4c0k - Revision history

OCA at 07:18, 1 May 2024

2024-05-01T07:18:09Z

←Older revision		Revision as of 07:18, 1 May 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>		[https://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, each paired with a canonical EF hand. Each EF hand pair is bound to a helix that structurally mimics an EF hand ligand. A key nucleotide-sensing element and a Pink1 phosphorylation site both lie within an extensive EF hand-cGTPase interface. Our results indicate structural mechanisms for calcium, nucleotide and phosphorylation-dependent regulation of mitochondrial function by Miro.
-
-	Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro.,Klosowiak JL, Focia PJ, Chakravarthy S, Landahl EC, Freymann DM, Rice SE EMBO Rep. 2013 Sep 27. doi: 10.1038/embor.2013.151. PMID:24071720<ref>PMID:24071720</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4c0k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:11, 15 November 2023

2023-11-15T09:11:18Z

←Older revision		Revision as of 09:11, 15 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.801Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0k OCA], [https://pdbe.org/4c0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0k RCSB], [https://www.ebi.ac.uk/pdbsum/4c0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0k OCA], [https://pdbe.org/4c0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0k RCSB], [https://www.ebi.ac.uk/pdbsum/4c0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>	+	[https://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, each paired with a canonical EF hand. Each EF hand pair is bound to a helix that structurally mimics an EF hand ligand. A key nucleotide-sensing element and a Pink1 phosphorylation site both lie within an extensive EF hand-cGTPase interface. Our results indicate structural mechanisms for calcium, nucleotide and phosphorylation-dependent regulation of mitochondrial function by Miro.
		+
		+	Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro.,Klosowiak JL, Focia PJ, Chakravarthy S, Landahl EC, Freymann DM, Rice SE EMBO Rep. 2013 Sep 27. doi: 10.1038/embor.2013.151. PMID:24071720<ref>PMID:24071720</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4c0k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:19, 7 September 2022

2022-09-07T17:19:18Z

←Older revision		Revision as of 17:19, 7 September 2022
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	<StructureSection load='4c0k' size='340' side='right'caption='[[4c0k]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4c0k' size='340' side='right'caption='[[4c0k]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c0k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C0K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c0j\|4c0j]], [[4c0l\|4c0l]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0k OCA], [https://pdbe.org/4c0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0k RCSB], [https://www.ebi.ac.uk/pdbsum/4c0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0k ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0k OCA], [~~http~~://pdbe.org/4c0k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c0k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c0k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0k ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>	+	[[https://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, each paired with a canonical EF hand. Each EF hand pair is bound to a helix that structurally mimics an EF hand ligand. A key nucleotide-sensing element and a Pink1 phosphorylation site both lie within an extensive EF hand-cGTPase interface. Our results indicate structural mechanisms for calcium, nucleotide and phosphorylation-dependent regulation of mitochondrial function by Miro.	+
-		+
-	Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro.,Klosowiak JL, Focia PJ, Chakravarthy S, Landahl EC, Freymann DM, Rice SE EMBO Rep. 2013 Sep 27. doi: 10.1038/embor.2013.151. PMID:24071720<ref>PMID:24071720</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4c0k" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
-	*[[Rho GTPase\|Rho GTPase]]	+	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chakravarthy, S]]	+	[[Category: Chakravarthy S]]
-	[[Category: Focia~~, P J~~]]	+	[[Category: Focia PJ]]
-	[[Category: Freymann~~, D M~~]]	+	[[Category: Freymann DM]]
-	[[Category: Klosowiak~~, J L~~]]	+	[[Category: Klosowiak JL]]
-	[[Category: Landahl~~, E C~~]]	+	[[Category: Landahl EC]]
-	[[Category: Rice~~, S E~~]]	+	[[Category: Rice SE]]
-	[[Category: Wawrzak, Z]]	+	[[Category: Wawrzak Z]]
-	~~[[Category: Calcium-binding gtpase]]~~	+
-	~~[[Category: Hidden ef hand]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Kinesin]]~~	+
-	~~[[Category: Mitochondrial transport]]~~	+
-	~~[[Category: Mitophagy~~]]	+

OCA at 13:45, 13 March 2019

2019-03-13T13:45:43Z

←Older revision		Revision as of 13:45, 13 March 2019
Line 1:		Line 1:

	==Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)==		==Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)==
-	<StructureSection load='4c0k' size='340' side='right' caption='[[4c0k]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4c0k' size='340' side='right'caption='[[4c0k]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0K FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4c0k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4c0k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rho GTPase\|Rho GTPase]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Chakravarthy, S]]		[[Category: Chakravarthy, S]]
	[[Category: Focia, P J]]		[[Category: Focia, P J]]

OCA at 14:13, 4 August 2016

2016-08-04T14:13:43Z

←Older revision		Revision as of 14:13, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)==		==Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)==
	<StructureSection load='4c0k' size='340' side='right' caption='[[4c0k]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4c0k' size='340' side='right' caption='[[4c0k]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c0j\|4c0j]], [[4c0l\|4c0l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c0j\|4c0j]], [[4c0l\|4c0l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0k RCSB], [http://www.ebi.ac.uk/pdbsum/4c0k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0k OCA], [http://pdbe.org/4c0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c0k RCSB], [http://www.ebi.ac.uk/pdbsum/4c0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c0k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:29, 24 December 2014

