4bic - Revision history

OCA at 11:52, 20 December 2023

2023-12-20T11:52:03Z

←Older revision		Revision as of 11:52, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4bic' size='340' side='right'caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='4bic' size='340' side='right'caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=IE4:N-(2-AMINOETHYL)-5-{1H-PYRROLO~~[~~2,3-B~~]~~PYRIDIN-3-YL}THIOPHENE-~~2~~-SULFONAMIDE'>IE4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.62Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[4bf2\|4bf2]], [[4bhn\|4bhn]], [[4bib\|4bib]], [[4bid\|4bid]], [[4bie\|4bie]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IE4:N-(2-AMINOETHYL)-5-{1H-PYRROLO[2,3-B]PYRIDIN-3-YL}THIOPHENE-2-SULFONAMIDE'>IE4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mitogen~~-~~activated_protein_kinase_kinase_kinase Mitogen~~-~~activated protein kinase kinase kinase]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.7.11.25 2.7.11.25]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [https://pdbe.org/4bic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [https://www.ebi.ac.uk/pdbsum/4bic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bic ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [https://pdbe.org/4bic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [https://www.ebi.ac.uk/pdbsum/4bic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bic ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/M3K5_HUMAN M3K5_HUMAN]] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).<ref>PMID:8940179</ref> <ref>PMID:8974401</ref> <ref>PMID:9564042</ref> <ref>PMID:9774977</ref> <ref>PMID:10411906</ref> <ref>PMID:10849426</ref> <ref>PMID:10688666</ref> <ref>PMID:11689443</ref> <ref>PMID:11029458</ref> <ref>PMID:11154276</ref> <ref>PMID:14749717</ref> <ref>PMID:11920685</ref> <ref>PMID:12697749</ref> <ref>PMID:15023544</ref> <ref>PMID:14688258</ref> <ref>PMID:16129676</ref> <ref>PMID:17220297</ref>	+	[https://www.uniprot.org/uniprot/M3K5_HUMAN M3K5_HUMAN] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).<ref>PMID:8940179</ref> <ref>PMID:8974401</ref> <ref>PMID:9564042</ref> <ref>PMID:9774977</ref> <ref>PMID:10411906</ref> <ref>PMID:10849426</ref> <ref>PMID:10688666</ref> <ref>PMID:11689443</ref> <ref>PMID:11029458</ref> <ref>PMID:11154276</ref> <ref>PMID:14749717</ref> <ref>PMID:11920685</ref> <ref>PMID:12697749</ref> <ref>PMID:15023544</ref> <ref>PMID:14688258</ref> <ref>PMID:16129676</ref> <ref>PMID:17220297</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Mitogen-activated protein kinase kinase kinase]]~~	+	[[Category: Blunt M]]
-	[[Category: Blunt, M]]	+	[[Category: Craggs P]]
-	[[Category: Craggs, P]]	+	[[Category: Hardwick P]]
-	[[Category: Hardwick, P]]	+	[[Category: Hobbs CI]]
-	[[Category: Hobbs~~, C I~~]]	+	[[Category: Rowland P]]
-	[[Category: Rowland, P]]	+	[[Category: Shillings A]]
-	[[Category: Shillings, A]]	+	[[Category: Singh O]]
-	[[Category: Singh, O]]	+	[[Category: Skarzynski T]]
-	[[Category: Skarzynski, T]]	+	[[Category: Smith KJ]]
-	[[Category: Smith~~, K J~~]]	+	[[Category: Tanner R]]
-	[[Category: Tanner, R]]	+	[[Category: Wall I]]
-	[[Category: Wall, I]]	+	[[Category: Witty DR]]
-	[[Category: Witty~~, D R]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:14, 31 August 2022

