4c6s - Revision history

OCA at 07:18, 1 May 2024

2024-05-01T07:18:18Z

←Older revision		Revision as of 07:18, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C6S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C6S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.751Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [https://pdbe.org/4c6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [https://www.ebi.ac.uk/pdbsum/4c6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c6s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [https://pdbe.org/4c6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [https://www.ebi.ac.uk/pdbsum/4c6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c6s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/WRK52_ARATH WRK52_ARATH]] Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Acts also as a disease resistance protein conferring resistance to Ralstonia solanacearum.	+	[https://www.uniprot.org/uniprot/WRK52_ARATH WRK52_ARATH] Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Acts also as a disease resistance protein conferring resistance to Ralstonia solanacearum.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:29, 7 September 2022

2022-09-07T17:29:25Z

←Older revision		Revision as of 17:29, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c6s' size='340' side='right'caption='[[4c6s]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4c6s' size='340' side='right'caption='[[4c6s]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C6S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c6r\|4c6r]], [[4c6t\|4c6t]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [https://pdbe.org/4c6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [https://www.ebi.ac.uk/pdbsum/4c6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c6s ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [~~http~~://pdbe.org/4c6s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c6s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c6s ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/WRK52_ARATH WRK52_ARATH]] Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Acts also as a disease resistance protein conferring resistance to Ralstonia solanacearum.	+	[[https://www.uniprot.org/uniprot/WRK52_ARATH WRK52_ARATH]] Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Acts also as a disease resistance protein conferring resistance to Ralstonia solanacearum.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Cytoplasmic plant immune receptors recognize specific pathogen effector proteins and initiate effector-triggered immunity. In Arabidopsis, the immune receptors RPS4 and RRS1 are both required to activate defense to three different pathogens. We show that RPS4 and RRS1 physically associate. Crystal structures of the N-terminal Toll-interleukin-1 receptor/resistance (TIR) domains of RPS4 and RRS1, individually and as a heterodimeric complex (respectively at 2.05, 1.75, and 2.65 angstrom resolution), reveal a conserved TIR/TIR interaction interface. We show that TIR domain heterodimerization is required to form a functional RRS1/RPS4 effector recognition complex. The RPS4 TIR domain activates effector-independent defense, which is inhibited by the RRS1 TIR domain through the heterodimerization interface. Thus, RPS4 and RRS1 function as a receptor complex in which the two components play distinct roles in recognition and signaling.	+
-		+
-	Structural basis for assembly and function of a heterodimeric plant immune receptor.,Williams SJ, Sohn KH, Wan L, Bernoux M, Sarris PF, Segonzac C, Ve T, Ma Y, Saucet SB, Ericsson DJ, Casey LW, Lonhienne T, Winzor DJ, Zhang X, Coerdt A, Parker JE, Dodds PN, Kobe B, Jones JD Science. 2014 Apr 18;344(6181):299-303. doi: 10.1126/science.1247357. PMID:24744375<ref>PMID:24744375</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4c6s" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bernoux, M]]	+	[[Category: Bernoux M]]
-	[[Category: Dodds~~, P N~~]]	+	[[Category: Dodds PN]]
-	[[Category: Ericsson~~, D J~~]]	+	[[Category: Ericsson DJ]]
-	[[Category: Jones~~, J D.G~~]]	+	[[Category: Jones JDG]]
-	[[Category: Kobe, B]]	+	[[Category: Kobe B]]
-	[[Category: Ma, Y]]	+	[[Category: Ma Y]]
-	[[Category: Parker, J]]	+	[[Category: Parker J]]
-	[[Category: Sarris, P]]	+	[[Category: Sarris P]]
-	[[Category: Saucet~~, S B~~]]	+	[[Category: Saucet SB]]
-	[[Category: Segonzac, C]]	+	[[Category: Segonzac C]]
-	[[Category: Sohn~~, K H~~]]	+	[[Category: Sohn KH]]
-	[[Category: Ve, T]]	+	[[Category: Ve T]]
-	[[Category: Wan, L]]	+	[[Category: Wan L]]
-	[[Category: Williams~~, S J~~]]	+	[[Category: Williams SJ]]
-	[[Category: Zhang, X]]	+	[[Category: Zhang X]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Plant tir domain]]~~	+
-	~~[[Category: Signal transduction~~]]	+

OCA at 09:56, 20 March 2019

2019-03-20T09:56:08Z

←Older revision		Revision as of 09:56, 20 March 2019
Line 1:		Line 1:

