4bbg - Revision history

OCA at 11:47, 20 December 2023

2023-12-20T11:47:17Z

←Older revision		Revision as of 11:47, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4bbg' size='340' side='right'caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='4bbg' size='340' side='right'caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BBG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=V02:3-[(R)-2-AZANYLETHYLSULFANYL-(3-ETHYLPHENYL)-PHENYL-METHYL]PHENOL'>V02</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6\|1ii6]], [[1q0b\|1q0b]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqv\|4aqv]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4b7b\|4b7b]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=V02:3-[(R)-2-AZANYLETHYLSULFANYL-(3-ETHYLPHENYL)-PHENYL-METHYL]PHENOL'>V02</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbg OCA], [https://pdbe.org/4bbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bbg RCSB], [https://www.ebi.ac.uk/pdbsum/4bbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbg OCA], [https://pdbe.org/4bbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bbg RCSB], [https://www.ebi.ac.uk/pdbsum/4bbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>	+	[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>	+	[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kaan~~, H Y.K~~]]	+	[[Category: Kaan HYK]]
-	[[Category: Kozielski, F]]	+	[[Category: Kozielski F]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Mitosis~~]]	+

OCA at 07:06, 31 August 2022

2022-08-31T07:06:50Z

←Older revision		Revision as of 07:06, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4bbg' size='340' side='right'caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='4bbg' size='340' side='right'caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BBG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=V02:3-[(R)-2-AZANYLETHYLSULFANYL-(3-ETHYLPHENYL)-PHENYL-METHYL]PHENOL'>V02</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=V02:3-[(R)-2-AZANYLETHYLSULFANYL-(3-ETHYLPHENYL)-PHENYL-METHYL]PHENOL'>V02</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1q0b\|1q0b]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqv\|4aqv]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4b7b\|4b7b]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6\|1ii6]], [[1q0b\|1q0b]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqv\|4aqv]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4b7b\|4b7b]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbg OCA], [~~http~~://pdbe.org/4bbg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bbg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bbg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbg OCA], [https://pdbe.org/4bbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bbg RCSB], [https://www.ebi.ac.uk/pdbsum/4bbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[~~http~~://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>	+	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>	+	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Kinesin\|Kinesin]]	+	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:09, 13 March 2019

2019-03-13T13:09:35Z

←Older revision		Revision as of 13:09, 13 March 2019
Line 1:		Line 1:

	==Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol==		==Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol==
-	<StructureSection load='4bbg' size='340' side='right' caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='4bbg' size='340' side='right'caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BBG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BBG FirstGlance]. <br>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kaan, H Y.K]]		[[Category: Kaan, H Y.K]]
	[[Category: Kozielski, F]]		[[Category: Kozielski, F]]

OCA at 21:15, 5 August 2016

2016-08-05T21:15:01Z

←Older revision		Revision as of 21:15, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol==		==Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol==
	<StructureSection load='4bbg' size='340' side='right' caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='4bbg' size='340' side='right' caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BBG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=V02:3-[(R)-2-AZANYLETHYLSULFANYL-(3-ETHYLPHENYL)-PHENYL-METHYL]PHENOL'>V02</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=V02:3-[(R)-2-AZANYLETHYLSULFANYL-(3-ETHYLPHENYL)-PHENYL-METHYL]PHENOL'>V02</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1q0b\|1q0b]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqv\|4aqv]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4b7b\|4b7b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1q0b\|1q0b]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqv\|4aqv]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4b7b\|4b7b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bbg RCSB], [http://www.ebi.ac.uk/pdbsum/4bbg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbg OCA], [http://pdbe.org/4bbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bbg RCSB], [http://www.ebi.ac.uk/pdbsum/4bbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bbg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kaan, H Y.K]]		[[Category: Kaan, H Y.K]]
	[[Category: Kozielski, F]]		[[Category: Kozielski, F]]

