4b8t - Revision history

OCA at 07:03, 31 August 2022

2022-08-31T07:03:50Z

←Older revision		Revision as of 07:03, 31 August 2022
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	<StructureSection load='4b8t' size='340' side='right'caption='[[4b8t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4b8t' size='340' side='right'caption='[[4b8t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B8T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B8T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8t OCA], [~~http~~://pdbe.org/4b8t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b8t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b8t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8t ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8t OCA], [https://pdbe.org/4b8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b8t RCSB], [https://www.ebi.ac.uk/pdbsum/4b8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FUBP2_HUMAN FUBP2_HUMAN]] Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.<ref>PMID:9136930</ref> <ref>PMID:8940189</ref> <ref>PMID:11003644</ref>	+	[[https://www.uniprot.org/uniprot/FUBP2_HUMAN FUBP2_HUMAN]] Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.<ref>PMID:9136930</ref> <ref>PMID:8940189</ref> <ref>PMID:11003644</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:06, 13 March 2019

2019-03-13T13:06:55Z

←Older revision		Revision as of 13:06, 13 March 2019
Line 1:		Line 1:

	==RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.==		==RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.==
-	<StructureSection load='4b8t' size='340' side='right' caption='[[4b8t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='4b8t' size='340' side='right'caption='[[4b8t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8T FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8T FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Briata, P]]		[[Category: Briata, P]]
	[[Category: Garcia-Mayoral, M F]]		[[Category: Garcia-Mayoral, M F]]

OCA at 15:52, 5 August 2016

2016-08-05T15:52:36Z

←Older revision		Revision as of 15:52, 5 August 2016
Line 1:		Line 1:
		+
	==RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.==		==RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.==
	<StructureSection load='4b8t' size='340' side='right' caption='[[4b8t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4b8t' size='340' side='right' caption='[[4b8t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b8t RCSB], [http://www.ebi.ac.uk/pdbsum/4b8t PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8t OCA], [http://pdbe.org/4b8t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b8t RCSB], [http://www.ebi.ac.uk/pdbsum/4b8t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b8t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Briata, P]]		[[Category: Briata, P]]
	[[Category: Garcia-Mayoral, M F]]		[[Category: Garcia-Mayoral, M F]]

OCA at 03:45, 25 December 2014

2014-12-25T03:45:27Z

←Older revision		Revision as of 03:45, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b8t RCSB], [http://www.ebi.ac.uk/pdbsum/4b8t PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b8t RCSB], [http://www.ebi.ac.uk/pdbsum/4b8t PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FUBP2_HUMAN FUBP2_HUMAN]] Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.<ref>PMID:9136930</ref> <ref>PMID:8940189</ref> <ref>PMID:11003644</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:40, 9 December 2014

2014-12-09T14:40:30Z

←Older revision		Revision as of 14:40, 9 December 2014
Line 1:		Line 1:
-	[[~~Image~~:4b8t.~~png\|left\|200px~~]]	+	==RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.==
		+	<StructureSection load='4b8t' size='340' side='right' caption='[[4b8t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8T FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b8t RCSB], [http://www.ebi.ac.uk/pdbsum/4b8t PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Let-7 is an important tumor-suppressive microRNA (miRNA) that acts as an on-off switch for cellular differentiation and regulates the expression of a set of human oncogenes. Binding of the human KSRP protein to let-7 miRNA precursors positively regulates their processing to mature let-7, thereby contributing to control of cell proliferation, apoptosis and differentiation. Here we analyze the molecular basis for KSRP-let-7 precursor selectivity and show how the third KH domain of the protein recognizes a G-rich sequence in the pre-let-7 terminal loop and dominates the interaction. The structure of the KH3-RNA complex explains the protein recognition of this noncanonical KH target sequence, and we demonstrate that the specificity of this binding is crucial for the functional interaction between the protein and the miRNA precursor.