2022-08-31T07:14:47Z

←Older revision		Revision as of 07:14, 31 August 2022
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	<StructureSection load='4bic' size='340' side='right'caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='4bic' size='340' side='right'caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IE4:N-(2-AMINOETHYL)-5-{1H-PYRROLO[2,3-B]PYRIDIN-3-YL}THIOPHENE-2-SULFONAMIDE'>IE4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IE4:N-(2-AMINOETHYL)-5-{1H-PYRROLO[2,3-B]PYRIDIN-3-YL}THIOPHENE-2-SULFONAMIDE'>IE4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bf2\|4bf2]], [[4bhn\|4bhn]], [[4bib\|4bib]], [[4bid\|4bid]], [[4bie\|4bie]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bf2\|4bf2]], [[4bhn\|4bhn]], [[4bib\|4bib]], [[4bid\|4bid]], [[4bie\|4bie]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [~~http~~://pdbe.org/4bic PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bic PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bic ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [https://pdbe.org/4bic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [https://www.ebi.ac.uk/pdbsum/4bic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bic ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/M3K5_HUMAN M3K5_HUMAN]] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).<ref>PMID:8940179</ref> <ref>PMID:8974401</ref> <ref>PMID:9564042</ref> <ref>PMID:9774977</ref> <ref>PMID:10411906</ref> <ref>PMID:10849426</ref> <ref>PMID:10688666</ref> <ref>PMID:11689443</ref> <ref>PMID:11029458</ref> <ref>PMID:11154276</ref> <ref>PMID:14749717</ref> <ref>PMID:11920685</ref> <ref>PMID:12697749</ref> <ref>PMID:15023544</ref> <ref>PMID:14688258</ref> <ref>PMID:16129676</ref> <ref>PMID:17220297</ref>	+	[[https://www.uniprot.org/uniprot/M3K5_HUMAN M3K5_HUMAN]] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).<ref>PMID:8940179</ref> <ref>PMID:8974401</ref> <ref>PMID:9564042</ref> <ref>PMID:9774977</ref> <ref>PMID:10411906</ref> <ref>PMID:10849426</ref> <ref>PMID:10688666</ref> <ref>PMID:11689443</ref> <ref>PMID:11029458</ref> <ref>PMID:11154276</ref> <ref>PMID:14749717</ref> <ref>PMID:11920685</ref> <ref>PMID:12697749</ref> <ref>PMID:15023544</ref> <ref>PMID:14688258</ref> <ref>PMID:16129676</ref> <ref>PMID:17220297</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:01, 13 March 2019

2019-03-13T13:01:07Z

←Older revision		Revision as of 13:01, 13 March 2019
Line 1:		Line 1:

	==Crystal Structures of Ask1-inhibitor Complexes==		==Crystal Structures of Ask1-inhibitor Complexes==
-	<StructureSection load='4bic' size='340' side='right' caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>	+	<StructureSection load='4bic' size='340' side='right'caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIC FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Mitogen-activated protein kinase kinase kinase]]		[[Category: Mitogen-activated protein kinase kinase kinase]]
	[[Category: Blunt, M]]		[[Category: Blunt, M]]

OCA at 14:22, 5 August 2016

2016-08-05T14:22:45Z

←Older revision		Revision as of 14:22, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structures of Ask1-inhibitor Complexes==		==Crystal Structures of Ask1-inhibitor Complexes==
	<StructureSection load='4bic' size='340' side='right' caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='4bic' size='340' side='right' caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IE4:N-(2-AMINOETHYL)-5-{1H-PYRROLO[2,3-B]PYRIDIN-3-YL}THIOPHENE-2-SULFONAMIDE'>IE4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IE4:N-(2-AMINOETHYL)-5-{1H-PYRROLO[2,3-B]PYRIDIN-3-YL}THIOPHENE-2-SULFONAMIDE'>IE4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bf2\|4bf2]], [[4bhn\|4bhn]], [[4bib\|4bib]], [[4bid\|4bid]], [[4bie\|4bie]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bf2\|4bf2]], [[4bhn\|4bhn]], [[4bib\|4bib]], [[4bid\|4bid]], [[4bie\|4bie]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [http://www.ebi.ac.uk/pdbsum/4bic PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [http://pdbe.org/4bic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [http://www.ebi.ac.uk/pdbsum/4bic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bic ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bic" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Mitogen-activated protein kinase kinase kinase]]		[[Category: Mitogen-activated protein kinase kinase kinase]]
	[[Category: Blunt, M]]		[[Category: Blunt, M]]