OCA at 09:05, 21 December 2014

2014-12-21T09:05:30Z

←Older revision		Revision as of 09:05, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bbg\| PDB=4bbg \| SCENE= }}~~	+	==Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol==
-	===Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol===	+	<StructureSection load='4bbg' size='340' side='right' caption='[[4bbg]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23394180}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4bbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BBG FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=V02:3-[(R)-2-AZANYLETHYLSULFANYL-(3-ETHYLPHENYL)-PHENYL-METHYL]PHENOL'>V02</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[1q0b\|1q0b]], [[1x88\|1x88]], [[1yrs\|1yrs]], [[2fky\|2fky]], [[2fl2\|2fl2]], [[2fl6\|2fl6]], [[2g1q\|2g1q]], [[2gm1\|2gm1]], [[2uyi\|2uyi]], [[2uym\|2uym]], [[2wog\|2wog]], [[2x2r\|2x2r]], [[2x7c\|2x7c]], [[2x7d\|2x7d]], [[2x7e\|2x7e]], [[2xae\|2xae]], [[4a1z\|4a1z]], [[4a28\|4a28]], [[4a50\|4a50]], [[4a51\|4a51]], [[4a5y\|4a5y]], [[4ap0\|4ap0]], [[4aqv\|4aqv]], [[4aqw\|4aqw]], [[4as7\|4as7]], [[4b7b\|4b7b]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bbg RCSB], [http://www.ebi.ac.uk/pdbsum/4bbg PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>		[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like properties, but moderate in vivo activity. We report here their further optimization to produce extremely potent inhibitors of Eg5 (K(i)(app) < 10 nM) with broad-spectrum activity against cancer cell lines comparable to the Phase II drug candidates ispinesib and SB-743921. They have good oral bioavailability and pharmacokinetics and induced complete tumor regression in nude mice explanted with lung cancer patient xenografts. Furthermore, they display fewer liabilities with CYP-metabolizing enzymes and hERG compared with ispinesib and SB-743921, which is important given the likely application of Eg5 inhibitors in combination therapies. We present the case for this preclinical series to be investigated in single and combination chemotherapies, especially targeting hematological malignancies.

-	~~==Function==~~	+	Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.,Good JA, Wang F, Rath O, Kaan HY, Talapatra SK, Podgorski D, MacKay SP, Kozielski F J Med Chem. 2013 Mar 14;56(5):1878-93. doi: 10.1021/jm3014597. Epub 2013 Feb 27. PMID:23394180<ref>PMID:23394180</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle~~. ~~Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays~~.<ref>PMID:~~19001501~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4bbg]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	<references ~~group="xtra"~~/><~~references~~/>	+	*[[Kinesin\|Kinesin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kaan, H Y.K.]]	+	[[Category: Kaan, H Y.K]]
-	[[Category: Kozielski, F.]]	+	[[Category: Kozielski, F]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Mitosis]]		[[Category: Mitosis]]

OCA at 07:20, 16 May 2013

2013-05-16T07:20:10Z

←Older revision		Revision as of 07:20, 16 May 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4bbg\| PDB=4bbg \| SCENE= }}
		+	===Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol===
		+	{{ABSTRACT_PUBMED_23394180}}

-	~~The~~ entry ~~4bbg~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>

-	~~Authors~~: ~~Kaan, H~~.Y.K.~~, Kozielski, F~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>

-	~~Description~~: ~~Eg5~~-~~inhibitor complex~~	+	==About this Structure==
		+	[[4bbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBG OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Kaan, H Y.K.]]
		+	[[Category: Kozielski, F.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Inhibitor]]
		+	[[Category: Mitosis]]

OCA: Protected "4bbg" [edit=sysop:move=sysop]

2012-10-03T05:36:29Z

Protected "4bbg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 3 October 2012

OCA: New page: '''Unreleased structure''' The entry 4bbg is ON HOLD until Paper Publication Authors: Kaan, H.Y.K., Kozielski, F. Description: Eg5-inhibitor complex

2012-10-03T05:36:28Z

New page: '''Unreleased structure''' The entry 4bbg is ON HOLD until Paper Publication Authors: Kaan, H.Y.K., Kozielski, F. Description: Eg5-inhibitor complex

New page

'''Unreleased structure'''

The entry 4bbg is ON HOLD until Paper Publication

Authors: Kaan, H.Y.K., Kozielski, F.

Description: Eg5-inhibitor complex