4blg - Revision history

OCA at 11:53, 20 December 2023

2023-12-20T11:53:53Z

←Older revision		Revision as of 11:53, 20 December 2023
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	<StructureSection load='4blg' size='340' side='right'caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4blg' size='340' side='right'caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mhv68 Mhv68~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BLG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Murid_gammaherpesvirus_4 Murid gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BLG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blg OCA], [https://pdbe.org/4blg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4blg RCSB], [https://www.ebi.ac.uk/pdbsum/4blg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4blg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blg OCA], [https://pdbe.org/4blg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4blg RCSB], [https://www.ebi.ac.uk/pdbsum/4blg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4blg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O41974_MHV68 O41974_MHV68]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mhv68~~]]	+	[[Category: Murid gammaherpesvirus 4]]
-	[[Category: Beauchemin, C]]	+	[[Category: Beauchemin C]]
-	[[Category: Carrondo~~, M A~~]]	+	[[Category: Carrondo MA]]
-	[[Category: Cerqueira~~, S A~~]]	+	[[Category: Cerqueira SA]]
-	[[Category: Correia, B]]	+	[[Category: Correia B]]
-	[[Category: Kaye~~, K M~~]]	+	[[Category: Kaye KM]]
-	[[Category: Li, S]]	+	[[Category: Li S]]
-	[[Category: McVey~~, C E~~]]	+	[[Category: McVey CE]]
-	[[Category: ~~Miranda, M~~ Pires De]]	+	[[Category: Pires De Miranda M]]
-	[[Category: Ponnusamy, R]]	+	[[Category: Ponnusamy R]]
-	[[Category: Rodrigues, L]]	+	[[Category: Rodrigues L]]
-	[[Category: Schneider~~, T R~~]]	+	[[Category: Schneider TR]]
-	[[Category: Simas~~, J P]]~~	+	[[Category: Simas JP]]
-	~~[[Category: Viral protein~~]]	+

OCA at 07:17, 31 August 2022

2022-08-31T07:17:40Z

←Older revision		Revision as of 07:17, 31 August 2022
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	<StructureSection load='4blg' size='340' side='right'caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4blg' size='340' side='right'caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4BLG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BLG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blg OCA], [~~http~~://pdbe.org/4blg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4blg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4blg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4blg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blg OCA], [https://pdbe.org/4blg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4blg RCSB], [https://www.ebi.ac.uk/pdbsum/4blg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4blg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:58, 29 January 2020

2020-01-29T16:58:30Z

←Older revision		Revision as of 16:58, 29 January 2020
Line 1:		Line 1:

	==Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain==		==Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain==
-	<StructureSection load='4blg' size='340' side='right' caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4blg' size='340' side='right'caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLG FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mhv68]]		[[Category: Mhv68]]
	[[Category: Beauchemin, C]]		[[Category: Beauchemin, C]]

OCA at 13:31, 5 August 2016

2016-08-05T13:31:21Z

←Older revision		Revision as of 13:31, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain==		==Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain==
	<StructureSection load='4blg' size='340' side='right' caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4blg' size='340' side='right' caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4blg RCSB], [http://www.ebi.ac.uk/pdbsum/4blg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blg OCA], [http://pdbe.org/4blg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4blg RCSB], [http://www.ebi.ac.uk/pdbsum/4blg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4blg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4blg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:22, 17 December 2014

2014-12-17T10:22:25Z

←Older revision		Revision as of 10:22, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4blg\| PDB=4blg \| SCENE= }}~~	+	==Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain==
-	===Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain===	+	<StructureSection load='4blg' size='340' side='right' caption='[[4blg]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24146618}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4blg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4blg RCSB], [http://www.ebi.ac.uk/pdbsum/4blg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Latency-associated nuclear antigen (LANA) mediates gamma2-herpesvirus genome persistence and regulates transcription. We describe the crystal structure of the murine gammaherpesvirus-68 LANA C-terminal domain at 2.2 A resolution. The structure reveals an alpha-beta fold that assembles as a dimer, reminiscent of Epstein-Barr virus EBNA1. A predicted DNA binding surface is present and opposite this interface is a positive electrostatic patch. Targeted DNA recognition substitutions eliminated DNA binding, while certain charged patch mutations reduced bromodomain protein, BRD4, binding. Virus containing LANA abolished for DNA binding was incapable of viable latent infection in mice. Virus with mutations at the charged patch periphery exhibited substantial deficiency in expansion of latent infection, while central region substitutions had little effect. This deficiency was independent of BRD4. These results elucidate the LANA DNA binding domain structure and reveal a unique charged region that exerts a critical role in viral latent infection, likely acting through a host cell protein(s).