	==Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1==		==Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1==
-	<StructureSection load='4c6s' size='340' side='right' caption='[[4c6s]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='4c6s' size='340' side='right'caption='[[4c6s]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C6S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c6r\|4c6r]], [[4c6t\|4c6t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c6r\|4c6r]], [[4c6t\|4c6t]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Bernoux, M]]		[[Category: Bernoux, M]]
	[[Category: Dodds, P N]]		[[Category: Dodds, P N]]

OCA at 09:36, 4 August 2016

2016-08-04T09:36:54Z

←Older revision		Revision as of 09:36, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1==		==Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1==
	<StructureSection load='4c6s' size='340' side='right' caption='[[4c6s]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4c6s' size='340' side='right' caption='[[4c6s]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c6r\|4c6r]], [[4c6t\|4c6t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c6r\|4c6r]], [[4c6t\|4c6t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [http://www.ebi.ac.uk/pdbsum/4c6s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [http://pdbe.org/4c6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [http://www.ebi.ac.uk/pdbsum/4c6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c6s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c6s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:22, 24 December 2014

2014-12-24T08:22:03Z

←Older revision		Revision as of 08:22, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C6S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C6S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c6r\|4c6r]], [[4c6t\|4c6t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c6r\|4c6r]], [[4c6t\|4c6t]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [http://www.ebi.ac.uk/pdbsum/4c6s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [http://www.ebi.ac.uk/pdbsum/4c6s PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/WRK52_ARATH WRK52_ARATH]] Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Acts also as a disease resistance protein conferring resistance to Ralstonia solanacearum.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	Structural basis for assembly and function of a heterodimeric plant immune receptor.,Williams SJ, Sohn KH, Wan L, Bernoux M, Sarris PF, Segonzac C, Ve T, Ma Y, Saucet SB, Ericsson DJ, Casey LW, Lonhienne T, Winzor DJ, Zhang X, Coerdt A, Parker JE, Dodds PN, Kobe B, Jones JD Science. 2014 Apr 18;344(6181):299-303. doi: 10.1126/science.1247357. PMID:24744375<ref>PMID:24744375</ref>		Structural basis for assembly and function of a heterodimeric plant immune receptor.,Williams SJ, Sohn KH, Wan L, Bernoux M, Sarris PF, Segonzac C, Ve T, Ma Y, Saucet SB, Ericsson DJ, Casey LW, Lonhienne T, Winzor DJ, Zhang X, Coerdt A, Parker JE, Dodds PN, Kobe B, Jones JD Science. 2014 Apr 18;344(6181):299-303. doi: 10.1126/science.1247357. PMID:24744375<ref>PMID:24744375</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bernoux, M.]]	+	[[Category: Bernoux, M]]
-	[[Category: Dodds, P N.]]	+	[[Category: Dodds, P N]]
-	[[Category: Ericsson, D J.]]	+	[[Category: Ericsson, D J]]
-	[[Category: Jones, J D.G.]]	+	[[Category: Jones, J D.G]]
-	[[Category: Kobe, B.]]	+	[[Category: Kobe, B]]
-	[[Category: Ma, Y.]]	+	[[Category: Ma, Y]]
-	[[Category: Parker, J.]]	+	[[Category: Parker, J]]
-	[[Category: Sarris, P.]]	+	[[Category: Sarris, P]]
-	[[Category: Saucet, S B.]]	+	[[Category: Saucet, S B]]
-	[[Category: Segonzac, C.]]	+	[[Category: Segonzac, C]]
-	[[Category: Sohn, K H.]]	+	[[Category: Sohn, K H]]
-	[[Category: Ve, T.]]	+	[[Category: Ve, T]]
-	[[Category: Wan, L.]]	+	[[Category: Wan, L]]
-	[[Category: Williams, S J.]]	+	[[Category: Williams, S J]]
-	[[Category: Zhang, X.]]	+	[[Category: Zhang, X]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Plant tir domain]]		[[Category: Plant tir domain]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]

OCA at 09:45, 28 May 2014

2014-05-28T09:45:45Z

←Older revision		Revision as of 09:45, 28 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1==
		+	<StructureSection load='4c6s' size='340' side='right' caption='[[4c6s]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4c6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C6S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c6r\|4c6r]], [[4c6t\|4c6t]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c6s RCSB], [http://www.ebi.ac.uk/pdbsum/4c6s PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytoplasmic plant immune receptors recognize specific pathogen effector proteins and initiate effector-triggered immunity. In Arabidopsis, the immune receptors RPS4 and RRS1 are both required to activate defense to three different pathogens. We show that RPS4 and RRS1 physically associate. Crystal structures of the N-terminal Toll-interleukin-1 receptor/resistance (TIR) domains of RPS4 and RRS1, individually and as a heterodimeric complex (respectively at 2.05, 1.75, and 2.65 angstrom resolution), reveal a conserved TIR/TIR interaction interface. We show that TIR domain heterodimerization is required to form a functional RRS1/RPS4 effector recognition complex. The RPS4 TIR domain activates effector-independent defense, which is inhibited by the RRS1 TIR domain through the heterodimerization interface. Thus, RPS4 and RRS1 function as a receptor complex in which the two components play distinct roles in recognition and signaling.