2014-12-24T15:29:53Z

←Older revision		Revision as of 15:29, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4c0k\| PDB=4c0k \| SCENE= }}~~	+	==Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)==
-	===Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)===	+	<StructureSection load='4c0k' size='340' side='right' caption='[[4c0k]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24071720}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4c0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0K FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c0j\|4c0j]], [[4c0l\|4c0l]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c0k RCSB], [http://www.ebi.ac.uk/pdbsum/4c0k PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>		[[http://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, each paired with a canonical EF hand. Each EF hand pair is bound to a helix that structurally mimics an EF hand ligand. A key nucleotide-sensing element and a Pink1 phosphorylation site both lie within an extensive EF hand-cGTPase interface. Our results indicate structural mechanisms for calcium, nucleotide and phosphorylation-dependent regulation of mitochondrial function by Miro.

-	~~==About this Structure==~~	+	Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro.,Klosowiak JL, Focia PJ, Chakravarthy S, Landahl EC, Freymann DM, Rice SE EMBO Rep. 2013 Sep 27. doi: 10.1038/embor.2013.151. PMID:24071720<ref>PMID:24071720</ref>
-	~~[[4c0k]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drome Drome]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4C0K OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024071720</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
-	[[Category: Chakravarthy, S.]]	+	[[Category: Chakravarthy, S]]
-	[[Category: Focia, P J.]]	+	[[Category: Focia, P J]]
-	[[Category: Freymann, D M.]]	+	[[Category: Freymann, D M]]
-	[[Category: Klosowiak, J L.]]	+	[[Category: Klosowiak, J L]]
-	[[Category: Landahl, E C.]]	+	[[Category: Landahl, E C]]
-	[[Category: Rice, S E.]]	+	[[Category: Rice, S E]]
-	[[Category: Wawrzak, Z.]]	+	[[Category: Wawrzak, Z]]
	[[Category: Calcium-binding gtpase]]		[[Category: Calcium-binding gtpase]]
	[[Category: Hidden ef hand]]		[[Category: Hidden ef hand]]

OCA at 06:17, 13 November 2013

2013-11-13T06:17:27Z

←Older revision		Revision as of 06:17, 13 November 2013
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4c0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA].	+	[[4c0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024071720</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024071720</ref><references group="xtra"/><references/>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Chakravarthy, S.]]		[[Category: Chakravarthy, S.]]
	[[Category: Focia, P J.]]		[[Category: Focia, P J.]]

OCA at 06:20, 10 October 2013

2013-10-10T06:20:03Z

←Older revision		Revision as of 06:20, 10 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4c0k\| PDB=4c0k \| SCENE= }}
		+	===Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)===
		+	{{ABSTRACT_PUBMED_24071720}}

-	~~The entry 4c0k is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>

-	~~Authors~~: ~~Klosowiak, J~~.L.~~, Focia, P~~.~~J., Wawrzak, Z., Chakravarthy, S., Landahl, E.C., Freymann, D~~.M.~~, Rice, S~~.E.	+	==About this Structure==
		+	[[4c0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA].

-	~~Description~~: ~~Crystal structure of the outer mitochondrial membrane protein Miro bound to one calcium ion~~	+	==Reference==
		+	<ref group="xtra">PMID:024071720</ref><references group="xtra"/><references/>
		+	[[Category: Drosophila melanogaster]]
		+	[[Category: Chakravarthy, S.]]
		+	[[Category: Focia, P J.]]
		+	[[Category: Freymann, D M.]]
		+	[[Category: Klosowiak, J L.]]
		+	[[Category: Landahl, E C.]]
		+	[[Category: Rice, S E.]]
		+	[[Category: Wawrzak, Z.]]
		+	[[Category: Calcium-binding gtpase]]
		+	[[Category: Hidden ef hand]]
		+	[[Category: Hydrolase]]
		+	[[Category: Kinesin]]
		+	[[Category: Mitochondrial transport]]
		+	[[Category: Mitophagy]]

OCA: Protected "4c0k" [edit=sysop:move=sysop]

2013-08-14T07:00:41Z

Protected "4c0k" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:00, 14 August 2013

OCA: New page: '''Unreleased structure''' The entry 4c0k is ON HOLD Authors: Klosowiak, J.L., Focia, P.J., Wawrzak, Z., Chakravarthy, S., Landahl, E.C., Freymann, D.M., Rice, S.E. Description: Crysta...

2013-08-14T07:00:40Z

New page: '''Unreleased structure''' The entry 4c0k is ON HOLD Authors: Klosowiak, J.L., Focia, P.J., Wawrzak, Z., Chakravarthy, S., Landahl, E.C., Freymann, D.M., Rice, S.E. Description: Crysta...

New page

'''Unreleased structure'''

The entry 4c0k is ON HOLD

Authors: Klosowiak, J.L., Focia, P.J., Wawrzak, Z., Chakravarthy, S., Landahl, E.C., Freymann, D.M., Rice, S.E.

Description: Crystal structure of the outer mitochondrial membrane protein Miro bound to one calcium ion