4c25 - Revision history

OCA at 12:02, 20 December 2023

2023-12-20T12:02:05Z

←Older revision		Revision as of 12:02, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c25]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C25 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c25]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C25 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c25 OCA], [https://pdbe.org/4c25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c25 RCSB], [https://www.ebi.ac.uk/pdbsum/4c25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c25 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c25 OCA], [https://pdbe.org/4c25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c25 RCSB], [https://www.ebi.ac.uk/pdbsum/4c25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c25 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/A0A0H2US48_STRPN A0A0H2US48_STRPN]]	+	[https://www.uniprot.org/uniprot/A0A0H2US48_STRPN A0A0H2US48_STRPN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fucose metabolism pathways are present in many bacterial species and typically contain the central fucose-processing enzymes fucose isomerase (FcsI), fuculose kinase (FcsK), and fuculose-1-phosphate aldolase (FcsA). Fucose initially undergoes isomerization by FcsI producing fuculose, which is then phosphorylated by FcsK. FcsA cleaves the fuculose-1-phosphate product into lactaldehyde and dihydroxyacetone phosphate, which can be incorporated into central metabolism allowing the bacterium to use fucose as an energy source. Streptococcus pneumoniae has fucose-processing operons containing homologs of FcsI, FcsK, and FcsA; however, this bacterium appears unable to utilize fucose as an energy source. To investigate this contradiction, we performed biochemical and structural studies of the S. pneumoniae fucose-processing enzymes SpFcsI, SpFcsK, and SpFcsA. These enzymes are demonstrated to act in a sequential manner to ultimately produce dihydroxyacetone phosphate and have structural features entirely consistent with their observed biochemical activities. Analogous to the regulation of the Escherichia coli fucose utilization operon, fuculose-1-phosphate appears to act as an inducing molecule for activation of the S. pneumoniae fucose operon. Despite our evidence that S. pneumoniae appears to have the appropriate regulatory and biochemical machinery for fucose metabolism, we confirmed the inability of the S. pneumoniae TIGR4 strain to grow on fucose or on the H-disaccharide, which is the probable substrate of the transporter for the pathway. On the basis of these observations, we postulate that the S. pneumoniae fucose-processing pathway has a non-metabolic role in the interaction of this bacterium with its human host.
		+
		+	Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus pneumoniae.,Higgins MA, Suits MD, Marsters C, Boraston AB J Mol Biol. 2013 Dec 12. pii: S0022-2836(13)00748-1. doi:, 10.1016/j.jmb.2013.12.006. PMID:24333485<ref>PMID:24333485</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4c25" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Aldolase 3D structures\|Aldolase 3D structures]]		*[[Aldolase 3D structures\|Aldolase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:21, 7 September 2022

2022-09-07T17:21:41Z

←Older revision		Revision as of 17:21, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c25' size='340' side='right'caption='[[4c25]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='4c25' size='340' side='right'caption='[[4c25]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c25]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strpn Strpn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C25 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c25]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C25 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c20\|4c20]], [[4c21\|4c21]], [[4c22\|4c22]], [[4c23\|4c23]], [[4c24\|4c24]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c25 OCA], [https://pdbe.org/4c25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c25 RCSB], [https://www.ebi.ac.uk/pdbsum/4c25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c25 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-fuculose-phosphate_aldolase L-fuculose-phosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.17 4.1.2.17] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c25 OCA], [~~http~~://pdbe.org/4c25 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c25 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c25 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c25 ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[[https://www.uniprot.org/uniprot/A0A0H2US48_STRPN A0A0H2US48_STRPN]]
-	Fucose metabolism pathways are present in many bacterial species and typically contain the central fucose-processing enzymes fucose isomerase (FcsI), fuculose kinase (FcsK), and fuculose-1-phosphate aldolase (FcsA). Fucose initially undergoes isomerization by FcsI producing fuculose, which is then phosphorylated by FcsK. FcsA cleaves the fuculose-1-phosphate product into lactaldehyde and dihydroxyacetone phosphate, which can be incorporated into central metabolism allowing the bacterium to use fucose as an energy source. Streptococcus pneumoniae has fucose-processing operons containing homologs of FcsI, FcsK, and FcsA; however, this bacterium appears unable to utilize fucose as an energy source. To investigate this contradiction, we performed biochemical and structural studies of the S. pneumoniae fucose-processing enzymes SpFcsI, SpFcsK, and SpFcsA. These enzymes are demonstrated to act in a sequential manner to ultimately produce dihydroxyacetone phosphate and have structural features entirely consistent with their observed biochemical activities. Analogous to the regulation of the Escherichia coli fucose utilization operon, fuculose-1-phosphate appears to act as an inducing molecule for activation of the S. pneumoniae fucose operon. Despite our evidence that S. pneumoniae appears to have the appropriate regulatory and biochemical machinery for fucose metabolism, we confirmed the inability of the S. pneumoniae TIGR4 strain to grow on fucose or on the H-disaccharide, which is the probable substrate of the transporter for the pathway. On the basis of these observations, we postulate that the S. pneumoniae fucose-processing pathway has a non-metabolic role in the interaction of this bacterium with its human host.	+
-		+
-	~~Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus pneumoniae.,Higgins MA, Suits MD, Marsters C, Boraston AB J Mol Biol. 2013 Dec 12. pii~~: ~~S0022-2836(13)00748-1. doi:, 10.1016~~/~~j.jmb.2013.12.006. PMID:24333485<ref>PMID:24333485<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 4c25" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Aldolase 3D structures\|Aldolase 3D structures]]		*[[Aldolase 3D structures\|Aldolase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-fuculose-phosphate aldolase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strpn~~]]	+	[[Category: Streptococcus pneumoniae TIGR4]]
-	[[Category: Boraston~~, A B~~]]	+	[[Category: Boraston AB]]
-	[[Category: Higgins~~, M A~~]]	+	[[Category: Higgins MA]]
-	[[Category: Marsters, C]]	+	[[Category: Marsters C]]
-	[[Category: Suits~~, M D.L]]~~	+	[[Category: Suits MDL]]
-	~~[[Category: Fucose processing]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 13:16, 13 March 2019

