4c8v - Revision history

OCA at 17:32, 7 September 2022

2022-09-07T17:32:38Z

←Older revision		Revision as of 17:32, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c8v' size='340' side='right'caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4c8v' size='340' side='right'caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Silurana_(xenopus)_tropicalis Silurana (xenopus)~~ tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C8V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C8V FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [https://pdbe.org/4c8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [https://www.ebi.ac.uk/pdbsum/4c8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8v ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [~~http~~://pdbe.org/4c8v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c8v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8v ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).	+	[[https://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and related RNF43 antagonize Wnt signalling. Rspo ligands have been reported to inhibit the ligase activity through direct interaction with ZNRF3 and RNF43. Here we report multiple crystal structures of the ZNRF3 ectodomain (ZNRF3ecto), a signalling-competent Furin1-Furin2 (Fu1-Fu2) fragment of Rspo2 (Rspo2Fu1-Fu2), and Rspo2Fu1-Fu2 in complex with ZNRF3ecto, or RNF43ecto. A prominent loop in Fu1 clamps into equivalent grooves in the ZNRF3ecto and RNF43ecto surface. Rspo binding enhances dimerization of ZNRF3ecto but not of RNF43ecto. Comparison of the four Rspo proteins, mutants and chimeras in biophysical and cellular assays shows that their signalling potency depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2.	+
-		+
-	Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.,Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776<ref>PMID:24225776</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4c8v" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Jones, E Y~~]]	+	[[Category: Xenopus tropicalis]]
-	[[Category: ~~Zebisch, M~~]]	+	[[Category: Jones EY]]
-	[[Category: ~~Lgr4]]~~	+	[[Category: Zebisch M]]
-	~~[[Category: Lgr5]]~~	+
-	~~[[Category: Lgr6]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: R-spo]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Rnf43]]~~	+
-	~~[[Category: Rspo]]~~	+
-	~~[[Category: Rspo1]]~~	+
-	~~[[Category: Rspo3]]~~	+
-	~~[[Category: Rspo4]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Signalling]]~~	+
-	~~[[Category: Wnt]]~~	+
-	~~[[Category: Znrf3~~]]	+

OCA at 06:17, 16 October 2019

2019-10-16T06:17:08Z

←Older revision		Revision as of 06:17, 16 October 2019
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	<StructureSection load='4c8v' size='340' side='right'caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4c8v' size='340' side='right'caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Xenopus_~~(~~silurana~~)_tropicalis ~~Xenopus~~ (~~silurana~~) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8V FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [http://pdbe.org/4c8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [http://www.ebi.ac.uk/pdbsum/4c8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [http://pdbe.org/4c8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [http://www.ebi.ac.uk/pdbsum/4c8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8v ProSAT]</span></td></tr>

OCA at 09:43, 20 March 2019

2019-03-20T09:43:21Z

←Older revision		Revision as of 09:43, 20 March 2019
Line 1:		Line 1:

	==Xenopus RSPO2 Fu1-Fu2 crystal form I==		==Xenopus RSPO2 Fu1-Fu2 crystal form I==
-	<StructureSection load='4c8v' size='340' side='right' caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4c8v' size='340' side='right'caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8V FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8V FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jones, E Y]]		[[Category: Jones, E Y]]
	[[Category: Zebisch, M]]		[[Category: Zebisch, M]]

OCA at 20:51, 4 August 2016

2016-08-04T20:51:51Z

←Older revision		Revision as of 20:51, 4 August 2016
Line 1:		Line 1:
		+
	==Xenopus RSPO2 Fu1-Fu2 crystal form I==		==Xenopus RSPO2 Fu1-Fu2 crystal form I==
	<StructureSection load='4c8v' size='340' side='right' caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4c8v' size='340' side='right' caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8V FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8V FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [http://www.ebi.ac.uk/pdbsum/4c8v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [http://pdbe.org/4c8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [http://www.ebi.ac.uk/pdbsum/4c8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c8v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:32, 24 December 2014

2014-12-24T19:32:26Z

←Older revision		Revision as of 19:32, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [http://www.ebi.ac.uk/pdbsum/4c8v PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [http://www.ebi.ac.uk/pdbsum/4c8v PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:42, 21 December 2014

