4bjk - Revision history

OCA at 11:52, 20 December 2023

2023-12-20T11:52:32Z

←Older revision		Revision as of 11:52, 20 December 2023
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	<StructureSection load='4bjk' size='340' side='right'caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='4bjk' size='340' side='right'caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=18I:3,3-DIFLUORO-N-[(2S)-3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL]BIPHENYL-4-CARBOXAMIDE'>18I</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.67Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=18I:3,3-DIFLUORO-N-[(2S)-3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL]BIPHENYL-4-CARBOXAMIDE'>18I</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjk OCA], [https://pdbe.org/4bjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjk RCSB], [https://www.ebi.ac.uk/pdbsum/4bjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjk OCA], [https://pdbe.org/4bjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjk RCSB], [https://www.ebi.ac.uk/pdbsum/4bjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q385E8_TRYB2 Q385E8_TRYB2]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4bjk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4bjk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Sterol 14-demethylase~~]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: Podust~~, L M]]~~	+	[[Category: Podust LM]]
-	~~[[Category: Ergosterol biosynthesis]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:15, 31 August 2022

2022-08-31T07:15:53Z

←Older revision		Revision as of 07:15, 31 August 2022
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	<StructureSection load='4bjk' size='340' side='right'caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='4bjk' size='340' side='right'caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BJK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=18I:3,3-DIFLUORO-N-[(2S)-3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL]BIPHENYL-4-CARBOXAMIDE'>18I</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=18I:3,3-DIFLUORO-N-[(2S)-3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL]BIPHENYL-4-CARBOXAMIDE'>18I</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjk OCA], [~~http~~://pdbe.org/4bjk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bjk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bjk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjk OCA], [https://pdbe.org/4bjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjk RCSB], [https://www.ebi.ac.uk/pdbsum/4bjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:16, 13 March 2019

2019-03-13T13:16:29Z

←Older revision		Revision as of 13:16, 13 March 2019
Line 1:		Line 1:

	==CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide==		==CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide==
-	<StructureSection load='4bjk' size='340' side='right' caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>	+	<StructureSection load='4bjk' size='340' side='right'caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJK FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]
	[[Category: Podust, L M]]		[[Category: Podust, L M]]
	[[Category: Ergosterol biosynthesis]]		[[Category: Ergosterol biosynthesis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 18:37, 5 August 2016

2016-08-05T18:37:33Z

←Older revision		Revision as of 18:37, 5 August 2016
Line 1:		Line 1:
		+
	==CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide==		==CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide==
	<StructureSection load='4bjk' size='340' side='right' caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='4bjk' size='340' side='right' caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=18I:3,3-DIFLUORO-N-[(2S)-3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL]BIPHENYL-4-CARBOXAMIDE'>18I</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=18I:3,3-DIFLUORO-N-[(2S)-3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL]BIPHENYL-4-CARBOXAMIDE'>18I</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bjk RCSB], [http://www.ebi.ac.uk/pdbsum/4bjk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjk OCA], [http://pdbe.org/4bjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bjk RCSB], [http://www.ebi.ac.uk/pdbsum/4bjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bjk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]
-	[[Category: Trypanosoma brucei]]
	[[Category: Podust, L M]]		[[Category: Podust, L M]]
	[[Category: Ergosterol biosynthesis]]		[[Category: Ergosterol biosynthesis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 09:14, 21 December 2014

2014-12-21T09:14:45Z

←Older revision		Revision as of 09:14, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bjk\| PDB=4bjk \| SCENE= }}~~	+	==CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide==
-	===CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide===	+	<StructureSection load='4bjk' size='340' side='right' caption='[[4bjk]], [[Resolution\|resolution]] 2.67Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24079662}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bjk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=18I:3,3-DIFLUORO-N-[(2S)-3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL]BIPHENYL-4-CARBOXAMIDE'>18I</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bjk RCSB], [http://www.ebi.ac.uk/pdbsum/4bjk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A new series of 4-aminopyridyl-based lead inhibitors targeting Trypanosoma cruzi CYP51 (TcCYP51) has been developed using structure-based drug design as well as structure-property relationship (SPR) analyses. The screening hit starting point, LP10 (KD </= 42 nM; EC50 = 0.65 muM), has been optimized to give the potential leads 14t, 27i, 27q, 27r, and 27t, which have low-nanomolar binding affinity to TcCYP51 and significant activity against T. cruzi amastigotes cultured in human myoblasts (EC50 = 14-18 nM for 27i and 27r). Many of the optimized compounds have improved microsome stability, and most are selective against human CYPs 1A2, 2D6, and 3A4 (<50% inhibition at 1 muM). A rationale for the improvement in microsome stability and selectivity of inhibitors against human metabolic CYP enzymes is presented. In addition, the binding mode of 14t with the Trypanosoma brucei CYP51 (TbCYP51) orthologue has been characterized by X-ray structure analysis.

-	~~==About this Structure==~~	+	Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas Agents.,Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR J Med Chem. 2013 Sep 30. PMID:24079662<ref>PMID:24079662</ref>
-	~~[[4bjk]] is a~~ 4 ~~chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_brucei Trypanosoma brucei]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024079662</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
-	[[Category: Podust, L M.]]	+	[[Category: Podust, L M]]
	[[Category: Ergosterol biosynthesis]]		[[Category: Ergosterol biosynthesis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 04:59, 10 October 2013

2013-10-10T04:59:34Z

←Older revision		Revision as of 04:59, 10 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4bjk\| PDB=4bjk \| SCENE= }}		{{STRUCTURE_4bjk\| PDB=4bjk \| SCENE= }}
	===CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide===		===CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide===
		+	{{ABSTRACT_PUBMED_24079662}}

	==About this Structure==		==About this Structure==
	[[4bjk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA].		[[4bjk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024079662</ref><references group="xtra"/><references/>
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]

OCA at 10:54, 4 September 2013

2013-09-04T10:54:29Z

←Older revision		Revision as of 10:54, 4 September 2013
Line 1:		Line 1:
-	''~~'Unreleased structure'''~~	+	{{STRUCTURE_4bjk\| PDB=4bjk \| SCENE= }}
		+	===CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1- (pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide===

-	~~The entry~~ 4bjk is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4bjk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJK OCA].
-	~~Authors~~: Podust, L.M.	+	[[Category: Sterol 14-demethylase]]
-		+	[[Category: Trypanosoma brucei]]
-	~~Description~~: ~~CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4-carboxamide~~	+	[[Category: Podust, L M.]]
		+	[[Category: Ergosterol biosynthesis]]
		+	[[Category: Oxidoreductase]]

OCA at 06:56, 2 May 2013

2013-05-02T06:56:46Z

←Older revision		Revision as of 06:56, 2 May 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4bjk is ON HOLD	+	The entry 4bjk is ON HOLD until Paper Publication

	Authors: Podust, L.M.		Authors: Podust, L.M.

	Description: CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4-carboxamide		Description: CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4-carboxamide

OCA: Protected "4bjk" [edit=sysop:move=sysop]

2013-04-24T10:44:33Z

Protected "4bjk" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:44, 24 April 2013

OCA: New page: '''Unreleased structure''' The entry 4bjk is ON HOLD Authors: Podust, L.M. Description: CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-...

2013-04-24T10:44:32Z

New page: '''Unreleased structure''' The entry 4bjk is ON HOLD Authors: Podust, L.M. Description: CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-...

New page

'''Unreleased structure'''

The entry 4bjk is ON HOLD

Authors: Podust, L.M.

Description: CYP51 of Trypanosoma brucei bound to (S)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4-carboxamide