4bl6 - Revision history

OCA at 07:17, 31 August 2022

2022-08-31T07:17:20Z

←Older revision		Revision as of 07:17, 31 August 2022
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	<StructureSection load='4bl6' size='340' side='right'caption='[[4bl6]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='4bl6' size='340' side='right'caption='[[4bl6]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bl6]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BL6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bl6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BL6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4bl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl6 OCA], [~~http~~://pdbe.org/4bl6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4bl6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4bl6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4bl6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl6 OCA], [https://pdbe.org/4bl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bl6 RCSB], [https://www.ebi.ac.uk/pdbsum/4bl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bl6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BICD_DROME BICD_DROME]] This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. BicD mutations cause Nanos mislocalization and thus bicaudal development.	+	[[https://www.uniprot.org/uniprot/BICD_DROME BICD_DROME]] This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. BicD mutations cause Nanos mislocalization and thus bicaudal development.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:08, 13 March 2019

2019-03-13T13:08:27Z

←Older revision		Revision as of 13:08, 13 March 2019
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	==Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein==		==Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein==
-	<StructureSection load='4bl6' size='340' side='right' caption='[[4bl6]], [[Resolution\|resolution]] 2.18Å' scene=''>	+	<StructureSection load='4bl6' size='340' side='right'caption='[[4bl6]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4bl6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BL6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4bl6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BL6 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Bullock, S L]]		[[Category: Bullock, S L]]
	[[Category: Holding, A N]]		[[Category: Holding, A N]]

OCA at 18:29, 5 August 2016

2016-08-05T18:29:38Z

←Older revision		Revision as of 18:29, 5 August 2016
Line 1:		Line 1:
		+
	==Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein==		==Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein==
	<StructureSection load='4bl6' size='340' side='right' caption='[[4bl6]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='4bl6' size='340' side='right' caption='[[4bl6]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4bl6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BL6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4bl6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BL6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bl6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bl6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl6 OCA], [http://pdbe.org/4bl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bl6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bl6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bl6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4bl6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Bullock, S L]]		[[Category: Bullock, S L]]
	[[Category: Holding, A N]]		[[Category: Holding, A N]]

OCA at 20:58, 25 December 2014

2014-12-25T20:58:14Z

←Older revision		Revision as of 20:58, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bl6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bl6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bl6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bl6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BICD_DROME BICD_DROME]] This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. BicD mutations cause Nanos mislocalization and thus bicaudal development.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:03, 21 December 2014

2014-12-21T09:03:53Z

←Older revision		Revision as of 09:03, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4bl6\| PDB=4bl6 \| SCENE= }}~~	+	==Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein==
-	===Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein===	+	<StructureSection load='4bl6' size='340' side='right' caption='[[4bl6]], [[Resolution\|resolution]] 2.18Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23723415}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4bl6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BL6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bl6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bl6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytoplasmic dynein is the major minus end-directed microtubule motor in eukaryotes. However, there is little structural insight into how different cargos are recognized and linked to the motor complex. Here we describe the 2.2 A resolution crystal structure of a cargo-binding region of the dynein adaptor Bicaudal-D (BicD), which reveals a parallel coiled-coil homodimer. We identify a shared binding site for two cargo-associated proteins-Rab6 and the RNA-binding protein Egalitarian (Egl)-within a region of the BicD structure with classical, homotypic core packing. Structure-based mutagenesis in Drosophila provides evidence that occupancy of this site drives association of BicD with dynein, thereby coupling motor recruitment to cargo availability. The structure also contains a region in which, remarkably, the same residues in the polypeptide sequence have different heptad registry in each chain. In vitro and in vivo analysis of a classical Drosophila dominant mutation reveals that this heterotypic region regulates the recruitment of dynein to BicD. Our results support a model in which the heterotypic segment is part of a molecular switch that promotes release of BicD autoinhibition following cargo binding to the neighboring, homotypic coiled-coil region. Overall, our data reveal a pivotal role of a highly asymmetric coiled-coil domain in coordinating the assembly of cargo-motor complexes.