2014-12-21T18:42:19Z

←Older revision		Revision as of 18:42, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4c8v\| PDB=4c8v \| SCENE= }}~~	+	==Xenopus RSPO2 Fu1-Fu2 crystal form I==
-	===Xenopus RSPO2 Fu1-Fu2 crystal form I===	+	<StructureSection load='4c8v' size='340' side='right' caption='[[4c8v]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24225776}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8V FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9r\|4c9r]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [http://www.ebi.ac.uk/pdbsum/4c8v PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and related RNF43 antagonize Wnt signalling. Rspo ligands have been reported to inhibit the ligase activity through direct interaction with ZNRF3 and RNF43. Here we report multiple crystal structures of the ZNRF3 ectodomain (ZNRF3ecto), a signalling-competent Furin1-Furin2 (Fu1-Fu2) fragment of Rspo2 (Rspo2Fu1-Fu2), and Rspo2Fu1-Fu2 in complex with ZNRF3ecto, or RNF43ecto. A prominent loop in Fu1 clamps into equivalent grooves in the ZNRF3ecto and RNF43ecto surface. Rspo binding enhances dimerization of ZNRF3ecto but not of RNF43ecto. Comparison of the four Rspo proteins, mutants and chimeras in biophysical and cellular assays shows that their signalling potency depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2.

-	~~==Function==~~	+	Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.,Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776<ref>PMID:24225776</ref>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of~~ the ~~canonical~~ Wnt ~~signaling pathway by acting as a ligand for lgr4~~-~~6 receptors~~. ~~Upon binding to lgr4-6 (lgr4~~, ~~lgr5 or lgr6)~~, ~~lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors~~, ~~triggering the canonical Wnt signaling pathway to increase expression of target genes~~. ~~Acts both in the canonical~~. ~~Wnt~~/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4c8v]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024225776</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	[[Category: Jones, E Y.]]	+	</StructureSection>
-	[[Category: Zebisch, M.]]	+	[[Category: Jones, E Y]]
		+	[[Category: Zebisch, M]]
	[[Category: Lgr4]]		[[Category: Lgr4]]
	[[Category: Lgr5]]		[[Category: Lgr5]]

OCA at 08:25, 27 November 2013

2013-11-27T08:25:30Z

←Older revision		Revision as of 08:25, 27 November 2013
Line 1:		Line 1:
	{{STRUCTURE_4c8v\| PDB=4c8v \| SCENE= }}		{{STRUCTURE_4c8v\| PDB=4c8v \| SCENE= }}
	===Xenopus RSPO2 Fu1-Fu2 crystal form I===		===Xenopus RSPO2 Fu1-Fu2 crystal form I===
		+	{{ABSTRACT_PUBMED_24225776}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA].		[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024225776</ref><references group="xtra"/><references/>
	[[Category: Jones, E Y.]]		[[Category: Jones, E Y.]]
	[[Category: Zebisch, M.]]		[[Category: Zebisch, M.]]

OCA at 13:40, 20 November 2013

2013-11-20T13:40:10Z

←Older revision		Revision as of 13:40, 20 November 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4c8v\| PDB=4c8v \| SCENE= }}
		+	===Xenopus RSPO2 Fu1-Fu2 crystal form I===

-	~~The entry 4c8v is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).

-	~~Authors~~: ~~Zebisch, M~~., Jones, E.Y.	+	==About this Structure==
-		+	[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA].
-	~~Description~~: ~~Xenopus RSPO2 Fu1~~-~~Fu2 crystal form I~~	+	[[Category: Jones, E Y.]]
		+	[[Category: Zebisch, M.]]
		+	[[Category: Lgr4]]
		+	[[Category: Lgr5]]
		+	[[Category: Lgr6]]
		+	[[Category: Membrane]]
		+	[[Category: R-spo]]
		+	[[Category: Receptor]]
		+	[[Category: Rnf43]]
		+	[[Category: Rspo]]
		+	[[Category: Rspo1]]
		+	[[Category: Rspo3]]
		+	[[Category: Rspo4]]
		+	[[Category: Signaling protein]]
		+	[[Category: Signalling]]
		+	[[Category: Wnt]]
		+	[[Category: Znrf3]]

OCA: Protected "4c8v" [edit=sysop:move=sysop]

2013-10-10T05:28:35Z

Protected "4c8v" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:28, 10 October 2013

OCA: New page: '''Unreleased structure''' The entry 4c8v is ON HOLD Authors: Zebisch, M., Jones, E.Y. Description: Xenopus RSPO2 Fu1-Fu2 crystal form I

2013-10-10T05:28:34Z

New page: '''Unreleased structure''' The entry 4c8v is ON HOLD Authors: Zebisch, M., Jones, E.Y. Description: Xenopus RSPO2 Fu1-Fu2 crystal form I

New page

'''Unreleased structure'''

The entry 4c8v is ON HOLD

Authors: Zebisch, M., Jones, E.Y.

Description: Xenopus RSPO2 Fu1-Fu2 crystal form I