OCA at 19:32, 25 December 2014

2014-12-25T19:32:28Z

←Older revision		Revision as of 19:32, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [http://www.ebi.ac.uk/pdbsum/4bic PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [http://www.ebi.ac.uk/pdbsum/4bic PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/M3K5_HUMAN M3K5_HUMAN]] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).<ref>PMID:8940179</ref> <ref>PMID:8974401</ref> <ref>PMID:9564042</ref> <ref>PMID:9774977</ref> <ref>PMID:10411906</ref> <ref>PMID:10849426</ref> <ref>PMID:10688666</ref> <ref>PMID:11689443</ref> <ref>PMID:11029458</ref> <ref>PMID:11154276</ref> <ref>PMID:14749717</ref> <ref>PMID:11920685</ref> <ref>PMID:12697749</ref> <ref>PMID:15023544</ref> <ref>PMID:14688258</ref> <ref>PMID:16129676</ref> <ref>PMID:17220297</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:51, 21 December 2014

2014-12-21T08:51:37Z

←Older revision		Revision as of 08:51, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bic\| PDB=4bic \| SCENE= }}~~	+	==Crystal Structures of Ask1-inhibitor Complexes==
-	===Crystal Structures of Ask1-inhibitor Complexes===	+	<StructureSection load='4bic' size='340' side='right' caption='[[4bic]], [[Resolution\|resolution]] 2.62Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23776076}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IE4:N-(2-AMINOETHYL)-5-{1H-PYRROLO[2,3-B]PYRIDIN-3-YL}THIOPHENE-2-SULFONAMIDE'>IE4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bf2\|4bf2]], [[4bhn\|4bhn]], [[4bib\|4bib]], [[4bid\|4bid]], [[4bie\|4bie]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bic RCSB], [http://www.ebi.ac.uk/pdbsum/4bic PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ASK1, a member of the MAPK Kinase Kinase family of proteins has been shown to play a key role in cancer, neurodegeneration and cardiovascular diseases and is emerging as a possible drug target. Here we describe a 'replacement-soaking' method that has enabled the high-throughput X-ray structure determination of ASK1/ligand complexes. Comparison of the X-ray structures of five ASK1/ligand complexes from 3 different chemotypes illustrates that the ASK1 ATP binding site is able to accommodate a range of chemical diversity and different binding modes. The replacement-soaking system is also able to tolerate some protein flexibility. This crystal system provides a robust platform for ASK1/ligand structure determination and future structure based drug design.

-	~~==Function==~~	+	Crystal structures of ASK1-inhibtor complexes provide a platform for structure based drug design.,Singh O, Shillings A, Craggs P, Wall I, Rowland P, Skarzynski T, Hobbs CI, Hardwick P, Tanner R, Blunt M, Witty DR, Smith KJ Protein Sci. 2013 Jun 15. doi: 10.1002/pro.2298. PMID:23776076<ref>PMID:23776076</ref>
-	~~[[http://www.uniprot.org/uniprot/M3K5_HUMAN M3K5_HUMAN]] Serine/threonine kinase which acts as an essential component~~ of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a ~~crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required~~ for ~~the innate immune response, which is essential for host defense against a wide range of pathogens~~. ~~Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals~~, ~~such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated~~, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, ~~MAP2K3/MKK3~~, ~~MAP2K6/MKK6 and MAP2K7/MKK7~~. ~~These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs)~~. ~~Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1)~~.~~<ref>PMID:8940179<~~/~~ref> <ref>~~PMID:8974401</ref> <ref>PMID:9564042</ref> <ref>PMID:9774977</ref> <ref>PMID:10411906</ref> <ref>PMID:10849426</ref> <ref>PMID:10688666</ref> <ref>PMID:11689443</ref> <ref>PMID:11029458</ref> <ref>PMID:11154276</ref> <ref>PMID:14749717</ref> <ref>PMID:11920685</ref> <ref>PMID:12697749</ref> <ref>PMID:15023544</ref> <ref>PMID:14688258</ref> <ref>PMID:16129676</ref> <ref>PMID:~~17220297~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4bic]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023776076</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Mitogen-activated protein kinase kinase kinase\|Mitogen-activated protein kinase kinase kinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mitogen-activated protein kinase kinase kinase]]		[[Category: Mitogen-activated protein kinase kinase kinase]]
-	[[Category: Blunt, M.]]	+	[[Category: Blunt, M]]
-	[[Category: Craggs, P.]]	+	[[Category: Craggs, P]]
-	[[Category: Hardwick, P.]]	+	[[Category: Hardwick, P]]
-	[[Category: Hobbs, C I.]]	+	[[Category: Hobbs, C I]]
-	[[Category: Rowland, P.]]	+	[[Category: Rowland, P]]
-	[[Category: Shillings, A.]]	+	[[Category: Shillings, A]]
-	[[Category: Singh, O.]]	+	[[Category: Singh, O]]
-	[[Category: Skarzynski, T.]]	+	[[Category: Skarzynski, T]]
-	[[Category: Smith, K J.]]	+	[[Category: Smith, K J]]
-	[[Category: Tanner, R.]]	+	[[Category: Tanner, R]]
-	[[Category: Wall, I.]]	+	[[Category: Wall, I]]
-	[[Category: Witty, D R.]]	+	[[Category: Witty, D R]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 14:03, 3 July 2013

