4bhc - Revision history

OCA at 11:00, 9 May 2024

2024-05-09T11:00:03Z

←Older revision		Revision as of 11:00, 9 May 2024
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	<StructureSection load='4bhc' size='340' side='right'caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4bhc' size='340' side='right'caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHC FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[4bhb\|4bhb]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methylated-DNA-~~-[~~protein]-cysteine_S-methyltransferase Methylated-DNA--~~[~~protein~~]~~-cysteine S-methyltransferase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.~~1.1.63 2.1.1.63] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [https://pdbe.org/4bhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [https://www.ebi.ac.uk/pdbsum/4bhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [https://pdbe.org/4bhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [https://www.ebi.ac.uk/pdbsum/4bhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/OGT_MYCTU OGT_MYCTU]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).	+	[https://www.uniprot.org/uniprot/OGT_MYCTU OGT_MYCTU] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Casazza, V]]	+	[[Category: Casazza V]]
-	[[Category: Ciaramella, M]]	+	[[Category: Ciaramella M]]
-	[[Category: Garavaglia, S]]	+	[[Category: Garavaglia S]]
-	[[Category: Miggiano, R]]	+	[[Category: Miggiano R]]
-	[[Category: Perugino, G]]	+	[[Category: Perugino G]]
-	[[Category: Rizzi, M]]	+	[[Category: Rizzi M]]
-	[[Category: Rossi, F]]	+	[[Category: Rossi F]]
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:13, 31 August 2022

2022-08-31T07:13:52Z

←Older revision		Revision as of 07:13, 31 August 2022
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	<StructureSection load='4bhc' size='340' side='right'caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4bhc' size='340' side='right'caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BHC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHC FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bhb\|4bhb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bhb\|4bhb]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [~~http~~://pdbe.org/4bhc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bhc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [https://pdbe.org/4bhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [https://www.ebi.ac.uk/pdbsum/4bhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/OGT_MYCTU OGT_MYCTU]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).	+	[[https://www.uniprot.org/uniprot/OGT_MYCTU OGT_MYCTU]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[DNA methyltransferase\|DNA methyltransferase]]	+	*[[DNA methyltransferase 3D structures\|DNA methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:39, 13 March 2019

2019-03-13T13:39:15Z

←Older revision		Revision as of 13:39, 13 March 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT==		==CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT==
-	<StructureSection load='4bhc' size='340' side='right' caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4bhc' size='340' side='right'caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BHC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BHC FirstGlance]. <br>
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Casazza, V]]		[[Category: Casazza, V]]

OCA at 18:40, 4 August 2016

2016-08-04T18:40:20Z

←Older revision		Revision as of 18:40, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT==		==CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT==
	<StructureSection load='4bhc' size='340' side='right' caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4bhc' size='340' side='right' caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BHC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BHC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bhb\|4bhb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bhb\|4bhb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [http://www.ebi.ac.uk/pdbsum/4bhc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [http://pdbe.org/4bhc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [http://www.ebi.ac.uk/pdbsum/4bhc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bhc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis h37rv~~]]	+	[[Category: Myctu]]
	[[Category: Casazza, V]]		[[Category: Casazza, V]]
	[[Category: Ciaramella, M]]		[[Category: Ciaramella, M]]

OCA at 18:19, 24 December 2014

2014-12-24T18:19:03Z

←Older revision		Revision as of 18:19, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [http://www.ebi.ac.uk/pdbsum/4bhc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [http://www.ebi.ac.uk/pdbsum/4bhc PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OGT_MYCTU OGT_MYCTU]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:48, 21 December 2014