-	~~==About this~~ Structure==	+	Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency.,Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE PLoS Pathog. 2013 Oct;9(10):e1003673. doi: 10.1371/journal.ppat.1003673. Epub, 2013 Oct 17. PMID:24146618<ref>PMID:24146618</ref>
-	~~[[4blg]] is a~~ 2 ~~chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Murid_herpesvirus_4 Murid herpesvirus 4]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4BLG OCA].~~	+

-	~~==Reference==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group="xtra"~~>~~PMID:024146618~~</~~ref~~><references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: ~~Murid herpesvirus 4~~]]	+	== References ==
-	[[Category: Beauchemin, C.]]	+	<references/>
-	[[Category: Carrondo, M A.]]	+	__TOC__
-	[[Category: Cerqueira, S A.]]	+	</StructureSection>
-	[[Category: Correia, B.]]	+	[[Category: Mhv68]]
-	[[Category: Kaye, K M.]]	+	[[Category: Beauchemin, C]]
-	[[Category: Li, S.]]	+	[[Category: Carrondo, M A]]
-	[[Category: McVey, C E.]]	+	[[Category: Cerqueira, S A]]
-	[[Category: Miranda, M Pires De.]]	+	[[Category: Correia, B]]
-	[[Category: Ponnusamy, R.]]	+	[[Category: Kaye, K M]]
-	[[Category: Rodrigues, L.]]	+	[[Category: Li, S]]
-	[[Category: Schneider, T R.]]	+	[[Category: McVey, C E]]
-	[[Category: Simas, J P.]]	+	[[Category: Miranda, M Pires De]]
		+	[[Category: Ponnusamy, R]]
		+	[[Category: Rodrigues, L]]
		+	[[Category: Schneider, T R]]
		+	[[Category: Simas, J P]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 09:42, 30 October 2013

2013-10-30T09:42:40Z

←Older revision		Revision as of 09:42, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4blg\| PDB=4blg \| SCENE= }}
		+	===Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain===
		+	{{ABSTRACT_PUBMED_24146618}}

-	~~The entry~~ 4blg is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4blg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Murid_herpesvirus_4 Murid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLG OCA].

-	~~Authors~~: ~~Correia~~, B., Cerqueira, S.A., ~~Beauchemin, C~~., ~~Pires De Miranda,~~ M., Li, S., Ponnusamy, R., Rodrigues, L., Schneider, T.R.~~, Carrondo, M.A., Kaye, K.M.,~~ Simas, J.P.~~, McVey, C.E.~~	+	==Reference==
-		+	<ref group="xtra">PMID:024146618</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain~~	+	[[Category: Murid herpesvirus 4]]
		+	[[Category: Beauchemin, C.]]
		+	[[Category: Carrondo, M A.]]
		+	[[Category: Cerqueira, S A.]]
		+	[[Category: Correia, B.]]
		+	[[Category: Kaye, K M.]]
		+	[[Category: Li, S.]]
		+	[[Category: McVey, C E.]]
		+	[[Category: Miranda, M Pires De.]]
		+	[[Category: Ponnusamy, R.]]
		+	[[Category: Rodrigues, L.]]
		+	[[Category: Schneider, T R.]]
		+	[[Category: Simas, J P.]]
		+	[[Category: Viral protein]]

OCA at 10:46, 19 June 2013

2013-06-19T10:46:17Z

←Older revision		Revision as of 10:46, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4blg is ON HOLD	+	The entry 4blg is ON HOLD until Paper Publication

	Authors: Correia, B., Cerqueira, S.A., Beauchemin, C., Pires De Miranda, M., Li, S., Ponnusamy, R., Rodrigues, L., Schneider, T.R., Carrondo, M.A., Kaye, K.M., Simas, J.P., McVey, C.E.		Authors: Correia, B., Cerqueira, S.A., Beauchemin, C., Pires De Miranda, M., Li, S., Ponnusamy, R., Rodrigues, L., Schneider, T.R., Carrondo, M.A., Kaye, K.M., Simas, J.P., McVey, C.E.

	Description: Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain		Description: Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain

OCA: Protected "4blg" [edit=sysop:move=sysop]

2013-05-08T07:06:34Z

Protected "4blg" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:06, 8 May 2013

OCA: New page: '''Unreleased structure''' The entry 4blg is ON HOLD Authors: Correia, B., Cerqueira, S.A., Beauchemin, C., Pires De Miranda, M., Li, S., Ponnusamy, R., Rodrigues, L., Schneider, T.R., ...

2013-05-08T07:06:31Z

New page: '''Unreleased structure''' The entry 4blg is ON HOLD Authors: Correia, B., Cerqueira, S.A., Beauchemin, C., Pires De Miranda, M., Li, S., Ponnusamy, R., Rodrigues, L., Schneider, T.R., ...

New page

'''Unreleased structure'''

The entry 4blg is ON HOLD

Authors: Correia, B., Cerqueira, S.A., Beauchemin, C., Pires De Miranda, M., Li, S., Ponnusamy, R., Rodrigues, L., Schneider, T.R., Carrondo, M.A., Kaye, K.M., Simas, J.P., McVey, C.E.

Description: Crystal structure of MHV-68 Latency-associated nuclear antigen (LANA) C-terminal DNA binding domain