4bji - Revision history

OCA at 07:15, 31 August 2022

2022-08-31T07:15:50Z

←Older revision		Revision as of 07:15, 31 August 2022
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	<StructureSection load='4bji' size='340' side='right'caption='[[4bji]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4bji' size='340' side='right'caption='[[4bji]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bji]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_927 Schizosaccharomyces pombe 927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_927 Schizosaccharomyces pombe 927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bjj\|4bjj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bjj\|4bjj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bji OCA], [~~http~~://pdbe.org/4bji PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bji RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bji PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bji ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bji OCA], [https://pdbe.org/4bji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bji RCSB], [https://www.ebi.ac.uk/pdbsum/4bji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bji ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SFC1_SCHPO SFC1_SCHPO]] TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.<ref>PMID:10906331</ref> <ref>PMID:16751097</ref>	+	[[https://www.uniprot.org/uniprot/SFC1_SCHPO SFC1_SCHPO]] TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.<ref>PMID:10906331</ref> <ref>PMID:16751097</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:06, 13 March 2019

2019-03-13T13:06:32Z

←Older revision		Revision as of 13:06, 13 March 2019
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	==Sfc1-DBD==		==Sfc1-DBD==
-	<StructureSection load='4bji' size='340' side='right' caption='[[4bji]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='4bji' size='340' side='right'caption='[[4bji]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bji]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_927 Schizosaccharomyces pombe 927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bji]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_927 Schizosaccharomyces pombe 927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJI FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 4bji" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4bji" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transcription factor tau\|Transcription factor tau]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Schizosaccharomyces pombe 927]]		[[Category: Schizosaccharomyces pombe 927]]
	[[Category: Baudin, F]]		[[Category: Baudin, F]]

OCA at 14:30, 5 August 2016

2016-08-05T14:30:43Z

←Older revision		Revision as of 14:30, 5 August 2016
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		+
	==Sfc1-DBD==		==Sfc1-DBD==
	<StructureSection load='4bji' size='340' side='right' caption='[[4bji]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4bji' size='340' side='right' caption='[[4bji]], [[Resolution\|resolution]] 1.45Å' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bjj\|4bjj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bjj\|4bjj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bji RCSB], [http://www.ebi.ac.uk/pdbsum/4bji PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bji OCA], [http://pdbe.org/4bji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bji RCSB], [http://www.ebi.ac.uk/pdbsum/4bji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bji ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bji" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:35, 25 December 2014

2014-12-25T19:35:11Z

←Older revision		Revision as of 19:35, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bji RCSB], [http://www.ebi.ac.uk/pdbsum/4bji PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bji RCSB], [http://www.ebi.ac.uk/pdbsum/4bji PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SFC1_SCHPO SFC1_SCHPO]] TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.<ref>PMID:10906331</ref> <ref>PMID:16751097</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:00, 21 December 2014

2014-12-21T09:00:51Z

←Older revision		Revision as of 09:00, 21 December 2014
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-	~~{{STRUCTURE_4bji~~\| ~~PDB~~=4bji \| ~~SCENE~~= }}	+	==Sfc1-DBD==
-	===~~Sfc1~~-~~DBD~~===	+	<StructureSection load='4bji' size='340' side='right' caption='[[4bji]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23921640}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bji]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_927 Schizosaccharomyces pombe 927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJI FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bjj\|4bjj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bji RCSB], [http://www.ebi.ac.uk/pdbsum/4bji PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transcription of tRNA-encoding genes by RNA polymerase (Pol) III requires the six-subunit general transcription factor IIIC that uses subcomplexes tauA and tauB to recognize two gene-internal promoter elements named A- and B-box. The Schizosaccharomyces pombe tauA subcomplex comprises subunits Sfc1, Sfc4 and Sfc7. The crystal structure of the Sfc1/Sfc7 heterodimer reveals similar domains and overall domain architecture to the Pol II-specific general transcription factor TFIIF Rap30/Rap74. The N-terminal Sfc1/Sfc7 dimerization module consists of a triple beta-barrel similar to the N-terminal TFIIF Rap30/Rap74 dimerization module, whereas the C-terminal Sfc1 DNA-binding domain contains a winged-helix domain most similar to the TFIIF Rap30 C-terminal winged-helix domain. Sfc1 DNA-binding domain recognizes single and double-stranded DNA by an unknown mechanism. Several features observed for A-box recognition by tauA resemble the recognition of promoters by bacterial RNA polymerase, where sigma factor unfolds double-stranded DNA and stabilizes the non-coding DNA strand in an open conformation. Such a function has also been proposed for TFIIF, suggesting that the observed structural similarity between Sfc1/Sfc7 and TFIIF Rap30/Rap74 might also reflect similar functions.