-	~~==Function==~~	+	Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein.,Liu Y, Salter HK, Holding AN, Johnson CM, Stephens E, Lukavsky PJ, Walshaw J, Bullock SL Genes Dev. 2013 Jun 1;27(11):1233-46. doi: 10.1101/gad.212381.112. Epub 2013 May , 30. PMID:23723415<ref>PMID:23723415</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/BICD_DROME BICD_DROME]] This protein is essential for differentiation~~. ~~It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes~~. ~~BicD mutations cause Nanos mislocalization and thus bicaudal development~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4bl6]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023723415</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Bullock, S L.]]	+	[[Category: Bullock, S L]]
-	[[Category: Holding, A N.]]	+	[[Category: Holding, A N]]
-	[[Category: Johnson, C M.]]	+	[[Category: Johnson, C M]]
-	[[Category: Liu, Y.]]	+	[[Category: Liu, Y]]
-	[[Category: Lukavsky, P J.]]	+	[[Category: Lukavsky, P J]]
-	[[Category: Salter, H K.]]	+	[[Category: Salter, H K]]
-	[[Category: Stephens, E.]]	+	[[Category: Stephens, E]]
-	[[Category: Walshaw, J.]]	+	[[Category: Walshaw, J]]
	[[Category: Cargo binding]]		[[Category: Cargo binding]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 13:46, 19 June 2013

2013-06-19T13:46:07Z

←Older revision		Revision as of 13:46, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4bl6\| PDB=4bl6 \| SCENE= }}
		+	===Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein===
		+	{{ABSTRACT_PUBMED_23723415}}

-	~~The entry 4bl6~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BICD_DROME BICD_DROME]] This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. BicD mutations cause Nanos mislocalization and thus bicaudal development.

-	~~Authors~~: ~~Liu, Y~~.~~, Salter, H~~.K.~~, Holding, A.N., Johnson, C.M., Stephens, E., Lukavsky, P.J~~.~~, Walshaw, J~~.~~, Bullock, S~~.L.	+	==About this Structure==
		+	[[4bl6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL6 OCA].

-	~~Description~~: ~~Bicaudal-D uses a parallel~~, ~~homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein~~	+	==Reference==
		+	<ref group="xtra">PMID:023723415</ref><references group="xtra"/><references/>
		+	[[Category: Drosophila melanogaster]]
		+	[[Category: Bullock, S L.]]
		+	[[Category: Holding, A N.]]
		+	[[Category: Johnson, C M.]]
		+	[[Category: Liu, Y.]]
		+	[[Category: Lukavsky, P J.]]
		+	[[Category: Salter, H K.]]
		+	[[Category: Stephens, E.]]
		+	[[Category: Walshaw, J.]]
		+	[[Category: Cargo binding]]
		+	[[Category: Protein transport]]

OCA: Protected "4bl6" [edit=sysop:move=sysop]

2013-05-08T07:06:16Z

Protected "4bl6" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:06, 8 May 2013

OCA: New page: '''Unreleased structure''' The entry 4bl6 is ON HOLD until Paper Publication Authors: Liu, Y., Salter, H.K., Holding, A.N., Johnson, C.M., Stephens, E., Lukavsky, P.J., Walshaw, J., Bul...

2013-05-08T07:06:15Z

New page: '''Unreleased structure''' The entry 4bl6 is ON HOLD until Paper Publication Authors: Liu, Y., Salter, H.K., Holding, A.N., Johnson, C.M., Stephens, E., Lukavsky, P.J., Walshaw, J., Bul...

New page

'''Unreleased structure'''

The entry 4bl6 is ON HOLD until Paper Publication

Authors: Liu, Y., Salter, H.K., Holding, A.N., Johnson, C.M., Stephens, E., Lukavsky, P.J., Walshaw, J., Bullock, S.L.

Description: Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to co-ordinate recruitment of cargos to dynein