2019-03-13T13:16:07Z

←Older revision		Revision as of 13:16, 13 March 2019
Line 1:		Line 1:

	==L-fuculose 1-phosphate aldolase==		==L-fuculose 1-phosphate aldolase==
-	<StructureSection load='4c25' size='340' side='right' caption='[[4c25]], [[Resolution\|resolution]] 2.03Å' scene=''>	+	<StructureSection load='4c25' size='340' side='right'caption='[[4c25]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c25]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C25 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c25]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C25 FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Aldolase\|Aldolase]]	+	*[[Aldolase 3D structures\|Aldolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: L-fuculose-phosphate aldolase]]		[[Category: L-fuculose-phosphate aldolase]]
		+	[[Category: Large Structures]]
	[[Category: Strpn]]		[[Category: Strpn]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]

OCA at 15:17, 11 August 2016

2016-08-11T15:17:30Z

←Older revision		Revision as of 15:17, 11 August 2016
Line 1:		Line 1:
		+
	==L-fuculose 1-phosphate aldolase==		==L-fuculose 1-phosphate aldolase==
	<StructureSection load='4c25' size='340' side='right' caption='[[4c25]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='4c25' size='340' side='right' caption='[[4c25]], [[Resolution\|resolution]] 2.03Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c20\|4c20]], [[4c21\|4c21]], [[4c22\|4c22]], [[4c23\|4c23]], [[4c24\|4c24]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c20\|4c20]], [[4c21\|4c21]], [[4c22\|4c22]], [[4c23\|4c23]], [[4c24\|4c24]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-fuculose-phosphate_aldolase L-fuculose-phosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.17 4.1.2.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-fuculose-phosphate_aldolase L-fuculose-phosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.17 4.1.2.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c25 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c25 RCSB], [http://www.ebi.ac.uk/pdbsum/4c25 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c25 OCA], [http://pdbe.org/4c25 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c25 RCSB], [http://www.ebi.ac.uk/pdbsum/4c25 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c25 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c25" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:40, 5 January 2015

2015-01-05T12:40:14Z

←Older revision		Revision as of 12:40, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4c25~~\| ~~PDB~~=4c25 \| ~~SCENE~~= }}	+	==L-fuculose 1-phosphate aldolase==
-	===L-fuculose 1-phosphate aldolase===	+	<StructureSection load='4c25' size='340' side='right' caption='[[4c25]], [[Resolution\|resolution]] 2.03Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24333485}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4c25]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C25 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c20\|4c20]], [[4c21\|4c21]], [[4c22\|4c22]], [[4c23\|4c23]], [[4c24\|4c24]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-fuculose-phosphate_aldolase L-fuculose-phosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.17 4.1.2.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c25 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c25 RCSB], [http://www.ebi.ac.uk/pdbsum/4c25 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fucose metabolism pathways are present in many bacterial species and typically contain the central fucose-processing enzymes fucose isomerase (FcsI), fuculose kinase (FcsK), and fuculose-1-phosphate aldolase (FcsA). Fucose initially undergoes isomerization by FcsI producing fuculose, which is then phosphorylated by FcsK. FcsA cleaves the fuculose-1-phosphate product into lactaldehyde and dihydroxyacetone phosphate, which can be incorporated into central metabolism allowing the bacterium to use fucose as an energy source. Streptococcus pneumoniae has fucose-processing operons containing homologs of FcsI, FcsK, and FcsA; however, this bacterium appears unable to utilize fucose as an energy source. To investigate this contradiction, we performed biochemical and structural studies of the S. pneumoniae fucose-processing enzymes SpFcsI, SpFcsK, and SpFcsA. These enzymes are demonstrated to act in a sequential manner to ultimately produce dihydroxyacetone phosphate and have structural features entirely consistent with their observed biochemical activities. Analogous to the regulation of the Escherichia coli fucose utilization operon, fuculose-1-phosphate appears to act as an inducing molecule for activation of the S. pneumoniae fucose operon. Despite our evidence that S. pneumoniae appears to have the appropriate regulatory and biochemical machinery for fucose metabolism, we confirmed the inability of the S. pneumoniae TIGR4 strain to grow on fucose or on the H-disaccharide, which is the probable substrate of the transporter for the pathway. On the basis of these observations, we postulate that the S. pneumoniae fucose-processing pathway has a non-metabolic role in the interaction of this bacterium with its human host.

