4c9r - Revision history

OCA at 17:33, 7 September 2022

2022-09-07T17:33:42Z

←Older revision		Revision as of 17:33, 7 September 2022
Line 3:		Line 3:
	<StructureSection load='4c9r' size='340' side='right'caption='[[4c9r]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4c9r' size='340' side='right'caption='[[4c9r]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Silurana_(xenopus)_tropicalis Silurana (xenopus)~~ tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4C9R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C9R FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8u\|4c8u]], [[4c8v\|4c8v]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9r OCA], [https://pdbe.org/4c9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c9r RCSB], [https://www.ebi.ac.uk/pdbsum/4c9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9r ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9r OCA], [~~http~~://pdbe.org/4c9r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4c9r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4c9r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9r ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZNRF3_XENTR ZNRF3_XENTR]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). [[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).	+	[[https://www.uniprot.org/uniprot/ZNRF3_XENTR ZNRF3_XENTR]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and related RNF43 antagonize Wnt signalling. Rspo ligands have been reported to inhibit the ligase activity through direct interaction with ZNRF3 and RNF43. Here we report multiple crystal structures of the ZNRF3 ectodomain (ZNRF3ecto), a signalling-competent Furin1-Furin2 (Fu1-Fu2) fragment of Rspo2 (Rspo2Fu1-Fu2), and Rspo2Fu1-Fu2 in complex with ZNRF3ecto, or RNF43ecto. A prominent loop in Fu1 clamps into equivalent grooves in the ZNRF3ecto and RNF43ecto surface. Rspo binding enhances dimerization of ZNRF3ecto but not of RNF43ecto. Comparison of the four Rspo proteins, mutants and chimeras in biophysical and cellular assays shows that their signalling potency depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2.	+
-		+
-	Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.,Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776<ref>PMID:24225776</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4c9r" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Jones, E Y~~]]	+	[[Category: Xenopus tropicalis]]
-	[[Category: ~~Zebisch, M~~]]	+	[[Category: Jones EY]]
-	[[Category: ~~Lgr4]]~~	+	[[Category: Zebisch M]]
-	~~[[Category: Lgr5]]~~	+
-	~~[[Category: Lgr6]]~~	+
-	~~[[Category: Ligase-signaling protein complex]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: R-spo]]~~	+
-	~~[[Category: R-spondin]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Rnf43]]~~	+
-	~~[[Category: Rspo]]~~	+
-	~~[[Category: Rspo1]]~~	+
-	~~[[Category: Rspo3]]~~	+
-	~~[[Category: Rspo4]]~~	+
-	~~[[Category: Signalling]]~~	+
-	~~[[Category: Wnt~~]]	+

OCA at 09:56, 20 March 2019

2019-03-20T09:56:40Z

←Older revision		Revision as of 09:56, 20 March 2019
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	==Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I==		==Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I==
-	<StructureSection load='4c9r' size='340' side='right' caption='[[4c9r]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4c9r' size='340' side='right'caption='[[4c9r]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9R FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9R FirstGlance]. <br>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jones, E Y]]		[[Category: Jones, E Y]]
	[[Category: Zebisch, M]]		[[Category: Zebisch, M]]

OCA at 06:27, 5 August 2016

2016-08-05T06:27:04Z

←Older revision		Revision as of 06:27, 5 August 2016
Line 1:		Line 1:
		+
	==Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I==		==Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I==
	<StructureSection load='4c9r' size='340' side='right' caption='[[4c9r]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4c9r' size='340' side='right' caption='[[4c9r]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9R FirstGlance]. <br>		<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9R FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8u\|4c8u]], [[4c8v\|4c8v]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8u\|4c8u]], [[4c8v\|4c8v]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c9r RCSB], [http://www.ebi.ac.uk/pdbsum/4c9r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9r OCA], [http://pdbe.org/4c9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c9r RCSB], [http://www.ebi.ac.uk/pdbsum/4c9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4c9r" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 23:50, 24 December 2014