2014-12-21T09:48:16Z

←Older revision		Revision as of 09:48, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bhc\| PDB=4bhc \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT==
-	===CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT===	+	<StructureSection load='4bhc' size='340' side='right' caption='[[4bhc]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23564173}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BHC FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bhb\|4bhb]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bhc RCSB], [http://www.ebi.ac.uk/pdbsum/4bhc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	M. tuberculosis displays a remarkable genetic stability despite continuous exposure to the hostile environment represented by the host's infected macrophages. Similarly to other organisms, M. tuberculosis possesses multiple systems to contrast the harmful potential of DNA alkylation. In particular, the suicidal enzyme O6-methylguanine-DNA methyltransferase (OGT) is responsible for the direct repair of O6-alkylguanine in double-stranded DNA and is therefore supposed to play a central role in protecting the mycobacterial genome from the risk of G:C to A:T transition mutations. Notably, a number of geographically widely distributed M. tuberculosis strains shows non-synonymous SNPs in their OGT encoding gene, leading to amino acid substitutions at position 15 (T15S) or 37 (R37L) of the N-terminal domain of the corresponding protein. However, the role of these mutations in M. tuberculosis pathogenesis is unknown.We describe here the in vitro characterization of M. tuberculosis OGT (MtOGT) and of two point-mutated versions of the protein mimicking the naturally occurring ones, revealing that both mutated proteins are impaired in their activity as a consequence of their lower affinity for alkylated DNA with respect to the wild-type protein. The analysis of the crystal structures of MtOGT and MtOGT-R37L confirms the high level of structural conservation featuring members of this protein family and provides cues to understand the molecular bases of the reduced affinity for the natural substrate displayed by mutated MtOGT. Our in vitro results could contribute to validate the inferred participation of mutated OGTs to M. tuberculosis phylogeny and biology.

-	~~==Function==~~	+	BIOCHEMICAL AND STRUCTURAL STUDIES ON THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE AND MUTATED VARIANTS.,Miggiano R, Casazza V, Garavaglia S, Ciaramella M, Perugino G, Rizzi M, Rossi F J Bacteriol. 2013 Apr 5. PMID:23564173<ref>PMID:23564173</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/OGT_MYCTU OGT_MYCTU]] Involved in the cellular defense against the biological effects of~~ O6-~~methylguanine (O6-MeG) in DNA~~. ~~Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme~~. ~~This is a suicide reaction~~: ~~the enzyme is irreversibly inactivated (By similarity).~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4bhc]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023564173</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[DNA methyltransferase\|DNA methyltransferase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
-	[[Category: Casazza, V.]]	+	[[Category: Casazza, V]]
-	[[Category: Ciaramella, M.]]	+	[[Category: Ciaramella, M]]
-	[[Category: Garavaglia, S.]]	+	[[Category: Garavaglia, S]]
-	[[Category: Miggiano, R.]]	+	[[Category: Miggiano, R]]
-	[[Category: Perugino, G.]]	+	[[Category: Perugino, G]]
-	[[Category: Rizzi, M.]]	+	[[Category: Rizzi, M]]
-	[[Category: Rossi, F.]]	+	[[Category: Rossi, F]]
	[[Category: Dna repair]]		[[Category: Dna repair]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 21:09, 19 June 2013

2013-06-19T21:09:04Z

←Older revision		Revision as of 21:09, 19 June 2013
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA].		[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023564173</ref><references group="xtra"/><references/>
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
	[[Category: Casazza, V.]]		[[Category: Casazza, V.]]

OCA: Protected "4bhc" [edit=sysop:move=sysop]

2013-04-17T20:27:18Z

Protected "4bhc" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:27, 17 April 2013

OCA: New page: {{STRUCTURE_4bhc| PDB=4bhc | SCENE= }} ===CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT=== {{ABSTRACT_PUBMED_23564173}} ==Function== [[http...

2013-04-17T20:27:13Z

New page: {{STRUCTURE_4bhc| PDB=4bhc | SCENE= }} ===CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT=== {{ABSTRACT_PUBMED_23564173}} ==Function== [[http...

New page

{{STRUCTURE_4bhc| PDB=4bhc | SCENE= }}
===CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT===
{{ABSTRACT_PUBMED_23564173}}

==Function==
[[http://www.uniprot.org/uniprot/OGT_MYCTU OGT_MYCTU]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).

==About this Structure==
[[4bhc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHC OCA].
[[Category: Mycobacterium tuberculosis h37rv]]
[[Category: Casazza, V.]]
[[Category: Ciaramella, M.]]
[[Category: Garavaglia, S.]]
[[Category: Miggiano, R.]]
[[Category: Perugino, G.]]
[[Category: Rizzi, M.]]
[[Category: Rossi, F.]]
[[Category: Dna repair]]
[[Category: Transferase]]