4bkj - Revision history

OCA at 11:53, 20 December 2023

2023-12-20T11:53:06Z

←Older revision		Revision as of 11:53, 20 December 2023
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	<StructureSection load='4bkj' size='340' side='right'caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4bkj' size='340' side='right'caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bki\|4bki]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [https://pdbe.org/4bkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [https://www.ebi.ac.uk/pdbsum/4bkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [https://pdbe.org/4bkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [https://www.ebi.ac.uk/pdbsum/4bkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DDR1_HUMAN DDR1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Receptor protein-tyrosine kinase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Bullock A]]
-	[[Category: Bullock, A]]	+	[[Category: Canning P]]
-	[[Category: Canning, P]]	+	[[Category: Edwards AM]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Elkins JM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Goubin S]]
-	[[Category: Elkins~~, J M~~]]	+	[[Category: Krojer T]]
-	[[Category: Goubin, S]]	+	[[Category: Mahajan P]]
-	[[Category: Krojer, T]]	+	[[Category: Vollmar M]]
-	[[Category: Mahajan, P]]	+	[[Category: Von Delft F]]
-	[[Category: Vollmar, M]]	+
-	[[Category: ~~Collagen]]~~	+
-	~~[[Category: Discoidin domain]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Receptor tyrosine kinase]]~~	+
-	~~[[Category: Rtk]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:16, 31 August 2022

2022-08-31T07:16:40Z

←Older revision		Revision as of 07:16, 31 August 2022
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	<StructureSection load='4bkj' size='340' side='right'caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4bkj' size='340' side='right'caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bki\|4bki]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bki\|4bki]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [~~http~~://pdbe.org/4bkj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bkj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [https://pdbe.org/4bkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [https://www.ebi.ac.uk/pdbsum/4bkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:35, 29 January 2020

2020-01-29T16:35:11Z

←Older revision		Revision as of 16:35, 29 January 2020
Line 1:		Line 1:

	==Crystal structure of the human DDR1 kinase domain in complex with imatinib==		==Crystal structure of the human DDR1 kinase domain in complex with imatinib==
-	<StructureSection load='4bkj' size='340' side='right' caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4bkj' size='340' side='right'caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4bkj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4bkj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Epithelial discoidin domain-containing receptor\|Epithelial discoidin domain-containing receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 16:48, 11 August 2016

2016-08-11T16:48:26Z

←Older revision		Revision as of 16:48, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the human DDR1 kinase domain in complex with imatinib==		==Crystal structure of the human DDR1 kinase domain in complex with imatinib==
	<StructureSection load='4bkj' size='340' side='right' caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4bkj' size='340' side='right' caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bki\|4bki]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bki\|4bki]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [http://www.ebi.ac.uk/pdbsum/4bkj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [http://pdbe.org/4bkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [http://www.ebi.ac.uk/pdbsum/4bkj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bkj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:34, 4 January 2015

2015-01-04T13:34:01Z

←Older revision		Revision as of 13:34, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bki\|4bki]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bki\|4bki]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [http://www.ebi.ac.uk/pdbsum/4bkj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [http://www.ebi.ac.uk/pdbsum/4bkj PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Bullock, A.]]	+	[[Category: Bullock, A]]
-	[[Category: Canning, P.]]	+	[[Category: Canning, P]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Elkins, J M.]]	+	[[Category: Elkins, J M]]
-	[[Category: Goubin, S.]]	+	[[Category: Goubin, S]]
-	[[Category: Krojer, T.]]	+	[[Category: Krojer, T]]
-	[[Category: Mahajan, P.]]	+	[[Category: Mahajan, P]]
-	[[Category: Vollmar, M.]]	+	[[Category: Vollmar, M]]
	[[Category: Collagen]]		[[Category: Collagen]]
	[[Category: Discoidin domain]]		[[Category: Discoidin domain]]

OCA at 05:20, 18 June 2014

2014-06-18T05:20:49Z

←Older revision		Revision as of 05:20, 18 June 2014
Line 2:		Line 2:
	<StructureSection load='4bkj' size='340' side='right' caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4bkj' size='340' side='right' caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. <br>	+	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKJ FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene><br>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bki\|4bki]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bki\|4bki]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [http://www.ebi.ac.uk/pdbsum/4bkj PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [http://www.ebi.ac.uk/pdbsum/4bkj PDBsum]</span></td></tr>
	<table>		<table>
Line 14:		Line 14:
	Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.,Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818<ref>PMID:24768818</ref>		Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.,Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818<ref>PMID:24768818</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 06:44, 7 May 2014

