J E]]
-	[[Category: Frezza, C.]]	+	[[Category: Frezza, C]]
-	[[Category: Gottlieb, E.]]	+	[[Category: Gottlieb, E]]
-	[[Category: Hillmann, P.]]	+	[[Category: Hillmann, P]]
-	[[Category: Holding, F P.]]	+	[[Category: Holding, F P]]
-	[[Category: Jankevics, A.]]	+	[[Category: Jankevics, A]]
-	[[Category: Maddocks, O D.K.]]	+	[[Category: Maddocks, O D.K]]
-	[[Category: Martin, A C.L.]]	+	[[Category: Martin, A C.L]]
-	[[Category: OReilly, M.]]	+	[[Category: OReilly, M]]
-	[[Category: Vousden, K H.]]	+	[[Category: Vousden, K H]]
-	[[Category: Zheng, L.]]	+	[[Category: Zheng, L]]
	[[Category: Glycolysis]]		[[Category: Glycolysis]]
	[[Category: Pkm2]]		[[Category: Pkm2]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tumour]]		[[Category: Tumour]]

OCA at 13:11, 6 February 2013

2013-02-06T13:11:44Z

←Older revision		Revision as of 13:11, 6 February 2013
Line 21:		Line 21:
	[[Category: Maddocks, O D.K.]]		[[Category: Maddocks, O D.K.]]
	[[Category: Martin, A C.L.]]		[[Category: Martin, A C.L.]]
-	[[Category: ~~Oreilly~~, M.]]	+	[[Category: OReilly, M.]]
	[[Category: Vousden, K H.]]		[[Category: Vousden, K H.]]
	[[Category: Zheng, L.]]		[[Category: Zheng, L.]]

OCA at 06:23, 24 October 2012

2012-10-24T06:23:57Z

←Older revision		Revision as of 06:23, 24 October 2012
Line 1:		Line 1:
-	[[Image:4b2d.~~jpg~~\|left\|200px]]	+	[[Image:4b2d.png\|left\|200px]]

	{{STRUCTURE_4b2d\| PDB=4b2d \| SCENE= }}		{{STRUCTURE_4b2d\| PDB=4b2d \| SCENE= }}
Line 5:		Line 5:
	===human PKM2 with L-serine and FBP bound.===		===human PKM2 with L-serine and FBP bound.===

		+	{{ABSTRACT_PUBMED_23064226}}

	==About this Structure==		==About this Structure==
-	[[4b2d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA].	+	[[4b2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA].
		+	[[Category: Homo sapiens]]
	[[Category: Pyruvate kinase]]		[[Category: Pyruvate kinase]]
	[[Category: Chaneton, B.]]		[[Category: Chaneton, B.]]

OCA at 07:26, 10 October 2012

2012-10-10T07:26:16Z

←Older revision		Revision as of 07:26, 10 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4b2d.jpg\|left\|200px]]

-	~~The entry~~ 4b2d ~~is ON HOLD~~	+	{{STRUCTURE_4b2d\| PDB=4b2d \| SCENE= }}

-	~~Authors: Chaneton, B., Hillmann, P., Zheng,~~ L.~~, Martin, A.C.L., Maddocks, O.D.K., Chokkathukalam, A., Coyle, J.E., Jankevics, A., Holding, F.P., Vousden, K.H., Frezza, C., OReilly, M., Gottlieb, E.~~	+	===human PKM2 with L-serine and FBP bound.===

-	~~Description~~: ~~human PKM2 with L~~-~~serine and FBP bound~~.	+
		+	==About this Structure==
		+	[[4b2d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2D OCA].
		+	[[Category: Pyruvate kinase]]
		+	[[Category: Chaneton, B.]]
		+	[[Category: Chokkathukalam, A.]]
		+	[[Category: Coyle, J E.]]
		+	[[Category: Frezza, C.]]
		+	[[Category: Gottlieb, E.]]
		+	[[Category: Hillmann, P.]]
		+	[[Category: Holding, F P.]]
		+	[[Category: Jankevics, A.]]
		+	[[Category: Maddocks, O D.K.]]
		+	[[Category: Martin, A C.L.]]
		+	[[Category: Oreilly, M.]]
		+	[[Category: Vousden, K H.]]
		+	[[Category: Zheng, L.]]
		+	[[Category: Glycolysis]]
		+	[[Category: Pkm2]]
		+	[[Category: Transferase]]
		+	[[Category: Tumour]]

OCA: Protected "4b2d" [edit=sysop:move=sysop]

2012-07-25T06:39:00Z

Protected "4b2d" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:39, 25 July 2012