-	~~==About this Structure==~~	+	Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus pneumoniae.,Higgins MA, Suits MD, Marsters C, Boraston AB J Mol Biol. 2013 Dec 12. pii: S0022-2836(13)00748-1. doi:, 10.1016/j.jmb.2013.12.006. PMID:24333485<ref>PMID:24333485</ref>
-	~~[[4c25]] is a~~ 1 ~~chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort?id=4C25 OCA]~~.	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase\|Aldolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024333485</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: L-fuculose-phosphate aldolase]]		[[Category: L-fuculose-phosphate aldolase]]
-	[[Category: Boraston, A B.]]	+	[[Category: Strpn]]
-	[[Category: Higgins, M A.]]	+	[[Category: Boraston, A B]]
-	[[Category: Marsters, C.]]	+	[[Category: Higgins, M A]]
-	[[Category: Suits, M D.L.]]	+	[[Category: Marsters, C]]
		+	[[Category: Suits, M D.L]]
	[[Category: Fucose processing]]		[[Category: Fucose processing]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 09:50, 19 March 2014

2014-03-19T09:50:21Z

←Older revision		Revision as of 09:50, 19 March 2014
Line 5:		Line 5:
	==About this Structure==		==About this Structure==
	[[4c25]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA].		[[4c25]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA].
		+
		+	==See Also==
		+	*[[Aldolase\|Aldolase]]

	==Reference==		==Reference==

OCA at 08:22, 8 January 2014

2014-01-08T08:22:08Z

←Older revision		Revision as of 08:22, 8 January 2014
Line 1:		Line 1:
	{{STRUCTURE_4c25\| PDB=4c25 \| SCENE= }}		{{STRUCTURE_4c25\| PDB=4c25 \| SCENE= }}
	===L-fuculose 1-phosphate aldolase===		===L-fuculose 1-phosphate aldolase===
		+	{{ABSTRACT_PUBMED_24333485}}

	==About this Structure==		==About this Structure==
	[[4c25]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA].		[[4c25]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024333485</ref><references group="xtra"/><references/>
	[[Category: L-fuculose-phosphate aldolase]]		[[Category: L-fuculose-phosphate aldolase]]
	[[Category: Boraston, A B.]]		[[Category: Boraston, A B.]]

OCA at 10:34, 18 December 2013

2013-12-18T10:34:16Z

←Older revision		Revision as of 10:34, 18 December 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4c25\| PDB=4c25 \| SCENE= }}
		+	===L-fuculose 1-phosphate aldolase===

-	~~The entry~~ 4c25 is ~~ON HOLD~~	+	==About this Structure==
-		+	[[4c25]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C25 OCA].
-	~~Authors~~: Higgins, M.A., Suits, M.D.L.~~, Marsters, C., Boraston, A.B.~~	+	[[Category: L-fuculose-phosphate aldolase]]
-		+	[[Category: Boraston, A B.]]
-	~~Description~~: ~~L-fuculose 1-phosphate aldolase~~	+	[[Category: Higgins, M A.]]
		+	[[Category: Marsters, C.]]
		+	[[Category: Suits, M D.L.]]
		+	[[Category: Fucose processing]]
		+	[[Category: Lyase]]

OCA: Protected "4c25" [edit=sysop:move=sysop]

2013-08-21T07:38:09Z

Protected "4c25" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:38, 21 August 2013

OCA: New page: '''Unreleased structure''' The entry 4c25 is ON HOLD Authors: Higgins, M.A., Suits, M.D.L., Marsters, C., Boraston, A.B. Description: L-fuculose 1-phosphate aldolase

2013-08-21T07:38:08Z

New page: '''Unreleased structure''' The entry 4c25 is ON HOLD Authors: Higgins, M.A., Suits, M.D.L., Marsters, C., Boraston, A.B. Description: L-fuculose 1-phosphate aldolase

New page

'''Unreleased structure'''

The entry 4c25 is ON HOLD

Authors: Higgins, M.A., Suits, M.D.L., Marsters, C., Boraston, A.B.

Description: L-fuculose 1-phosphate aldolase