-	~~{{STRUCTURE_4b8t\| PDB=4b8t \| SCENE= }}~~	+	Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis.,Nicastro G, Garcia-Mayoral MF, Hollingworth D, Kelly G, Martin SR, Briata P, Gherzi R, Ramos A Nat Struct Mol Biol. 2012 Nov 11. doi: 10.1038/nsmb.2427. PMID:23142982<ref>PMID:23142982</ref>

-	~~===RNA BINDING PROTEIN Solution structure~~ of the ~~third KH domain~~ of ~~KSRP in complex with the G-rich target sequence~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23142982}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4b8t]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017437720<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Briata, P.]]	+	[[Category: Briata, P]]
-	[[Category: Garcia-Mayoral, M F.]]	+	[[Category: Garcia-Mayoral, M F]]
-	[[Category: Gherzi, R.]]	+	[[Category: Gherzi, R]]
-	[[Category: Hollingworth, D.]]	+	[[Category: Hollingworth, D]]
-	[[Category: Kelly, G.]]	+	[[Category: Kelly, G]]
-	[[Category: Martin, S R.]]	+	[[Category: Martin, S R]]
-	[[Category: Nicastro, G.]]	+	[[Category: Nicastro, G]]
-	[[Category: Ramos, A.]]	+	[[Category: Ramos, A]]
	[[Category: Transcription-rna complex]]		[[Category: Transcription-rna complex]]

OCA at 14:44, 28 November 2012

2012-11-28T14:44:35Z

←Older revision		Revision as of 14:44, 28 November 2012
Line 21:		Line 21:
	[[Category: Nicastro, G.]]		[[Category: Nicastro, G.]]
	[[Category: Ramos, A.]]		[[Category: Ramos, A.]]
-	[[Category: ~~Protein~~-rna complex]]	+	[[Category: Transcription-rna complex]]

OCA at 09:37, 21 November 2012

2012-11-21T09:37:35Z

←Older revision		Revision as of 09:37, 21 November 2012
Line 1:		Line 1:
-	[[Image:4b8t.~~jpg~~\|left\|200px]]	+	[[Image:4b8t.png\|left\|200px]]

	{{STRUCTURE_4b8t\| PDB=4b8t \| SCENE= }}		{{STRUCTURE_4b8t\| PDB=4b8t \| SCENE= }}
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	===RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.===		===RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.===

		+	{{ABSTRACT_PUBMED_23142982}}

	==About this Structure==		==About this Structure==

OCA at 14:01, 8 November 2012

2012-11-08T14:01:13Z

←Older revision		Revision as of 14:01, 8 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4b8t.jpg\|left\|200px]]

-	~~The entry~~ 4b8t ~~is ON HOLD~~	+	{{STRUCTURE_4b8t\| PDB=4b8t \| SCENE= }}

-	~~Authors: Nicastro,~~ G~~., Garcia~~-~~Mayoral, M.F., Hollingworth, D., Kelly, G., Martin, S.R., Briata, P., Gherzi, R., Ramos, A~~.	+	===RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.===

-	~~Description: RNA BINDING PROTEIN Solution~~ structure ~~of the third KH domain of KSRP in complex~~ with ~~the G-rich target~~ sequence.	+
		+	==About this Structure==
		+	[[4b8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:017437720</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Briata, P.]]
		+	[[Category: Garcia-Mayoral, M F.]]
		+	[[Category: Gherzi, R.]]
		+	[[Category: Hollingworth, D.]]
		+	[[Category: Kelly, G.]]
		+	[[Category: Martin, S R.]]
		+	[[Category: Nicastro, G.]]
		+	[[Category: Ramos, A.]]
		+	[[Category: Protein-rna complex]]

OCA at 04:42, 12 September 2012

2012-09-12T04:42:18Z

←Older revision		Revision as of 04:42, 12 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b8t is ON HOLD ~~until sometime in the future~~	+	The entry 4b8t is ON HOLD

	Authors: Nicastro, G., Garcia-Mayoral, M.F., Hollingworth, D., Kelly, G., Martin, S.R., Briata, P., Gherzi, R., Ramos, A.		Authors: Nicastro, G., Garcia-Mayoral, M.F., Hollingworth, D., Kelly, G., Martin, S.R., Briata, P., Gherzi, R., Ramos, A.

	Description: RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.		Description: RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.

OCA: Protected "4b8t" [edit=sysop:move=sysop]

2012-09-05T04:44:54Z

Protected "4b8t" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:44, 5 September 2012