2014-05-07T06:44:00Z

←Older revision		Revision as of 06:44, 7 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bkj\| PDB=4bkj \| SCENE= }}~~	+	==Crystal structure of the human DDR1 kinase domain in complex with imatinib==
-	===Crystal structure of the human DDR1 kinase domain in complex with imatinib===	+	<StructureSection load='4bkj' size='340' side='right' caption='[[4bkj]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bki\|4bki]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkj RCSB], [http://www.ebi.ac.uk/pdbsum/4bkj PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The discoidin domain receptors, DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical collagen. Excessive signaling by DDR1 and DDR2 has been linked to the progression of various human diseases, including fibrosis, atherosclerosis and cancer. We report the inhibition of these unusual receptor tyrosine kinases by the multi-targeted cancer drugs imatinib and ponatinib as well as the selective type II inhibitor DDR1-IN-1. Ponatinib is identified as the more potent molecule, which inhibits DDR1 and DDR2 with an IC50 of 9 nM. Co-crystal structures of human DDR1 reveal a DFG-out conformation of the kinase domain that is stabilized by an unusual salt bridge between the activation loop and alphaD helix. Differences to Abelson kinase (ABL) are observed in the DDR1 P-loop, where a beta-hairpin replaces the cage-like structure of ABL. P-loop residues in DDR1 that confer drug resistance in ABL are therefore accommodated outside the ATP pocket. Whereas imatinib and ponatinib bind potently to both the DDR and ABL kinases, the hydrophobic interactions of the ABL P-loop appear poorly satisfied by DDR1-IN-1 suggesting a structural basis for its DDR1 selectivity. Such inhibitors may have applications in clinical indications of DDR1 and DDR2 overexpression or mutation, including lung cancer.

-	~~==About this Structure==~~	+	Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.,Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818<ref>PMID:24768818</ref>
-	~~[[4bkj]] is a 2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki~~/~~Human Human]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4BKJ OCA].~~	+
		+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]

OCA at 06:09, 23 April 2014

2014-04-23T06:09:04Z

←Older revision		Revision as of 06:09, 23 April 2014
Line 3:		Line 3:

	==About this Structure==		==About this Structure==
-	[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA].	+	[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA].
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA at 06:24, 20 June 2013

2013-06-20T06:24:20Z

←Older revision		Revision as of 06:24, 20 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4bkj\| PDB=4bkj \| SCENE= }}
		+	===Crystal structure of the human DDR1 kinase domain in complex with imatinib===

-	~~The entry~~ 4bkj is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4bkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKJ OCA].
-	~~Authors~~: ~~Canning, P~~.~~, Elkins, J~~.M.~~, Goubin, S~~., ~~Mahajan, P~~., ~~Krojer, T~~., ~~Vollmar, M~~., ~~von~~ Delft, F.~~, Arrowsmith, C.H.,~~ Edwards, A.M., ~~Bountra~~, C., ~~Bullock~~, A.	+	[[Category: Homo sapiens]]
-		+	[[Category: Receptor protein-tyrosine kinase]]
-	~~Description~~: ~~Crystal structure of the human DDR1 kinase~~ domain ~~in complex with imatinib~~	+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Bullock, A.]]
		+	[[Category: Canning, P.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Elkins, J M.]]
		+	[[Category: Goubin, S.]]
		+	[[Category: Krojer, T.]]
		+	[[Category: Mahajan, P.]]
		+	[[Category: Vollmar, M.]]
		+	[[Category: Collagen]]
		+	[[Category: Discoidin domain]]
		+	[[Category: Receptor]]
		+	[[Category: Receptor tyrosine kinase]]
		+	[[Category: Rtk]]
		+	[[Category: Transferase]]

OCA at 07:05, 8 May 2013

2013-05-08T07:05:34Z

←Older revision		Revision as of 07:05, 8 May 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4bkj is ON HOLD	+	The entry 4bkj is ON HOLD until Paper Publication

	Authors: Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Krojer, T., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.		Authors: Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Krojer, T., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

	Description: Crystal structure of the human DDR1 kinase domain in complex with imatinib		Description: Crystal structure of the human DDR1 kinase domain in complex with imatinib