2013-07-03T14:03:27Z

←Older revision		Revision as of 14:03, 3 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4bic\| PDB=4bic \| SCENE= }}
		+	===Crystal Structures of Ask1-inhibitor Complexes===
		+	{{ABSTRACT_PUBMED_23776076}}

-	~~The entry 4bic~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/M3K5_HUMAN M3K5_HUMAN]] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).<ref>PMID:8940179</ref> <ref>PMID:8974401</ref> <ref>PMID:9564042</ref> <ref>PMID:9774977</ref> <ref>PMID:10411906</ref> <ref>PMID:10849426</ref> <ref>PMID:10688666</ref> <ref>PMID:11689443</ref> <ref>PMID:11029458</ref> <ref>PMID:11154276</ref> <ref>PMID:14749717</ref> <ref>PMID:11920685</ref> <ref>PMID:12697749</ref> <ref>PMID:15023544</ref> <ref>PMID:14688258</ref> <ref>PMID:16129676</ref> <ref>PMID:17220297</ref>

-	~~Authors~~: ~~Singh, O~~.~~, Shillings, A~~.~~, Craggs, P~~.~~, Wall, I., Rowland, P., Skarzynski, T., Hobbs, C., Hardwick, P., Tanner, R., Blunt, M~~.~~, Witty, D~~.~~, Smith, K~~.J.	+	==About this Structure==
		+	[[4bic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIC OCA].

-	~~Description~~: ~~Crystal Structures of Ask1~~-~~inhibitor Complexes~~	+	==Reference==
		+	<ref group="xtra">PMID:023776076</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Mitogen-activated protein kinase kinase kinase]]
		+	[[Category: Blunt, M.]]
		+	[[Category: Craggs, P.]]
		+	[[Category: Hardwick, P.]]
		+	[[Category: Hobbs, C I.]]
		+	[[Category: Rowland, P.]]
		+	[[Category: Shillings, A.]]
		+	[[Category: Singh, O.]]
		+	[[Category: Skarzynski, T.]]
		+	[[Category: Smith, K J.]]
		+	[[Category: Tanner, R.]]
		+	[[Category: Wall, I.]]
		+	[[Category: Witty, D R.]]
		+	[[Category: Transferase]]

OCA: Protected "4bic" [edit=sysop:move=sysop]

2013-04-17T19:43:18Z

Protected "4bic" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:43, 17 April 2013

OCA: New page: '''Unreleased structure''' The entry 4bic is ON HOLD until Paper Publication Authors: Singh, O., Shillings, A., Craggs, P., Wall, I., Rowland, P., Skarzynski, T., Hobbs, C., Hardwick, P...

2013-04-17T19:43:17Z

New page: '''Unreleased structure''' The entry 4bic is ON HOLD until Paper Publication Authors: Singh, O., Shillings, A., Craggs, P., Wall, I., Rowland, P., Skarzynski, T., Hobbs, C., Hardwick, P...

New page

'''Unreleased structure'''

The entry 4bic is ON HOLD until Paper Publication

Authors: Singh, O., Shillings, A., Craggs, P., Wall, I., Rowland, P., Skarzynski, T., Hobbs, C., Hardwick, P., Tanner, R., Blunt, M., Witty, D., Smith, K.J.

Description: Crystal Structures of Ask1-inhibitor Complexes