-	~~==Function==~~	+	RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74.,Taylor NM, Baudin F, von Scheven G, Muller CW Nucleic Acids Res. 2013 Aug 5. PMID:23921640<ref>PMID:23921640</ref>
-	~~[[http:/~~/~~www~~.~~uniprot.org/uniprot/SFC1_SCHPO SFC1_SCHPO]] TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site~~, ~~TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA~~, ~~which is sufficient for RNA polymerase III recruitment and function~~. ~~Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes~~. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.<ref>PMID:~~10906331</ref>~~ <ref>PMID:~~16751097~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4bji]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Schizosaccharomyces_pombe_927 Schizosaccharomyces pombe 927]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BJI OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023921640</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Schizosaccharomyces pombe 927]]		[[Category: Schizosaccharomyces pombe 927]]
-	[[Category: Baudin, F.]]	+	[[Category: Baudin, F]]
-	[[Category: Muller, C W.]]	+	[[Category: Muller, C W]]
-	[[Category: Scheven, G von.]]	+	[[Category: Scheven, G von]]
-	[[Category: Taylor, N M.I.]]	+	[[Category: Taylor, N M.I]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]

OCA at 08:25, 21 August 2013

2013-08-21T08:25:43Z

←Older revision		Revision as of 08:25, 21 August 2013
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	{{STRUCTURE_4bji\| PDB=4bji \| SCENE= }}		{{STRUCTURE_4bji\| PDB=4bji \| SCENE= }}
	===Sfc1-DBD===		===Sfc1-DBD===
		+	{{ABSTRACT_PUBMED_23921640}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023921640</ref><references group="xtra"/><references/>
	[[Category: Schizosaccharomyces pombe 927]]		[[Category: Schizosaccharomyces pombe 927]]
	[[Category: Baudin, F.]]		[[Category: Baudin, F.]]

OCA at 05:13, 1 August 2013

2013-08-01T05:13:11Z

←Older revision		Revision as of 05:13, 1 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4bji\| PDB=4bji \| SCENE= }}
		+	===Sfc1-DBD===

-	~~The entry 4bji~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SFC1_SCHPO SFC1_SCHPO]] TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.<ref>PMID:10906331</ref> <ref>PMID:16751097</ref>

-	~~Authors~~: ~~Taylor, N~~.M.I.~~, Baudin, F~~.~~, von Scheven, G~~.~~, Muller, C~~.W.	+	==About this Structure==
		+	[[4bji]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_927 Schizosaccharomyces pombe 927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJI OCA].

-	~~Description~~: ~~Sfc1-DBD~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Schizosaccharomyces pombe 927]]
		+	[[Category: Baudin, F.]]
		+	[[Category: Muller, C W.]]
		+	[[Category: Scheven, G von.]]
		+	[[Category: Taylor, N M.I.]]
		+	[[Category: Dna binding protein]]

OCA: Protected "4bji" [edit=sysop:move=sysop]

2013-04-24T10:44:29Z

Protected "4bji" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:44, 24 April 2013

OCA: New page: '''Unreleased structure''' The entry 4bji is ON HOLD Authors: Taylor, N.M.I., Baudin, F., von Scheven, G., Muller, C.W. Description: Sfc1-DBD

2013-04-24T10:44:28Z

New page: '''Unreleased structure''' The entry 4bji is ON HOLD Authors: Taylor, N.M.I., Baudin, F., von Scheven, G., Muller, C.W. Description: Sfc1-DBD

New page

'''Unreleased structure'''

The entry 4bji is ON HOLD

Authors: Taylor, N.M.I., Baudin, F., von Scheven, G., Muller, C.W.

Description: Sfc1-DBD