-	~~The entry 4c6s is ON HOLD until Paper Publication~~	+	Structural basis for assembly and function of a heterodimeric plant immune receptor.,Williams SJ, Sohn KH, Wan L, Bernoux M, Sarris PF, Segonzac C, Ve T, Ma Y, Saucet SB, Ericsson DJ, Casey LW, Lonhienne T, Winzor DJ, Zhang X, Coerdt A, Parker JE, Dodds PN, Kobe B, Jones JD Science. 2014 Apr 18;344(6181):299-303. doi: 10.1126/science.1247357. PMID:24744375<ref>PMID:24744375</ref>

-	~~Authors: Wan~~, L.~~, Williams,~~ S.J.~~, Sohn, K.H.,~~ Bernoux, M., ~~Ma, Y~~., ~~Segonzac, C~~., ~~Ve, T~~., ~~Sarris, P~~., ~~Ericsson, D~~.J., Saucet, S.B., ~~Zhang~~, X., ~~Parker, J~~., ~~Dodds, P.N~~., ~~Jones,~~ J.~~D.G.~~, ~~Kobe, B~~.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of the TIR~~ domain ~~from the Arabidopsis Thaliana disease resistance protein RRS1~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bernoux, M.]]
		+	[[Category: Dodds, P N.]]
		+	[[Category: Ericsson, D J.]]
		+	[[Category: Jones, J D.G.]]
		+	[[Category: Kobe, B.]]
		+	[[Category: Ma, Y.]]
		+	[[Category: Parker, J.]]
		+	[[Category: Sarris, P.]]
		+	[[Category: Saucet, S B.]]
		+	[[Category: Segonzac, C.]]
		+	[[Category: Sohn, K H.]]
		+	[[Category: Ve, T.]]
		+	[[Category: Wan, L.]]
		+	[[Category: Williams, S J.]]
		+	[[Category: Zhang, X.]]
		+	[[Category: Immune system]]
		+	[[Category: Plant tir domain]]
		+	[[Category: Signal transduction]]

OCA at 06:39, 6 November 2013

2013-11-06T06:39:48Z

←Older revision		Revision as of 06:39, 6 November 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4c6s is ON HOLD	+	The entry 4c6s is ON HOLD until Paper Publication

	Authors: Wan, L., Williams, S.J., Sohn, K.H., Bernoux, M., Ma, Y., Segonzac, C., Ve, T., Sarris, P., Ericsson, D.J., Saucet, S.B., Zhang, X., Parker, J., Dodds, P.N., Jones, J.D.G., Kobe, B.		Authors: Wan, L., Williams, S.J., Sohn, K.H., Bernoux, M., Ma, Y., Segonzac, C., Ve, T., Sarris, P., Ericsson, D.J., Saucet, S.B., Zhang, X., Parker, J., Dodds, P.N., Jones, J.D.G., Kobe, B.

	Description: Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1		Description: Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1

OCA: Protected "4c6s" [edit=sysop:move=sysop]

2013-09-29T07:16:30Z

Protected "4c6s" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:16, 29 September 2013

OCA: New page: '''Unreleased structure''' The entry 4c6s is ON HOLD Authors: Wan, L., Williams, S.J., Sohn, K.H., Bernoux, M., Ma, Y., Segonzac, C., Ve, T., Sarris, P., Ericsson, D.J., Saucet, S.B., Z...

2013-09-29T07:16:29Z

New page: '''Unreleased structure''' The entry 4c6s is ON HOLD Authors: Wan, L., Williams, S.J., Sohn, K.H., Bernoux, M., Ma, Y., Segonzac, C., Ve, T., Sarris, P., Ericsson, D.J., Saucet, S.B., Z...

New page

'''Unreleased structure'''

The entry 4c6s is ON HOLD

Authors: Wan, L., Williams, S.J., Sohn, K.H., Bernoux, M., Ma, Y., Segonzac, C., Ve, T., Sarris, P., Ericsson, D.J., Saucet, S.B., Zhang, X., Parker, J., Dodds, P.N., Jones, J.D.G., Kobe, B.

Description: Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1