2014-12-24T23:50:56Z

←Older revision		Revision as of 23:50, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4c9r\| PDB=4c9r \| SCENE= }}~~	+	==Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I==
-	===Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I===	+	<StructureSection load='4c9r' size='340' side='right' caption='[[4c9r]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24225776}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4c9r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9R FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4c84\|4c84]], [[4c85\|4c85]], [[4c86\|4c86]], [[4c8a\|4c8a]], [[4c8c\|4c8c]], [[4c8f\|4c8f]], [[4c8p\|4c8p]], [[4c8t\|4c8t]], [[4c8u\|4c8u]], [[4c8v\|4c8v]], [[4c8w\|4c8w]], [[4c99\|4c99]], [[4c9a\|4c9a]], [[4c9e\|4c9e]], [[4c9u\|4c9u]], [[4c9v\|4c9v]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c9r RCSB], [http://www.ebi.ac.uk/pdbsum/4c9r PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/ZNRF3_XENTR ZNRF3_XENTR]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). [[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).		[[http://www.uniprot.org/uniprot/ZNRF3_XENTR ZNRF3_XENTR]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). [[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and related RNF43 antagonize Wnt signalling. Rspo ligands have been reported to inhibit the ligase activity through direct interaction with ZNRF3 and RNF43. Here we report multiple crystal structures of the ZNRF3 ectodomain (ZNRF3ecto), a signalling-competent Furin1-Furin2 (Fu1-Fu2) fragment of Rspo2 (Rspo2Fu1-Fu2), and Rspo2Fu1-Fu2 in complex with ZNRF3ecto, or RNF43ecto. A prominent loop in Fu1 clamps into equivalent grooves in the ZNRF3ecto and RNF43ecto surface. Rspo binding enhances dimerization of ZNRF3ecto but not of RNF43ecto. Comparison of the four Rspo proteins, mutants and chimeras in biophysical and cellular assays shows that their signalling potency depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2.
		+
		+	Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.,Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776<ref>PMID:24225776</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4c9r]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024225776</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
-	[[Category: Jones, E Y.]]	+	== References ==
-	[[Category: Zebisch, M.]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jones, E Y]]
		+	[[Category: Zebisch, M]]
	[[Category: Lgr4]]		[[Category: Lgr4]]
	[[Category: Lgr5]]		[[Category: Lgr5]]

OCA at 08:56, 27 November 2013

2013-11-27T08:56:15Z

←Older revision		Revision as of 08:56, 27 November 2013
Line 1:		Line 1:
	{{STRUCTURE_4c9r\| PDB=4c9r \| SCENE= }}		{{STRUCTURE_4c9r\| PDB=4c9r \| SCENE= }}
	===Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I===		===Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I===
		+	{{ABSTRACT_PUBMED_24225776}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4c9r]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA].	+	[[4c9r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024225776</ref><references group="xtra"/><references/>
	[[Category: Jones, E Y.]]		[[Category: Jones, E Y.]]
	[[Category: Zebisch, M.]]		[[Category: Zebisch, M.]]

OCA at 13:40, 20 November 2013

2013-11-20T13:40:32Z

←Older revision		Revision as of 13:40, 20 November 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4c9r\| PDB=4c9r \| SCENE= }}
		+	===Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I===

-	~~The entry 4c9r is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ZNRF3_XENTR ZNRF3_XENTR]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). [[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).

-	~~Authors~~: ~~Zebisch, M~~., Jones, E.Y.	+	==About this Structure==
-		+	[[4c9r]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9R OCA].
-	~~Description~~: ~~Xenopus ZNRF3 ectodomain in~~ complex ~~with Xenopus RSPO2 Fu1~~-~~Fu2 crystal form I~~	+	[[Category: Jones, E Y.]]
		+	[[Category: Zebisch, M.]]
		+	[[Category: Lgr4]]
		+	[[Category: Lgr5]]
		+	[[Category: Lgr6]]
		+	[[Category: Ligase-signaling protein complex]]
		+	[[Category: Membrane]]
		+	[[Category: R-spo]]
		+	[[Category: R-spondin]]
		+	[[Category: Receptor]]
		+	[[Category: Rnf43]]
		+	[[Category: Rspo]]
		+	[[Category: Rspo1]]
		+	[[Category: Rspo3]]
		+	[[Category: Rspo4]]
		+	[[Category: Signalling]]
		+	[[Category: Wnt]]

OCA: Protected "4c9r" [edit=sysop:move=sysop]

2013-10-10T05:29:35Z

Protected "4c9r" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:29, 10 October 2013

OCA: New page: '''Unreleased structure''' The entry 4c9r is ON HOLD Authors: Zebisch, M., Jones, E.Y. Description: Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I

2013-10-10T05:29:35Z

New page: '''Unreleased structure''' The entry 4c9r is ON HOLD Authors: Zebisch, M., Jones, E.Y. Description: Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I

New page

'''Unreleased structure'''

The entry 4c9r is ON HOLD

Authors: Zebisch, M., Jones, E.Y.

Description: Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I